FR2786698A1 - Encapsulated or powdered bacteriostats and bactericides are activated by moisture to neutralize the emission of odors from blood, urine or sweat - Google Patents

Abstract

The use of encapsulated and/or powdered bacteriostats and/or bactericides that are activated by moisture, especially body fluids from the genital tissue and neighboring areas, to neutralize the emission of odors. The bacteriostats and bactericides are preferably encapsulated inside a continuous outer layer that is impermeable to the active material but is water soluble or water degradable and so liberates the active material when wetted or when physically ruptured. The use of microcapsules having a particle size in the range 0.1 - 500 mu m is preferred. The active material is preferably pasty or oily at ambient temperature and is hypoallergenic. The active material may further contain perfumes, emollients, ointments, calming agents, analgesics, decongestants, cicatrizing agents, toning agents, astringents, colors, water and their mixtures.

Description

- 1 - USE OF BACTERIOSTATLIC AND / OR BACTERICIDE AGENTS AS

  AS CARE AND NEUTRALIZATION AGENTS FOR ODOR TRAINING

FIELD OF THE INVENTION

  The present invention relates to a new use of bacteriostatic and / or bactericidal agents for providing skin care and / or neutralizing the formation of odors. It relates more specifically to the use of encapsulated bacteriostatic and / or bactericidal agents which are made active by degradation of their capsule in the presence of water and / or by mechanical rupture of the envelope already partially degraded or not by water, and which consequently act as an effect

  sanitizing, purifying, healing aid, decongestant, calming and anti

  redness, especially in their application to the care of genital and surrounding tissues, and neutralization of the formation of odors sometimes resulting from

The emission of a bodily fluid.

PRIOR ART

  Encapsulation techniques are known, in particular from US-A-4,883,507, US-A-4,490,407, FR-B-2,403,078, FR-B-2,539,626 and FR-A-2,642,329. of a

active ingredient.

  In particular, US-A-4 883 507 describes a method of coating or encapsulating one or more active ingredients, in particular cosmetic ingredients, so as to obtain submicronic particles, that is to say having a medium size less than 1 micrometer, and collecting said particles. This patent teaches that in the form of submicron particles, the

  availability and effectiveness of the coated active ingredient.

  FR-A-2 642 329 describes a technique for coating or encapsulating an active ingredient, in particular a cosmetic compound, which may be liquid. According to this technique is recommended the formation of a coating by surface crosslinking, around the ingredient to be encapsulated, of a film-forming mixture of (i) de-crosslinked collagen and (ii) of a glycosaminoglycan in particular chosen from the group consisting by the substances chondroitin sulfate. The process of

  Preparation of the de-crosslinked collagen is described in Example la of FR-A-2 642 329.

  The operating methods relating to the formation of the de-crosslinked collagen / chondroitin 4-sulfate wall appear in example l c-lg of FR-A-2 642 329 35 according to the work Merchk Index, 1 l1 edition (1989), page 344 (product no. 2217), it is reported that chondroitin sulfate Qu chondroitin sulfuric acid comprises

  in particular chondroitin 4-sulfate and chondroitin 6-sulfate.

  According to another known technique for encapsulating a cosmetic component, which is (i) gaseous or respectively (ii) liquid but volatile, said component is (i) absorbed on a porous support which is coated inside

of a continuous wall.

  The prior art neither describes nor suggests the use of encapsulated bacteriostatic and / or bactericidal agents which would be released in the presence of water and / or by crushing, as a sanitizing, purifying effect, of aid to healing, decongestant, calming, anti-redness and neutralization of odor formation in their application to dressings, diapers, sanitary napkins, panty liners, toilet paper, cotton pads and sticks

cotton swab type.

PURPOSE OF THE INVENT1ON

  There is a need for a means of caring for the skin, in particular of the genital and surrounding tissues, with a sanitizing, purifying, healing aid, decongestant, calming, anti-redness, and neutralization of the formation of odors acting effect. independently, which is reliable, simple without requiring the setting

  with complicated equipment by highly qualified personnel, and quickly.

  To meet this need, it is proposed according to the invention to provide a new technical solution which calls for the use of bacteriostatic agents and / or encapsulated bactericides. In the presence of water and / or by crushing, the wall inside which said bacteriostatic and / or bactericidal agent is housed is

  hydrolyzed, degraded or ruptured, and allows said agent to spread over the epidermis ,.

  The release of the bacteriostatic and / or bactericidal agent constitutes here a

  preventive or curative care.

  This new technical solution is particularly suitable for skin care and for neutralizing the formation of unpleasant odors under the effect of the presence of water, and therefore in the presence of bodily fluids such as urine, blood and sweat, especially in the areas of dressings, diapers, sanitary napkins, panty liners, toilet paper, cotton

  remove makeup and cotton swab stick, bandage.

OBJECT OF THE INVENT1ON

  The new technical solution according to the invention lies in the use of an encapsulated bacteriostatic and / or bactericidal and / or antiseptic agent which, released from its envelope in the presence of water and / or by mechanical rupture, can be distributed on the skin, especially on the genitals and surrounding tissues, and thus induce

  sanitizing, purifying, healing aid, decongestant, calming, anti-

  redness and odor neutralization.

  Thus according to the invention, a new use of an encapsulated bacteriostatic and / or bactericidal agent is recommended, said use being characterized in that use is made of a bacteriostatic and / or bactericidal agent placed inside a continuous-wall coating, said coating being (i) impermeable to said bacteriostatic and / or bactericidal agent, and (ii) water-soluble or degradable by

  water, and in particular by a bodily fluid such as urine, blood or sweat.

  The diffusion of the said bacteriostatic and / or bactericidal agent on the body constituting a means making it possible to carry out a care, in particular with regard to the genital tissues and surrounding, and to neutralize the sometimes unpleasant odors

  resulting from the emission of a bodily fluid.

  DETAILED DESCRIPTION OF THE INVENTION

  The terms "bacteriostatic and / or bactericidal agents" as used herein, designate any product which is generally recommended to obtain a bacteriostatic, bactericidal, antiseptic and / or antibiotic effect, having the main effects of neutralizing and / or destroying bacteria and microbes, and therefore to cleanse, purify, help healing, decongest, calm, avoid redness, especially with regard to the genitals and surrounding tissues and neutralize the sometimes unpleasant odors resulting the emission of bodily fluids, this in a preventive and / or curative way. With regard to this definition, the

  the term "bacteriostatic and / or bactericidal agent" here encompasses any bacteriostatic agent

  tick, bactericide, antiseptic and / or antibiotic proper, natural or synthetic, in the solid, powdery, pasty or oily liquid state, encapsulated or not, in its applications to all soma and / or genital tissue ( or germen)

and neighboring.

  Given the applications of the bacteriostatic and / or bacteriocidal agents encapsulated according to the invention described below, it is preferable rather that said agents are chosen from substances which can be rendered by the presence of water simultaneously pasty or liquid at the temperature ambient (15 "-25 C.) and (ii) hypoallergenic, which do not sting, do not stain the skin,

and don't stain clothes.

  According to the invention, in particular, the bacteriostatic and / or bactericidal agents which are chosen from the group consisting of natural substances of plant origin such as certain essential oils, for example

lavender or rosemary.

  The coating of the bacteriostatic and / or bactericidal agent is a so-called continuous wall envelope. The material of this coating is an organic polymer which is soluble in water or degradable by water but which is impermeable with respect to the bacteriostatic and / or bactericidal agent in an anhydrous medium. Among the polymer materials which are suitable, mention may in particular be made of polyvinyl alcohols, polyacrylic compounds, dextrins, polysacaharides,

  Deregulated collagen / glycosaminoglycan copolymers and mixtures thereof.

  The acrylic compounds generally comprise the polymers obtained from one of the following monomers: acrylic acid, methacrylic acid, lower C 4 -C 4 alkyl acrylate (in particular methyl, ethyl, n- propyl, i-propyl, n-butyl, t-butyl, s-butyl or i-butyl), acrylate

  of lower CA.-C4 hydroxyalkyWe (in particular 2-hydroxyethyl acrylates, 2-

  hydroxypropyl or 2-hydroxy-2methylpropyl), lower C1-C4 methacrylate

  (in particular methyl, ethyl, n-propyl, i-propyl, n-butyl, methacrylates, t-

  butyl, s-butyl or i-butyl), C lower hydroxyalkyl methacrylate, .- C /

  (especially 2-hydroxyethyl, 2-hydroxypropyl or 2hydroxy-2- methacrylates

  methylpropyl), N-vinylpyrolidone, or mixtures of these polymers, or else the products obtained by the copolymerization of these monomers either between themselves or with one or more other ethylenically unsaturated monomers, such as

  in particular styrene, butadiene, isoprene, vinylpyridine, vinyl acetate.

  In practice, in copolymers of the acrylic monomer / other ethylenically unsaturated monomer type, the molar ratio of the acrylic monomers to the said other ethylenically unsaturated monomers will be greater than or equal to

  / 70 and better greater than or equal to 60/40.

  When the water acting on the wall of the microcapsule is a body fluid, such as urine, blood or sweat, one or more of the enzymes contained in said body fluid can facilitate the cleavage of the polymer coating. wall continues or participate in said cleavage. This is the case of the continuous-wall polymer coating constituted by the de-crosslinked collagen / glycosaminoglycan copolymer described in FR-A-6 642 329 which is degraded by the collagenase present in perspiration. From a practical point of view, the encapsulation of the bacteriostatic and / or bactericidal agent is advantageously carried out according to two conventional methods. The first method consists in forming a polymer membrane of the continuous wall type around a droplet of bacteriostatic agent and / or bactericidal liquid oily or pasty. The second method consists in absorbing the oily liquid bacteriostatic and / or bactericidal agent in a porous matrix which is water-soluble or degradable by water, then forming around said matrix.

  porous polymer shell with continuous wall.

  The mechanical rupture of the microcapsule could possibly also occur by pressure and / or friction exerted on the envelope already partially

degraded, or not, by water.

  The dimensions of the encapsulated emollient particles are not critical.

  Particularly, it is possible to use particles having a particle size between nm and 2.5 mm. In practice, particles having a

  particle size between about 0.1 and 500 μm.

  If necessary, it is possible to combine with the bacteriostatic and / or bactericidal agent encapsulated an additive chosen from the group consisting of perfumes, emollients, ointments, calming, decongestant, healing, cleansing, astringent agents, painkillers, dyes, water and mixtures thereof. In practice, said additive (s) will either be encapsulated with the bacteriostatic and / or bactericidal agent, or be encapsulated separately. It will also be possible to condition purified water as a diluting additive to the bacteriostatic and / or bactericidal agent and / or to other active products, in capsules impermeable to said water but degradable by the external action of the bacteriostatic and / or bactericidal agent, additives associated therewith, and / or contained enzymes

in bodily fluids.

  The bacteriostatic and / or bactericidal agent encapsulated according to the invention is particularly useful for providing preventive and / or curative care to the epidermis in the presence of a bodily fluid such as urine, blood and sweat, and avoiding the

  formation or dispersion of unpleasant odors.

  In the field of baby diapers, it suffices to apply and / or introduce the capsules containing the bacteriostatic and / or bactericidal agent: 1) on and / or inside the nonwoven fabric of the diaper direct contact with the skin, 2) in the fibrous layer of said layer. The release of said agent from its continuous-walled polymer envelope resulting from the presence of water and / or

  Crushing provides care and protection, especially to the genital and surrounding tissues

  6- nants, and / or neutralizes unpleasant odors. Diapers for incontinence and

  bedridden will be similar to those described above for babies.

  As a variant, the particles of encapsulated bacteriostatic and / or bactericidal agents can be incorporated into a fibrous web, in particular a non-woven fabric, of the compress type packaged in hermetic packaging, in order to

  to be used as an active manual skin care.

  It is also conceivable to moisten and / or voluntarily crush the micro-capsules of agents already partially degraded or not, of the support of the compress or nonwoven type, to obtain the desired effect. By way of indication and in no way limitative, the release by voluntary act of the active product (s) could be used in applications such as: the support to be removed with bacteriostatic and / or bactericidal active agents, emollients, diluents and / or cleansers; the make-up support with additional release of emollient and foundation;

  the medium to cleanse the epidermis with additional release of cleansing agents

  yants, toners, emollients, perfume; the cotton swab stick with additional emollient agent; wipes; animal bedding, etc. The use of cellulose type fibers at the heart of which said bacteriostatic and / or bactericidal agents would have been impregnated is conceivable for

  the treatments, effects and applications described above.

  The use of bacteriostatic and / or bactericidal agents can possibly-

  ment be conceived as a powder of encapsulated products or not. By way of nonlimiting example, this powder of bacteriostatic and / or bactericidal agents could be added to the litters for domestic animals or of industrial breeding, applied in sports shoes etc., with the aim of preventive action and /

or curative.

  The encapsulated bacteriostatic and / or bactericidal agent which can give off its own odor, apart from the action which it delivers, can also offer the non-negligible advantage of helping to partially mask from the start of its action, the body odors which result from the emission of urine and / or blood, on the one hand, and / or from the breakdown of the components of sweat by the fermentation of microorganisms present on the skin on the other hand. With this in mind, it is possible to incorporate particles of bacteriostatic and / or bactericidal agents encapsulated in a fine fibrous sheet housed inside or applied to underwear. The possible odor of bacteriostatic agents

  and / or bactericides can also serve as an olfactory signal.

  7- Other advantages and characteristics of the invention will be better understood on reading the following examples of embodiments, of course, all of these

  elements is in no way limiting but is provided by way of illustration.

EXAMPLE 1

  Microcapsules are prepared in which the bacteriostatic and / or bactericidal agent in oily form is housed inside a film of de-crosslinked collagen / glycosaminoglycan copolymer according to the above-mentioned FR-A-2 642 329 (grain size of the microcapsules: 0.1 pm). These microcapsules are placed: 1) on and / or in a nonwoven fabric intended to be in direct contact with the skin 2) on and / or in the fibrous web; for applications such as bandages, baby diapers, panty liners, sanitary napkins, cotton pads, toilet paper, cotton swabs. The bacteriostatic and / or bactericidal agent thus conditioned is not released during storage or during the time when the support is dry. The action of the bacteriostatic and / or bactericidal agent occurs only after urination, bleeding

sweating or humidification.

EXAMPLE 2

  Microcapsules are prepared in which the bacteriostatic and / or bactericidal agent is absorbed on a porous matrix housed inside a polymeric coating with a continuous wall, namely the aforementioned collagen / glycosaminoglycan copolymer copolymer (granulometry of the microcapsules: 1 μm ). These microcapsules are placed: 1) on and / or in a nonwoven fabric intended to be in direct contact with the skin 2) on and / or in the fibrous web; for applications such as bandages, baby diapers, panty liners, sanitary napkins, cotton pads, toilet paper, cotton swabs. The bacteriostatic and / or bactericidal agent thus conditioned is not

  not released during storage or during the time the media is dry.

  The action of the bacteriostatic and / or bactericidal agent occurs only after urination,

  bleeding, sweating or humidification.

BEVENDICATIQONIS

  1. Use of bacteriostatic and / or bactericidal agents encapsulated and / or in powder form to be made active in the presence of water, and in particular in the presence of a bodily fluid, for their care action, in particular of the genital and surrounding tissues, and neutralization of odors resulting from the emission of certain

body fluids.

  2. Use of bacteriostatic and / or bactericidal agents encapsulated for their care and neutralizing odor action, said use being characterized in that use is made of a bacteriostatic and / or bactericidal agent placed inside the '' a continuous-wall coating, said coating being (i) impermeable to said bacteriostatic and / or bactericidal agent and (ii) water-soluble or degradable by water, the release of said bacteriostatic and / or bactericidal agent occurring in the presence of water , and in particular in the presence of a bodily fluid and / or due to the mechanical rupture of the envelope already partially degraded by water or

no, by pressure or friction.

  3. Use according to claim 2, characterized in that said bacteriostatic and / or bactericidal agent is chosen from the group consisting of pasty substances and / or oily liquids at room temperature (15-25 ° C.),

and hypoallergenic.

  4. Use according to claim 3, characterized in that said bacteriostatic and / or bactericidal agent is chosen from the group consisting of

  natural substances of plant origin.

  5. Use according to claim 1 or 2, characterized in that said bacteriostatic and / or bactericidal agent is encapsulated in the form of

  microcapsules having a particle size between about 0.1 and 500 µm.

  6. Use according to claims 1 or 4, characterized in that one

  uses the said bacteriostatic and / or bactericidal agent in powder form

encapsulated or not.

  7. Use according to claim 1 or 2, characterized in that the said bacteriostatic and / or bactericidal agent is associated with a substance chosen from the group consisting of perfumes, emollients, ointments, calming, analgesic, decongestant agents , healing, toning, astringent,

  dyes, water and mixtures thereof.