GB1073213A - Tetracycline derivatives - Google Patents
Tetracycline derivativesInfo
- Publication number
- GB1073213A GB1073213A GB24775/66A GB2477566A GB1073213A GB 1073213 A GB1073213 A GB 1073213A GB 24775/66 A GB24775/66 A GB 24775/66A GB 2477566 A GB2477566 A GB 2477566A GB 1073213 A GB1073213 A GB 1073213A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetracycline
- gentamicin
- methyl
- moles
- formaldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 8
- 229960002180 tetracycline Drugs 0.000 title abstract 8
- 229930101283 tetracycline Natural products 0.000 title abstract 7
- 235000019364 tetracycline Nutrition 0.000 title abstract 7
- 150000003522 tetracyclines Chemical class 0.000 title abstract 4
- 229930182566 Gentamicin Natural products 0.000 abstract 5
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical group O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 4
- 229960002518 gentamicin Drugs 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- RMVMLZHPWMTQGK-SOUFLCLCSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=CC=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O RMVMLZHPWMTQGK-SOUFLCLCSA-N 0.000 abstract 1
- 239000004100 Oxytetracycline Substances 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 abstract 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 abstract 1
- JCSGAUKCDAVARS-UHFFFAOYSA-N demethyltetracycline Natural products CN(C1C(=C(C(C2(C(=C3C(C4=C(C=CC=C4C(C3CC12)O)O)=O)O)O)=O)C(=O)N)O)C JCSGAUKCDAVARS-UHFFFAOYSA-N 0.000 abstract 1
- CEAZRRDELHUEMR-UHFFFAOYSA-N gentamicin Chemical class O1C(C(C)NC)CCC(N)C1OC1C(O)C(OC2C(C(NC)C(C)(O)CO2)O)C(N)CC1N CEAZRRDELHUEMR-UHFFFAOYSA-N 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 229960000625 oxytetracycline Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 tetracycline compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM66209A DE1298100B (de) | 1965-08-04 | 1965-08-04 | Verfahren zur Herstellung von N-Gentamycinomethyltetracyclinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1073213A true GB1073213A (en) | 1967-06-21 |
Family
ID=7311730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB24775/66A Expired GB1073213A (en) | 1965-08-04 | 1966-06-03 | Tetracycline derivatives |
Country Status (6)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3510555A (en) * | 1965-08-04 | 1970-05-05 | Merck Ag E | Antibiotics prepared from tetracycline and gentamicin |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9301557A (es) * | 1992-04-16 | 1993-10-01 | Mexico Quimica Agronomica | Composicion bactericida para ser usada en plantas. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3091572A (en) * | 1962-07-16 | 1963-05-28 | Schering Corp | Gentamycin and method of production |
| DE1298100B (de) * | 1965-08-04 | 1969-06-26 | Merck Ag E | Verfahren zur Herstellung von N-Gentamycinomethyltetracyclinen |
-
1965
- 1965-08-04 DE DEM66209A patent/DE1298100B/de active Pending
-
1966
- 1966-05-06 CH CH658166A patent/CH472437A/de not_active IP Right Cessation
- 1966-06-01 FR FR63682A patent/FR5510M/fr not_active Expired
- 1966-06-03 GB GB24775/66A patent/GB1073213A/en not_active Expired
- 1966-08-03 ES ES0329851A patent/ES329851A1/es not_active Expired
-
1968
- 1968-09-11 US US759163A patent/US3510555A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3510555A (en) * | 1965-08-04 | 1970-05-05 | Merck Ag E | Antibiotics prepared from tetracycline and gentamicin |
Also Published As
| Publication number | Publication date |
|---|---|
| ES329851A1 (es) | 1967-08-16 |
| DE1298100B (de) | 1969-06-26 |
| CH472437A (de) | 1969-05-15 |
| FR5510M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-12-11 |
| US3510555A (en) | 1970-05-05 |
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