FR2953837B1 - DISUBSTITUTED 9H-PYRIDINO [3,4-B] INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE - Google Patents

DISUBSTITUTED 9H-PYRIDINO [3,4-B] INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Info

Publication number
FR2953837B1
FR2953837B1 FR0958830A FR0958830A FR2953837B1 FR 2953837 B1 FR2953837 B1 FR 2953837B1 FR 0958830 A FR0958830 A FR 0958830A FR 0958830 A FR0958830 A FR 0958830A FR 2953837 B1 FR2953837 B1 FR 2953837B1
Authority
FR
France
Prior art keywords
pyridino
disubstituted
preparation
therapeutic use
indole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0958830A
Other languages
French (fr)
Other versions
FR2953837A1 (en
Inventor
Didier Babin
Olivier Bedel
Thierry Gouyon
Alexandre Gross
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0958830A priority Critical patent/FR2953837B1/en
Priority to ARP100104536A priority patent/AR079328A1/en
Priority to TW099143086A priority patent/TW201130833A/en
Priority to PCT/FR2010/052652 priority patent/WO2011070298A1/en
Priority to UY33099A priority patent/UY33099A/en
Publication of FR2953837A1 publication Critical patent/FR2953837A1/en
Application granted granted Critical
Publication of FR2953837B1 publication Critical patent/FR2953837B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0958830A 2009-12-10 2009-12-10 DISUBSTITUTED 9H-PYRIDINO [3,4-B] INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE Expired - Fee Related FR2953837B1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR0958830A FR2953837B1 (en) 2009-12-10 2009-12-10 DISUBSTITUTED 9H-PYRIDINO [3,4-B] INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
ARP100104536A AR079328A1 (en) 2009-12-10 2010-12-09 DERIVATIVES OF 9H-PIRIDINO [3,4-B] INDOL DISPOSED, METHOD TO PREPARE THEM, SYNTHESIS INTERMEDIARIES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN CANCER THERAPY.
TW099143086A TW201130833A (en) 2009-12-10 2010-12-09 Disubstituted 9H-pyridino[3,4-b]indole derivatives, preparation thereof and therapeutic use thereof
PCT/FR2010/052652 WO2011070298A1 (en) 2009-12-10 2010-12-09 Di-substituted 9h-pyrido[3,4-b]indole derivatives, preparation of same and therapeutic use thereof
UY33099A UY33099A (en) 2009-12-10 2010-12-10 DERIVATIVES OF 9H-PIRIDINO [3,4-B] INDOL DISPOSED, METHOD TO PREPARE THEM, SYNTHESIS INTERMEDIARIES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN CANCER THERAPY.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0958830A FR2953837B1 (en) 2009-12-10 2009-12-10 DISUBSTITUTED 9H-PYRIDINO [3,4-B] INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Publications (2)

Publication Number Publication Date
FR2953837A1 FR2953837A1 (en) 2011-06-17
FR2953837B1 true FR2953837B1 (en) 2012-03-09

Family

ID=42062609

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0958830A Expired - Fee Related FR2953837B1 (en) 2009-12-10 2009-12-10 DISUBSTITUTED 9H-PYRIDINO [3,4-B] INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE

Country Status (5)

Country Link
AR (1) AR079328A1 (en)
FR (1) FR2953837B1 (en)
TW (1) TW201130833A (en)
UY (1) UY33099A (en)
WO (1) WO2011070298A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3407B1 (en) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd Tetrahydropyrazolopyrimidine Compounds
CN106588918B (en) * 2016-12-08 2019-02-19 广东省测试分析研究所（中国广州分析测试中心） A kind of preparation method and applications of 3- amino-beta-carboline
US11485734B2 (en) 2018-10-02 2022-11-01 Northwestern University Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DK240084D0 (en) * 1984-05-15 1984-05-15 Ferrosan As NEW BETA-CARBOLINE-3-OXADIAZOLYL DERIVATIVES
DE3540653A1 (en) * 1985-11-13 1987-05-14 Schering Ag NEW 3-OXADIAZOLE AND 3-CARBONIC ACID SS-CARBOLINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
AU619203B2 (en) * 1987-08-28 1992-01-23 Schering Aktiengesellschaft Isoxazole-beta-carboline derivatives
US5502194A (en) 1992-02-19 1996-03-26 Bayer Aktiengesellschaft Process for the preparation of 2-halogeno-pyridine derivatives
DE4233708A1 (en) 1992-10-07 1994-04-14 Ruetgerswerke Ag Process for the preparation of pure 2,5-dichloropyridine and recovery of the 2,3-dichloropyridine obtained as a by-product
ATE223915T1 (en) * 1995-05-05 2002-09-15 British Tech Group Int NEW HETEROCYCLIC CHEMISTRY
AU3958100A (en) * 1999-04-20 2000-11-02 Novo Nordisk A/S New compounds, their preparation and use
US6492406B1 (en) * 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
EP1209158A1 (en) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substituted beta-carbolines
EP1443927B1 (en) * 2001-11-07 2007-01-10 Millennium Pharmaceuticals, Inc. Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma
FR2869540B1 (en) * 2004-04-30 2008-05-16 Centre Nat Rech Scient Cnrse PHARMACEUTICAL COMPOSITIONS CONTAINING B-CARBOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
MY157724A (en) * 2007-04-03 2016-07-15 Array Biopharma Inc IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS
GB0723815D0 (en) * 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds

Also Published As

Publication number Publication date
WO2011070298A1 (en) 2011-06-16
TW201130833A (en) 2011-09-16
UY33099A (en) 2011-07-29
AR079328A1 (en) 2012-01-18
FR2953837A1 (en) 2011-06-17

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Effective date: 20130830