FR2616322A1 - Aseptic device for setting reactive components in solution - Google Patents

Aseptic device for setting reactive components in solution Download PDF

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Publication number
FR2616322A1
FR2616322A1 FR8708118A FR8708118A FR2616322A1 FR 2616322 A1 FR2616322 A1 FR 2616322A1 FR 8708118 A FR8708118 A FR 8708118A FR 8708118 A FR8708118 A FR 8708118A FR 2616322 A1 FR2616322 A1 FR 2616322A1
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FR
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Application
Patent type
Prior art keywords
container
rigid
base
closed
rupturable membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR8708118A
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French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALCINDOR LOUIS
BOISSEL JEAN FRANCOIS
CASSIN JAMET NELLY
Original Assignee
ALCINDOR LOUIS
BOISSEL JEAN FRANCOIS
CASSIN JAMET NELLY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/24Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/2807Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container
    • B65D51/2814Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it
    • B65D51/2821Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials the closure presenting means for placing the additional articles or materials in contact with the main contents by acting on a part of the closure without removing the closure, e.g. by pushing down, pulling up, rotating or turning a part of the closure, or upon initial opening of the container the additional article or materials being released by piercing, cutting or tearing an element enclosing it said element being a blister, a capsule or like sealed container

Abstract

This device comprises a first rigid container 1, containing a reactive liquid 4 and closed by a tear-off membrane 5. The second reactant 11 is contained in a second container 8 closed at its base by a second tear-off membrane 12 which is placed in contact with the first. The upper rigid part 15 of the container 8 can be moved downwards with respect to a rigid cylindrical part 10 by deforming the flexible part 14 when a plug 19 is completely screwed down after removal of a tamper-proof strip 20. The lower cross-shaped tip 17 then perforates the two membranes, which sets the two reactants in solution together antiseptically. This device can be used in analysis laboratories, for unstable solutions, etc. <IMAGE>

Description

La présente invention a-pour objet un dispositif aseptique de mise en solution de composants réactifs. The present invention-relates to an aseptic device dissolution of reactive components.

L'invention concerne la conservation et le transport en un contenant unique de substances liquides ou solides qui se conservent mal en solution et/ou sont instables en asncia- tion avec d'autres réactifs. The invention relates to the storage and transport in a single container of liquid or solid substances that harm retain in solution and / or are unstable in asncia- tion with other reagents.

A titre d'exemple, on citera certains ensembles de réac tifs-chimiques de dosage enzymatiques, la liqueur de Dakin instable en solution aqueuse, l'eau de Dalibour, et enfin certains antibiotiques à mise en solution extemporanée. For example, there may be mentioned certain sets of reac tive chemical-enzymatic assay, Dakin liquor unstable in aqueous solution, water Dalibour, and finally some antibiotics setting extemporaneous solution.

Dans tous les cas évoqués ci-dessus, les composants sont conservés: In all cases mentioned above, the components are stored:
soit séparément dans des récipients indépendants, le mélange en solution s'effectuant manuellement et de manière non aseptique, risquant en outre d'etre allergisant pour le ma nipulateurJ or separately in separate containers, the mixture solution is manually engaged and not aseptically, risking further to be allergenic for my nipulateurJ
. . soit en une solution préparée à l'avance qui se dégrade rapidement, de sorte qu'une quantité importante doit être jetée avant d'être totalement utilisée. either in a solution prepared in advance which deteriorates rapidly, so that a significant amount must be discarded before being completely used.

La présente invention a précisément pour but de permettre de façon totalement aseptique le mélange en solution de composants réactifs juste au moment de l'emploi,et d'en préparer la quantité nécessaire et suffisante pour éviter tout gaspillage. The present invention is precisely to allow totally aseptically mixing into a solution of the reactive components just before use, and to prepare the necessary and sufficient amount for wastage.

A cet effet, l'invention a pour objet un dispositif aseptique de mise en solution de composants réactifs du genre comprenant deux contenants distincts pour chacun des deux réactifs, caractérisé, en combinaison,en ce que l'un des contenants est un premier récipient rigide contenant le premier réactif etprésentant une ouverture fermée par une première membrane déchirable coaxiale avec un organe poussoir susceptible d'être rapproché par actionnement manuel vers l'intérieur du premier récipient,et que le second contenant est un second récipient contenant le second réactif et comprenant un corps cylindrique rigide présentant à sa base une ouverture fermée par une seconde rJrr- brane déchirable destinée à venir reposer sur la première rrbra- ne déchirable et reliée par une partie souple supérieure à un élément rigide dont la base est juste au contact du centre de la seconde membrane déchirable et dont la partie supérieure est juste au contact de la paroi intern To this end, the invention relates to an aseptic device of dissolution of the reactive components of the type comprising two distinct containers for each of the two reagents, characterized in combination in that one of the containers is a first rigid container containing the first reagent andhaving an opening closed by a first rupturable membrane coaxial with a pusher member capable of being approximated by manual operation inwardly of the first container and the second container is a second container containing the second reagent and comprising a rigid cylindrical body having at its base an opening closed by a second rupturable rJrr- brane intended to rest on the first rrbra- not tear and connected by a flexible upper portion to a rigid member whose base is just in contact with the center of the second rupturable membrane and whose upper part is just in contact with the wall intern e dudit organe poussoir. e of said pusher member.

Ainsi, on comprend aisément que, par exemple après qu'un moyen de garantie de virginité ait été retiré, on rapproche le poussoir vers l'intérieur du premier récipient, l'élément rigide du second récipient, poussé par le poussoir déplacé, vienne par sa base perforer les deux membranes déchirables accolées et mettre ainsi en communication les deux volumes intérieurs des deux récipients: par écoulement ou gravité, la substance sous forme de liquide ou de poudre contenue dans le second récipient tombe à l'intérieur du premier et s'y mélange en solution avec la substance, liquide par exemple, contenue dans le premier récipient. Thus, it is understandable that, for example after a means guarantee virgin has been removed, the pusher are brought together inwards of the first container, the rigid element of the second container, pushed by the pusher moved, come by its base perforate tearable two contiguous membrane and thus put in communication the two interior volumes of the two containers: by flow or gravity, the substance in liquid form or powder contained in the second container falls within the first and s' y mixture in solution with the substance, liquid for example contained in the first container.

L'invention définie ci-dessus de manière générique fonctionnelle, peut se mettre en oeuvre d'un grand nombre de manières diverses. The invention defined above functional generically, may implement a number of different ways.

Pour bien faire comprendre l'invention, on en décrira ci-après un mode particulier de réalisation, donné uniquement à titre d'exemple illustratif. For a better understanding the invention, as described below one particular embodiment, given only as an illustrative example.

On se réfèrera à la figure unique du dessin qui représente schématiquement, vu en coupe axiale, un dispositif selon l'invention. Reference is made to the single figure of the drawing which shows diagrammatically, seen in axial section, a device according to the invention.

Le dispositif, représenté sur la figure unique, com prend un premier récipient rigide constitué ici d'un flacon en verre (1) présentant à sa partie supérieure une ouverture (2) co-axiale avec un goulot fileté (3). The device shown in the single figure, com prises a first rigid container made here of a glass vial (1) having at its upper part an opening (2) co-axial with a threaded neck (3). Le flacon contient un soluté (4) et, après introduction de ce soluté dans des conditions d'aseptie connues en soi, est fermé avec étanchéité par une première membrane déchirable (5). The vial contains a solute (4) and, after introduction of the solute in aseptic conditions known per se, is sealed closed by a first rupturable membrane (5). rouir ce faire, on peut par exemple utiliser une membrane mince d'un matériau métallique tel que l'aluminium solidarisée par un joint de soudure appropriée (6), constitué par exemple d'un film de polyéthylène basse densité soudé à chaud, avec une couronne plane (7) constituant les limites de l'ouverture (2). Ret do this, one can for example use a thin membrane of a metal material such as aluminum fastened by a suitable weld joint (6), consisting for example of a film of low density polyethylene heat-sealed with a planar ring (7) forming the boundaries of the opening (2). Cette technique, connue en soi, est celle utilisée par exemple pour assurer la fermeture étanche de bocaux contenant des produits lyophilisés. This technique, known per se, is that used for example to ensure the seal of jars containing lyophilized products.

Le second récipient (8), contenant la poudre (9) destinée à être mise en solution avec le soluté (4),et réalisé en une matière plastique appropriée, telle que du polyéthylène haute densité, comprend un corps cylindrique rigide (10) présentant à-la base une ouverture (11) fermée par une seconde membrane déchirable (12) qui vient reposer sur la première membrane déchirable (5); The second container (8) containing the powder (9) intended to be placed in solution with the solute (4) and made of a suitable plastics material such as high density polyethylene, comprises a rigid cylindrical body (10) having to the base an opening (11) closed by a second rupturable membrane (12) which rests on the first rupturable membrane (5); une collerette (13) prévue à la base du corps (10) assure, avec un grand jeu, le centrage des deux récipients (1) et (8) l'un par rapport à l'autre. a collar (13) provided at the base of the body (10) provides, with a large play, centering of the two containers (1) and (8) relative to each other.

Le corps cylindrique rigide (10) est relié par une partie supérieure (14) rendue souple en raison de son épaisseur diminuée avec sa partie centrale supérieure (15) qui est solidaire d'un élément rigide (16). The rigid cylindrical body (10) is connected by an upper part (14) made flexible because of its reduced thickness with its upper central part (15) which is secured to a rigid element (16). La base (17) de l'élément rigide (16) vient jus-te au contact de la membrane déchirable (121 tandis que sa surface supérieure (18) vient juste au contact de la paroi inférieure d'un bouchon fileté (19) qui, après mise en place d'une bande de garantie de virginité (20), vient se visser à fond autour du goulot fileté (3). The base (17) of the rigid element (16) is just in contact with the rupturable membrane (121 while the upper surface (18) is just in contact with the bottom wall of a threaded cap (19) after establishment of a virgin guarantee strip (20) is screwed tight around the threaded neck (3).

L'élément rigide (16) a, par exemple et comme représente, une forme de croisillon conique. The rigid element (16) has, for example and as illustrated, a form of conical cross.

Le fonctionnement du dispositif décrit ci-dessus, à titre d'exemple, est simple à comprendre: après avoir retiré la bande de garantie (20), et lorsque l'on visse à fond le bouchon poussoir (19),l'élément rigide (16) vient par sa base (17) déchirer d'un seul coup les deux membranes déchirables acco lées (5) et (12). Operation of the device described above, for example, is easy to understand: after removal of the guarantee strip (20), and when the push cap is screwed to the bottom (19), the rigid element (16) has its base (17) tear one stroke the two membranes tearable acco Lées (5) and (12). La poudre (9) tombe alors dans le soluté (4) et s'y dissout. The powder (9) falls into the solute (4) and dissolves. Cette opération s'est évidemment déroulée dans des conditions d'aseptie totale. This was obviously conducted in conditions of total asepsis.

I1 est bien évident que l'invention peut être mise en oeuvre avec bien des variantes dans la réalisation de tel ou tel détail sans que, toutefois, on s'écarte de la combinaison inventive de moyens fonctionnels génériques revendiqués. I1 is obvious that the invention can be implemented with many variants in the realization of this or that detail without, however, a departure from the inventive combination of generic functional means claimed.

Claims (2)

    REVENDICATIONS
  1. 1 - Dispositif aseptique de mise en solution de composants réactifs du genre comprenant deux contenants distincts, (1) et (8) pour chacun des deux réactifs, caractérisé en ce que l'un des contenants est un premier récipient rigide (1) contenant le premier réactif (4) et présentant une ouverture (2) fermée par une première membrane déchirable (5) coaxiale avec un organe poussoir (19) susceptible d'être rapproché par actionnement manuel vers l'intérieur du premier récipient, et que le second contenant est un second récipient (8) contenant le. 1 - Aseptic device solutionizing reagents gender components comprising two separate containers, (1) and (8) for each of two reactants, characterized in that one of the containers is a first rigid container (1) containing the first reagent (4) and having an opening (2) closed by a first rupturable membrane (5) coaxial with a pusher member (19) which can be approximated by manual operation inwardly of the first container and the second container is a second container (8) containing the. second réactif (9) et comprenant un corps cylindrique rigide (10) présentant à sa base une ouverture (11) fermée par une seconde membrane déchirable (12) destinée à venir reposer sur la première membrane déchirable (5) et reliée par une partie souple supérieure (14) à un élément rigide (16) dont la base (17) est juste au contact du centre de la seconde membrane déchirable (12) et dont la partie supérieure (15) est juste au contact de la paroi interne dudit poussoir (19). second reagent (9) and comprising a rigid cylindrical body (10) having at its base an aperture (11) closed by a second rupturable membrane (12) intended to rest on the first rupturable membrane (5) and connected by a flexible portion upper (14) to a rigid element (16) whose base (17) is just in contact with the center of the second rupturable membrane (12) and whose upper part (15) is just in contact with the inner wall of said pusher ( 19).
  2. 2 - Dispositif selon la revendication 1 caractérisé en ce qu'il permet, apres avoir retiré la-bande de garantie (20) et lorsqu'on visse à fond le bouchon poussoir (19), que l'élément rigide (16) vienne par sa base (17) déchirer d'un seul coup les deux membranes déchirables accolées (5) et (12) et que la poudre (9) tombe alors dans le soluté (4) et s'y dissolve. 2 - Device according to claim 1 characterized in that it makes it possible, after removing the guarantee band (20) and when screwed onto the bottom plug pusher (19), that the rigid element (16) comes by its base (17) tear in one fell swoop contiguous two rupturable membranes (5) and (12) and the powder (9) falls into the solute (4) and it dissolves.
FR8708118A 1987-06-11 1987-06-11 Aseptic device for setting reactive components in solution Pending FR2616322A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8708118A FR2616322A1 (en) 1987-06-11 1987-06-11 Aseptic device for setting reactive components in solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8708118A FR2616322A1 (en) 1987-06-11 1987-06-11 Aseptic device for setting reactive components in solution

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2750397A1 (en) * 1996-06-28 1998-01-02 Oreal Device for separate storage of at least two products, mixing and distribution of the mixture thus obtained and method of manufacture
FR2802180A1 (en) * 1999-11-26 2001-06-15 Lily Hsu Container device for separate enclosure of two different substances comprises airtight closing unit fitted in the cap element and cutting device to release the second substance
WO2005093002A1 (en) 2004-03-23 2005-10-06 Sika Technology Ag Two-component adhesion promoter composition and use of packaging comprising two compartments
WO2008047087A1 (en) * 2006-10-20 2008-04-24 Kenneth Mccluskey Container
WO2008147757A1 (en) * 2007-05-22 2008-12-04 3M Innovative Properties Company Devices and methods for dispensing reagents into samples
EP2055647A1 (en) * 2003-04-02 2009-05-06 Nestlé Waters Management &amp; Technology, (Societe anonyme) Stopper equipped with a capsule containing a substance to be added to the contents of a container and corresponding container
WO2010051556A3 (en) * 2008-11-03 2010-09-23 Meadwestvaco Corporation Hair coloration dye dispensing kit
US8276748B2 (en) 2007-03-16 2012-10-02 The Coca-Cola Company Ingredient release spout
US8372937B2 (en) 2004-03-23 2013-02-12 Sika Technology Ag Two-component adhesion promoter composition and use of packaging comprising two compartments
US8443969B2 (en) 2007-03-16 2013-05-21 The Coca-Cola Company Ingredient release spout

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2158142A1 (en) * 1971-11-05 1973-06-15 Sodima
FR2311727A1 (en) * 1975-05-21 1976-12-17 Tuboplast France Container for pharmaceutical products separated until required - sterile mixing by internal plunger piercing dividing membrane
EP0099754A2 (en) * 1982-07-19 1984-02-01 Kao Soap Company, Ltd. Two-part liquid container with breakable partition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2158142A1 (en) * 1971-11-05 1973-06-15 Sodima
FR2311727A1 (en) * 1975-05-21 1976-12-17 Tuboplast France Container for pharmaceutical products separated until required - sterile mixing by internal plunger piercing dividing membrane
EP0099754A2 (en) * 1982-07-19 1984-02-01 Kao Soap Company, Ltd. Two-part liquid container with breakable partition

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816253A1 (en) * 1996-06-28 1998-01-07 L'oreal Device and process for the separate storage of at least two products, for the mixture and distribution of these products
US5884759A (en) * 1996-06-28 1999-03-23 L'oreal Device for separately storing at least two substances, for mixing them together, and for dispensing the mixture obtained thereby, and a method of manufacture
USRE38067E1 (en) 1996-06-28 2003-04-08 L'oreal Device for separately storing at least two substances, for mixing them together, and for dispensing the mixture obtained thereby, and a method of manufacture
FR2750397A1 (en) * 1996-06-28 1998-01-02 Oreal Device for separate storage of at least two products, mixing and distribution of the mixture thus obtained and method of manufacture
FR2802180A1 (en) * 1999-11-26 2001-06-15 Lily Hsu Container device for separate enclosure of two different substances comprises airtight closing unit fitted in the cap element and cutting device to release the second substance
EP2055647A1 (en) * 2003-04-02 2009-05-06 Nestlé Waters Management &amp; Technology, (Societe anonyme) Stopper equipped with a capsule containing a substance to be added to the contents of a container and corresponding container
CN1973010B (en) 2004-03-23 2011-01-19 Sika技术股份公司 Two-component adhesion promoter composition and use of packaging comprising two compartments
WO2005093002A1 (en) 2004-03-23 2005-10-06 Sika Technology Ag Two-component adhesion promoter composition and use of packaging comprising two compartments
US8372937B2 (en) 2004-03-23 2013-02-12 Sika Technology Ag Two-component adhesion promoter composition and use of packaging comprising two compartments
WO2008047087A1 (en) * 2006-10-20 2008-04-24 Kenneth Mccluskey Container
US8443969B2 (en) 2007-03-16 2013-05-21 The Coca-Cola Company Ingredient release spout
US8276748B2 (en) 2007-03-16 2012-10-02 The Coca-Cola Company Ingredient release spout
WO2008147757A1 (en) * 2007-05-22 2008-12-04 3M Innovative Properties Company Devices and methods for dispensing reagents into samples
WO2010051556A3 (en) * 2008-11-03 2010-09-23 Meadwestvaco Corporation Hair coloration dye dispensing kit

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