FI972935A0 - Kalpaiinin ja/tai katepsiini B:n substituoituja oksatsolidiiniestäjiä - Google Patents
Kalpaiinin ja/tai katepsiini B:n substituoituja oksatsolidiiniestäjiäInfo
- Publication number
- FI972935A0 FI972935A0 FI972935A FI972935A FI972935A0 FI 972935 A0 FI972935 A0 FI 972935A0 FI 972935 A FI972935 A FI 972935A FI 972935 A FI972935 A FI 972935A FI 972935 A0 FI972935 A0 FI 972935A0
- Authority
- FI
- Finland
- Prior art keywords
- calpain
- cathepsin
- inhibitors
- substituted oxazolidine
- oxazolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37119295A | 1995-01-11 | 1995-01-11 | |
PCT/US1995/016565 WO1996021655A2 (en) | 1995-01-11 | 1995-12-15 | Substituted oxazolidine calpain and/or cathepsin b inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
FI972935A0 true FI972935A0 (fi) | 1997-07-10 |
FI972935A FI972935A (fi) | 1997-07-10 |
Family
ID=23462894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI972935A FI972935A (fi) | 1995-01-11 | 1997-07-10 | Kalpaiinin ja/tai katepsiini B:n substituoituja oksatsolidiiniestäjiä |
Country Status (23)
Country | Link |
---|---|
US (1) | US5691368A (da) |
EP (1) | EP0802909B1 (da) |
JP (1) | JP4157601B2 (da) |
KR (1) | KR100393701B1 (da) |
CN (1) | CN1088456C (da) |
AR (1) | AR001787A1 (da) |
AT (1) | ATE206413T1 (da) |
AU (1) | AU692044B2 (da) |
CA (1) | CA2210258C (da) |
DE (1) | DE69523072T2 (da) |
DK (1) | DK0802909T3 (da) |
ES (1) | ES2165441T3 (da) |
FI (1) | FI972935A (da) |
HU (1) | HUT77649A (da) |
IL (1) | IL116724A (da) |
MX (1) | MX9705235A (da) |
NO (1) | NO309267B1 (da) |
NZ (1) | NZ298999A (da) |
PT (1) | PT802909E (da) |
SI (1) | SI0802909T1 (da) |
TW (1) | TW454001B (da) |
WO (1) | WO1996021655A2 (da) |
ZA (1) | ZA96100B (da) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1270882B (it) * | 1993-10-05 | 1997-05-13 | Isagro Srl | Oligopeptidi ad attivita' fungicida |
US5925633A (en) * | 1996-03-06 | 1999-07-20 | Synphar Laboraties, Inc. | 3-Substituted-4-oxa-1-azabicyclo 3,2,0!heptan-7-one as cysteine protease inhibitors |
AU6134498A (en) * | 1997-03-07 | 1998-09-22 | Hoechst Marion Roussel, Inc. | Method of treating trauma associated with brain, spinal cord or peripheral nerveinjury using carbobenzyloxy n-protected di- and tripeptide phenylalaninals |
WO2000021550A2 (en) * | 1998-10-13 | 2000-04-20 | President And Fellows Of Harvard College | Methods and compositions for treating neurodegenerative diseases |
JP2002529422A (ja) * | 1998-11-12 | 2002-09-10 | リサーチ コーポレイション テクノロジーズ,インコーポレイテッド | 虚血により傷害を受けた組織の処置法 |
CA2360740A1 (en) * | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
EP1516877A1 (en) * | 1999-03-15 | 2005-03-23 | Axys Pharmaceuticals, Inc. | Amine derivatives as protease inhibitors |
WO2000055124A2 (en) | 1999-03-15 | 2000-09-21 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as protease inhibitors |
TW200404789A (en) * | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
US6420364B1 (en) * | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
FR2800737B1 (fr) * | 1999-11-05 | 2006-06-30 | Sod Conseils Rech Applic | Nouveaux composes heterocycliques et leur application a titre de medicaments |
KR100725198B1 (ko) | 1999-11-05 | 2007-06-07 | 소시에떼 드 꽁세이으 드 르세르세 에 따블리까시옹 시앙띠피끄 (에스.세.에르.아.에스.) | 신규 헤테로시클릭 화합물 및 의약으로서의 용도 |
AU2001278084A1 (en) * | 2000-07-31 | 2002-02-13 | The Regents Of The University Of California | Model for alzheimer's disease and other neurodegenerative diseases |
EP1383748A2 (en) | 2000-12-22 | 2004-01-28 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as cathepsin inhibitors |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
EP1436255A1 (en) | 2001-09-14 | 2004-07-14 | Aventis Pharmaceuticals, Inc. | Novel compounds and compositions as cathepsin inhibitors |
CA2467391A1 (en) | 2001-11-14 | 2003-05-22 | Aventis Pharmaceuticals Inc. | Oligopeptides and compositions containing them as cathepsin s inhibitors |
WO2004084830A2 (en) * | 2003-03-21 | 2004-10-07 | Buck Institute | Method for treating alzheimer’s dementia |
US7384970B2 (en) * | 2003-03-24 | 2008-06-10 | Irm Llc | Inhibitors of cathepsin S |
US7109243B2 (en) * | 2003-03-24 | 2006-09-19 | Irm Llc | Inhibitors of cathepsin S |
WO2004089395A2 (en) * | 2003-04-01 | 2004-10-21 | Aventis Pharmaceuticals Inc. | Use of an inhibitor of cathepsin-s or -b to treat or prevent chronic obstructive pulmonary disease |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
US7173051B2 (en) * | 2003-06-13 | 2007-02-06 | Irm, Llc | Inhibitors of cathepsin S |
US7256207B2 (en) * | 2003-08-20 | 2007-08-14 | Irm Llc | Inhibitors of cathepsin S |
FR2863268B1 (fr) * | 2003-12-09 | 2006-02-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments |
US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
KR20090115951A (ko) | 2007-03-01 | 2009-11-10 | 프로비오드룩 아게 | 글루타미닐 사이클라제 저해제의 신규 용도 |
US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
EP2300000A1 (en) * | 2008-07-03 | 2011-03-30 | University of Massachusetts | Methods and compositions for reducing inflammation and treating inflammatory disorders |
JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
EP2545047B9 (en) | 2010-03-10 | 2015-06-10 | Probiodrug AG | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
WO2024018245A1 (en) | 2022-07-22 | 2024-01-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of calpain inhibitors for the treatment of the diabetic kidney disease |
WO2024153744A1 (en) | 2023-01-20 | 2024-07-25 | Institut National de la Santé et de la Recherche Médicale | Autophagy activators for the treatment of rhabdomyolysis |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3867364A (en) * | 1968-11-21 | 1975-02-18 | Microbial Chem Res Found | Process for the synthesis of leupeptins and their analogues |
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US4277395A (en) * | 1980-06-16 | 1981-07-07 | Richardson-Merrell Inc. | Novel enzyme inhibitors |
JPS5754157A (en) * | 1980-09-19 | 1982-03-31 | Nippon Kayaku Co Ltd | L-argininal derivative and its preparation |
US4535167A (en) * | 1981-12-14 | 1985-08-13 | Merck & Co. Inc. | Chiral, N-protected, N-substituted α-amino acids |
WO1984000365A1 (en) * | 1982-07-19 | 1984-02-02 | Nat Res Dev | Synthetic peptides and their preparation |
US4845079A (en) * | 1985-01-23 | 1989-07-04 | Luly Jay R | Peptidylaminodiols |
US5214129A (en) * | 1985-01-23 | 1993-05-25 | Abbott Laboratories | Peptidylaminodiols |
US5091575A (en) * | 1985-01-23 | 1992-02-25 | Abbott Laboratories | Peptidylaminodiols |
US5496927A (en) * | 1985-02-04 | 1996-03-05 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
JPH079705B2 (ja) * | 1986-05-28 | 1995-02-01 | オリンパス光学工業株式会社 | 光カ−ド用デ−タ記録再生装置 |
EP0264106B1 (en) * | 1986-10-14 | 1994-03-16 | Banyu Pharmaceutical Co., Ltd. | 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use |
US5032577A (en) * | 1986-12-31 | 1991-07-16 | Abbott Laboratories | Peptidylaminodiols |
NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
US4820691A (en) * | 1987-06-24 | 1989-04-11 | E. R. Squibb & Sons, Inc. | Amino acid 1,2-diketo derivatives as renin inhibitors |
EP0313847A3 (en) * | 1987-10-01 | 1989-11-29 | G.D. Searle & Co. | Non-peptidyl alpha-succinamidoacyl aminodiols as anti-hypertensive agents |
WO1989007109A1 (en) * | 1988-02-01 | 1989-08-10 | The Upjohn Company | Renin inhibiting peptides with polar end groups |
HUT58764A (en) * | 1988-07-08 | 1992-03-30 | Smithkline Beckman Corp | Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates |
ZA897515B (en) * | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
US4990525A (en) * | 1988-12-22 | 1991-02-05 | Rohm And Haas Company | Synergistic microbicidal combinations containing 3-isothiazolone and commerical biocides |
US5510531A (en) * | 1989-04-10 | 1996-04-23 | Suntory Limited | Proteinase inhibitor |
JP2701932B2 (ja) * | 1989-04-10 | 1998-01-21 | サントリー株式会社 | タンパク質分解酵素阻害剤 |
CA2032259A1 (en) * | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Hiv protease inhibitors useful for the treatment of aids |
EP0532693A1 (en) * | 1990-06-01 | 1993-03-24 | The Du Pont Merck Pharmaceutical Company | 1,4-diamino-2,3-dihydroxybutanes |
DE4037437A1 (de) * | 1990-11-24 | 1992-05-27 | Hoechst Ag | Aminodiol-derivate |
US5444042A (en) * | 1990-12-28 | 1995-08-22 | Cortex Pharmaceuticals | Method of treatment of neurodegeneration with calpain inhibitors |
JPH06504061A (ja) * | 1990-12-28 | 1994-05-12 | コーテックス ファーマシューティカルズ インコーポレイテッド | 神経変性の治療および予防におけるカルパイン阻害剤の使用 |
EP0564561A4 (en) * | 1990-12-28 | 1994-08-10 | Georgia Tech Res Inst | Peptides ketoamides, ketoacids, and ketoesters |
CA2071621C (en) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
JP3190431B2 (ja) * | 1991-07-01 | 2001-07-23 | 三菱化学株式会社 | ケトン誘導体 |
ZA926185B (en) * | 1991-08-22 | 1993-03-01 | Merrell Dow Pharma | Novel orally-active elastase inhibitors. |
EP0580161A1 (en) * | 1992-07-22 | 1994-01-26 | THE McLEAN HOSPITAL CORPORATION | Prophylactic and therapeutic treatment of Alzheimer's disease |
DK0603769T3 (da) * | 1992-12-25 | 1999-06-14 | Mitsubishi Chem Corp | Alfa-aminoketonderivater |
JP2848232B2 (ja) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | アルデヒド誘導体 |
US5541290A (en) * | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
CN1078886C (zh) * | 1993-10-01 | 2002-02-06 | 默里尔药物公司 | 抑制β-淀粉样蛋白产生的抑制剂 |
-
1995
- 1995-12-11 US US08/552,139 patent/US5691368A/en not_active Expired - Lifetime
- 1995-12-15 KR KR1019970704709A patent/KR100393701B1/ko not_active IP Right Cessation
- 1995-12-15 DE DE69523072T patent/DE69523072T2/de not_active Expired - Lifetime
- 1995-12-15 EP EP95943478A patent/EP0802909B1/en not_active Expired - Lifetime
- 1995-12-15 NZ NZ298999A patent/NZ298999A/xx unknown
- 1995-12-15 CA CA002210258A patent/CA2210258C/en not_active Expired - Lifetime
- 1995-12-15 HU HU9800041A patent/HUT77649A/hu unknown
- 1995-12-15 WO PCT/US1995/016565 patent/WO1996021655A2/en active IP Right Grant
- 1995-12-15 JP JP52166996A patent/JP4157601B2/ja not_active Expired - Lifetime
- 1995-12-15 DK DK95943478T patent/DK0802909T3/da active
- 1995-12-15 PT PT95943478T patent/PT802909E/pt unknown
- 1995-12-15 CN CN95197320A patent/CN1088456C/zh not_active Expired - Fee Related
- 1995-12-15 MX MX9705235A patent/MX9705235A/es unknown
- 1995-12-15 AU AU44731/96A patent/AU692044B2/en not_active Ceased
- 1995-12-15 ES ES95943478T patent/ES2165441T3/es not_active Expired - Lifetime
- 1995-12-15 SI SI9530539T patent/SI0802909T1/xx unknown
- 1995-12-15 AT AT95943478T patent/ATE206413T1/de not_active IP Right Cessation
-
1996
- 1996-01-08 ZA ZA96100A patent/ZA96100B/xx unknown
- 1996-01-09 IL IL11672496A patent/IL116724A/xx not_active IP Right Cessation
- 1996-01-09 AR AR33495896A patent/AR001787A1/es unknown
- 1996-01-10 TW TW085100250A patent/TW454001B/zh not_active IP Right Cessation
-
1997
- 1997-07-10 FI FI972935A patent/FI972935A/fi not_active IP Right Cessation
- 1997-07-10 NO NO973216A patent/NO309267B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL116724A (en) | 2000-08-31 |
NZ298999A (en) | 1999-01-28 |
DK0802909T3 (da) | 2002-01-28 |
EP0802909A2 (en) | 1997-10-29 |
JP4157601B2 (ja) | 2008-10-01 |
JPH10512257A (ja) | 1998-11-24 |
TW454001B (en) | 2001-09-11 |
EP0802909B1 (en) | 2001-10-04 |
AR001787A1 (es) | 1997-12-10 |
NO973216L (no) | 1997-09-09 |
US5691368A (en) | 1997-11-25 |
AU4473196A (en) | 1996-07-31 |
SI0802909T1 (en) | 2002-02-28 |
NO309267B1 (no) | 2001-01-08 |
ATE206413T1 (de) | 2001-10-15 |
PT802909E (pt) | 2002-03-28 |
CN1088456C (zh) | 2002-07-31 |
CA2210258A1 (en) | 1996-07-18 |
DE69523072T2 (de) | 2002-06-20 |
ES2165441T3 (es) | 2002-03-16 |
ZA96100B (en) | 1996-07-24 |
KR100393701B1 (ko) | 2003-11-28 |
WO1996021655A2 (en) | 1996-07-18 |
IL116724A0 (en) | 1996-05-14 |
MX9705235A (es) | 1997-10-31 |
NO973216D0 (no) | 1997-07-10 |
HUT77649A (hu) | 1998-07-28 |
CA2210258C (en) | 2002-10-01 |
DE69523072D1 (en) | 2001-11-08 |
FI972935A (fi) | 1997-07-10 |
CN1173174A (zh) | 1998-02-11 |
AU692044B2 (en) | 1998-05-28 |
WO1996021655A3 (en) | 1996-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |