FR2733426A1 - MEDICAL DEVICE FOR FILLING SKIN VOLUME DEFORMATIONS SUCH AS WRINKLES AND SCARS BY INJECTION OF 2 DIFFERENT PHYSICO-CHEMICAL FORMS OF A BIOLOGICAL POLYMER - Google Patents

MEDICAL DEVICE FOR FILLING SKIN VOLUME DEFORMATIONS SUCH AS WRINKLES AND SCARS BY INJECTION OF 2 DIFFERENT PHYSICO-CHEMICAL FORMS OF A BIOLOGICAL POLYMER Download PDF

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Publication number
FR2733426A1
FR2733426A1 FR9505181A FR9505181A FR2733426A1 FR 2733426 A1 FR2733426 A1 FR 2733426A1 FR 9505181 A FR9505181 A FR 9505181A FR 9505181 A FR9505181 A FR 9505181A FR 2733426 A1 FR2733426 A1 FR 2733426A1
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France
Prior art keywords
microspheres
polymer
scars
wrinkles
medical device
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Granted
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FR9505181A
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French (fr)
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FR2733426B1 (en
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Priority to FR9505181A priority Critical patent/FR2733426B1/en
Priority to PCT/FR1996/000636 priority patent/WO1996033751A1/en
Priority to FR9605224A priority patent/FR2733427B1/en
Priority to AU57667/96A priority patent/AU5766796A/en
Publication of FR2733426A1 publication Critical patent/FR2733426A1/en
Application granted granted Critical
Publication of FR2733426B1 publication Critical patent/FR2733426B1/en
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Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/044—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof

Abstract

Dual-phase compositions containing a polymer selected from hyaluronic acid and its salts, method for preparing the compositions, and filler material useful in corrective and plastic surgery based on said dual-phase compositions. The compositions comprise an injectable suspension with a dispersed phase composed of insoluble fragments of a hydrogel of said strongly cross-linked polymer and a continuous phase composed of an aqueous solution of said polymer and/or another biocompatible polymer, selected from proteins, polysaccharides and derivatives thereof, non cross-linked or weakly cross-linked.

Description

La présente invention concerne un dispositif médical destiné au comblement des défauts de volume de la peau, notamment les rides et cicatrices du visage, mais pouvant aussi s'appliquer à d'autres défauts de volume situés endehors du visage; ce dispositif est destiné à être introduit dans la peau par injection.The present invention relates to a medical device intended for filling volume defects in the skin, in particular facial wrinkles and scars, but which can also be applied to other volume defects located outside the face; this device is intended to be introduced into the skin by injection.

Traditionnellement le comblement des défauts de la peau tels que rides et cicatrices est effectué à l'aide de produits biologiques liquides comportant une seule phase physico-chimique , ou par des produits synthétiques, ou par des produits solides (fils ou bandelettes).Traditionally the filling of skin defects such as wrinkles and scars is carried out using liquid biological products comprising a single physicochemical phase, or by synthetic products, or by solid products (threads or strips).

Les polymères biologiques actuellement employés ne permettent pas un temps de comblement important du fait que leur forme liquide ou gel se degrade par métabolisation cellulaire très rapide; ou que les formes rendues plus stables par polymérisation, qui se dégradent moins vite, deviennent difficiles à injecter à cause de la viscosité, si on les polymérise trop fortement, limitant ainsi par la forme physique l'effet dans le temps du comblement.The biological polymers currently used do not allow a significant filling time because their liquid or gel form degrades by very rapid cellular metabolism; or that the forms made more stable by polymerization, which degrade less quickly, become difficult to inject because of the viscosity, if they are polymerized too strongly, thus limiting the physical effect of the filling time.

Les polymères synthétiques également employés dans cette application sont beaucoup plus mal tolérés, moins biocompatibles,
plus inflammatoires, et présentent plus d'inconvénients que d'avantages, d'autant plus que leur non biodégradabilité peut être dangeureuse en cas de réaction inflammatoire retardée, traduite dans la littérature par la description fréquente de granulomes.The synthetic polymers also used in this application are much more poorly tolerated, less biocompatible,
more inflammatory, and have more disadvantages than advantages, especially since their non-biodegradability can be dangerous in the event of a delayed inflammatory reaction, translated in the literature by the frequent description of granulomas.

La présente invention se propose de diminuer tous ces inconvénients. Elle associe en fait deux formes physico-chimiques différentes d'un même polymère d'origine biologique, pouvant être soit une protéïne animale ou végétale, soit un glycosaminoglycanne comme l'acide hyaluronique, obtenu par une extraction et purification faisant appel aux techniques de la biochimie extractive, ou par culture cellulaire suivie d'une extraction purification, puis transformés si nécessaire pour diminuer leur catabolisme par polymérisation ou pontage intercaténaire (réticulation) Ces deux formes physico-chimiques étant la microsphère en suspension dans un gel.The present invention proposes to reduce all these drawbacks. It actually combines two different physicochemical forms of the same polymer of biological origin, which can either be an animal or vegetable protein, or a glycosaminoglycan such as hyaluronic acid, obtained by extraction and purification using the techniques of extractive biochemistry, or by cell culture followed by an extraction purification, then transformed if necessary to reduce their catabolism by polymerization or intercatenary bypass (crosslinking) These two physicochemical forms being the microsphere suspended in a gel.

L'association au sein d'une suspension complexe de ces deux formes physico-chimiques différentes que sont les microsphères et un gel, permettent la mise en place d'un polymère biocompatible très polymérisé sous forme physique solide (la microsphère), forme qui augmente le temps de métabolisation, avec un gel du même polymère qui sert de vecteur d'injection dans la peau, cette association réalise une synergie entre les deux présentations dans la mesure ou chaque forme physico-chimique a une fonction particulière de comblement durable, et de vecteur d'introduction, permettant une meilleure biocompatibilité car il n'y a pas d'utilisation de solvant.L'association des deux composants ayant une durée de vie dans la peau plus longue que chacun des constituants seuls.The association within a complex suspension of these two different physicochemical forms that are microspheres and a gel, allow the establishment of a biocompatible polymer highly polymerized in solid physical form (the microsphere), a form which increases the time of metabolization, with a gel of the same polymer which serves as a vector for injection into the skin, this association achieves a synergy between the two presentations insofar as each physico-chemical form has a particular function of lasting filling, and of vector of introduction, allowing a better biocompatibility because there is no use of solvent. The association of the two components having a longer lifespan in the skin than each of the constituents alone.

Les microsphères ont un diamètre compris entre 15 et 50 microns, mensurations qui leur évitent d'être métabolisées et phagocytées, elles sont obtenues par vaporisation-séchage, ou lyophilisation et
proviennent de produits déjà commercialisés et disponibles à
l'achat. Elles peuvent être constituées, par exemple de collagène ou d'acide hyaluronique. Les microsphères insolubles sont mises en suspension dans un gel à une concentration telle que le volume des microsphères représente plus de 50% du volume total de la suspension.The microspheres have a diameter between 15 and 50 microns, measurements which prevent them from being metabolized and phagocytosed, they are obtained by vaporization-drying, or lyophilization and
come from products already marketed and available at
purchase. They can consist, for example, of collagen or hyaluronic acid. The insoluble microspheres are suspended in a gel at a concentration such that the volume of the microspheres represents more than 50% of the total volume of the suspension.

Une variante de l'invention est telle que les microsphères peuvent être mises en suspension dans un gel constitué d'un polymère biologique différent dans sa composition chimique et sa nature. A variant of the invention is such that the microspheres can be suspended in a gel made up of a biological polymer different in its chemical composition and its nature.

Claims (4)

REVENDICATIONS 1/ Dispositif médical pour le comblement des rides et cicatrices de la peau, caractérisé par l'association d'un polymère naturel biologique tel que glycosaminoglycanne ou protéïne d'origine animale ou végétale, obtenu par extraction et purification ou culture cellulaire,copolymérisé par pontage intercaténaire, puis transformé en microsphères, avec un gel du même polymère réticulé ou non; l'association formant une suspension des microsphères dans le gel telle que le volume des microsphères ne soit pas inférieur à 50% du volume total de la suspension.1 / Medical device for the filling of wrinkles and scars of the skin, characterized by the association of a natural biological polymer such as glycosaminoglycan or protein of animal or vegetable origin, obtained by extraction and purification or cell culture, copolymerized by bridging intercatenary, then transformed into microspheres, with a gel of the same crosslinked polymer or not; the combination forming a suspension of the microspheres in the gel such that the volume of the microspheres is not less than 50% of the total volume of the suspension. 2/ Dispositif selon la revendication numéro 1 caractérisé par le fait que les dimensions des microsphères soient comprises entre 15 et 50 microns.2 / Device according to claim number 1 characterized in that the dimensions of the microspheres are between 15 and 50 microns. 3/ Dispositif selon les revendications 1 et 2 caractérisé aussi par le fait que le gel est de même nature que les microsphères en suspension, ou d'une nature telle que les deux composants réalisent une synergie permettant une meilleure biocompatibilité, une durée de comblement (effet) plus long que l'un des deux composants injectés seul. 3 / Device according to claims 1 and 2 also characterized in that the gel is of the same nature as the microspheres in suspension, or of a nature such that the two components achieve a synergy allowing better biocompatibility, a filling time ( effect) longer than one of the two components injected alone. 4/ Dispositif selon les revendications précedentes caractérisé aussi par le fait que les composants sont toujours des polymères transformés ou non d'origine biologique. 4 / Device according to the preceding claims also characterized in that the components are always polymers transformed or not of biological origin.
FR9505181A 1995-04-25 1995-04-25 MEDICAL DEVICE FOR FILLING SKIN VOLUME DEFORMATIONS SUCH AS WRINKLES AND SCARS BY INJECTION OF 2 DIFFERENT PHYSICO-CHEMICAL FORMS OF A BIOLOGICAL POLYMER Expired - Lifetime FR2733426B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR9505181A FR2733426B1 (en) 1995-04-25 1995-04-25 MEDICAL DEVICE FOR FILLING SKIN VOLUME DEFORMATIONS SUCH AS WRINKLES AND SCARS BY INJECTION OF 2 DIFFERENT PHYSICO-CHEMICAL FORMS OF A BIOLOGICAL POLYMER
PCT/FR1996/000636 WO1996033751A1 (en) 1995-04-25 1996-04-25 Injectable hyaluronic acid-containing dual-phase compositions, particularly useful in corrective and plastic surgery
FR9605224A FR2733427B1 (en) 1995-04-25 1996-04-25 INJECTABLE BIPHASIC COMPOSITIONS CONTAINING HYALURONIC ACID, ESPECIALLY USEFUL IN REPAIRING AND AESTHETIC SURGERIES
AU57667/96A AU5766796A (en) 1995-04-25 1996-04-25 Injectable hyaluronic acid-containing dual-phase composition s, particularly useful in corrective and plastic surgery

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9505181A FR2733426B1 (en) 1995-04-25 1995-04-25 MEDICAL DEVICE FOR FILLING SKIN VOLUME DEFORMATIONS SUCH AS WRINKLES AND SCARS BY INJECTION OF 2 DIFFERENT PHYSICO-CHEMICAL FORMS OF A BIOLOGICAL POLYMER

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FR2733426A1 true FR2733426A1 (en) 1996-10-31
FR2733426B1 FR2733426B1 (en) 1997-07-18

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009787A1 (en) * 2000-07-31 2002-02-07 Iscience Corporation Microparticulate biomaterial composition for medical use
US8574629B2 (en) 2008-08-01 2013-11-05 Anteis S.A. Injectable hydrogel with an enhanced remanence and with an enhanced ability to create volume
US9339590B2 (en) * 2006-02-24 2016-05-17 Cutanea Life Sciences, Inc. Biomaterial, injectable implant comprising it, its method of preparation and its uses
CN107281549A (en) * 2010-11-23 2017-10-24 艾拉斯塔根私人有限公司 The preparation for the protein being crosslinked with polysaccharide and/or preparation

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764514B1 (en) 1997-06-13 1999-09-03 Biopharmex Holding Sa IMPLANT INJECTED IN SUBCUTANEOUS OR INTRADERMAL WITH CONTROLLED BIORESORBABILITY FOR REPAIR OR PLASTIC SURGERY AND AESTHETIC DERMATOLOGY
ITFI980104A1 (en) * 1998-05-04 1999-11-04 Hibiscus S R L STABILIZED COMPOSITIONS CONTAINING HYALURONIC ACID, THEIR PREPARATION AND USE
FR2780730B1 (en) * 1998-07-01 2000-10-13 Corneal Ind INJECTABLE BIPHASIC COMPOSITIONS, ESPECIALLY USEFUL IN RESTORATIVE AND AESTHETIC SURGERIES
CN1157191C (en) * 1998-11-10 2004-07-14 电气化学工业株式会社 Hyaluronic acid gel, process for preparation thereof and medical materials containing the same
FR2819722B1 (en) * 2001-01-19 2006-11-24 Corneal Ind USE OF HYALURONIC ACID OR AT LEAST ONE OF ITS SALTS IN THE CONTEXT OF A SURGICAL TREATMENT OF PRESBYOPIA
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
FR2850282B1 (en) 2003-01-27 2007-04-06 Jerome Asius INJECTABLE IMPLANT BASED ON CERAMIC FOR THE FILLING OF WRINKLES, CUTANEOUS DEPRESSIONS AND SCARS, AND ITS PREPARATION
FR2861734B1 (en) 2003-04-10 2006-04-14 Corneal Ind CROSSLINKING OF LOW AND HIGH MOLECULAR MASS POLYSACCHARIDES; PREPARATION OF INJECTABLE SINGLE PHASE HYDROGELS; POLYSACCHARIDES AND HYDROGELS OBTAINED
JP2007527279A (en) 2004-01-23 2007-09-27 アラーガン、インコーポレイテッド One-piece adjustable gastric band that can be fixed removably
FR2865737B1 (en) 2004-02-03 2006-03-31 Anteis Sa BIOCOMPATIBLE RETICLE GEL
US20060040895A1 (en) * 2004-08-19 2006-02-23 Kipling Thacker Aesthetic use of hyaluronan
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
FR2909560B1 (en) * 2006-12-06 2012-12-28 Fabre Pierre Dermo Cosmetique HYALURONIC ACID GEL FOR INTRADERMAL INJECTION
US7776840B2 (en) 2007-02-21 2010-08-17 Cutanea Life Sciences, Inc. Methods of use of biomaterial and injectable implant containing biomaterial
JP5670196B2 (en) 2007-11-16 2015-02-18 バイセプト セラピューティクス、インク． Compositions and methods for treating purpura
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
FR2924615B1 (en) 2007-12-07 2010-01-22 Vivacy Lab HYDROGEL COHESIVE BIODEGRADABLE.
WO2009079555A2 (en) 2007-12-17 2009-06-25 Anna Love Soft tissue filler
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
ES2829971T3 (en) 2008-09-02 2021-06-02 Tautona Group Lp Hyaluronic acid threads and / or derivatives thereof, methods to manufacture them and uses thereof
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US8840541B2 (en) 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
KR101764451B1 (en) 2010-03-12 2017-08-02 알러간 인더스트리 에스에이에스 A Fluid Composition Comprising A Hyaluronan Polymer and Mannitol For Improving Skin Condition
PL3078388T3 (en) 2010-03-22 2019-08-30 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
KR102312056B1 (en) 2011-06-03 2021-10-12 알러간 인더스트리 에스에이에스 Dermal filler compositions including antioxidants
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
TWI424007B (en) 2011-12-22 2014-01-21 Ind Tech Res Inst Method for crosslinking a colloid, and crosslinked colloid therefrom
WO2014198406A1 (en) * 2013-06-11 2014-12-18 Anteis S.A. Method for crosslinking hyaluronic acid; method for preparing an injectable hydrogel; hydrogel obtained; use of the obtained hydrogel
FR3006689A1 (en) * 2013-06-11 2014-12-12 Benedicte Vincente Tauzin PROCESS FOR CROSSLINKING HYALURONIC ACID; PROCESS FOR PREPARING AN INJECTABLE HYDROGEL; HYDROGEL OBTAINED; USE OF HYDROGET OBTAINED
ES2761558T3 (en) 2014-09-30 2020-05-20 Allergan Ind Sas Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
GB201616838D0 (en) * 2016-10-04 2016-11-16 Nat Univ Ireland Hyaluronan compositions, and uses thereof in treatment of interstitial cystitis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013755A1 (en) * 1992-01-16 1993-07-22 Coletica Injectable composition containing collagen microcapsules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013755A1 (en) * 1992-01-16 1993-07-22 Coletica Injectable composition containing collagen microcapsules

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009787A1 (en) * 2000-07-31 2002-02-07 Iscience Corporation Microparticulate biomaterial composition for medical use
US9339590B2 (en) * 2006-02-24 2016-05-17 Cutanea Life Sciences, Inc. Biomaterial, injectable implant comprising it, its method of preparation and its uses
US10086111B2 (en) * 2006-02-24 2018-10-02 Cutanea Life Sciences, Inc. Biomaterial, injectable implant comprising it, its method of preparation and its uses
US8574629B2 (en) 2008-08-01 2013-11-05 Anteis S.A. Injectable hydrogel with an enhanced remanence and with an enhanced ability to create volume
CN107281549A (en) * 2010-11-23 2017-10-24 艾拉斯塔根私人有限公司 The preparation for the protein being crosslinked with polysaccharide and/or preparation
CN107281549B (en) * 2010-11-23 2021-10-15 爱力根制药国际有限公司 Preparation and/or formulation of proteins cross-linked with polysaccharides

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WO1996033751A1 (en) 1996-10-31
AU5766796A (en) 1996-11-18

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