FR2347336A1 - Derives peptidiques - Google Patents
Derives peptidiquesInfo
- Publication number
- FR2347336A1 FR2347336A1 FR7710668A FR7710668A FR2347336A1 FR 2347336 A1 FR2347336 A1 FR 2347336A1 FR 7710668 A FR7710668 A FR 7710668A FR 7710668 A FR7710668 A FR 7710668A FR 2347336 A1 FR2347336 A1 FR 2347336A1
- Authority
- FR
- France
- Prior art keywords
- opt
- alkyl
- ala
- substd
- lys
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical group NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 3
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 2
- ROHFNLRQFUQHCH-RXMQYKEDSA-N D-leucine Chemical compound CC(C)C[C@@H](N)C(O)=O ROHFNLRQFUQHCH-RXMQYKEDSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine group Chemical group N[C@H](CCCCN)C(=O)O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 2
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 abstract 2
- AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical group C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 abstract 2
- -1 Met Chemical compound 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000418 D-alanino group Chemical group C(=O)(O)[C@@H](C)N* 0.000 abstract 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 1
- 125000000734 D-serino group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C07K14/702—Enkephalins with at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB14362/76A GB1523812A (en) | 1976-04-08 | 1976-04-08 | Polypeptide |
| GB2106376 | 1976-05-21 | ||
| GB2205576 | 1976-05-27 | ||
| GB2929876 | 1976-07-14 | ||
| GB4483876 | 1976-10-28 | ||
| GB4483776 | 1976-10-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2347336A1 true FR2347336A1 (fr) | 1977-11-04 |
| FR2347336B1 FR2347336B1 (enrdf_load_stackoverflow) | 1980-07-18 |
Family
ID=27546664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7710668A Granted FR2347336A1 (fr) | 1976-04-08 | 1977-04-07 | Derives peptidiques |
Country Status (13)
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2359120A1 (fr) * | 1976-07-19 | 1978-02-17 | Sandoz Sa | Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments |
| FR2359817A1 (fr) * | 1976-07-27 | 1978-02-24 | Reckitt & Colmann Prod Ltd | Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant |
| FR2364890A1 (fr) * | 1976-09-16 | 1978-04-14 | Richter Gedeon Vegyeszet | Nouveaux pentapeptides et procede pour leur preparation |
| FR2365553A1 (fr) * | 1976-09-27 | 1978-04-21 | Lilly Co Eli | Derives amides de pentapeptides et tetrapeptides et leur utilisation comme medicaments |
| FR2371422A1 (fr) * | 1976-11-23 | 1978-06-16 | Wellcome Found | Nouveaux peptides et medicament contenant ces substances |
| FR2381746A1 (fr) * | 1976-09-01 | 1978-09-22 | Coy David | Nouveaux derives encephaliniques a la methionine |
| EP0000559A1 (en) * | 1977-07-22 | 1979-02-07 | The Wellcome Foundation Limited | Pentapeptide-N-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them |
| EP0002236A1 (en) * | 1977-11-24 | 1979-06-13 | The Wellcome Foundation Limited | Peptides, their salts, their acid addition salts, pharmaceutical formulations containing them and their use as morphine antagonists and anaesthetics |
| FR2411829A1 (fr) * | 1977-12-15 | 1979-07-13 | Reckitt & Colmann Prod Ltd | Derives de tetrapeptides, leurs procedes d'obtention et compositions pharmaceutiques les contenant |
| FR2424253A1 (fr) * | 1978-04-27 | 1979-11-23 | Brun Lab Sa Le | Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique |
| EP0008196A1 (en) * | 1978-08-08 | 1980-02-20 | American Home Products Corporation | Pentapeptides, processes for their preparation, intermediates used in such processes, use in pharmaceutical compositions and compositions containing them |
| EP0018072A1 (en) * | 1979-03-30 | 1980-10-29 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| FR2488253A1 (fr) * | 1980-08-08 | 1982-02-12 | Roques Bernard | Nouveaux peptides et leur application en therapeutique |
| EP0451763A3 (en) * | 1990-04-09 | 1991-12-04 | Fuji Photo Film Co., Ltd. | Peptide derivatives with amphiphatic properties, intermediates thereof and liposomes and films comprising said derivatives |
| EP3710467A4 (en) * | 2017-11-17 | 2021-08-04 | Cytogel Pharma, LLC | MU-OPIOID RECEPTOR POLYMERIC AGONISTS |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2933947A1 (de) * | 1979-08-22 | 1981-03-12 | Hoechst Ag, 6000 Frankfurt | Neue peptidamide und verfahren zu ihrer herstellung. |
| JPS5692846A (en) * | 1979-12-27 | 1981-07-27 | Takeda Chem Ind Ltd | Tetrapeptide derivative and its preparation |
| US4495178A (en) * | 1983-10-06 | 1985-01-22 | G. D. Searle & Co. | Enkephalin analogs |
| EP1975153A3 (en) * | 2003-05-30 | 2010-03-31 | Prozymex A/S | Protease inhibitors |
| JP6149279B2 (ja) * | 2011-02-09 | 2017-06-21 | オーガノバランス ゲーエムベーハー | 皮膚状態の治療に使用するためのペプチド |
| JP2013043885A (ja) * | 2011-08-26 | 2013-03-04 | Kansai Bunri Sogo Gakuen | デヒドロアミノ酸含有グリセロール誘導体 |
| CZ303858B6 (cs) * | 2012-05-11 | 2013-05-29 | Zetor Tractors A.S. | Usporádání reverzacní dvoutoké prevodovky, zejména pro motorová vozidla a stavební stroje, s dvema vetvemi toku výkonu |
-
1977
- 1977-03-28 NZ NZ183712A patent/NZ183712A/xx unknown
- 1977-03-31 AU AU23819/77A patent/AU510760B2/en not_active Expired
- 1977-04-04 FI FI771049A patent/FI771049A7/fi not_active Application Discontinuation
- 1977-04-06 DK DK158077A patent/DK158077A/da not_active IP Right Cessation
- 1977-04-06 SE SE7704043A patent/SE7704043L/ not_active Application Discontinuation
- 1977-04-06 HU HU77IE774A patent/HU176260B/hu unknown
- 1977-04-06 CS CS772289A patent/CS202568B2/cs unknown
- 1977-04-07 DE DE19772715803 patent/DE2715803A1/de not_active Withdrawn
- 1977-04-07 DD DD7700198316A patent/DD130348A5/xx unknown
- 1977-04-07 FR FR7710668A patent/FR2347336A1/fr active Granted
- 1977-04-08 SU SU772470259A patent/SU904518A3/ru active
- 1977-04-08 PL PL1977197302A patent/PL106210B1/pl unknown
- 1977-04-08 JP JP4023077A patent/JPS52139039A/ja active Pending
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2359120A1 (fr) * | 1976-07-19 | 1978-02-17 | Sandoz Sa | Nouveaux composes polypeptidiques, leur preparation et leur application comme medicaments |
| FR2359817A1 (fr) * | 1976-07-27 | 1978-02-24 | Reckitt & Colmann Prod Ltd | Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant |
| FR2381746A1 (fr) * | 1976-09-01 | 1978-09-22 | Coy David | Nouveaux derives encephaliniques a la methionine |
| FR2364890A1 (fr) * | 1976-09-16 | 1978-04-14 | Richter Gedeon Vegyeszet | Nouveaux pentapeptides et procede pour leur preparation |
| FR2365553A1 (fr) * | 1976-09-27 | 1978-04-21 | Lilly Co Eli | Derives amides de pentapeptides et tetrapeptides et leur utilisation comme medicaments |
| FR2371422A1 (fr) * | 1976-11-23 | 1978-06-16 | Wellcome Found | Nouveaux peptides et medicament contenant ces substances |
| EP0000559A1 (en) * | 1977-07-22 | 1979-02-07 | The Wellcome Foundation Limited | Pentapeptide-N-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them |
| EP0002236A1 (en) * | 1977-11-24 | 1979-06-13 | The Wellcome Foundation Limited | Peptides, their salts, their acid addition salts, pharmaceutical formulations containing them and their use as morphine antagonists and anaesthetics |
| FR2411829A1 (fr) * | 1977-12-15 | 1979-07-13 | Reckitt & Colmann Prod Ltd | Derives de tetrapeptides, leurs procedes d'obtention et compositions pharmaceutiques les contenant |
| EP0005658A1 (fr) * | 1978-04-27 | 1979-11-28 | Laboratoire le Brun S.A. Société dite: | Nouveaux dérivés de peptides analogues des enképhalines, leur procédé de préparation et leur application thérapeutique |
| FR2424253A1 (fr) * | 1978-04-27 | 1979-11-23 | Brun Lab Sa Le | Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique |
| EP0008196A1 (en) * | 1978-08-08 | 1980-02-20 | American Home Products Corporation | Pentapeptides, processes for their preparation, intermediates used in such processes, use in pharmaceutical compositions and compositions containing them |
| EP0018072A1 (en) * | 1979-03-30 | 1980-10-29 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| FR2488253A1 (fr) * | 1980-08-08 | 1982-02-12 | Roques Bernard | Nouveaux peptides et leur application en therapeutique |
| EP0046113A1 (fr) * | 1980-08-08 | 1982-02-17 | Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | Nouveaux peptides et leur application en thérapeutique |
| EP0451763A3 (en) * | 1990-04-09 | 1991-12-04 | Fuji Photo Film Co., Ltd. | Peptide derivatives with amphiphatic properties, intermediates thereof and liposomes and films comprising said derivatives |
| US5252706A (en) * | 1990-04-09 | 1993-10-12 | Fuji Photo Film Co., Ltd. | Peptide derivative amphiphatic compound, intermediate thereof and liposome and film comprising peptide derivative amphiphatic compound |
| EP3710467A4 (en) * | 2017-11-17 | 2021-08-04 | Cytogel Pharma, LLC | MU-OPIOID RECEPTOR POLYMERIC AGONISTS |
| US12037416B2 (en) * | 2017-11-17 | 2024-07-16 | Cytogel Pharma, Llc | Polymer agonists of mu opioid receptors |
| US12146002B2 (en) | 2017-11-17 | 2024-11-19 | Cytogel Pharma, Llc | Polymer agonists of mu opioid receptors |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2347336B1 (enrdf_load_stackoverflow) | 1980-07-18 |
| NZ183712A (en) | 1979-10-25 |
| AU510760B2 (en) | 1980-07-10 |
| PL197302A1 (pl) | 1978-02-13 |
| JPS52139039A (en) | 1977-11-19 |
| PL106210B1 (pl) | 1979-12-31 |
| DE2715803A1 (de) | 1977-10-27 |
| DK158077A (da) | 1977-10-09 |
| DD130348A5 (de) | 1978-03-22 |
| FI771049A7 (enrdf_load_stackoverflow) | 1977-10-09 |
| CS202568B2 (en) | 1981-01-30 |
| HU176260B (en) | 1981-01-28 |
| SU904518A3 (ru) | 1982-02-07 |
| SE7704043L (sv) | 1977-10-09 |
| AU2381977A (en) | 1978-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |