FR2489819A1 - Antibiotique bmg162-af2 ayant notamment une activite antitumorale et son procede de preparation a partir d'une souche du genre bacillus - Google Patents

Antibiotique bmg162-af2 ayant notamment une activite antitumorale et son procede de preparation a partir d'une souche du genre bacillus Download PDF

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Publication number
FR2489819A1
FR2489819A1 FR8116856A FR8116856A FR2489819A1 FR 2489819 A1 FR2489819 A1 FR 2489819A1 FR 8116856 A FR8116856 A FR 8116856A FR 8116856 A FR8116856 A FR 8116856A FR 2489819 A1 FR2489819 A1 FR 2489819A1
Authority
FR
France
Prior art keywords
bmg162
antibiotic
weight
culture
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8116856A
Other languages
English (en)
French (fr)
Other versions
FR2489819B1 (instruction
Inventor
Hamao Umezawa
Tomio Takeuchi
Hiroshi Naganawa
Hironobu Iinuma
Setsuko Kunimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of FR2489819A1 publication Critical patent/FR2489819A1/fr
Application granted granted Critical
Publication of FR2489819B1 publication Critical patent/FR2489819B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR8116856A 1980-09-08 1981-09-04 Antibiotique bmg162-af2 ayant notamment une activite antitumorale et son procede de preparation a partir d'une souche du genre bacillus Granted FR2489819A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55123585A JPS5748957A (en) 1980-09-08 1980-09-08 Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient

Publications (2)

Publication Number Publication Date
FR2489819A1 true FR2489819A1 (fr) 1982-03-12
FR2489819B1 FR2489819B1 (instruction) 1985-02-15

Family

ID=14864227

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8116856A Granted FR2489819A1 (fr) 1980-09-08 1981-09-04 Antibiotique bmg162-af2 ayant notamment une activite antitumorale et son procede de preparation a partir d'une souche du genre bacillus

Country Status (18)

Country Link
US (2) US4416899A (instruction)
JP (1) JPS5748957A (instruction)
KR (1) KR870001373B1 (instruction)
AT (1) AT376239B (instruction)
AU (1) AU523222B2 (instruction)
BE (1) BE890229A (instruction)
CA (1) CA1175763A (instruction)
CH (1) CH655498B (instruction)
CS (1) CS226036B2 (instruction)
DE (1) DE3134353C2 (instruction)
DK (1) DK157890C (instruction)
ES (1) ES8302090A1 (instruction)
FR (1) FR2489819A1 (instruction)
GB (1) GB2084999B (instruction)
HU (1) HU188077B (instruction)
IT (1) IT1209896B (instruction)
NL (1) NL8104069A (instruction)
SE (1) SE450836B (instruction)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505330A1 (fr) * 1981-05-11 1982-11-12 Microbial Chem Res Found Nouvelle substance carcinostatique a base d'un derive de n-(4-(3-aminopropyl) aminobutyl)-2-((s)-7-guanidino-3-hydroxyhaptanamido)-2-hydroxyethanamide et son procede de preparation
EP0153720A3 (en) * 1984-03-02 1986-06-11 Microbial Chemistry Research Foundation Spergualin-related compounds having a phenylene group, a process for their preparation and their use as medicaments
EP0349297A1 (en) * 1988-07-01 1990-01-03 Takara Shuzo Co. Ltd. Purification of spergualin-related compounds

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4851446A (en) * 1984-11-13 1989-07-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Immunosuppressing method
JPS61134312A (ja) * 1984-12-06 1986-06-21 Microbial Chem Res Found 移植免疫抑制剤並びに抗アレルギ−剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
DE3770680D1 (de) * 1986-04-04 1991-07-18 Microbial Chem Res Found Spergualinaehnliche verbindungen und ihr herstellungsverfahren.
JP2873340B2 (ja) * 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質ｔａｎ―１０５７，その製造法および用途
JPH0263181U (instruction) * 1988-10-27 1990-05-11
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2998438A (en) * 1958-03-31 1961-08-29 Merck & Co Inc Eulicin and process for production
US3617448A (en) * 1967-10-03 1971-11-02 Research Corp Antibiotic and methods of producing and using it
US3743580A (en) * 1970-04-28 1973-07-03 Microbial Chem Res Found Antibiotic,negamycin,and processes for the preparation thereof
US4163796A (en) * 1977-12-14 1979-08-07 The Dow Chemical Company Stabilized aqueous amide antimicrobial composition
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
US4226808A (en) * 1979-08-17 1980-10-07 Schering Corporation 1-Aryl-2-dihalogenodeuterioalkanoylamido-1,3-propanediol antibacterial agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE JOURNAL OF ANTIBIOTICS, vol. XXXIV, no. 12, décembre 1981, Japan Antibiotics Research Association (Tokyo, JP) pages 1622-1624 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505330A1 (fr) * 1981-05-11 1982-11-12 Microbial Chem Res Found Nouvelle substance carcinostatique a base d'un derive de n-(4-(3-aminopropyl) aminobutyl)-2-((s)-7-guanidino-3-hydroxyhaptanamido)-2-hydroxyethanamide et son procede de preparation
EP0153720A3 (en) * 1984-03-02 1986-06-11 Microbial Chemistry Research Foundation Spergualin-related compounds having a phenylene group, a process for their preparation and their use as medicaments
EP0349297A1 (en) * 1988-07-01 1990-01-03 Takara Shuzo Co. Ltd. Purification of spergualin-related compounds

Also Published As

Publication number Publication date
CS226036B2 (en) 1984-03-19
SE450836B (sv) 1987-08-03
DE3134353C2 (de) 1986-03-13
US4474880A (en) 1984-10-02
ES505256A0 (es) 1983-01-01
JPS5748957A (en) 1982-03-20
FR2489819B1 (instruction) 1985-02-15
NL8104069A (nl) 1982-04-01
IT8149237A0 (it) 1981-09-04
GB2084999A (en) 1982-04-21
IT1209896B (it) 1989-08-30
DE3134353A1 (de) 1982-04-22
ES8302090A1 (es) 1983-01-01
GB2084999B (en) 1984-06-13
DK394281A (da) 1982-03-09
US4416899A (en) 1983-11-22
HU188077B (en) 1986-03-28
CA1175763A (en) 1984-10-09
KR870001373B1 (ko) 1987-07-24
KR830007834A (ko) 1983-11-07
SE8105079L (sv) 1982-03-09
AT376239B (de) 1984-10-25
AU7489281A (en) 1982-03-18
AU523222B2 (en) 1982-07-15
BE890229A (fr) 1982-01-04
JPS6316380B2 (instruction) 1988-04-08
DK157890B (da) 1990-02-26
CH655498B (instruction) 1986-04-30
DK157890C (da) 1990-07-23
ATA386081A (de) 1984-03-15

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