FR2696318A1 - Insecticidal compsns. against head-lice, body lice, fleas, etc. - contain antioxidants as well as insecticides including essential oils. - Google Patents

Insecticidal compsns. against head-lice, body lice, fleas, etc. - contain antioxidants as well as insecticides including essential oils. Download PDF

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Publication number
FR2696318A1
FR2696318A1 FR9212170A FR9212170A FR2696318A1 FR 2696318 A1 FR2696318 A1 FR 2696318A1 FR 9212170 A FR9212170 A FR 9212170A FR 9212170 A FR9212170 A FR 9212170A FR 2696318 A1 FR2696318 A1 FR 2696318A1
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Prior art keywords
lice
antioxidants
fleas
insecticides
essential oils
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FR9212170A
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FR2696318B1 (en
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Sincholle Daniel
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Medicinal or cosmetic compsns. (I) for use against lice, comprise a mixt. of insecticides and antioxidants at 0.5-10 wt.%. The compsn. is obtd. and stabilised by dilution and suspension of the active ingredients in an aq. or hydro-organic base. It is in the form of lotions, shampoos, milks, gels, collars or hair accessories. For use against fleas it contains essential oils at 2-10 wt.% associated with antioxidants at 0.1-5 wt.%. USE/ADVANTAGE - (I) are used to treat infestations of lice(pediculus capitis) and their nits and related parasites (p. humans and p. pubis) in man and animals, and in animals, partic. dogs and cats, to reduce or destroy fleas and ticks. (I) can be used in a delayed release form in animal collars, head-bands and the side-pieces of spectacles. Compsns. of prior art pose problems of insecticide resistance, local intolerance, bad odour and in the destruction of nits, limited efficacy. The antioxidants in (I) interfere with sclerotization and hence envelope formation in the nit, glue to the hair and exoskeleton formation. Thus the sensitivity to insecticides is increased possibly allowing reduced dosages.

Description

- Description
La présente invention concerne des préparations médicamenteuses ou d'hygiène corporelle, solides, liquides (y compris les compresses dermatologiques imprégnées) ou pâteuses, permettant d'éloigner etlou d'éliminer les parasites du corps, des cheveux, du cuir chevelu et des poils de l'homme et des animaux. Elle concerne des préparations médicinales ou d'hygiène corporelle contenant àtitre de principe actif, un mélange d'insecticides et de substances connues pour leurs propriétés anti -oxydantes. - Description
The present invention relates to medicinal or personal hygiene preparations, solid, liquid (including impregnated dermatological compresses) or pasty, making it possible to remove and / or eliminate parasites from the body, hair, scalp and body hair. humans and animals. It relates to medicinal preparations or personal hygiene containing as active ingredient, a mixture of insecticides and substances known for their antioxidant properties.

Les préparations pâteuses ou liquides, par exemple en pommade, en gel, en lotion, en shampoing ou en crème, ou sous forme de compresses imprégnées, pourront être utilisées plus particulièrement en dermatologie et en cosmétologie ou en parasitologie pour traiter les infestations du corps ou partie de corps de l'homme ou des animaux par un parasite comme le poux (pédiculus capitis) et ses lentes ou des espèces de parasites voisins (p. humanus, p. pubis). Chez les animaux, en particulier les chiens et les chats, l'invention pourra être utilisée comme moyen efficace pour éloigner et ou détruire les puces et les tiques. Pasty or liquid preparations, for example as an ointment, gel, lotion, shampoo or cream, or in the form of impregnated compresses, may be used more particularly in dermatology and cosmetology or parasitology to treat infestations of the body or part of the body of man or animals by a parasite such as lice (pediculus capitis) and its nits or neighboring parasite species (p. humanus, p. pubis). In animals, in particular dogs and cats, the invention can be used as an effective means to repel and or destroy fleas and ticks.

Le traitement des parasitoses superficielles, notamment les pédiculoses du cuir chevelu, est classiquement réalisé par utilisation localisée d'insecticides en lotion ou en shampoing. Au fil des années, I'emploi des méthodes traditionnelles faisant appel aux insecticides classiques a généré quelques inconvénients dont l'apparition de résistances des insectes aux produits, une mauvaise tolérance locale, des problèmes de mauvaise odeur, une efficacité partielle pour détruire les lentes. The treatment of superficial parasitosis, in particular pediculosis of the scalp, is conventionally carried out by localized use of insecticides in lotion or in shampoo. Over the years, the use of traditional methods using conventional insecticides has generated some drawbacks, including the appearance of insect resistance to the products, poor local tolerance, bad odor problems, partial effectiveness in destroying nits.

L'invention repose sur le fait que le phénomène de sclérotization, qui intervient à plusieurs stades de la vie des insectes (formation de l'enveloppe de la lente, glue adhésive sur le cheveu, formation de l'exosquelette) nécessiterait l'intervention de composés phénoliques, passage par oxydation à un stade quinone, conduisant à la formation d'un polymère biologique. En bloquant le stade d'oxydation, la physiologie de l'insecte est profondément modifiée, sa sensibilité aux substances toxiques considérablement augmentée pour chacune des étapes mentionnées plus haut.C'est ainsi que des substances qui n'étaient pas totalement létales à certaines concentrations deviennent mortelles aux mêmes concentrations pour l'insecte dont la cuticule a été fragilisée, que la glue fait preuve d'une force d'adhésion plus faible sur le cheveu, et que l'enveloppe de la lente devient fragile et plus perméable aux substances toxiques
L'invention repose sur la démonstration de l'effet synergique qui existe entre certaines substances reconnues pour leur propriétés insecticides et les substances anti-oxydantes présentent dans la formule.The invention is based on the fact that the phenomenon of sclerotization, which occurs at several stages of the life of insects (formation of the envelope of the slow, adhesive glue on the hair, formation of the exoskeleton) would require the intervention of phenolic compounds, passage by oxidation to a quinone stage, leading to the formation of a biological polymer. By blocking the oxidation stage, the physiology of the insect is profoundly modified, its sensitivity to toxic substances considerably increased for each of the stages mentioned above. This is how substances which were not completely lethal at certain concentrations become lethal at the same concentrations for the insect whose cuticle has been weakened, that the glue shows a weaker adhesion force on the hair, and that the envelope of the lentil becomes fragile and more permeable to toxic substances
The invention is based on the demonstration of the synergistic effect which exists between certain substances recognized for their insecticidal properties and the antioxidant substances present in the formula.

L'invention, en permettant d'utiliser des doses d'insecticides plus faibles que celles habituellement utilisées, s'inscrit dans le courant écologique actuel et permet de prendre en compte l'environnement de l'homme et de préserver la qualité de la vie. The invention, by making it possible to use lower doses of insecticides than those usually used, is part of the current ecological current and makes it possible to take into account the environment of man and to preserve the quality of life. .

L'inventeur a découvert et mis en évidence que certaines compositions étudiées présentent, indépendamment des propriétés thérapeutiques traditionnelles, comme par exemple les propriétés anthelmintiques de certaines huiles essentielles, la remarquable propriété d'éloigner et d'éliminer les poux et de détruire les oeufs de ces parasites (lentes), alors même que cette dernière activité est extrêmement difficile à obtenir avec les traitements classiques disponibles commercialement, et que des solutions aqueuses ou hydro-organiques préparées par mélange ou émulsification de certaines substances insecticides, dans un solvant approprié, permettent d'obtenir ces
résultats.The inventor has discovered and demonstrated that certain compositions studied exhibit, independently of traditional therapeutic properties, such as for example the anthelmintic properties of certain essential oils, the remarkable property of repelling and eliminating lice and destroying eggs. these parasites (slow), even though this latter activity is extremely difficult to obtain with the conventional treatments available commercially, and that aqueous or hydro-organic solutions prepared by mixing or emulsifying certain insecticidal substances, in an appropriate solvent, make it possible to 'get these
results.

A titre d'exemple, nous donnons ci-après les expériences entreprises avec deux lotions hydro-alcooliques contenant, pour la première (solution 1), 2 p. cent d'huile essentielle de Niaouli, 1 p. cent d'huile essentielle d'aspic, 1 p. cent d'huile essentielle de lavande, 5 p. cent de polysorbate 80 , 40 p.cent d'alcool éthylique et
eau purifiée qsp 100 mi; la deuxième solution (solution 2) est identique à la première, avec en plus 0,2 % de l'anti-oxydant: butylhydroxyanisole, et de l'eau prise comme témoin.As an example, we give below the experiments undertaken with two hydro-alcoholic lotions containing, for the first (solution 1), 2 p. hundred Niaouli essential oil, 1 p. cent of aspic essential oil, 1 p. cent of lavender essential oil, 5 p. one hundred polysorbate 80, 40 percent ethyl alcohol and
purified water qs 100 mi; the second solution (solution 2) is identical to the first, with an additional 0.2% of the antioxidant: butylhydroxyanisole, and water taken as a control.

Les experiences ont été realisees sur des poux et sur les lentes prélevés ou observés sur des chevelures d'enfants.  The experiments were carried out on lice and on nits taken or observed on children's hair.

Les lotions à l'étude sont laissées en contact 10 minutes avec les cheveux,
puis rinçées trois fois à l'eau.The study lotions are left in contact with the hair for 10 minutes,
then rinsed three times with water.

Viabilité des poux : en % de survivants
lotion 1 lotion 2 eau
50 5 100
Viabilité des lentes en %
20 0 100
Présence des lentes dans les cheveux 48 heures après + ~ I I I
En conséquence, la présente invention a pour objet des compositions médicamenteuses ou d'hygiène corporelle pour éloigner ou détruire les parasites des hommes ou des animaux comme les poux et leurs lentes, caractérisées en ce qu'elles contiennent à titre de principe actif un mélange de substances ayant des propriétés insecticides et de substances anti-oxydantes.Viability of lice: in% of survivors
lotion 1 lotion 2 water
50 5 100
Nit viability in%
20 0 100
Presence of nits in the hair 48 hours after + ~ III
Consequently, the subject of the present invention is medicinal or body hygiene compositions for repelling or destroying parasites from humans or animals such as lice and their nits, characterized in that they contain, as active principle, a mixture of substances with insecticidal properties and antioxidant substances.

Les compositions de l'invention peuvent
contenir un mélange de substances insecticides et de
substances anti-oxydantes à la concentration de 0,5 à 10%
en poids. Lorsqu'on utilise des huiles essentielles en
tant qu'insecticides, le mélange d'huiles essentielles
peut représenter de 2 à 10% en poids et les substances
anti-oxydantes de 0,1 à 5% en poids.The compositions of the invention can
contain a mixture of insecticidal substances and
antioxidant substances at a concentration of 0.5 to 10%
in weight. When using essential oils in
as insecticides, the mixture of essential oils
can represent from 2 to 10% by weight and the substances
antioxidants from 0.1 to 5% by weight.

Les préparations médicamenteuses ou d'hygiène corporelle selon l'invention
peuvent être présentées sous toutes les formes utilisées en thérapeutique ou en
cosmétologie, crème ou gel en pots ou en tubes, lait, lotion en flacon de verre ou
de plastique, en ampoules ou en flacons doseurs, flacons uni-doses ou
multi-doses, en dispositif à libération retardée comme les colliers anti-parasitaires
pour les êtres humains et pour les animaux ou en application sur des accessoires de la chevelure comme les bandeaux serre-tête, ou les branches de lunettes
imprégnées. The medicinal or personal hygiene preparations according to the invention
can be presented in all forms used in therapy or in
cosmetology, cream or gel in jars or tubes, milk, lotion in glass bottle or
of plastic, in ampoules or in dosing bottles, single-dose bottles or
multi-dose, in delayed release device like anti-parasitic collars
for humans and animals or applied to hair accessories such as headbands, or the branches of glasses
impregnated.

Les substances reconnues comme insecticides pourront être utilisées comme les dérivés du pyrethre, la permethrine, la phenothrine, les hormones mimiques comme le methoprène, le malathion, la rotenone, le benzoate de benzyle, les
huiles essentielles riches en cinéol, particulièrement l'huile essentielle de niaouli
associéeé à l'huile essentielle de lavandin ou d'aspic, ou l'huile essentielle de
chénopode riche en peroxyde comme l'ascaridol. Pour chaque forme particulière,
on a recours à des excipients appropriés. Ces excipients doivent avoir toutes les qualités habituellement demandées.Substances recognized as insecticides may be used such as pyrethrum derivatives, permethrin, phenothrin, mimic hormones such as methoprene, malathion, rotenone, benzyl benzoate,
essential oils rich in cineol, particularly niaouli essential oil
associated with lavandin or aspic essential oil, or essential oil of
lamb's quarters rich in peroxide such as ascaridol. For each particular form,
appropriate excipients are used. These excipients must have all the qualities usually required.

A titre d'exemples, on peut citer: le propylèneglycol, la glycérine, les polyols,
les phospholipides mis dans des liposomes ou non, les huiles végétales,
animales, minérales, les mouillants, les épaississants, stabilisants et émulsionnants
couramment utilisés, I'édétate disodique, les parabens. Comme conservateur
antimicrobien, on préconisera l'acide benzoïque et ses esters, notamment l'ester
benzylique, les dérivés cellulosiques, les carbopols ;; on pourra utiliser dans les formules les différents anti-oxydants connus non seulement pour synergiser l'effet
des insecticides mais aussi pour améliorer leur conservation, comme le
butylhydroxyanisole ou le butylhydroxytoluène, l'ascorbate de sodium, le tocophérol, des acides phénols comme l'acide cholorogénique et l'acide
caféique, certains flavonoides au pouvoir antioxydant comme la quercetine, les
esters de l'acide gallique, les tanins, I'acide sorbique, I'acide salycilique ou ses
esters, I'acide nordihydroguaïarétique, le gaïacol, les agents réducteurs connus comme les thiols, la cystéine, la methionine, le glutathion.By way of examples, mention may be made of: propylene glycol, glycerin, polyols,
phospholipids put in liposomes or not, vegetable oils,
animal, mineral, wetting, thickening, stabilizing and emulsifying
commonly used, disodium edetate, parabens. As a curator
antimicrobial, we will recommend benzoic acid and its esters, especially the ester
benzyl, cellulose derivatives, carbopols; we can use in the formulas the various known antioxidants not only to synergize the effect
insecticides but also to improve their conservation, such as
butylhydroxyanisole or butylhydroxytoluene, sodium ascorbate, tocopherol, phenol acids like cholorogenic acid and acid
caffeic, certain flavonoids with antioxidant power such as quercetin,
esters of gallic acid, tannins, sorbic acid, salycilic acid or its
esters, nordihydroguaiaretic acid, guaiacol, known reducing agents such as thiols, cysteine, methionine, glutathione.

Des substances complexantes comme l'acide citrique ou l'acide édétique et
ses sels pourront être utilisés comme potentialisateur de l'effet anti-oxydant.Complexing substances such as citric acid or edetic acid and
its salts can be used as potentiator of the antioxidant effect.

Les différentes formes pharmaceutiques ou cosmétiques mentionnées
ci-dessus sont obtenues selon les méthodes utilisées dans ce domaine. On
donnera, ci-après, des exemples de compositions (en parties en poids): 1 lotion hydro-alcoolique
Huile essentielle de niaouli 3,0 g
Huile essentielle d'aspic 1,0 g
Huile essentielle de lavande 1,0 g
.Butyl hydroxyanisole 0,2 g
Polysorbate 80 5,0 g
.Benzoate de benzyle 1,0 g
Propylène glycol 1,0 g
Alcool éthylique 42,0 g
.Eauqsp 100 g 2 - Hydrogel alcoolique
Huile essentielle de niaouli 2,0 g
Huile essentielle d'aspic 2,0 g
Huile essentielle de lavande 1,0 g
.Butyl hydroxyanisole 0,2 g
. Polysorbate 80 5,0 g
. Benzoate de benzyle 1,0 g
Huile de ricin 1,0 g
Triéthanolamine 1,5 g
Oarbopol 940 1,5 g
eau purifiée qsp 100 g 3 - Hydrogel glycériné
. Permethrine 0,3 g
. Butyl hydroxyanisole 0,2 g
. Polysorbate 80 5,0 g
. Benzoate de benzyle 1,0 g
. Alginate sodique 8,0 g
. Glycérol 25,0 g
. Solution de borax (15 %) dans le glycérol 20,0 g
Thymol 2,0 g
Eau qsp 100 g 4- ShamDoing 1
Huile essentielle de niaouli 2,0 g
Huile essentielle d'aspic 2,0 g
.Huile essentielle de lavande 1,0 g
. Polysorbate 80 5,0 g
. Butyl hydroxyanisole 0,2 g
. Benzoate de benzyle 1,0 g
. laurylsulfate de sodium 30,0 g
. Eau qsp 100 g 5- Shampoing 2
. Methoprène 0,1 g
. Butyl hydroxyanisole 0,2 g
. Benzoate de benzyle 1,0 g
. laurylsulfate de sodium 30,0 g
. Eau qsp 100 g 6- Shampoing 3
. Permethrine ou phénothrine 0,3g
. Butyl hydroxyanisole 0,2 g
. Benzoate de benzyle 1,0 g
. laurylsulfate de sodium 30,0 g
. Eau qsp 100 g 7- Shampoing 4
. Extrait de pyrethre 1,0 g
. Polysorbate 80 5,0
. Butyl hydroxyanisole 0,2 g
. Benzoate de benzyle 1,0 g
. laurylsulfate de sodium 30,0 g
. Eau qsp 100 g The different pharmaceutical or cosmetic forms mentioned
above are obtained according to the methods used in this field. We
will give, below, examples of compositions (in parts by weight): 1 hydro-alcoholic lotion
Niaouli essential oil 3.0 g
Aspic essential oil 1.0 g
Lavender essential oil 1.0 g
.Butyl hydroxyanisole 0.2 g
Polysorbate 80 5.0 g
Benzyl benzoate 1.0 g
Propylene glycol 1.0 g
Ethyl alcohol 42.0 g
.Eauqsp 100 g 2 - Alcoholic hydrogel
Niaouli essential oil 2.0 g
Aspic essential oil 2.0 g
Lavender essential oil 1.0 g
.Butyl hydroxyanisole 0.2 g
. Polysorbate 80 5.0 g
. Benzyl benzoate 1.0 g
Castor oil 1.0 g
Triethanolamine 1.5 g
Oarbopol 940 1.5 g
purified water qs 100 g 3 - Glycerin hydrogel
. Permethrin 0.3 g
. Butyl hydroxyanisole 0.2 g
. Polysorbate 80 5.0 g
. Benzyl benzoate 1.0 g
. Alginate sodium 8.0 g
. Glycerol 25.0 g
. Borax solution (15%) in glycerol 20.0 g
Thymol 2.0 g
Water qs 100 g 4- ShamDoing 1
Niaouli essential oil 2.0 g
Aspic essential oil 2.0 g
Lavender essential oil 1.0 g
. Polysorbate 80 5.0 g
. Butyl hydroxyanisole 0.2 g
. Benzyl benzoate 1.0 g
. sodium lauryl sulfate 30.0 g
. Water qs 100 g 5- Shampoo 2
. Methoprene 0.1 g
. Butyl hydroxyanisole 0.2 g
. Benzyl benzoate 1.0 g
. sodium lauryl sulfate 30.0 g
. Water qs 100 g 6- Shampoo 3
. Permethrin or phenothrin 0.3g
. Butyl hydroxyanisole 0.2 g
. Benzyl benzoate 1.0 g
. sodium lauryl sulfate 30.0 g
. Water qs 100 g 7- Shampoo 4
. Pyrethrum extract 1.0 g
. Polysorbate 80 5.0
. Butyl hydroxyanisole 0.2 g
. Benzyl benzoate 1.0 g
. sodium lauryl sulfate 30.0 g
. Water qs 100 g

Claims (4)

- Revendications -- Claims - 1 - Compositions médicamenteuses ou cosmétologiques contre les poux, comprenant à titre de principe actif un mélange de substances insecticides et de substances anti-oxydantes à la concentration de 0,5 à 10 pour cent en poids. 1 - Medicinal or cosmetic compositions against lice, comprising as active principle a mixture of insecticidal substances and antioxidant substances at a concentration of 0.5 to 10 percent by weight. 2 - Composition selon la revendication 1, caractérisée en ce qu'elle est obtenue et stabilisée, par dilution et mise en suspension des actifs dans une base aqueuse ou hydro-organique. 2 - Composition according to claim 1, characterized in that it is obtained and stabilized, by dilution and suspension of the active agents in an aqueous or hydro-organic base. 3 - Compositions selon la revendication 1 ou 2, sous forme de lotions3 de shampoings, de laits, de gels, de colliers ou d'accessoires pour cheveux. 3 - Compositions according to claim 1 or 2, in the form of lotions3 of shampoos, milks, gels, necklaces or hair accessories. 4 - Utilisation d'un mélange d'huiles essentielles contre les poux à la concentration de 2 à 10 p. cent en poids associés à des substances anti-oxydantes à la concentration 5 à 0,1 pour cent en poids.  4 - Use of a mixture of essential oils against lice at a concentration of 2 to 10 p. hundred percent by weight combined with antioxidants at a concentration of 5 to 0.1 percent by weight.
FR9212170A 1992-10-01 1992-10-01 NEW MEDICINAL PRODUCTS OR BODY HYGIENE FOR THE ELIMINATION OF BODY, HAIR AND SCALP PESTS, CONTAINING A COMBINATION OF INSECTICIDES AND ANTI-OXIDANT SUBSTANCES. Expired - Fee Related FR2696318B1 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0714601A1 (en) * 1994-11-28 1996-06-05 Laboratoires Virbac Residual control of parasites by long-acting shampoo formulations
FR2766331A1 (en) * 1997-07-25 1999-01-29 Gandhour Lab TREATMENT AND PREVENTIVE PEST CONTROL COMPOSITION COMPRISING PEDICULICIDAL AND LARVICIDAL AGENTS IN ASSOCIATION WITH REPULSIVE ESSENTIAL OILS FOR INSECTS
WO2006097185A1 (en) * 2005-03-12 2006-09-21 Unilever Plc Hair and/or scalp care compositions incorporating terpenoid compounds
EP1967177A2 (en) * 2003-10-06 2008-09-10 Laboratoire de Dermo-Cosmetique Animale Dermocosmetic composition for pets
US7807707B2 (en) 2005-03-12 2010-10-05 Conopco Inc. Hair and/or scalp care compositions incorporating amino-oxo-indole-ylidene compounds

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WO1986003374A1 (en) * 1984-12-05 1986-06-19 Adams Veterinary Research Laboratories, Inc. Long-acting pyrethrum/pyrethroid based pesticides with silicone stabilizers
WO1990014006A1 (en) * 1989-05-26 1990-11-29 The Wellcome Foundation Limited Pesticidal compositions
EP0445924A1 (en) * 1990-02-09 1991-09-11 Euroceltique S.A. Phenothrin shampoo
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GB2095109A (en) * 1981-03-09 1982-09-29 Wellcome Found Insecticidal compositions
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WO1986003374A1 (en) * 1984-12-05 1986-06-19 Adams Veterinary Research Laboratories, Inc. Long-acting pyrethrum/pyrethroid based pesticides with silicone stabilizers
WO1990014006A1 (en) * 1989-05-26 1990-11-29 The Wellcome Foundation Limited Pesticidal compositions
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CHEMICAL PATENTS INDEX, DOCUMENTATION ABSTRACTS JOURNAL Section Ch, Week 8912, 17 Mai 1989 Derwent Publications Ltd., London, GB; Class C, AN 085788 & AU-A-8 811 220 (V.H.GUERRINI) 19 Janvier 1989 *
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L.VIDAL 'Dictionnaire Vidal' 1991 , EDITIONS DU VIDAL , PARIS, FR Marie Rose Suractivée lotion *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0714601A1 (en) * 1994-11-28 1996-06-05 Laboratoires Virbac Residual control of parasites by long-acting shampoo formulations
AU715843B2 (en) * 1994-11-28 2000-02-10 Laboratoires Virbac Residual control of parasites by long-acting shampoo formulations
FR2766331A1 (en) * 1997-07-25 1999-01-29 Gandhour Lab TREATMENT AND PREVENTIVE PEST CONTROL COMPOSITION COMPRISING PEDICULICIDAL AND LARVICIDAL AGENTS IN ASSOCIATION WITH REPULSIVE ESSENTIAL OILS FOR INSECTS
EP0894435A1 (en) * 1997-07-25 1999-02-03 Laboratoire Gandhour Anti-parasite composition for treatment and prevention containing pediculicides and larvicides in association with insect repelling essential oils
EP1967177A2 (en) * 2003-10-06 2008-09-10 Laboratoire de Dermo-Cosmetique Animale Dermocosmetic composition for pets
EP1967177A3 (en) * 2003-10-06 2008-10-15 Laboratoire de Dermo-Cosmetique Animale Dermocosmetic composition for pets
WO2006097185A1 (en) * 2005-03-12 2006-09-21 Unilever Plc Hair and/or scalp care compositions incorporating terpenoid compounds
US7807707B2 (en) 2005-03-12 2010-10-05 Conopco Inc. Hair and/or scalp care compositions incorporating amino-oxo-indole-ylidene compounds

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