FR2507909A1 - Plasma sampling device partic. for artificial kidney patient - has semipermeable membrane to arrest blood cells while passing plasma - Google Patents

Plasma sampling device partic. for artificial kidney patient - has semipermeable membrane to arrest blood cells while passing plasma Download PDF

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Publication number
FR2507909A1
FR2507909A1 FR8112129A FR8112129A FR2507909A1 FR 2507909 A1 FR2507909 A1 FR 2507909A1 FR 8112129 A FR8112129 A FR 8112129A FR 8112129 A FR8112129 A FR 8112129A FR 2507909 A1 FR2507909 A1 FR 2507909A1
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FR
France
Prior art keywords
plasma
blood
blood cells
chamber
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8112129A
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French (fr)
Inventor
Denis Messier
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LAYME INVESTMENT BV
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LAYME INVESTMENT BV
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Filing date
Publication date
Application filed by LAYME INVESTMENT BV filed Critical LAYME INVESTMENT BV
Priority to FR8112129A priority Critical patent/FR2507909A1/en
Publication of FR2507909A1 publication Critical patent/FR2507909A1/en
Application status is Withdrawn legal-status Critical

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/491Blood by separating the blood components
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/367Circuit parts not covered by the preceding subgroups of group A61M1/3621

Abstract

Blood sampling device in which plasma is sepd. from blood cells. This is highly advantageous when an artificial kidney patient requires repeated tests or the plasma, which can now be carried out without removing any blood cells. The separator comprises a plasma reception chamber divided from a flow passage for the patient's blood by a semi-permeable membrane which will pass plasma but arrest blood cells. Pref. the plasma reception chamber has at least one wall of elastomeric material thick enough to be self-sealing when a syringe needle is withdrawn after extracting a sample of plasma from the chamber.

Description

La présente invention est relative, à un dispositif pour séparer le plasma des globules du sang. The present invention relates to a device for separating plasma from blood cells.

Les malades qui subissent un traitement tel qu un traitement impliquant l'utilisation d'un rein ar tificiel, doivent faire examiner leur sang régulièrement pour déterminer le progrès du traitement ainsi que dans d'autres buts. Patients who undergo treatment such that a treatment involving the use of ar tificial kidney, have to examine blood regularly to determine the progress of treatment as well as for other purposes. Dans un processus caractéristique de traitement du sang du patient est extrait de son corps, on le fait passer a travers un rein artificiel pour le purifier, et on le renvoie dans le courant sanguin du malade. In a typical process of treatment patient's blood is extracted from his body, it is passed through an artificial kidney machine to purify it, and it returns to the bloodstream of the patient. Ce traitement peut durer de cinq a sept heures et doit être effectué trois fois par semaine ; This treatment can last from five to seven hours and should be done three times a week; pendant ce traitement, des échantillons du sang du malade doivent être prélevés et examinés. during this treatment, blood samples of the patient must be taken and examined.

Les échantillons du sang du malade contiennent des globules ainsi que du plasma, bien que seul ce dernier présente un intérêt pour le médecin. The samples of the patient's blood contains blood cells and plasma, although only the latter is relevant for the doctor. En raison de l'examen périodique, le malade perd progressivement des globules, bien que ces globules euxmemes ne présentent aucun intérêt pour le médecin. Because of the periodic review, the patient gradually loses blood cells, although the cells themselves are of no interest to the physician. Du fait que d'une façon caractéristique les malades subissant un tel traitement n'ont pas une capacité normale de production de globules du sang, la perte progressive des globules sains constitue un problème important. Because characteristically patients undergoing such treatment does not have a normal capacity of blood cells, the progressive loss of healthy blood cells is a significant problem.

L'invention a en conséquence pour but de fournir un dispositif pour séparer le plasma des globules du sang du malade de façon que seul le plasma soit extrait aux fins d'examen, laissant les globules normaux sains dans le système circulato re du malade. The invention accordingly seeks to provide a device for separating plasma from blood cells of the patient so that only the plasma be extracted for review, leaving normal, healthy cells in the system re circulato the patient.

L'invention est utilisée dans le contexte d'un processus de traitement par rein artificiel, avec un tube pour amener le sang du malade au rein artificiel et ramener le sang du malade au rein artificiel au malade. The invention is used in the context of an artificial kidney treatment process, with a tube to bring the patient's blood to the artificial kidney and bring the patient's blood to the artificial kidney to the patient. D'une façon typique, on utilise dans un tel circuit une pompe å sang. Typically, use is made in such a circuit a blood pump. Le dispositif de séparation du plasma est de préférence disposé entre la pompe et un organe de serrage de manière qu'une pression de sang puisse se développer dans le dispositif séparateur de plasma. Plasma separation device is preferably disposed between the pump and a clamping member such that blood pressure can develop in the plasma separator device. Une dépression peut également être appliquée dans la chambre du dispos i- tif indiquée ci-dessous, ce qui améliore encore l'effet de séparation du plasma du sang. Depression may also be applied in the chamber rested tif i indicated below, which further improves the plasma separation effect of blood.

Le dispositif de séparation du plasma lui-même consiste en un organe élastique qui délimite une chambre. The plasma separation device itself consists of an elastic member defining a chamber. La chambre est séparée du flux sanguin passant dans le circuit par un élément semi-perméable qui permet le passage du plasma mas qui bloque celui des globules du sang. The room is separated from the blood flow flowing in the circuit by a semi-permeable element which allows passage of the mas plasma blocking that of blood cells. Une aiguille de prélèvement peut alors être enfoncée a travers l'organe élastique dans la chambre, et le plasma peut en être extrait sans extraction de globules. A sampling needle can then be inserted through the elastic member in the chamber, and the plasma can be separated without extraction of blood cells.

Une grille protectrice est prévue pour protéger la membrane des déteriorations par l'aiguille de prélèvement. A protective grid is provided to protect the membrane against deterioration by the sampling needle.

D'autres caractéristiques et avantages de l'invention apparaîtront au cours de la description qui va suivre, faite en se référant aux dessins annexés, donnés uniquement à titre d'exemple et dans lesquels Other features and advantages of the invention will emerge during the following description, with reference to the accompanying drawings given by way of example and in which
- la Fig. - Fig. 1 montre schématiquement le circuit du sang avec le dispositif suivant l'invention de séparation du plasma 1 shows diagrammatically the circuit of the blood with the device according to the plasma separating invention
la Fig. Fig. 2 est une vue du dispositif suivant l'invention pour la séparation du plasma, 2 is a view of the device according to the invention for the separation of plasma,
En se référant aux dessins , la Fig. Referring to the drawings, Fig. 1 montre schématiquement le circuit du sang comportant un dispositif suivant l'invention de séparation du plasma. 1 schematically shows the blood circuit comprising a device according to the plasma separating invention. Le sang est prélevé sur le malade et parvient a la pompe à sang 2 par l'intermédiaire d'un conduit 1.Le sang traverse le dispositif 3 de séparation du plasma, franchit un organe de serrage 4 et est traité dans un appareil 6 qui est de façon typique un rein artificiel, avant d'être renvoyé dans le corps du malade par l'intermédiaire d'un conduit 5. Blood is collected from the patient and reaches the blood pump 2 through a conduit 1. The blood passes through the device 3 for separating the plasma, passes a clamping member 4 and is treated in an apparatus 6 which is typically an artificial kidney, before being returned to the body of the patient via a conduit 5.

La fonction de l'organe de serrage 4 consis- te à engendrer une contre-pression dans le tube conduisant le sang de façon à forcer le sang dans le dispositif 3 de séparation du plasma. The function of the clamping member 4 Consist- you against generating a pressure in the tube conducting the blood so as to force the blood into the device 3 for separating plasma. L'action de la pompe 2 située avant le dispositif de séparation 3, assure avec l'organe de serrage 4 l'établissement de cette contre-pression dans le dispositif 3 de séparation du plasma. The action of the pump 2 located before the separating device 3 ensures with the clamping member 4 against the establishment of this pressure in the device 3 for separating plasma.

La Fig.2 montre le dispositif 3 de séparation du plasma d'une façon détaillée. 2 shows the device 3 for separating a plasma detail. Le sang s'écoule à travers un tube 7 vers le dispositif 6 de traitement comme indiqué plus haut. The blood flows through a tube 7 to the device 6 for processing as described above. Un organe élastique 8, qui peut être en latex, est disposé dans le tube 7 de façon à former une chambre 9. L'organe élastique 8 peut être fixé sur le tube 7 par un moyen quelconque approprié, par exemple au moyen d'un connecteur 10 en matière plastique et d'un adhésif approprie. An elastic member 8, which may be made of latex, is disposed in the tube 7 so as to form a chamber 9. The elastic member 8 may be fastened to the pipe 7 by any suitable means, for example by means of a connector 10 in plastic material and a suitable adhesive.

AA l'interface entre le sang se trouvant dans le tube 7 et la chambre 9 est disposée une membrane ll semiperméable qui peut être realdsee en l'un quelconque des matériaux bien connus qui filtrent efficacement toutes les molécules ayant une dimension inférieure à 50,000 Dalton. AA the interface between the blood in the tube 7 and the chamber 9 is arranged a semipermeable membrane lt realdsee which may be in any well-known materials which effectively filter all molecules having a size of less than 50,000 Dalton.

La membrane peut être serrée entre l'organe en latex et la paroi du tube comme représenté en 13. The membrane may be clamped between the latex body and the tube wall as shown at 13.

Du fait de l'action combinée de la pompe 2 et de l'organe de serrage 4 indiquée en référence à la Fig.l, le plasma est forcé sous pression de passer dans la chambre 9 tandis que la membrane semi#perméable ll retient les globules du sang. Due to the combined action of the pump 2 and the clamping member 4 shown with reference to fig.l, the plasma is forced under pressure to pass into the chamber 9 while the semi-permeable membrane # ll retains blood cells.

Il est également prévu une grille protectrice 12 en matière plastique qui protège la membrane Il et 1'em- pêche d'être perforée par l'aiguille de prélèvement. There is also provided a protective grid 12 of plastic material which protects the membrane and it 1'em- fishing to be punctured by the sampling needle.

En service, après avoir fixé l'organe 4 de serrage de la Fig. In use, after fixing the clamping member 4 of Fig. 1, le praticien introduit l'aiguille de prélèvement dans la chambre 9 a travers l'élément 8 en latex. 1, the practitioner introduces the sampling needle into the chamber 9 through the element 8 in the latex. Il n'y a pas de risque de déterioration de la membrane ll du fait que la grille protectrice 12 empêche l'aiguille de s'enfoncer trop profondément. There is no risk of deterioration of the membrane ll that the protective grid 12 prevents the needle from sinking too deeply. La chambre 9 contient seulement du plasma, qui est alors extrait au moyen de l'aiguille de prélèvement, l'aiguille est retirée et l'élément 8 en matière élastique assure de lui-même l'étanchéité. The chamber 9 contains only plasma, which is then extracted by the sampling needle, the needle is withdrawn and the element 8 made of elastic material ensures itself the seal.

Le sang du malade peut ainsi être examiné souvent en prélevant seulement le plasma, qui est la seule substance présentant un intérêt aux fins d'examens. The blood of the patient can thus be examined often only taking the plasma, which is the only substance of interest for exams. Ainsi, les précieux globules du sang, que de façon caractéristique le malade ne peut reproduire, ne sont pas diminués. Thus the precious blood cells that typically the patient can not reproduce, are not diminished.

Claims (4)

REVENDICXTIONS REVENDICXTIONS
1 - Dispositif pour séparer le plasma du sang, caractérisé en ce qu'il comprend une chambre (9) isolée du sang du malade au moyen d'une membrane semi-perméable (11) laissant pénétrer le plasma dans ladite chambre (9) mais arretant les globules du sang. 1 - An apparatus for separating plasma from blood, characterized in that it comprises a chamber (9) isolated from the blood of the patient by means of a semipermeable membrane (11) which admits the plasma in said chamber (9) but LAYING DOWN blood cells.
2 - Dispositif suivant la revendication l, carac térise en ce que ladite chambre (q) comporte un organe (8) en un matériau du type élastique assurant de lui-même l'étanchéité lorsqu'il est perforé, et qui est adjacent à ladite chambre te). 2 - Device according to claim l, charac acterised in that said chamber (q) comprises a member (8) of a material of the elastic type ensuring the seal itself when it is perforated and which is adjacent to said you room).
3 - Dispositif suivant la revendication 2, carac térisé en ce qu'un organe protecteur (12) est disposé entre la chambre (9.) et la membrane (11). 3 - Device according to Claim 2, charac terized in that a protective member (12) is arranged between the chamber (9) and the diaphragm (11).
4. Dispositif suivant la revendication 3, caractérisé en ce qu'il comprend un organe disposé en aval adapté pour augmenter la pression sanguine dans le dispositif de séparation. 4. Device according to Claim 3, characterized in that it comprises a member disposed downstream adapted to increase the blood pressure in the separation device.
FR8112129A 1981-06-19 1981-06-19 Plasma sampling device partic. for artificial kidney patient - has semipermeable membrane to arrest blood cells while passing plasma Withdrawn FR2507909A1 (en)

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FR8112129A FR2507909A1 (en) 1981-06-19 1981-06-19 Plasma sampling device partic. for artificial kidney patient - has semipermeable membrane to arrest blood cells while passing plasma

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FR8112129A FR2507909A1 (en) 1981-06-19 1981-06-19 Plasma sampling device partic. for artificial kidney patient - has semipermeable membrane to arrest blood cells while passing plasma

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3405706A1 (en) * 1983-03-14 1984-11-08 Gelman Sciences Inc Process for extraction of blood plasma and filter apparatus for carrying out this method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1528430A (en) * 1966-06-24 1968-06-07 Beckman Instruments Inc Device and method for sampling a component of a fluid dialysable
US3459176A (en) * 1966-06-24 1969-08-05 Beckman Instruments Inc Apparatus and method of sampling a dialyzable component of blood
FR2049513A5 (en) * 1969-06-12 1971-03-26 Monsallier Julien Blood sampler for external circulations
FR2117471A5 (en) * 1970-12-11 1972-07-21 Hyden Viktor
FR2325390A1 (en) * 1975-09-26 1977-04-22 Asahi Chemical Ind Blood Processing System
FR2398485A1 (en) * 1977-07-29 1979-02-23 Fresenius Chem Pharm Ind Device for continuous chemical analysis in the living human body

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1528430A (en) * 1966-06-24 1968-06-07 Beckman Instruments Inc Device and method for sampling a component of a fluid dialysable
US3459176A (en) * 1966-06-24 1969-08-05 Beckman Instruments Inc Apparatus and method of sampling a dialyzable component of blood
FR2049513A5 (en) * 1969-06-12 1971-03-26 Monsallier Julien Blood sampler for external circulations
FR2117471A5 (en) * 1970-12-11 1972-07-21 Hyden Viktor
US3848580A (en) * 1970-12-11 1974-11-19 Hasselblad Apparatus for controlled selective separation of undesirable constituents from blood to achieve a therapeutic effect
FR2325390A1 (en) * 1975-09-26 1977-04-22 Asahi Chemical Ind Blood Processing System
FR2398485A1 (en) * 1977-07-29 1979-02-23 Fresenius Chem Pharm Ind Device for continuous chemical analysis in the living human body

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3405706A1 (en) * 1983-03-14 1984-11-08 Gelman Sciences Inc Process for extraction of blood plasma and filter apparatus for carrying out this method

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