GB1015784A - 10 - substituted 1,3 - diazaphenothiazines - Google Patents

10 - substituted 1,3 - diazaphenothiazines

Info

Publication number
GB1015784A
GB1015784A GB3692361A GB3692361A GB1015784A GB 1015784 A GB1015784 A GB 1015784A GB 3692361 A GB3692361 A GB 3692361A GB 3692361 A GB3692361 A GB 3692361A GB 1015784 A GB1015784 A GB 1015784A
Authority
GB
United Kingdom
Prior art keywords
substituted
alkyl
amino
hydroxy
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3692361A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB2195160A priority Critical patent/GB990857A/en
Priority to US123342A priority patent/US3248393A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB3692361A priority patent/GB1015784A/en
Priority to GB3692261A priority patent/GB1014881A/en
Priority to US331903A priority patent/US3337543A/en
Publication of GB1015784A publication Critical patent/GB1015784A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention comprises: (1) the compounds of the general formula <FORM:1015784/C2/1> wherein R is alkyl, aralkyl, aminoalkyl (including N-substituted aminoalkyl) or hydroxyalkyl (including polyhydroxyalkyl) and each of R1, R2, W and X is a hydrogen or halogen atom or an alkyl, alkoxy, or alkylthio group and the preparation thereof by alkylating the corresponding 10-unsubstituted-1,3-diazaphenothiazine, and (2) the compounds of the general formula <FORM:1015784/C2/2> wherein R, R1 and R2 are as defined above, Y is a hydrogen atom, a C1- 4-alkyl, hydroxy, amino, substituted amino (alkylamino, dialkylamino, dialkylaminoalkylamino, 1-pyrrolidyl, 1-piperidyl, 4-morpholinyl or 4-alkyl-1-piperazinyl) group, Z is a hydroxy, mercapto, amino, or substituted amino group (as defined in Y) and B is a hydroxy, amino or substituted amino group and the preparation thereof by ring closure of a compound of the general formula <FORM:1015784/C2/3> Pharmaceutical compositions, having anti-bacterial activity, comprise the 10-substituted 1,3-diazaphenothiazines of the invention. The compositions may be formulated as tablets, capsules, cachets, ampoules, suppositories, powders, granules, solutions, suspensions, emulsions and ointments.
GB3692361A 1960-06-23 1961-10-13 10 - substituted 1,3 - diazaphenothiazines Expired GB1015784A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB2195160A GB990857A (en) 1961-10-13 1960-06-23 1,3-diazaphenothiazines
US123342A US3248393A (en) 1960-06-23 1961-06-05 1, 3-diazaphenothiazines and method
GB3692361A GB1015784A (en) 1961-10-13 1961-10-13 10 - substituted 1,3 - diazaphenothiazines
GB3692261A GB1014881A (en) 1961-10-13 1961-10-13 1,3-diazaphenothiazines and method
US331903A US3337543A (en) 1960-10-28 1963-12-19 Novel method of preparing 1, 3-diazaphenothiazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3692361A GB1015784A (en) 1961-10-13 1961-10-13 10 - substituted 1,3 - diazaphenothiazines

Publications (1)

Publication Number Publication Date
GB1015784A true GB1015784A (en) 1966-01-05

Family

ID=10392273

Family Applications (3)

Application Number Title Priority Date Filing Date
GB2195160A Expired GB990857A (en) 1960-06-23 1960-06-23 1,3-diazaphenothiazines
GB3692361A Expired GB1015784A (en) 1960-06-23 1961-10-13 10 - substituted 1,3 - diazaphenothiazines
GB3692261A Expired GB1014881A (en) 1961-10-13 1961-10-13 1,3-diazaphenothiazines and method

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2195160A Expired GB990857A (en) 1960-06-23 1960-06-23 1,3-diazaphenothiazines

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB3692261A Expired GB1014881A (en) 1961-10-13 1961-10-13 1,3-diazaphenothiazines and method

Country Status (1)

Country Link
GB (3) GB990857A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9567318B2 (en) 2009-08-17 2017-02-14 Memorial Sloan-Kettering Cancer Center Substituted pyrimidine compounds and uses thereof
US9878987B2 (en) 2014-05-13 2018-01-30 Memorial Sloan Kettering Cancer Center HSP70 modulators and methods for making and using the same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3222914A1 (en) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg SUBSTITUTED 5-PHENYLTHIO-6-AMINO-PYRIMIDINONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE, AND PREPARATIONS CONTAINING THESE COMPOUNDS
DE19917785A1 (en) * 1999-04-20 2000-10-26 Bayer Ag New 2,4-diamino-pyrimidine derivatives useful as microbicides in protection of plants and materials and as herbicides
EP3596088A4 (en) 2017-03-17 2021-01-06 The University of Ottawa Azaphenothiazines and azaphenoxazines as antioxidants

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9567318B2 (en) 2009-08-17 2017-02-14 Memorial Sloan-Kettering Cancer Center Substituted pyrimidine compounds and uses thereof
US10052325B2 (en) 2009-08-17 2018-08-21 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
US10758538B2 (en) 2009-08-17 2020-09-01 Memorial Sloan-Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
US9878987B2 (en) 2014-05-13 2018-01-30 Memorial Sloan Kettering Cancer Center HSP70 modulators and methods for making and using the same
US10160729B2 (en) 2014-05-13 2018-12-25 Memorial Sloan Kettering Cancer Center Hsp70 modulators and methods for making and using the same
US10647683B2 (en) 2014-05-13 2020-05-12 Memorial Sloan Kettering Cancer Center Hsp70 modulators and methods for making and using the same

Also Published As

Publication number Publication date
GB1014881A (en) 1965-12-31
GB990857A (en) 1965-05-05

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