FR2370510A1 - PROCESS FOR ENCAPSULATING A LABILE BIOLOGICAL MATERIAL - Google Patents

PROCESS FOR ENCAPSULATING A LABILE BIOLOGICAL MATERIAL

Info

Publication number
FR2370510A1
FR2370510A1 FR7634482A FR7634482A FR2370510A1 FR 2370510 A1 FR2370510 A1 FR 2370510A1 FR 7634482 A FR7634482 A FR 7634482A FR 7634482 A FR7634482 A FR 7634482A FR 2370510 A1 FR2370510 A1 FR 2370510A1
Authority
FR
France
Prior art keywords
monomer
encapsulating
causes
biological material
continuous phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7634482A
Other languages
French (fr)
Other versions
FR2370510B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Damon Corp
Original Assignee
Damon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/606,166 external-priority patent/US4324683A/en
Priority to GB39727/76A priority Critical patent/GB1540461A/en
Application filed by Damon Corp filed Critical Damon Corp
Priority to FR7634482A priority patent/FR2370510A1/en
Publication of FR2370510A1 publication Critical patent/FR2370510A1/en
Application granted granted Critical
Publication of FR2370510B1 publication Critical patent/FR2370510B1/fr
Granted legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0006—Organic membrane manufacture by chemical reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/16—Interfacial polymerisation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/26—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from polyamines and polycarboxylic acids
    • C08G69/28—Preparatory processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Abstract

L'invention décrit un procédé de polymérisation interfaciale en deux stades pour encapsuler des substances chimiquement ou biologiquement actives dans des membranes semi-perméables de haute qualité. On forme une émulsion dont la phase discontinue contient la substance à encapsuler et un premier monomère. L'addition d'un second monomere à la phase continue provoque la formation d'une membrane imparfaite autour des gouttelettes de la phase discontinue. On enlève la phase continue, on remet les micro-capsules en suspension et l'on ajoute une seconde portion du second monomère, ce qui provoque une nouvelle polymérisation renforçant et bouchant leurs défauts macro-poreux. On peut ainsi encapsuler une enzyme, de l'hémoglobine, etc.The invention describes a two-stage interfacial polymerization process for encapsulating chemically or biologically active substances in high quality semi-permeable membranes. An emulsion is formed, the discontinuous phase of which contains the substance to be encapsulated and a first monomer. The addition of a second monomer to the continuous phase causes the formation of an imperfect membrane around the droplets of the discontinuous phase. The continuous phase is removed, the microcapsules are resuspended and a second portion of the second monomer is added, which causes a new polymerization which reinforces and closes their macroporous defects. It is thus possible to encapsulate an enzyme, hemoglobin, etc.

FR7634482A 1975-08-20 1976-11-16 PROCESS FOR ENCAPSULATING A LABILE BIOLOGICAL MATERIAL Granted FR2370510A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB39727/76A GB1540461A (en) 1975-08-20 1976-09-24 Chemical processes
FR7634482A FR2370510A1 (en) 1975-08-20 1976-11-16 PROCESS FOR ENCAPSULATING A LABILE BIOLOGICAL MATERIAL

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/606,166 US4324683A (en) 1975-08-20 1975-08-20 Encapsulation of labile biological material
FR7634482A FR2370510A1 (en) 1975-08-20 1976-11-16 PROCESS FOR ENCAPSULATING A LABILE BIOLOGICAL MATERIAL

Publications (2)

Publication Number Publication Date
FR2370510A1 true FR2370510A1 (en) 1978-06-09
FR2370510B1 FR2370510B1 (en) 1981-12-18

Family

ID=26219706

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7634482A Granted FR2370510A1 (en) 1975-08-20 1976-11-16 PROCESS FOR ENCAPSULATING A LABILE BIOLOGICAL MATERIAL

Country Status (2)

Country Link
FR (1) FR2370510A1 (en)
GB (1) GB1540461A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444497A1 (en) * 1978-12-19 1980-07-18 Mars Inc MICRO-ENCAPSULATION PROCESS
FR2452285A1 (en) * 1979-03-28 1980-10-24 Damon Corp METHOD OF ENCAPSULATION OF A LIVABLE TISSUE OR OF A BIOLOGICALLY ACTIVE MATERIAL TO BE IMPLANTED, AND CAPSULES OBTAINED
EP0367475A2 (en) * 1988-10-29 1990-05-09 Nippon Oil And Fats Company, Limited Process for producing haemoglobin concentrate

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390521A (en) * 1980-04-11 1983-06-28 Exxon Research And Engineering Co. Artificial red cells
US4376059A (en) * 1980-04-11 1983-03-08 Exxon Research And Engineering Co. Process for preparing artificial red cells
EP0120061A4 (en) * 1982-09-29 1986-08-21 Theodore E Spielberg Encapsulated genetically programmed living organisms producing therapeutic substances.
WO1988001165A1 (en) * 1986-08-11 1988-02-25 Innovata Biomed Limited Pharmaceutical formulations comprising microcapsules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1427085A (en) * 1963-12-13 1966-02-04 Wallace & Tiernan Capsule filling process
US3954678A (en) * 1974-07-11 1976-05-04 E. I. Du Pont De Nemours And Company Semipermeable microcapsules containing a silica gel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1427085A (en) * 1963-12-13 1966-02-04 Wallace & Tiernan Capsule filling process
US3954678A (en) * 1974-07-11 1976-05-04 E. I. Du Pont De Nemours And Company Semipermeable microcapsules containing a silica gel

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444497A1 (en) * 1978-12-19 1980-07-18 Mars Inc MICRO-ENCAPSULATION PROCESS
FR2452285A1 (en) * 1979-03-28 1980-10-24 Damon Corp METHOD OF ENCAPSULATION OF A LIVABLE TISSUE OR OF A BIOLOGICALLY ACTIVE MATERIAL TO BE IMPLANTED, AND CAPSULES OBTAINED
EP0367475A2 (en) * 1988-10-29 1990-05-09 Nippon Oil And Fats Company, Limited Process for producing haemoglobin concentrate
EP0367475A3 (en) * 1988-10-29 1990-07-04 Nippon Oil And Fats Company, Limited Process for producing haemoglobin concentrate

Also Published As

Publication number Publication date
GB1540461A (en) 1979-02-14
FR2370510B1 (en) 1981-12-18

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ST Notification of lapse