GB1013900A - 1,4-benzodiazepine derivatives and a process for the manufacture thereof - Google Patents
1,4-benzodiazepine derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1013900A GB1013900A GB4791264A GB4791264A GB1013900A GB 1013900 A GB1013900 A GB 1013900A GB 4791264 A GB4791264 A GB 4791264A GB 4791264 A GB4791264 A GB 4791264A GB 1013900 A GB1013900 A GB 1013900A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid addition
- group
- alkanoyl
- aralkanoyl
- halogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 206010039897 Sedation Diseases 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- -1 aralkanoyl Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000036280 sedation Effects 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Inductance-Capacitance Distribution Constants And Capacitance-Resistance Oscillators (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17855162A | 1962-03-09 | 1962-03-09 | |
| US240750A US3340253A (en) | 1962-11-28 | 1962-11-28 | Preparation of certain benzodiazepine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1013900A true GB1013900A (en) | 1965-12-22 |
Family
ID=26874429
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4791264A Expired GB1013900A (en) | 1962-03-09 | 1963-03-07 | 1,4-benzodiazepine derivatives and a process for the manufacture thereof |
| GB909463A Expired GB1013229A (en) | 1962-03-09 | 1963-03-07 | A process for the manufacture of benzodiazepine derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB909463A Expired GB1013229A (en) | 1962-03-09 | 1963-03-07 | A process for the manufacture of benzodiazepine derivatives |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE629227A (enrdf_load_stackoverflow) |
| CA (1) | CA976547A (enrdf_load_stackoverflow) |
| CH (2) | CH442326A (enrdf_load_stackoverflow) |
| DE (4) | DE1545955A1 (enrdf_load_stackoverflow) |
| DK (1) | DK127507B (enrdf_load_stackoverflow) |
| ES (1) | ES285854A1 (enrdf_load_stackoverflow) |
| GB (2) | GB1013900A (enrdf_load_stackoverflow) |
| NL (3) | NL7010711A (enrdf_load_stackoverflow) |
| SE (2) | SE328583B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0167920A3 (en) * | 1984-06-26 | 1986-11-05 | Merck & Co. Inc. | Benzodiazepine derivatives and pharmaceutical compositions containing them |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES405260A1 (es) * | 1972-07-28 | 1975-07-01 | Stabilimenti Chim Farmac Riuni | Procedimiento para la preparacion de 3-hidroxi-5-aril-7- sustituidos-1, 3-dihidro-2h-1, 4-benzodiacepin-2-onas. |
| NL173269C (nl) * | 1974-04-30 | 1984-01-02 | Ferrer Int | Werkwijze voor de bereiding van een geneesmiddel met als werkzaam bestanddeel een 1,4-benzodiazepinederivaat, alsmede werkwijze voor de bereiding van het 1,4-benzodiazepinederivaat. |
| DE3413592C2 (de) * | 1984-04-11 | 1986-06-05 | Dolorgiet GmbH & Co KG, 5205 St Augustin | Arzneimittel enthaltend 5-(2-Fluorphenyl)-1,3-dihydro-3-hydroxy-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-on |
-
0
- NL NL289735D patent/NL289735A/xx unknown
-
1963
- 1963-02-21 CH CH222063A patent/CH442326A/de unknown
- 1963-02-21 CH CH1765866A patent/CH457464A/de unknown
- 1963-02-23 DE DE19631545955 patent/DE1545955A1/de active Pending
- 1963-02-23 DE DE19631445873 patent/DE1445873A1/de active Pending
- 1963-02-23 DE DE19631545957 patent/DE1545957A1/de active Pending
- 1963-02-23 DE DE19631545956 patent/DE1545956A1/de active Pending
- 1963-02-27 CA CA869,700A patent/CA976547A/en not_active Expired
- 1963-03-06 BE BE629227A patent/BE629227A/fr unknown
- 1963-03-07 GB GB4791264A patent/GB1013900A/en not_active Expired
- 1963-03-07 GB GB909463A patent/GB1013229A/en not_active Expired
- 1963-03-08 SE SE02566/63A patent/SE328583B/xx unknown
- 1963-03-08 ES ES285854A patent/ES285854A1/es not_active Expired
-
1970
- 1970-07-20 NL NL7010711A patent/NL7010711A/xx unknown
- 1970-07-20 NL NL7010712A patent/NL7010712A/xx unknown
- 1970-09-11 SE SE12424/70A patent/SE361174B/xx unknown
-
1972
- 1972-01-18 DK DK25372A patent/DK127507B/da unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0167920A3 (en) * | 1984-06-26 | 1986-11-05 | Merck & Co. Inc. | Benzodiazepine derivatives and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1545956A1 (de) | 1969-11-20 |
| ES285854A1 (es) | 1963-08-16 |
| SE328583B (enrdf_load_stackoverflow) | 1970-09-21 |
| GB1013229A (en) | 1965-12-15 |
| NL289735A (enrdf_load_stackoverflow) | |
| DE1545957A1 (de) | 1969-12-11 |
| CH457464A (de) | 1968-06-15 |
| CH442326A (de) | 1967-08-31 |
| BE629227A (fr) | 1963-10-21 |
| DE1545955A1 (de) | 1969-11-20 |
| NL7010711A (enrdf_load_stackoverflow) | 1970-10-26 |
| CA976547A (en) | 1975-10-21 |
| SE361174B (enrdf_load_stackoverflow) | 1973-10-22 |
| NL7010712A (enrdf_load_stackoverflow) | 1970-10-26 |
| DE1445873A1 (de) | 1969-04-10 |
| DK127507B (da) | 1973-11-19 |
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