FR2613611A1 - Thermoelectric-effect device and its control and regulating members, for treating cancers and other tumours, by the method of iterative cryogenic applications - Google Patents

Thermoelectric-effect device and its control and regulating members, for treating cancers and other tumours, by the method of iterative cryogenic applications Download PDF

Info

Publication number
FR2613611A1
FR2613611A1 FR8704835A FR8704835A FR2613611A1 FR 2613611 A1 FR2613611 A1 FR 2613611A1 FR 8704835 A FR8704835 A FR 8704835A FR 8704835 A FR8704835 A FR 8704835A FR 2613611 A1 FR2613611 A1 FR 2613611A1
Authority
FR
France
Prior art keywords
control
iterative
treatment
cold
thermoelectric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8704835A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BAUMGARTEN FREDERIC
Original Assignee
BAUMGARTEN FREDERIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BAUMGARTEN FREDERIC filed Critical BAUMGARTEN FREDERIC
Priority to FR8704835A priority Critical patent/FR2613611A1/en
Publication of FR2613611A1 publication Critical patent/FR2613611A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B2018/044—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0075—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a Peltier element, e.g. near the spot to be heated or cooled

Abstract

Cryogenic device for treating tumours. The invention relates to a device allowing intense, well-localised cold to be applied to a tumour, with precise adjustment of the amount of cold delivered. Because of its small size, the device can be coupled onto an endoscopic probe. The device according to the invention is suited to treating cancers.

Description

La présente invention corcerne un dispositif pour dé-
truire les cellules tumorales ou non.Il permet d'appliquer
sur elles un froid intense très focalisé provoquant leur
destruction.The present invention relates to a device for
whether to kill tumor cells or not.
on them a very focused intense cold causing them
destruction.

Il permet également par son action locale sur la tueur
de stimuler une réponse immunitaire contre celle-ci.It also allows by its local action on the killer
to stimulate an immune response against it.

En effet,la cellule canczreuse tuée nar le froid,conser
vée dans ses structures antigéniques,induit une immunité
relative dirige contre les métastases déjà existantes,
ralentissant la croissance de celles-ci (expériences ran
domismes chez l'animal) et ce,en corrzlation avec la for
nation de cellules cytotoxiques dirigées contre les cellu-
les t'orales (expzrience in vi-tro). Références:"Immunothe-
rapeutic Effect of Cryosurgical Tumor Necrosis". Veterinary
Clinics of North America Small Animal Practice. Novembre
1980, pages 763 n 769.Indeed, the canczrous cell killed nar cold, conser
vee in its antigenic structures, induces immunity
relative points against already existing metastases,
slowing the growth of these (ran experiments
domisms in animals) and this, in correlation with the for
nation of cytotoxic cells against cells
les t'orales (experience in vi-tro). References: "Immunothe-
rapeutic Effect of Cryosurgical Tumor Necrosis ". Veterinary
Clinics of North America Small Animal Practice. November
1980, pages 763 no 769.

Il permet donc,d'une façon classique,d'induire une ré
ponse immunitaire après la cryocoagulation globale o la
tumeur, réponse immunitaire liée à l'effet dose (masse de
tumeur congelée.)
Mais,de plus,il permet de provoquer des cryocoagulations
itératives sur des zones différentes de la tumeur.Ces cro-
applications par zone peuvent etre l'équivalent de la réin-
troduction d'un vaccin in situ.It therefore allows, in a conventional manner, to induce a re
immune response after global cryocoagulation where the
tumor, dose-related immune response (mass of
frozen tumor.)
But, moreover, it makes it possible to cause cryocoagulations
iterative on different areas of the tumor.
applications per area can be the equivalent of rein-
production of a vaccine in situ.

En effet,dès lors que la cellule cancéreuse congelée est
reconnue comme dotant un substrat de la réponse immunitaire,
il convient peut être de gérer sur l'animal la tumeur en
tière en essayant de l'utiliser à la manière d'un vaccin.Indeed, as soon as the frozen cancer cell is
recognized as providing a substrate for the immune response,
it may be appropriate to manage the tumor on the animal by
trying to use it like a vaccine.

Il est impossible de juger, priori, de la supériorit
u non de l'effet "dose répétition" par rapport à l'effet
'dose simple".It is impossible to judge, a priori, of the superiority
u no of the "repeat dose" effect compared to the effect
'single dose'.

Exemple de rzalisation: la tumeur est soumise à des cryo-
apnlications itératives, à des intervalles de temps laissant
entre eux la possibilité d'une mémorisation immunitaire optimale,
Ces cryoapllications itératives sont effectuées sur des
zones à chaque fois différentes de la tumeur.la première zone à cryocoaguler couvre la périphérie de la tumeur, les zones suivantes étant de plus en plus rapprochées du centre de celle-ci.Example of alignment: the tumor is subjected to cryopresence
iterative applications, at time intervals leaving
between them the possibility of an optimal immune memorization,
These iterative cryoapllications are performed on
each time different areas of the tumor. the first area to cryocoagulate covers the periphery of the tumor, the following areas being closer and closer to the center of the latter.

le procsdz décrit (cryoapplications itératives) correspond à une innovation qui ncessite,poursa réalisation,un dispositif cryogenique adapté. the described procsdz (iterative cryoapplications) corresponds to an innovation which requires, for its realization, a suitable cryogenic device.

Les dispositifs cryogdniques traditionnellement utilisés en médecine,dans le traitement des cancers et autres destructions cellulaires (sondes cryochirurgicales),utilisent l'effet d'un gaz réfrigéré (azote liquide ou autre gaz froid) applique directement sur le tissu cellulaire à traiter.Leurs inconvénients: le maniement très aléatoire des gaz froids,le contrôle à postériori de la quantité de froid délivrée et la mauvaise focalisation dua à la diffusion. The cryogenic devices traditionally used in medicine, in the treatment of cancers and other cellular destruction (cryosurgical probes), use the effect of a refrigerated gas (liquid nitrogen or other cold gas) applied directly to the cellular tissue to be treated. : the very random handling of cold gases, the a posteriori control of the quantity of cold delivered and the poor focusing due to diffusion.

Le dispositif,selon l'invention,permet de remédie à ces inconvénients. The device according to the invention overcomes these drawbacks.

Il permet un réglage avant l'expérience et indique en retour la quantitd de chaleur réellement absorbée (qui varie avec le contact réel de la face absorbante du dispositif avec la tumeur.)
Il focalise le refroidissement du tissu cellulaire suivant l'axe choisi par l'opérateur,sans diffusion parasité.It allows adjustment before the experiment and indicates in return the quantity of heat actually absorbed (which varies with the actual contact of the absorbent face of the device with the tumor.)
It focuses the cooling of the cellular tissue along the axis chosen by the operator, without parasitic diffusion.

Il permet de traiter des surfaces de l'ordre du millimètre carré,par exemple,tout en pouvant délivrer un froid très intense en profondeur. It makes it possible to treat surfaces of the order of a square millimeter, for example, while being able to deliver very intense cold at depth.

Le dispositif,selon l'invention,est constitué d'un boitier extérieur étanche (I) contenant un empilement de modules thermoélectriques reliés entre eux,en série, par des connections électriques alimentées par un courant continu. The device according to the invention consists of a sealed outer casing (I) containing a stack of thermoelectric modules connected together, in series, by electrical connections supplied by a direct current.

L'échangeur du dispositif (2),en réfrigérant la face chaude du premier module (3),permet d'en améliorer le rendevent thermique. The device exchanger (2), by refrigerating the hot face of the first module (3), improves its thermal rendering.

La puissance thermique produite par chaque module est décroissante du premier module au dernier module,d'où il résulte que la température des faces froides est de plus er ,)'uv basse de la première à la dernière face froide (4). The thermal power produced by each module decreases from the first module to the last module, from which it follows that the temperature of the cold faces is higher,) 'uv low from the first to the last cold face (4).

Selon une variante,le dernier module présente une sonde de traitement par réfrigération (5),c'est à dire une pièce rapportée, aux dimensions choisieS,accole à la surface froide (5) la figure I représente, en coupe, le dispositif de traitement
selon l'invention.According to a variant, the last module has a refrigeration treatment probe (5), that is to say an insert, with the chosen dimensions, attached to the cold surface (5) FIG. I represents, in section, the device for treatment
according to the invention.

Ta figure 2 reprzsente la grandeur approximative de ce dis
positif.Your figure 2 represents the approximate size of this dis
positive.

La figure 3 représente une varianteselon la disposition
des éléments constitutifs du dispositif,pouvant
permettre,en outre,une utilisation par voie
endoscopique.Figure 3 shows a variant according to the arrangement
component parts of the device, which can
allow, in addition, use by
endoscopic.

Sa figure 4 représente, selon une deuxième variante,la der
nière pièce froide épointée (6). Il ne sera pas
nécessaire d'y adjoindre une pièce rapportée
telle que (5).Its figure 4 represents, according to a second variant, the der
neat blunt cold room (6). He will not be
necessary to add a patch
such as (5).

la figure 5 schématise le dispositif de traitement,accom
pagnd de ses organes de régulation d'une part
et de mesure d'autre part:
- enceinte réfrigérée isothermique (7).Figure 5 shows schematically the treatment device, accom
pagnd of its regulatory bodies on the one hand
and on the other hand:
- isothermal refrigerated enclosure (7).

- contrôle de température (8). - temperature control (8).

-pompe de réglage du débit du liquide r4frigé-
rant (9).-pump for adjusting the flow rate of the refrigerated liquid
rant (9).

-alimentation en courant continu (I0). - DC power supply (I0).

- voltmètre réglable,avec régulateur de ten
sion (II). - adjustable voltmeter, with voltage regulator
Zion (II).

- thermosonde de contrôle (I2) de la sne de
traitement par réfrigération (5).- control thermoprobe (I2) of the
refrigeration treatment (5).

- régulateur de température (I3) de commande
du voltmètre (II).- control temperature controller (I3)
of the voltmeter (II).

La figure 6 représente, en coupe, le dispositif selon une
variante,qui permet d'adapter celui-ci sur la
tumeur,en tant que prothèse amarrée par des
attaches de fixation latérales (I5). FIG. 6 represents, in section, the device according to a
variant, which allows it to be adapted to the
tumor, as a prosthesis moored by
lateral fixing clips (I5).

Le dispositif est utilisable manuellement et également
comme thermocautère par hmersion du sens du courant
d'alimentation. The device can be used manually and also
as a thermocautery by reversing the direction of the current
power supply.

Claims (7)

REVENDICATIONS I)Dispositif cryogznique pour détruire les cancers et autres cellules ,utilisant la thermoélectricite',l'effet Peltier par exemple,caractéris4 en ce qu'il comporte: -d'une part: des organes de régulation:enceinte réfrigérée isothermique (7),contrôle de température (8),pompe de réglage du débit du liquide réfrigérant (9), -d'autre part:des organes de mesure :alimentation en courant continu (20),voltmètre réglable avec régulateur de tension (II),thermosonde de contrôle (I2)de la sonde de traitement par réfrigération (5),régulateur de température (I3) de commande de voltmètre (il).CLAIMS I) Cryogenic device for destroying cancers and other cells, using thermoelectricity, the Peltier effect for example, characterized in that it comprises: on the one hand: regulatory organs: isothermal refrigerated enclosure (7) , temperature control (8), coolant flow adjustment pump (9), - on the other hand: measuring devices: direct current supply (20), adjustable voltmeter with voltage regulator (II), thermoprobe control (I2) of the refrigeration treatment probe (5), temperature regulator (I3) of voltmeter control (II). 2) Dispositif selon la revendication caractérise en ce qu'il comporte un boitier extérieur étanche (I) renfermant un empilement de modules n effet thermoélectrique (I4) et un échangeur de chaleur (2). 2) Device according to claim characterized in that it comprises a sealed outer casing (I) containing a stack of modules n thermoelectric effect (I4) and a heat exchanger (2). 3)Dispositif selon la revendication 2 caractérisé en ce qu'il comporte une pièce rapportée aux dimensions choi sies,accolée à la surface froide (5). 3) Device according to claim 2 characterized in that it comprises a part attached to the chosen dimensions, attached to the cold surface (5). 4) Dispositif selon la revendication 2 caractérisé en ce qu'il comporte une dernière pièce froide épointée (6) qui remplace la dernière pièce froide (4). 4) Device according to claim 2 characterized in that it comprises a last blunt cold room (6) which replaces the last cold room (4). 5) Dispositif selon l'une quelconque des revendications précédentes, caractérisé en ce qu'il est utilisable manuellement. 5) Device according to any one of the preceding claims, characterized in that it can be used manually. C) Dispositif selon lune quelconque des revendications précédentes,caractérîsé en ce qu'il est appareillable sur un appareil endoscopique. C) Device according to any one of the preceding claims, characterized in that it can be fitted to an endoscopic device. 7) Dispositif selon l'une quelconque des revendications précédentes,caractérisé en ce qu'il est utilisable également comme thermocautère,par inversion du sens du courant d'alimentation. 7) Device according to any one of the preceding claims, characterized in that it can also be used as a thermocautery, by reversing the direction of the supply current. 8) Dispositif selon l'une quelconqe des revendications précêdentes,caractérisé en ce qu'il est utilisable également sous forme de prothèse fixée à la tumeur par des attaches de fixation latzrales (I5), prothèse présentant une ou plusieurs sondes de traitement par rfrigération(S).  8) Device according to any one of the preceding claims, characterized in that it can also be used in the form of a prosthesis fixed to the tumor by lateral fixing attachments (I5), prosthesis having one or more probes for treatment by refrigeration ( S). 9) Utilisation du dispositif décrit et de ses organes de régulation et de contrôle dans la méthode de traitement des cancers ou autres cellules, par cryoapplications itéra tives.  9) Use of the device described and of its regulatory and control organs in the method of treatment of cancers or other cells, by iterative cryoapplications.
FR8704835A 1987-04-07 1987-04-07 Thermoelectric-effect device and its control and regulating members, for treating cancers and other tumours, by the method of iterative cryogenic applications Withdrawn FR2613611A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8704835A FR2613611A1 (en) 1987-04-07 1987-04-07 Thermoelectric-effect device and its control and regulating members, for treating cancers and other tumours, by the method of iterative cryogenic applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8704835A FR2613611A1 (en) 1987-04-07 1987-04-07 Thermoelectric-effect device and its control and regulating members, for treating cancers and other tumours, by the method of iterative cryogenic applications

Publications (1)

Publication Number Publication Date
FR2613611A1 true FR2613611A1 (en) 1988-10-14

Family

ID=9349853

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8704835A Withdrawn FR2613611A1 (en) 1987-04-07 1987-04-07 Thermoelectric-effect device and its control and regulating members, for treating cancers and other tumours, by the method of iterative cryogenic applications

Country Status (1)

Country Link
FR (1) FR2613611A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386111A1 (en) * 1987-11-02 1990-09-12 Raj K Anand Thermoelectrically controlled heat medical catheter.
WO1992020289A1 (en) * 1991-05-13 1992-11-26 Hamilton Archie C Electronic cryogenic surgical probe apparatus and method
EP0672400A2 (en) * 1994-02-22 1995-09-20 Trop Life Ltd. Cooling cylindrical device for therapeutic treatment of hemorrhoids
WO1998006339A1 (en) * 1996-08-14 1998-02-19 Stephen James Rowland Medical cryo-surgical device
EP0840078A1 (en) * 1996-11-04 1998-05-06 Luc Pira Cryoprobe based on a Peltier module
GB2331847A (en) * 1996-08-14 1999-06-02 Stephen James Rowland Medical cryo-surgical device
EP2687174A1 (en) 2012-07-19 2014-01-22 Jose Antonio Sanchez Jaime Head end for device for cool therapy and method for applying locally a cool therapy with the use of the head end
EP2988690A4 (en) * 2012-04-30 2017-03-08 Berger Thermal Research Ltd. Cyrocatheter with coolant fluid cooled thermoelectric module

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386111A1 (en) * 1987-11-02 1990-09-12 Raj K Anand Thermoelectrically controlled heat medical catheter.
EP0386111A4 (en) * 1987-11-02 1991-01-16 Raj K. Anand Thermoelectrically controlled heat medical catheter
WO1992020289A1 (en) * 1991-05-13 1992-11-26 Hamilton Archie C Electronic cryogenic surgical probe apparatus and method
EP0672400A2 (en) * 1994-02-22 1995-09-20 Trop Life Ltd. Cooling cylindrical device for therapeutic treatment of hemorrhoids
EP0672400A3 (en) * 1994-02-22 1995-12-20 Trop Life Ltd Cooling cylindrical device for therapeutic treatment of hemorrhoids.
WO1998006339A1 (en) * 1996-08-14 1998-02-19 Stephen James Rowland Medical cryo-surgical device
GB2331847B (en) * 1996-08-14 2001-07-18 Stephen James Rowland Medical cryo-surgical device
GB2331847A (en) * 1996-08-14 1999-06-02 Stephen James Rowland Medical cryo-surgical device
US6017337A (en) * 1996-11-04 2000-01-25 Pira; Luc Cryoprobe based on a peltier module
EP0840078A1 (en) * 1996-11-04 1998-05-06 Luc Pira Cryoprobe based on a Peltier module
EP1239239A2 (en) * 1996-11-04 2002-09-11 Luc Pira Cryoprobe based on a Peltier module
EP1239239A3 (en) * 1996-11-04 2004-08-11 Luc Pira Cryoprobe based on a Peltier module
EP2988690A4 (en) * 2012-04-30 2017-03-08 Berger Thermal Research Ltd. Cyrocatheter with coolant fluid cooled thermoelectric module
US9820795B2 (en) 2012-04-30 2017-11-21 Berger Thermal Research Ltd. Cryocatheter with single phase coolant fluid cooled thermoelectric module and cerebral medical procedures employing local ice ball
US11160596B2 (en) 2012-04-30 2021-11-02 Berger Thermal Research Ltd. Catheter with jet impingement cooled thermoelectric module
EP2687174A1 (en) 2012-07-19 2014-01-22 Jose Antonio Sanchez Jaime Head end for device for cool therapy and method for applying locally a cool therapy with the use of the head end

Similar Documents

Publication Publication Date Title
US6273885B1 (en) Handheld photoepilation device and method
FR2613611A1 (en) Thermoelectric-effect device and its control and regulating members, for treating cancers and other tumours, by the method of iterative cryogenic applications
US20200397498A1 (en) Method and apparatus for rapid and selective tissue ablation with cooling
CA2562496C (en) Device and method for generating thermal units with magnetocaloric material
US8728064B2 (en) Devices for the treatment of biological tissue
US5997530A (en) Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations
Putra et al. The characterization of a cascade thermoelectric cooler in a cryosurgery device
FR2563325A1 (en) ROTARY MAGNETIC REFRIGERATOR
US20020111043A1 (en) Ultra fast rapid thermal processing chamber and method of use
WO1998056462A1 (en) Ultrasound intratissular applicator for thermotherapy
CY1108320T1 (en) APO-2 AND ANTI-HER-2 TEMPERATURE SYSTEM
Verkruysse et al. Dynamics of cryogen deposition relative to heat extraction rate during cryogen spray cooling
JP2021522676A (en) Injection Dopant Activation for Wide Bandgap Semiconductor Electronics
EP0291616B1 (en) Apparatus for disinfecting surfaces by an aerial way in closed enclosures
Svaasand et al. On the physics of laser-induced selective photothermolysis of hair follicles: Influence of wavelength, pulse duration, and epidermal cooling
EP2182876B1 (en) Cooled handpiece for treating the skin with visible radiation
ES475158A1 (en) Fluid laser flow channel liner
FR2660057A1 (en) Cooling (refrigerating) plate for presenting and preserving goods
Metwally et al. A multipurpose integrated preclinical device for the treatment of glioblastoma
Konstantinova et al. Eosin Thermoluminescence in Polyvinyl Alcohol Films After Doubl Vis-IR Laser Excitation in a Wide Temperature Range
Feng et al. Dynamic behaviors of PbS irradiated by laser pulse
EP1274481A1 (en) Device for locally applying cold during a traumatic treatment of the skin
FR2812542A1 (en) Device for local application of cold to the skin for use in traumatic skin treatments, such as hair removal or techniques similar to tattooing where the skin penetration is not as deep
Jung et al. Successful Therapeutic Effect of 1,064-nm Nd: YAG Laser on Lupus Miliaris Disseminatus Faciei Solely on Neck
Brownscombe The electrification of ice and the charging of rime deposits

Legal Events

Date Code Title Description
ST Notification of lapse