GB1024021A - New azepine derivatives and process for their production - Google Patents

New azepine derivatives and process for their production

Info

Publication number
GB1024021A
GB1024021A GB4802063A GB4802063A GB1024021A GB 1024021 A GB1024021 A GB 1024021A GB 4802063 A GB4802063 A GB 4802063A GB 4802063 A GB4802063 A GB 4802063A GB 1024021 A GB1024021 A GB 1024021A
Authority
GB
United Kingdom
Prior art keywords
antagonistic
solvent
reduction
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4802063A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of GB1024021A publication Critical patent/GB1024021A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises dibenzazepine derivatives of the formula <FORM:1024021/C2/1> wherein X and Y independently of each other represent hydrogen or chlorine atoms, Z represents a straight or branched chain alkylene radical having 2 to 4 carbon atoms, R1 represents a hydrogen atom or a C1-4 alkyl radical and R2 represents a C1-4 alkyl radical, and pharmaceutically - acceptable, water - soluble, acid-addition salts thereof. The compounds and their acid-addition salts are prepared by reducing a compound of the formula <FORM:1024021/C2/2> and, if desired, converting the free base obtained into a salt with an inorganic or organic salt. The reduction may be carried out by means of a complex hydride, e.g. lithium aluminium hydride, in the presence of diethyl ether, dibutyl ether, tetrahydrofuran or dioxan as solvent, or sodium borohydride in methanol as solvent. The reduction may also be carried out by means of catalytically activated hydrogen, e.g. Raney nickel or palladium. Pharmaceutical compositions having reserpine - antagonistic, serotonin - antagonistic and cholin-antagonistic activity for oral or parenteral administration comprise a compound of the invention together with a carrier. The compositions may be in the form of aqueous solutions of the salts. Reference has been directed by the Comptroller to Specification 943,275.
GB4802063A 1962-12-06 1963-12-05 New azepine derivatives and process for their production Expired GB1024021A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1432662A CH412907A (en) 1962-12-06 1962-12-06 Process for the production of new azepine derivatives

Publications (1)

Publication Number Publication Date
GB1024021A true GB1024021A (en) 1966-03-30

Family

ID=4399864

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4802063A Expired GB1024021A (en) 1962-12-06 1963-12-05 New azepine derivatives and process for their production

Country Status (6)

Country Link
AT (1) AT243810B (en)
CH (1) CH412907A (en)
DE (1) DE1445827A1 (en)
DK (1) DK103777C (en)
ES (1) ES294197A1 (en)
GB (1) GB1024021A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181655A (en) 1973-08-24 1980-01-01 Research Institute For Medicine And Chemistry Inc. 5(3-Substituted aminopropyl)-10-trifluoromethoxy-5H-dibenz[b,f]azepines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181655A (en) 1973-08-24 1980-01-01 Research Institute For Medicine And Chemistry Inc. 5(3-Substituted aminopropyl)-10-trifluoromethoxy-5H-dibenz[b,f]azepines

Also Published As

Publication number Publication date
CH412907A (en) 1966-05-15
AT243810B (en) 1965-12-10
DK103777C (en) 1966-02-21
ES294197A1 (en) 1964-06-01
DE1445827A1 (en) 1969-09-25

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