FR06C0009I2 - - Google Patents

Info

Publication number
FR06C0009I2
FR06C0009I2 FR06C0009C FR06C0009C FR06C0009I2 FR 06C0009 I2 FR06C0009 I2 FR 06C0009I2 FR 06C0009 C FR06C0009 C FR 06C0009C FR 06C0009 C FR06C0009 C FR 06C0009C FR 06C0009 I2 FR06C0009 I2 FR 06C0009I2
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR06C0009C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22622452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR06C0009(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of FR06C0009I1 publication Critical patent/FR06C0009I1/fr
Application granted granted Critical
Publication of FR06C0009I2 publication Critical patent/FR06C0009I2/fr
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FR06C0009C 1993-12-21 2006-03-13 Active FR06C0009I2 (instruction)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17108393A 1993-12-21 1993-12-21
PCT/US1994/014236 WO1995017407A1 (en) 1993-12-21 1994-12-20 Tetrahydrofuran antifungals

Publications (2)

Publication Number Publication Date
FR06C0009I1 FR06C0009I1 (instruction) 2006-05-19
FR06C0009I2 true FR06C0009I2 (instruction) 2006-12-29

Family

ID=22622452

Family Applications (1)

Application Number Title Priority Date Filing Date
FR06C0009C Active FR06C0009I2 (instruction) 1993-12-21 2006-03-13

Country Status (28)

Country Link
EP (1) EP0736030B1 (instruction)
JP (1) JP2834889B2 (instruction)
KR (1) KR0179990B1 (instruction)
CN (1) CN1064685C (instruction)
AT (1) ATE204875T1 (instruction)
AU (1) AU681753B2 (instruction)
BR (1) BR1100154B1 (instruction)
CA (1) CA2179396C (instruction)
CO (1) CO4520281A1 (instruction)
CZ (1) CZ294823B6 (instruction)
DE (2) DE69428125T2 (instruction)
DK (1) DK0736030T3 (instruction)
ES (1) ES2159623T3 (instruction)
FI (1) FI118470B (instruction)
FR (1) FR06C0009I2 (instruction)
HU (1) HU225062B1 (instruction)
IL (1) IL112081A (instruction)
LU (1) LU91216I2 (instruction)
MY (1) MY130217A (instruction)
NL (1) NL300219I2 (instruction)
NO (2) NO316173B1 (instruction)
NZ (1) NZ278713A (instruction)
PL (1) PL181193B1 (instruction)
PT (1) PT736030E (instruction)
SK (1) SK283035B6 (instruction)
TW (1) TW377349B (instruction)
WO (1) WO1995017407A1 (instruction)
ZA (1) ZA9410142B (instruction)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0741737T1 (en) * 1994-01-24 2000-02-29 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
HUP9701690A3 (en) * 1995-06-02 1998-04-28 Schering Corp Kenilwort Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
EP0837859B1 (en) * 1995-06-19 2003-08-13 Schering Corporation Tetrahydrofuran antifungals
HUP9902115A3 (en) * 1995-12-20 2000-06-28 Schering Corp Process for preparation of hydrazides
RU2207119C2 (ru) * 1996-05-24 2003-06-27 Шеринг Корпорейшн Противогрибковый состав с повышенной биодоступностью
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
DE69730241T2 (de) * 1996-06-28 2005-08-11 Schering Corp. Feste lösung eines fungizids mit erhöhter bioverfügbarkeit
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
EP0914100A1 (en) * 1996-06-28 1999-05-12 Schering Corporation Oral composition comprising a triazole antifungal compound
WO1998021203A1 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,s,r- and 2s,4r,s,r-hydroxyitraconazole
AU5432698A (en) * 1996-11-12 1998-06-03 Sepracor, Inc. 2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole
CA2269617A1 (en) * 1996-11-12 1998-05-22 Chris H. Senanayake 2r,4s,r,s- and 2s,4r,r,s-hydroxyitraconazole- and hydroxysaperconazole derivatives
WO1998021205A1 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole
US5684197A (en) * 1996-12-12 1997-11-04 Schering Corporation Process for preparation of hydrazides
CN1238353C (zh) 1997-02-11 2006-01-25 詹森药业有限公司 含氨基酸酯之唑类抗真菌剂
MY133775A (en) * 1997-09-25 2007-11-30 Schering Corp Tetrahydrofuran antifungal phosphate
US6043245A (en) * 1997-09-25 2000-03-28 Schering Corporation Tetrahydrofuran antifungal phosphate
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
AU759982B2 (en) * 1997-10-07 2003-05-01 Merck Sharp & Dohme Corp. Crystalline antifungal polymorph
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US5883097A (en) * 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
US6147077A (en) * 1999-04-29 2000-11-14 Sepracor Inc. 2R,4S-hydroxyitraconazole isomers
EP1177192B1 (en) 1999-05-04 2003-03-19 Janssen Pharmaceutica N.V. Antifungal ethers
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
PL212985B1 (pl) * 2001-04-03 2012-12-31 Schering Corp Ciekla zawiesina zawierajaca przeciwgrzybiczo skuteczna ilosc posakonazolu oraz zastosowanie zmikronizowanych czastek posakonazolu
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
CA2477923C (en) 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
JP2005535602A (ja) 2002-05-31 2005-11-24 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 新規コナゾール結晶形及び関連方法、医薬組成物及び方法
CN100360117C (zh) 2002-06-21 2008-01-09 转化医药公司 具有提高的溶出度的药物组合物
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
ITMI20032020A1 (it) 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
JP4792032B2 (ja) * 2004-08-13 2011-10-12 シェーリング−プラウ・リミテッド 抗生物質、トリアゾールおよびコルチコステロイドを含む薬学的処方物
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
WO2011003992A1 (en) 2009-07-09 2011-01-13 Sandoz Ag A crystalline form of posaconazole
WO2011158248A2 (en) * 2010-05-12 2011-12-22 Glenmark Generics Limited Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole
RU2585683C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Очистка позаконазола и промежуточных продуктов для синтеза позаконазола
WO2011144656A1 (en) * 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
US9199919B2 (en) 2010-05-19 2015-12-01 Sandoz Ag Process for the preparation of chiral hydrazides
JP6013326B2 (ja) * 2010-05-19 2016-10-25 サンド・アクチエンゲゼルシヤフト キラルトリアゾロンの調製のための方法
RS62583B1 (sr) 2010-06-29 2021-12-31 Merck Sharp & Dohme Formulacije intravenskog rastvora sa posakonazolom, stabilisane supstituisanim beta-ciklodekstrinom
WO2012172015A1 (en) 2011-06-16 2012-12-20 Sandoz Ag Process for the preparation of a chiral compound
EP2789610A1 (en) 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
CN105579448B (zh) * 2013-07-25 2018-12-21 桑多斯股份公司 制备泊沙康唑的晶型iv的改进方法
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN105287403A (zh) * 2014-08-02 2016-02-03 陕西合成药业股份有限公司 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
CN107001343B (zh) 2014-12-05 2020-12-11 普尔莫赛德有限公司 抗真菌的化合物
JP6811727B2 (ja) * 2015-05-21 2021-01-20 プルモシデ リミテド 抗真菌性の4−(4−(4−(((3r,5r)−5−((1h−1,2,4−トリアゾール−1−イル)メチル)−5−(2,4−ジフルオロフェニル)テトラヒドロフラン−3−イル)メトキシ)−3−メチルフェニル)ピペラジン−1−イル)−n−(2−ヒドロキシシクロヘキシル)ベンズアミド、又はその医薬として許容し得る塩
CN106317032A (zh) * 2015-06-15 2017-01-11 重庆圣华曦药业股份有限公司 一种制备高纯度的泊沙康唑的方法
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
WO2017051342A1 (en) * 2015-09-23 2017-03-30 Biocon Limited Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
ES2893793T3 (es) * 2016-03-04 2022-02-10 Zhejiang Ausun Pharmaceutical Co Ltd Posaconazol, composición, producto intermedio, método de preparación para el mismo y usos del mismo
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
WO2018115319A2 (en) 2016-12-23 2018-06-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
CN106967054A (zh) * 2017-03-30 2017-07-21 成都绿林科技有限公司 一种泊沙康唑的制备方法
CN106883221A (zh) * 2017-04-17 2017-06-23 兰州大学 一种无定形泊沙康唑及其制备方法
CN108341754A (zh) * 2018-03-12 2018-07-31 扬子江药业集团有限公司 泊沙康唑杂质及其制备方法和用途
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN112778369B (zh) * 2019-11-05 2024-01-26 华创合成制药股份有限公司 一种三唑类衍生物及其制备方法和用途
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
ES2065340T3 (es) * 1987-11-20 1995-02-16 Schering Corp Oxetanos y tetrahidrofuranos tri- y tetra-sustituidos y compuestos intermedios para los mismos.
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals

Also Published As

Publication number Publication date
LU91216I2 (en) 2006-03-27
CA2179396C (en) 2001-04-17
NO2006002I2 (no) 2011-03-07
FI118470B (fi) 2007-11-30
CN1064685C (zh) 2001-04-18
CN1142828A (zh) 1997-02-12
NZ278713A (en) 1997-12-19
IL112081A (en) 2001-08-26
BR1100154B1 (pt) 2013-11-26
NO316173B1 (no) 2003-12-22
FI962577A0 (fi) 1996-06-20
NO962616D0 (no) 1996-06-20
DE122006000004I1 (de) 2006-04-27
NL300219I1 (nl) 2006-04-03
DK0736030T3 (da) 2001-10-29
HK1008820A1 (en) 1999-05-21
FR06C0009I1 (instruction) 2006-05-19
PL181193B1 (pl) 2001-06-29
JPH09500658A (ja) 1997-01-21
CZ294823B6 (cs) 2005-03-16
PL315169A1 (en) 1996-10-14
EP0736030B1 (en) 2001-08-29
HU9601709D0 (en) 1996-08-28
CO4520281A1 (es) 1997-10-15
NO962616L (no) 1996-08-07
AU1512795A (en) 1995-07-10
KR0179990B1 (en) 1999-03-20
IL112081A0 (en) 1995-03-15
FI962577L (fi) 1996-06-20
ES2159623T3 (es) 2001-10-16
DE69428125D1 (de) 2001-10-04
SK283035B6 (sk) 2003-02-04
ATE204875T1 (de) 2001-09-15
HUT75879A (en) 1997-05-28
DE122006000004I2 (de) 2007-03-29
MY130217A (en) 2007-06-29
CZ180596A3 (en) 1997-01-15
AU681753B2 (en) 1997-09-04
CA2179396A1 (en) 1995-06-29
EP0736030A1 (en) 1996-10-09
WO1995017407A1 (en) 1995-06-29
TW377349B (en) 1999-12-21
JP2834889B2 (ja) 1998-12-14
PT736030E (pt) 2002-01-30
ZA9410142B (en) 1996-05-02
SK82696A3 (en) 1997-03-05
NO2006002I1 (no) 2006-02-20
HU225062B1 (en) 2006-05-29
DE69428125T2 (de) 2002-05-02
NL300219I2 (nl) 2006-05-01

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