FR2613227A1 - PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OR ECONAZOLE NITRATE FOR THE TREATMENT OF NAIL FUNGAL INFECTIONS - Google Patents
PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OR ECONAZOLE NITRATE FOR THE TREATMENT OF NAIL FUNGAL INFECTIONS Download PDFInfo
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- FR2613227A1 FR2613227A1 FR8704560A FR8704560A FR2613227A1 FR 2613227 A1 FR2613227 A1 FR 2613227A1 FR 8704560 A FR8704560 A FR 8704560A FR 8704560 A FR8704560 A FR 8704560A FR 2613227 A1 FR2613227 A1 FR 2613227A1
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- nitrate
- glycol
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
Abstract
COMPOSITION PHARMACEUTIQUE ANTI-FONGIQUE. LA COMPOSITION CONTIENT DU NITRATE DE MICONAZOLE OU DU NITRATE D'ECONAZOLE, A L'ETAT DISSOUS, DANS UN MELANGE CONSTITUE D'EAU, D'UREE ET D'UN TIERS SOLVANT SOLUBLE DANS L'EAU, LE RAPPORT EN POIDS DE L'UREE A L'EAU ETANT INFERIEUR A 1. UTILISATION DANS LE TRAITEMENT DES INFECTIONS FONGIQUES DES ONGLES ET DES TISSUS ENVIRONNANTS.ANTI-FUNGAL PHARMACEUTICAL COMPOSITION. THE COMPOSITION CONTAINS MICONAZOLE NITRATE OR ECONAZOLE NITRATE, IN THE DISSOLVED STATE, IN A MIXTURE CONSISTING OF WATER, UREA AND A THIRD WATER-SOLUBLE SOLVENT, THE WEIGHT RATIO OF WATER UREA LESS THAN 1. USE IN TREATMENT OF FUNGAL INFECTIONS OF NAILS AND SURROUNDING TISSUES.
Description
26 1 322726 1 3227
La présente invention a pour objet des compositions pharmaceuti- The present invention relates to pharmaceutical compositions
ques à base de nitrate de miconazole ou de nitrate d'éconazole dans le based on miconazole nitrate or econazole nitrate in the
traitement des infections fongiques des ongles et des tissus environnants. treatment of fungal infections of the fingernails and surrounding tissues.
Le nitrate de miconazole ainsi que le nitrate d'éconazole sont des dérivés imidazolés doués d'une excellente activité antifongique et antibactérienne. Ces dérivés imidazolés sont plus particulièrement préconisés dans le traitement local des candidoses, des dermatophyties, du pityriasis Both miconazole nitrate and econazole nitrate are imidazole derivatives with excellent antifungal and antibacterial activity. These imidazole derivatives are more particularly recommended in the local treatment of candidiasis, dermatophytosis, pityriasis
versicolor et des onychomycoses.versicolor and onychomycosis.
Les formes galéniques, jusqu'ici proposées à base de nitrate de miconazole ou de nitrate d'éconazole ne permettent pas d'assurer une bonne bio-disponibilité des principes actifs car ils se trouvent en suspension à The dosage forms, heretofore proposed based on miconazole nitrate or econazole nitrate, do not make it possible to ensure good bio-availability of the active principles because they are in suspension at
l'état cristallin.the crystalline state.
En vue d'assurer une meilleure bio-disponibilité, on a proposé dans le brevet européen n O 064 830, des solutions de ces dérivés imidazolés dans des excipients gras, notamment dans l'acide undécylénique, In order to ensure better bio-availability, solutions of these imidazole derivatives in fatty excipients, in particular in undecylenic acid, have been proposed in European Patent No. 0 064 830.
ce qui en favorise une meilleure solubilité. which promotes a better solubility.
Toutefois, de telles solutions ne sont cependant pas appropriées car elles présentent l'inconvénient d'être anhydres et, par conséquent, de However, such solutions are however not appropriate because they have the disadvantage of being anhydrous and, consequently, of
ne pas hydrater l'ongle et donc de ralentir la bio-disponibilité des princi- do not hydrate the nail and therefore slow down the bio-availability of
pes actifs.active pes.
Le nitrate de miconazole ainsi que le nitrate d'éconazole n'étant pas solubles dans l'eau et très peu solubles dans les solutions hydroalcooliques, il n'a pas été possible à ce jour de mettre au point des compositions anti-fongiques aqueuses contenant ces substances actives à l'état solubilisé à des concentrations suffisantes en vue d'assurer un bon Since miconazole nitrate and econazole nitrate are not soluble in water and are not very soluble in hydroalcoholic solutions, it has not been possible to date to develop aqueous antifungal compositions containing these active substances in the solubilized state at concentrations sufficient to ensure a good
effet thérapeutique.therapeutic effect.
La présence d'eau apporte en effet un intérêt particulier dans la mesure o elle permet de bien hydrater l'ongle et de délivrer le principe The presence of water brings a particular interest to the extent that it allows to moisturize the nail and deliver the principle
actif en profondeur.active in depth.
On vient de constater qu'il était possible d'obtenir des composi- We have just seen that it was possible to obtain composi-
tions anti-fongiques contenant, en solution aqueuse, du nitrate de miconazole ou du r-trate d'éconazole en utilisant comme agent solubilisant anti-fungal preparations containing, in aqueous solution, miconazole nitrate or econazole r-treat using as a solubilising agent
de l'urée.urea.
Les étuaus qui ont été réalisées ont en effet permis de mettre en évidence que la présence d'urée dans les solutions aqueuses avait pour effet d'augmenter de façon particulièrement significative la solubilité du The tests that have been carried out have made it possible to demonstrate that the presence of urea in the aqueous solutions has the effect of significantly increasing the solubility of the aqueous solution.
nitrate de miconazole et du nitrate d'éconazole. miconazole nitrate and econazole nitrate.
La présente invention a donc pour objet une composition anti- The subject of the present invention is therefore an anti-
fongique sous forme d'une lotion, d'un gel ou d'un vernis à base de nitrate -2- de miconazole ou de nitrate d'éconazole contenant ces substances actives, à in the form of a lotion, gel or varnish based on miconazole nitrate -2 or econazole nitrate containing these active substances,
l'état dissous, dans un mélange constitué d'eau, d'urée et d'un tiers sol- the dissolved state, in a mixture of water, urea and a third
vant soluble dans l'eau, le rapport en poids de l'urée à l'eau étant infé- soluble in water, the ratio by weight of urea to water being less than
rieur ou égal à 1.less than or equal to 1.
Comme ceci a été précisé ci-dessus, la présence d'urée augmente la solubilité du nitrate de miconazole ou du nitrate d'éconazole et ceci quelque soit la nature du tiers solvant soluble dans l'eau utilisé pour la As was stated above, the presence of urea increases the solubility of miconazole nitrate or econazole nitrate and this whatever the nature of the water soluble third solvent used for the
formation de la phase aqueuse.formation of the aqueous phase.
Dans les compositions anti-fongiques selon l'invention, le ni- In the anti-fungal compositions according to the invention, the
trate de miconazole ou le nitrate d'éconazole est généralement présent, à miconazole or econazole nitrate is generally present at
l'état dissous, en une proportion de 0,1 à 2% en poids. the dissolved state, in a proportion of 0.1 to 2% by weight.
La proportion d'eau par rapport au poids total de la composition The proportion of water relative to the total weight of the composition
est généralement comprise entre 5 et 20% et la proportion d'urée par rap- is usually between 5 and 20% and the proportion of urea
port au poids total de la composition est généralement comprise entre 1 et the total weight of the composition is generally between 1 and
20%Z.20% Z.
Comme mentionné ci-dessus, il importe toutefois que le rapport en As mentioned above, however, it is important that the report in
poids de l'urée à l'eau soit inférieur ou égal à 1. weight of urea to water is less than or equal to 1.
Le tiers solvant peut être un alcool primaire ou secondaire, une The third solvent may be a primary or secondary alcohol, a
cétone, un glycol ou un éther de glycol ou encore un mélange de ces sol- ketone, a glycol or a glycol ether or a mixture of these sol-
vants.solvents.
Le tiers solvant doit non seulement être soluble dans l'eau mais également, dans le cas des vernis, capable de solubiliser la résine The third solvent must not only be soluble in water but also, in the case of varnishes, able to solubilize the resin
filmogène et ainsi laisser un film après évaporation et/ou pénétration. film-forming and thus leave a film after evaporation and / or penetration.
Parmi les alcools primaires ou secondaires, on peut en particu- Of the primary or secondary alcohols, in particular
lier mentionner le méthanol, l'éthanol, l'isopropanol, le n-propanol et mention mentioning methanol, ethanol, isopropanol, n-propanol and
l'alcool benzylique.benzyl alcohol.
Parmi les cétones, on peut mentionner l'acétone, la diéthylcétone, la diisobutyl cétone, l'éthylbutyl cétone, la méthylisobutyl Among the ketones, there may be mentioned acetone, diethylketone, diisobutylketone, ethylbutylketone, methylisobutyl
cétone et la méthylpropyl cétone. ketone and methylpropyl ketone.
Parmi les glycols et éthers de glycols, on peut en particulier citer l'éthylène glycol, le propylène glycol, le diéthylène glycol, le dipropylène glycol, l'éthylène glycol méthyléther, l'éthylène glycol éthyléther, le diéthylène glycol méthyléther, etc. Selon une forme de réalisation préférée de l'invention, le tiers Among the glycols and glycol ethers, mention may in particular be made of ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, ethylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol methyl ether, and the like. According to a preferred embodiment of the invention, the third
solvant est l'éthanol ou un mélange d'éthanol et de propylène glycol. solvent is ethanol or a mixture of ethanol and propylene glycol.
Comme ceci a été mentionné ci-dessus, les compositions anti- As mentioned above, the anti-
fongiques selon l'invention peuvent se présenter sous forme de lotions, de in accordance with the invention may be in the form of lotions,
gels (compositions épaissies) ou encore sous forme d'un vernis. gels (thickened compositions) or in the form of a varnish.
Lorsque les compositions selon l'invention se présentent sous forme d'un gel, celles-ci sont obtenues à l'aide d'un agent épaississant ou When the compositions according to the invention are in the form of a gel, they are obtained using a thickening agent or
3 2 6 1 32 273 2 6 1 32 27
gélifiant tel que par exemple les dérivés de montmorillonite et de bentonite, la bentone, l'hectorite, le kaolin, l'attapulgite,, l'hydroxypropyl guar, les dérivés de cellulose tels que la méthylcellulose, l'hydroxyméthylcellulose, l'hydroxybutylcellulose, l'hydroxyéthylcellulose, l'hydroxypropylcellulose, la méthylhydroxyéthylcellulose ou la méthylhydroxypropylcellulose, ou encore les acides polyacryliques réticulés tels que ceux vendus sous la dénomination commerciale de "CARBOPOL" par la gelling agent such as, for example, montmorillonite and bentonite derivatives, bentone, hectorite, kaolin, attapulgite, hydroxypropyl guar, cellulose derivatives such as methylcellulose, hydroxymethylcellulose, hydroxybutylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylhydroxyethylcellulose or methylhydroxypropylcellulose, or the crosslinked polyacrylic acids such as those sold under the trade name "CARBOPOL" by the
Société GOODRICH.GOODRICH Company.
Selon cette forme de réalisation, les agents épaississants ou gélifiants sont utilisés dans une proportion comprise entre 0,5 et 2Z et de According to this embodiment, the thickening or gelling agents are used in a proportion of between 0.5 and 2Z and
préférence entre 0,7 et 1,5% en poids. preferably between 0.7 and 1.5% by weight.
Lorsque les compositions selon l'invention se présentent sous forme d'un vernis, elles contiennent une résine susceptible de laisser When the compositions according to the invention are in the form of a varnish, they contain a resin capable of leaving
subsister un film après évaporation des solvants. a film remains after evaporation of the solvents.
Parmi les résines utilisables pour la formation des vernis selon l'invention, on peut en particulier mentionner le polymère polyvinylpyrrolidone/acétate de vinyle vendu par la Société GAF corporation sous la dénomination de "PVP-VA E335", le polyacétate de vinyle vendu par la Société RHONE-POULENC sous la dénomination de "Rhodopas M60A", le polyacrylamide vendu par la Société AMERICAN CYANAMID sous la dénomination Among the resins that can be used for the formation of the varnishes according to the invention, mention may in particular be made of the polyvinylpyrrolidone / vinyl acetate polymer sold by the GAF Corporation under the name "PVP-VA E335", the polyvinyl acetate sold by the company. RHONE-POULENC company under the name "Rhodopas M60A", the polyacrylamide sold by AMERICAN CYANAMID under the name
de "Gelamide 250", le phtalate d'hydroxyméthylcellulose vendu par la Socié- "Gelamide 250", the hydroxymethylcellulose phthalate sold by the Company
té SEPPIC sous la dénomination de "HP55", le diméthylaminoéthyl méthacrylate/méthacrylate d'alkyle inférieur vendu par la Société ROHM et HAAS sous la dénomination de "Eudragit E100", le copolymère acétate de SEPPIC under the name "HP55", dimethylaminoethyl methacrylate / lower alkyl methacrylate sold by the company ROHM and HAAS under the name "Eudragit E100", the acetate copolymer of
vinyle/acide crotonique vendu par la Société NATIONAL STARCH sous la dénomi- vinyl / crotonic acid sold by the NATIONAL STARCH under the name
nation de "Resin 28-1310", le copolymère méthylvinyléther/monomoléate de butyle vendu par la Société GAF Corporation sous la dénomination de "Gantrez ES 425", les polymères à base d'acrylate ou de méthacrylate d'alkyle et d'acide acrylique ou méthacrylique ainsi que tout autre "Resin 28-1310", the methyl vinyl ether / butyl monomoleate copolymer sold by GAF Corporation under the name "Gantrez ES 425", polymers based on acrylate or on alkyl methacrylate and acrylic acid or methacrylic as well as any other
polymère et copolymère compatible avec le mélange solvant. polymer and copolymer compatible with the solvent mixture.
Selon cette forme de réalisation, la résine peut être présente dans les compositions en une proportion comprise entre 7,5 et 30% et de According to this embodiment, the resin may be present in the compositions in a proportion of between 7.5 and 30% and
préférence entre 10 et 20% par rapport au poids total de la composition. preferably between 10 and 20% relative to the total weight of the composition.
Les com -sitions selon l'invention peuvent en outre contenir d'autres ingrédients tels que par exemple des agents conservateurs, des agents anti-oxydants et dans le cas des vernis des agents plastifiants The compositions according to the invention may also contain other ingredients such as, for example, preserving agents, antioxidants and, in the case of varnishes, plasticizing agents.
comme par exemple le glycérol.as for example glycerol.
On va maintenant donner à titre d'illustration et sans aucun caractère limitatif, plusieurs exemples de compositions anti-fongiques selon l'invention: -4- Exemple I Vernis: - Nitrate de miconazole................ Several examples of anti-fungal compositions according to the invention will now be given by way of non-limiting illustration. EXAMPLE I Varnish: - Miconazole nitrate ............ ....
...........2 % - Eau...............................................9,5 Z Urée..............................................9 Z - Ethanol absolu...................................25,5 Z Acétone...................DTD: .......................14 Z - Polymère PVP-VA E 335 vendu par la Société GAF (solution à 50%)..................40 Z Exemple II Gel: - Nitrate d'éconazole................................ ........... 2% - Water ................................... ............ 9.5 Z Urea ................................. ............. 9 Z - Absolute Ethanol ................................ ... 25.5 Z Acetone ................... DTD: ..................... .. 14 Z - PVP-VA E 335 polymer sold by GAF (50% solution) .................. 40 Z Example II Gel: - Nitrate of econazole ................................
1 Z - Eau...............DTD: ................................10 Z Urée...............................DTD: ................1 Z - Water ............... DTD: ............................. ... 10 Z Urea ............................... DTD: ........... .....
1 Z - Propylène glycol................................. .43,5% - Ethanol absolu....................................43, 5% - Hydroxypropylcellulose vendu sous la dénomination de "KLUCEL H" par la Société HERCULES..............1 Z EXEMPLE III Lotion - Nitrate de miconazole..............................1 Z - Propylene glycol ................................. .43.5% - Absolute ethanol .... ................................ 43, 5% - Hydroxypropylcellulose sold under the name "KLUCEL H" by the Company HERCULES .............. 1 EXAMPLE III Lotion - Miconazole nitrate .......................... ....
1 Z Eau..........................DTD: ......................5 Z Urée.....................................5 - Propylène glycol..................................45,5 Z - Ethanol absolu....................................43,5 EXEMPLE IV Vernis - Nitrate de miconazole............................1 Z Water .......................... DTD: ................... ... 5 Z Urea ..................................... 5 - Propylene glycol ... ............................... 45,5 Z - Ethanol absolute ............ ........................ 43.5 EXAMPLE IV Varnish - Miconazole Nitrate ................ ............
2 Z - Eau.................DTD: ..............................10 Z Urée.................................DTD: .............10 Z - Ethanol absolu....................................2 Z - Water ................. DTD: ........................... ... 10 Z Urea ................................. DTD: ......... .... 10 Z - Ethanol absolute ....................................
64 Z Glycérol..........................................64 Z Glycerol ..........................................
2 Z - Polymère de diméthylaminoéthyle méthacrylate/ méthacrylate d'alkyle inférieur vendu sous la dénomination de "Eudragit E 100" par la Société ROHMet HAAS...DTD: ........................12 Z..DTD: _5_ 26132272 Z - Lower alkyl dimethylaminoethyl methacrylate / methacrylate polymer sold under the name "Eudragit E 100" by the company Rohm Haas ... DTD: ................. ....... 12 Z..DTD: _5_ 2613227
Claims (11)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8704560A FR2613227B1 (en) | 1987-04-01 | 1987-04-01 | PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OR ECONAZOLE NITRATE IN THE TREATMENT OF NAIL FUNGAL INFECTIONS |
| DE3810897A DE3810897A1 (en) | 1987-04-01 | 1988-03-30 | PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OR ECONAZOLE NITRATE FOR THE TREATMENT OF FUNGAL INFECTIONS OF THE NAILS |
| IT20055/88A IT1218204B (en) | 1987-04-01 | 1988-03-31 | PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OF ECONAZOLE IN THE TREATMENT OF NAIL INFECTIONS CAUSED BY MUSHROOMS |
| JP63080226A JPS63258814A (en) | 1987-04-01 | 1988-03-31 | Medicinal composition for treating nail mycotic infection by nitric acid miconazole or nitric acid econazole |
| GB8807788A GB2202743B (en) | 1987-04-01 | 1988-03-31 | Topical antifungal composition |
| CH1220/88A CH674710A5 (en) | 1987-04-01 | 1988-03-31 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8704560A FR2613227B1 (en) | 1987-04-01 | 1987-04-01 | PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OR ECONAZOLE NITRATE IN THE TREATMENT OF NAIL FUNGAL INFECTIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2613227A1 true FR2613227A1 (en) | 1988-10-07 |
| FR2613227B1 FR2613227B1 (en) | 1990-12-28 |
Family
ID=9349669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8704560A Expired - Fee Related FR2613227B1 (en) | 1987-04-01 | 1987-04-01 | PHARMACEUTICAL COMPOSITIONS BASED ON MICONAZOLE NITRATE OR ECONAZOLE NITRATE IN THE TREATMENT OF NAIL FUNGAL INFECTIONS |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS63258814A (en) |
| CH (1) | CH674710A5 (en) |
| DE (1) | DE3810897A1 (en) |
| FR (1) | FR2613227B1 (en) |
| GB (1) | GB2202743B (en) |
| IT (1) | IT1218204B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7588753B2 (en) | 2002-09-05 | 2009-09-15 | Galderma S.A. | Synergistically pro-penetrating solutions for ungual/peri-ungual dermatological/cosmetic applications |
| FR2937250A1 (en) * | 2008-10-21 | 2010-04-23 | Fabre Pierre Dermo Cosmetique | UREA-BASED FILMOGENOUS SOLUTION FOR THE TREATMENT OF NAIL PSORASIS |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2008775C (en) * | 1989-02-24 | 1998-12-22 | Alberto Ferro | Nail lacquer |
| FR2673537B1 (en) * | 1991-03-08 | 1993-06-11 | Oreal | USE OF HYDROPHILIC PENETRATION AGENTS IN DERMATOLOGICAL COMPOSITIONS FOR THE TREATMENT OF ONYCHOMYCOSES, AND CORRESPONDING COMPOSITIONS. |
| AU3328693A (en) * | 1991-12-18 | 1993-07-19 | Advanced Oxygen Technologies, Inc. | Treatment of fungal infections |
| DE4212105A1 (en) * | 1992-04-10 | 1993-10-14 | Roehm Pharma Gmbh | Nail polish for the treatment of onychomycoses |
| US5464610A (en) * | 1992-10-15 | 1995-11-07 | Schering-Plough Healthcare Products, Inc. | Method for treating onychomycosis |
| US5391367A (en) * | 1993-07-28 | 1995-02-21 | Pfizer Inc. | Antifungal nail solution |
| JPH07126164A (en) * | 1993-10-29 | 1995-05-16 | Taisho Pharmaceut Co Ltd | Prolonged action antifungal agent |
| CA2325553A1 (en) * | 1998-04-17 | 1999-10-28 | Penederm Inc. | Topical formulations for the treatment of nail fungal diseases |
| US8257688B2 (en) | 2000-03-27 | 2012-09-04 | Taro Pharmaceuticals Industries | Controlled delivery system of antifungal and keratolytic agents for local treatment of fungal infections of the nail and surrounding tissues |
| US7074392B1 (en) * | 2000-03-27 | 2006-07-11 | Taro Pharmaceutical Industries Limited | Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections |
| DE10126501A1 (en) | 2001-05-30 | 2002-12-12 | Aventis Pharma Gmbh | Composition used for detaching abnormal keratin material e.g. warts or fungally damage nails, comprises mixture of urea, film former and water or aqueous alcohol |
| FR2844197B1 (en) * | 2002-09-05 | 2006-06-23 | Galderma Res & Dev | SOLUTION FOR UNIGEAL AND PERI-UNGEAL APPLICATION |
| PL2106805T3 (en) * | 2003-03-21 | 2011-10-31 | Nexmed Holdings Inc | Antifungal nail coat and method of use |
| EP1557375A1 (en) * | 2004-01-23 | 2005-07-27 | Neubourg Skin Care GmbH & Co. KG | Spray dispenser for nail tincture |
| DE502005006082D1 (en) * | 2005-09-26 | 2009-01-08 | Faber Castell Ag | Cosmetic liquid for coloring the nails and the skin |
| KR20080080355A (en) * | 2005-12-28 | 2008-09-03 | 데이코쿠 세이야쿠 가부시키가이샤 | Pharmaceutical composition for application to nail |
| AU2010226476B2 (en) * | 2009-03-20 | 2013-02-07 | Stiefel Laboratories, Inc. | Fatty acid monoglyceride compositions |
| CN105496958A (en) * | 2015-12-24 | 2016-04-20 | 广东同德药业有限公司 | Econazole nitrate spray and preparation method thereof |
| EP4129292A1 (en) | 2021-08-04 | 2023-02-08 | OnychoPharm GmbH | Formulation for substituted 2-aminothiazoles in the treatment of fungal and fungal-bacterial infections of the nail |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0125759A2 (en) * | 1983-03-17 | 1984-11-21 | Warner Lambert Holland B.V. | Topical composition of antibiotics for application to the mucosa |
| EP0156507A1 (en) * | 1984-02-23 | 1985-10-02 | Ortho Pharmaceutical Corporation | Antifungal dermatological solution |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3210138A1 (en) * | 1982-03-19 | 1983-09-22 | Röhm Pharma GmbH, 6100 Darmstadt | ANTIMYCOTIC, THERAPEUTIC PREPARATIONS ON A CREAM AND OINTAGE BASIS |
-
1987
- 1987-04-01 FR FR8704560A patent/FR2613227B1/en not_active Expired - Fee Related
-
1988
- 1988-03-30 DE DE3810897A patent/DE3810897A1/en not_active Withdrawn
- 1988-03-31 IT IT20055/88A patent/IT1218204B/en active
- 1988-03-31 CH CH1220/88A patent/CH674710A5/fr not_active IP Right Cessation
- 1988-03-31 JP JP63080226A patent/JPS63258814A/en active Pending
- 1988-03-31 GB GB8807788A patent/GB2202743B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0125759A2 (en) * | 1983-03-17 | 1984-11-21 | Warner Lambert Holland B.V. | Topical composition of antibiotics for application to the mucosa |
| EP0156507A1 (en) * | 1984-02-23 | 1985-10-02 | Ortho Pharmaceutical Corporation | Antifungal dermatological solution |
Non-Patent Citations (1)
| Title |
|---|
| JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 56, janvier-décembre 1967, pages 370-375, American Pharmaceutical Association, US; S. FELDMAN et al.: "Effect of urea on solubility" * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7588753B2 (en) | 2002-09-05 | 2009-09-15 | Galderma S.A. | Synergistically pro-penetrating solutions for ungual/peri-ungual dermatological/cosmetic applications |
| FR2937250A1 (en) * | 2008-10-21 | 2010-04-23 | Fabre Pierre Dermo Cosmetique | UREA-BASED FILMOGENOUS SOLUTION FOR THE TREATMENT OF NAIL PSORASIS |
| WO2010046375A1 (en) * | 2008-10-21 | 2010-04-29 | Pierre Fabre Dermo-Cosmetique | Urea-based film-forming solution for treating nail psoriasis |
| AU2009306462B2 (en) * | 2008-10-21 | 2013-08-22 | Pierre Fabre Dermo-Cosmetique | Urea-based film-forming solution for treating nail psoriasis |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2613227B1 (en) | 1990-12-28 |
| IT1218204B (en) | 1990-04-12 |
| GB2202743B (en) | 1990-11-21 |
| IT8820055A0 (en) | 1988-03-31 |
| CH674710A5 (en) | 1990-07-13 |
| GB2202743A (en) | 1988-10-05 |
| JPS63258814A (en) | 1988-10-26 |
| DE3810897A1 (en) | 1988-10-20 |
| GB8807788D0 (en) | 1988-05-05 |
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| AP | Petition for property claim | ||
| AP | Petition for property claim |
Free format text: BO 36/92 LIRE 9004560 AU LIEU DE 8704560 |
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| ST | Notification of lapse |