FR2678614A1 - Compose presentant une activite en tant qu'inhibiteur de la collagenase et medicament le contenant. - Google Patents

Compose presentant une activite en tant qu'inhibiteur de la collagenase et medicament le contenant. Download PDF

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Publication number
FR2678614A1
FR2678614A1 FR9108303A FR9108303A FR2678614A1 FR 2678614 A1 FR2678614 A1 FR 2678614A1 FR 9108303 A FR9108303 A FR 9108303A FR 9108303 A FR9108303 A FR 9108303A FR 2678614 A1 FR2678614 A1 FR 2678614A1
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FR
France
Prior art keywords
compounds
furanyl
formula
oil
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9108303A
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English (en)
French (fr)
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FR2678614B1 (enrdf_load_stackoverflow
Inventor
Rancurel Alain
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Laboratoires Pharmascience SA
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Laboratoires Pharmascience SA
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Filing date
Publication date
Application filed by Laboratoires Pharmascience SA filed Critical Laboratoires Pharmascience SA
Priority to FR9108303A priority Critical patent/FR2678614A1/fr
Publication of FR2678614A1 publication Critical patent/FR2678614A1/fr
Application granted granted Critical
Publication of FR2678614B1 publication Critical patent/FR2678614B1/fr
Granted legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/17—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/003—Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/36—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9108303A 1991-07-03 1991-07-03 Compose presentant une activite en tant qu'inhibiteur de la collagenase et medicament le contenant. Granted FR2678614A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR9108303A FR2678614A1 (fr) 1991-07-03 1991-07-03 Compose presentant une activite en tant qu'inhibiteur de la collagenase et medicament le contenant.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108303A FR2678614A1 (fr) 1991-07-03 1991-07-03 Compose presentant une activite en tant qu'inhibiteur de la collagenase et medicament le contenant.

Publications (2)

Publication Number Publication Date
FR2678614A1 true FR2678614A1 (fr) 1993-01-08
FR2678614B1 FR2678614B1 (enrdf_load_stackoverflow) 1995-03-03

Family

ID=9414656

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9108303A Granted FR2678614A1 (fr) 1991-07-03 1991-07-03 Compose presentant une activite en tant qu'inhibiteur de la collagenase et medicament le contenant.

Country Status (1)

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FR (1) FR2678614A1 (enrdf_load_stackoverflow)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775480A1 (en) * 1993-10-25 1997-05-28 S. Richard Huber Novel lipidic furans useful for skin therapeutics
WO1999055657A1 (fr) * 1998-04-29 1999-11-04 Laboratoires Pharmascience Nouveaux composes extraits d'huile vegetale utilisables dans l'industrie pharmaceutique et cosmetique, notamment pour l'inhibition de la croissance cellulaire
FR2798667A1 (fr) * 1999-09-22 2001-03-23 Pharmascience Lab Procede d'extraction des composes furaniques et alcools gras polyhydroxyles de l'avocat, composition a base de et utilisation de ces composes en therapeutique, cosmetique et alimentaire
WO2004016106A1 (fr) * 2002-07-29 2004-02-26 Laboratoires Expanscience Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques
FR2870742A1 (fr) * 2004-05-28 2005-12-02 Expanscience Laboratoires Sa Utilisation d'alkyle furannes pour la preparation d'un medicament destine au traitement du diabete, de l'obesite et pour le traitement cosmetique de la cellulite et de la surcharge ponderale
US7589121B2 (en) 2004-05-28 2009-09-15 Laboratoires Expanscience Use of furan alkyls for preparing a drug for treating obesity and cosmetically treating overweight
US7872043B2 (en) 2004-05-28 2011-01-18 Laboratories Expanscience Use of furan alkyls for a cellulite cosmetic treatment
JP2016515585A (ja) * 2013-03-29 2016-05-30 アボサイエンス、リミテッド、ライアビリティー、カンパニーＡｖｏｓｃｉｅｎｃｅ， Ｌｌｃ 癌、神経障害及び線維性障害の治療のための、脂質フラン、ピロール及びチオフェン化合物
US10905673B2 (en) 2016-04-27 2021-02-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425343A (en) * 1972-02-14 1976-02-18 Unilever Ltd Phthalic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1425343A (en) * 1972-02-14 1976-02-18 Unilever Ltd Phthalic acid derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 103, no. 19, 11 Novembre 1985, Columbus, Ohio, US; abstract no. 157333D, L. PREVITERA ET AL.: 'Acetogenins from the aquatic plant Elodea canadensis' page 411 ;colonne 2 ; *
CHEMICAL ABSTRACTS, vol. 105, no. 21, 24 Novembre 1986, Columbus, Ohio, US; abstract no. 187627M, D. MEROLA: 'Elodea canadensis metabolites' page 421 ;colonne 1 ; *
CHEMICAL ABSTRACTS, vol. 115, no. 21, 25 Novembre 1991, Columbus, Ohio, US; abstract no. 232007D, ULKU OYMAN: 'Dehydration of some 1-(2-furyl) and 1-(2-thienyl)-1-alkanols using cobalt(II) sulfate as catalyst' page 924 ;colonne 2 ; *
CHEMICAL ABSTRACTS, vol. 72, no. 25, 22 Juin 1970, Columbus, Ohio, US; abstract no. 129380Q, L. NEEMAN ET AL.: 'New antibacterial agent isolated from the avocado pear' page 75 ;colonne 1 ; *
CHEMICAL ABSTRACTS, vol. 75, no. 19, 8 Novembre 1971, Columbus, Ohio, US; abstract no. 115910N, H. M. ALVES ET AL.: 'Avocatins. New class of natural products' page 27 ;colonne 2 ; *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775480A1 (en) * 1993-10-25 1997-05-28 S. Richard Huber Novel lipidic furans useful for skin therapeutics
WO1999055657A1 (fr) * 1998-04-29 1999-11-04 Laboratoires Pharmascience Nouveaux composes extraits d'huile vegetale utilisables dans l'industrie pharmaceutique et cosmetique, notamment pour l'inhibition de la croissance cellulaire
FR2778181A1 (fr) * 1998-04-29 1999-11-05 Pharmascience Lab Nouveaux composes extraits d'huile vegetale utilisables dans l'industrie pharmaceutique et cosmetique,notamment pour l'inhibition de la croissance cellulaire
FR2798667A1 (fr) * 1999-09-22 2001-03-23 Pharmascience Lab Procede d'extraction des composes furaniques et alcools gras polyhydroxyles de l'avocat, composition a base de et utilisation de ces composes en therapeutique, cosmetique et alimentaire
WO2001021605A3 (fr) * 1999-09-22 2001-10-25 Pharmascience Lab Procede d'extraction des composes lipides furaniques et alcools gras polyhydroxyles de l'avocat, composition a base de ces composes et leur utilisation en therapeutique, cosmetique et alimentaire
JP2003509506A (ja) * 1999-09-22 2003-03-11 ラボラトワール ファルマシアンス アボガドのフラン脂質化合物およびポリヒドロキシル化された脂肪族アルコールを抽出する方法、該化合物に基く組成物および治療、美容並びに食品における該化合物の使用
US6582688B1 (en) 1999-09-22 2003-06-24 Pharmascience Method for extracting compounds of furan lipids and polyhydroxylated fatty alcohols of avocado, composition based on said compounds, and therapeutic, cosmetical or food use of said compounds
JP5021879B2 (ja) * 1999-09-22 2012-09-12 ラボラトワール エクスパンシアンス アボガドのフラン脂質化合物およびポリヒドロキシル化された脂肪族アルコールを抽出する方法、該化合物に基く組成物および治療、美容並びに食品における該化合物の使用
US7371420B2 (en) 2002-07-29 2008-05-13 Laboratoires Expanscience Method for producing an avocado unsaponifiable rich in furan lipids
WO2004016106A1 (fr) * 2002-07-29 2004-02-26 Laboratoires Expanscience Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques
WO2004012496A3 (fr) * 2002-07-29 2004-04-08 Expanscience Lab Procede d'obtention d'un insaponifiable d'avocat riche en lipides furaniques
US7589121B2 (en) 2004-05-28 2009-09-15 Laboratoires Expanscience Use of furan alkyls for preparing a drug for treating obesity and cosmetically treating overweight
WO2005117856A1 (fr) * 2004-05-28 2005-12-15 Laboratoires Expanscience Utilisation d’alkyle furannes pour la preparation d’un medicament destine au traitement du diabete
CN1960722B (zh) * 2004-05-28 2010-09-08 科学发展实验室 烷基呋喃在制备抗糖尿病药物中的用途
US7872043B2 (en) 2004-05-28 2011-01-18 Laboratories Expanscience Use of furan alkyls for a cellulite cosmetic treatment
FR2870742A1 (fr) * 2004-05-28 2005-12-02 Expanscience Laboratoires Sa Utilisation d'alkyle furannes pour la preparation d'un medicament destine au traitement du diabete, de l'obesite et pour le traitement cosmetique de la cellulite et de la surcharge ponderale
US8859617B2 (en) 2004-05-28 2014-10-14 Laboratoires Expanscience Use of furan alkyl for preparing an antidiabetic drug
JP2016515585A (ja) * 2013-03-29 2016-05-30 アボサイエンス、リミテッド、ライアビリティー、カンパニーＡｖｏｓｃｉｅｎｃｅ， Ｌｌｃ 癌、神経障害及び線維性障害の治療のための、脂質フラン、ピロール及びチオフェン化合物
US10085962B2 (en) 2013-03-29 2018-10-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
US10525031B2 (en) 2013-03-29 2020-01-07 Avoscience, Llc Lipid furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
US11058663B2 (en) 2013-03-29 2021-07-13 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
US11833129B2 (en) 2013-03-29 2023-12-05 Avoscience, Llc Thiophene compound for treatment of exfoliating glaucoma
US10905673B2 (en) 2016-04-27 2021-02-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
US11602518B2 (en) 2016-04-27 2023-03-14 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis

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Publication number Publication date
FR2678614B1 (enrdf_load_stackoverflow) 1995-03-03

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