FR2614791A1 - Medicinal combination based on plants and trace elements for the treatment of rheumatism and inflammatory states - Google Patents

Abstract

The invention relates to a new composition having anti-inflammatory properties: addition of certain trace elements (in this instance selenium and zinc) to an anti-inflammatory plant (in this instance Harpagophytum procumbens). Application in dietetics/pharmacy and veterinary products.

Description

The present invention relates to the combination of anti-inflammatory plants and more specifically Harpagophytum procumbens, with trace elements, with Selenium and Zinc in mind.

Today, the essential nature of minerals is well recognized. Six of them, called macro-elements, are needed every day, in relatively large quantities, greater than 100 mg per day.

These are: Calcium - Xagnésiua - Potassio - Sodium - Phosphorus - Sulfur
Others, no less essential to life, are necessary in smaller quantities, dosed in mocrograms or milligrams (much less than 100 mg). They are called microelements or trace elements.6 They are essentially: Copper - Xhnganbse - Zinc - Iron - Selenin
Chromium - Cobalt - Tin - Xolydbne - Nickel - Vanadium - Iodine - Fluorine
Silicon
These trace elements have a catalytic role. They can be incorporated asxenzymes (metallo-enzymes) or associated with them (co-enzymes), playing the role of activators. They also have an important role at the level of hormones, as constituents or activators.

Certainly, trace elements are found in our diet. But at least two factors make it insufficient in our body - the proportion of these minerals found in our food has decreased
because of "yield".

- our organism on the other hand needs a greater quantity of
these minerals, which are "burned" in greater proportion by
more and more assaults (stress).

Hence the development of a large number of diseases dependent (at least partially) on trace elements, such as: cancers, cardiovascular disease, degenerative diseases (inflammatory rheumatism).

This implies the need to introduce "supplements" in the diet, as part of the presentation. But also to enrich the therapeutic arsenal with drugs containing trace elements.

This is the object of our invention - to associate with a plant whose anti-inflammatory effects have been demonstrated as we will recall, trace elements playing a major role in inflammation, such as Selenlun and Zinc, but also Fnese .

Harpagohpytum has been known for centuries and especially since the 18th century. It belongs to the family of pedaliaceae.

on obtient l'harpagoside par saponification (la fraction cinnamique a disparu). Quant au 3ème principe actif, la procumbide, il se distingue du précédent par un OH en 7.Its active principles are 3 bitter manoterpene glucosides of the aucuboside type. Harpagoside is the main one, here is its formula

harpagoside is obtained by saponification (the cinnamic fraction has disappeared). As for the 3rd active ingredient, procumbide, it differs from the previous one by an OH in 7.

This plant is native to South Africa, where the Major indication consists of rheumatic disease.

The active ingredients are mainly concentrated in the secondary root.

ZORN carried out the first experimental work in
Federal Germany (especially in 1958).

The work of the international Bio Research institute in Hanover confirmed its harmlessness (January 1975).

The work of ZORN, TUNMAN, LUX, SEEGER (animal experiments) confirmed the powerful anti-inflammatory properties of Harpagophytum.

In 1978, SPRECHER entrusted the work of HAVER: Harpagophytum contains B-sitosterols. These inhibit the formation of prostaglandin synthetase, which is partly responsible for the anti-inflammatory process.

German researchers called Harpagophutum: "phenylbultazone-like".

In France, in 1982, a double-blind experiment against placebo and clofenac, in a hospital environment, confirmed the analgesic and anti-inflammatory nature of this plant.

The inventor recommends the use of Harpagophytum nebulis i guaranteed content (4%) of harpagoside. Daily dosages. will of course depend on the condition to be treated and the patient's terrain.

The inventor above all recommends the enrichment of this plant with trace elements. He insists on the major role of Selenium and Zinc, while recognizing a good place for Kanganêse, Fluor,
Calcium, Silica, Magnesium and Phosphorus.

Selenium is the Se example of the trace element essential for life,
At high concentrations it is very toxic in runners (Marco Polo had already noticed the loss of horses' hooves, in certain regions, without making the connection of course), but at doses
Selenium is contained in gluthation peroxidase, an enzyme which, together with superoxide dismutases and catalase, protects the body against attack by oxidants.

Animal testing has highlighted the anti-inflammatory nature of
Selenium: at a dose of 9 mictog. per Kg, Selenium is a powerful anti-inflammatory in mice or rabbits, Since 1979, it is proposed in the United States in the treatment of burns or other inflammations.

Zinc: it is the essential constituent of more than 80 enzymes. It is likely that it also plays a role in a very large number of biological reactions.

Numerous studies, particularly in the United States, have shown that in many inflammatory phenomena, there is an accumulation of Copper in the tissues. there is also a competition between Zinc and
Copper, a strong rise in Copper causing a decrease in Zinc. The administration of Zinc will dislodge excess copper in the tissues.

The inventor has used Arpagophytum as an anti-inflammatory in around 3000 cases in the past 8 years. The addition of Selenium and
Zinc in this treatment for 18 Months, allows to improve the improvement and to speed up the process.

The inventor recommends the use of Arpagophytum nebuliser with guaranteed harpagoside content (4%), at a rate of 400 mg per unit, associated with 20 microg. of Selenium and 25 microg. Zinc (the best support for these minerals being a protein support constituted by yeast.

The presentation can be in the form of capsules, tablets, capsules, ampoules, suspensions or syrup. The external route can also be considered.

Claims (4)

Claims 1) Drug combination for the treatment of rheumatism and inflammatory conditions characterized in that it contains the HARPAGOPHYTUM plant with guaranteed harpagoside content (4%) associated with selenium and zinc with an appropriate support for these minerals, in particular a support protein consisting of yeast. 2) Association according to claim 1, characterized in that it is in the form of nebulizer and in that it contains per unit 400 mg of Harpagophytu 20 mg of selenium and 25 mg of zinc. 3) Association according to claim 1 or 2 characterized in that it is in the form of nebulizer, capsules, tablets, capsules, ampoules, suspension or syrup. 4) Application of the association according to claim 1, 2 or 3 to dietetic, pharmaceutical or veterinary products which contain said association optionally supplemented with other trace elements, in particular manganese.