FR2953838B1 - TRISUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDINO [3,4-B] INDOLE) DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE - Google Patents

TRISUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDINO [3,4-B] INDOLE) DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Info

Publication number
FR2953838B1
FR2953838B1 FR0958831A FR0958831A FR2953838B1 FR 2953838 B1 FR2953838 B1 FR 2953838B1 FR 0958831 A FR0958831 A FR 0958831A FR 0958831 A FR0958831 A FR 0958831A FR 2953838 B1 FR2953838 B1 FR 2953838B1
Authority
FR
France
Prior art keywords
pyridino
carboline
trisubstituted
indole
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0958831A
Other languages
French (fr)
Other versions
FR2953838A1 (en
Inventor
Didier Babin
Olivier Bedel
Thierry Gouyon
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0958831A priority Critical patent/FR2953838B1/en
Priority to PCT/FR2010/052653 priority patent/WO2011070299A1/en
Priority to ARP100104537A priority patent/AR079613A1/en
Priority to TW099143088A priority patent/TW201124414A/en
Priority to UY33100A priority patent/UY33100A/en
Publication of FR2953838A1 publication Critical patent/FR2953838A1/en
Application granted granted Critical
Publication of FR2953838B1 publication Critical patent/FR2953838B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
FR0958831A 2009-12-10 2009-12-10 TRISUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDINO [3,4-B] INDOLE) DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE Expired - Fee Related FR2953838B1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR0958831A FR2953838B1 (en) 2009-12-10 2009-12-10 TRISUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDINO [3,4-B] INDOLE) DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
PCT/FR2010/052653 WO2011070299A1 (en) 2009-12-10 2010-12-09 Tri-substituted 9h-beta-carboline (or 9h-pyrido[3,4-b]indole) derivatives, preparation of same and therapeutic use thereof
ARP100104537A AR079613A1 (en) 2009-12-10 2010-12-09 DERIVATIVES OF 9H-BETA-CARBOLINA (OR 9H-PYRIDINE (3,4-B) INDOL) TRISUSTITUIDOS, ITS PREPARATION AND ITS THERAPEUTIC USE
TW099143088A TW201124414A (en) 2009-12-10 2010-12-09 Trisubstituted derivatives of 9H-beta-carboline (or 9H-pyridino[3,4-b]indole), preparation thereof and therapeutic use thereof
UY33100A UY33100A (en) 2009-12-10 2010-12-10 DERIVATIVES OF 9H-BETA-CARBOLINA (OR 9H-PYRIDINE (3,4-B) INDOL) TRISUSTITUIDOS, ITS PREPARATION AND ITS THERAPEUTIC USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0958831A FR2953838B1 (en) 2009-12-10 2009-12-10 TRISUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDINO [3,4-B] INDOLE) DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Publications (2)

Publication Number Publication Date
FR2953838A1 FR2953838A1 (en) 2011-06-17
FR2953838B1 true FR2953838B1 (en) 2012-02-24

Family

ID=42062314

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0958831A Expired - Fee Related FR2953838B1 (en) 2009-12-10 2009-12-10 TRISUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDINO [3,4-B] INDOLE) DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Country Status (5)

Country Link
AR (1) AR079613A1 (en)
FR (1) FR2953838B1 (en)
TW (1) TW201124414A (en)
UY (1) UY33100A (en)
WO (1) WO2011070299A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105330665B (en) * 2015-11-04 2017-10-03 衡阳师范学院 A kind of compound, preparation method and purposes for suppressing kallikrein KLK7
WO2020072675A1 (en) 2018-10-02 2020-04-09 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DK240084D0 (en) * 1984-05-15 1984-05-15 Ferrosan As NEW BETA-CARBOLINE-3-OXADIAZOLYL DERIVATIVES
DE3540653A1 (en) * 1985-11-13 1987-05-14 Schering Ag NEW 3-OXADIAZOLE AND 3-CARBONIC ACID SS-CARBOLINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE3608089A1 (en) * 1986-03-08 1987-09-10 Schering Ag HETEROARYL-OXY-SS-CARBOLINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
AU619203B2 (en) * 1987-08-28 1992-01-23 Schering Aktiengesellschaft Isoxazole-beta-carboline derivatives
PT823909E (en) * 1995-05-05 2002-12-31 British Tech Group Inter Corpo NEW HETEROCYCLIC CHEMISTRY
EP1171438A1 (en) * 1999-04-20 2002-01-16 Novo Nordisk A/S Compounds, their preparation and use
US6492406B1 (en) * 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
JP4599501B2 (en) * 2001-11-07 2010-12-15 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Carboline derivatives as inhibitors of IκB in the treatment of multiple myeloma and other cancers
FR2869540B1 (en) * 2004-04-30 2008-05-16 Centre Nat Rech Scient Cnrse PHARMACEUTICAL COMPOSITIONS CONTAINING B-CARBOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
MY157724A (en) * 2007-04-03 2016-07-15 Array Biopharma Inc IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
AR072084A1 (en) * 2008-06-12 2010-08-04 Sanofi Aventis DERIVATIVES OF AZACARBOLINAS, ITS PREPARATION AND ITS THERAPEUTIC USE AS INHIBITORS OF PIM KINASES

Also Published As

Publication number Publication date
UY33100A (en) 2011-07-29
TW201124414A (en) 2011-07-16
AR079613A1 (en) 2012-02-08
FR2953838A1 (en) 2011-06-17
WO2011070299A1 (en) 2011-06-16

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20130830