FI962021A0 - 5,6-dihydropyronijohdannaiset proteaasi-inhibiittoreina ja antiviraalisina aineina - Google Patents
5,6-dihydropyronijohdannaiset proteaasi-inhibiittoreina ja antiviraalisina aineinaInfo
- Publication number
- FI962021A0 FI962021A0 FI962021A FI962021A FI962021A0 FI 962021 A0 FI962021 A0 FI 962021A0 FI 962021 A FI962021 A FI 962021A FI 962021 A FI962021 A FI 962021A FI 962021 A0 FI962021 A0 FI 962021A0
- Authority
- FI
- Finland
- Prior art keywords
- antivirals
- dihydropyrone derivatives
- protease inhibitors
- dihydropyrone
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
- C07C321/26—Thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15544393A | 1993-11-19 | 1993-11-19 | |
US08/319,821 US5789440A (en) | 1993-11-19 | 1994-10-12 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
PCT/US1994/012234 WO1995014011A2 (en) | 1993-11-19 | 1994-10-26 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FI962021A0 true FI962021A0 (fi) | 1996-05-13 |
FI962021A FI962021A (fi) | 1996-07-12 |
Family
ID=26852339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI962021A FI962021A (fi) | 1993-11-19 | 1996-05-13 | 5,6-dihydropyronijohdannaiset proteaasi-inhibiittoreina ja antiviraalisina aineina |
Country Status (27)
Country | Link |
---|---|
US (1) | US5936128A (fi) |
EP (1) | EP0729463B1 (fi) |
JP (1) | JP3698435B2 (fi) |
AT (1) | ATE217871T1 (fi) |
AU (1) | AU680064B2 (fi) |
BG (1) | BG63012B1 (fi) |
CA (1) | CA2176041A1 (fi) |
CZ (1) | CZ291856B6 (fi) |
DE (1) | DE69430671T2 (fi) |
DK (1) | DK0729463T3 (fi) |
EE (1) | EE9600045A (fi) |
ES (1) | ES2176263T3 (fi) |
FI (1) | FI962021A (fi) |
HR (1) | HRP940936B1 (fi) |
HU (1) | HUT75225A (fi) |
IL (1) | IL111673A (fi) |
MD (2) | MD1560F2 (fi) |
NO (1) | NO315117B1 (fi) |
NZ (1) | NZ275318A (fi) |
PL (1) | PL180634B1 (fi) |
PT (1) | PT729463E (fi) |
RO (1) | RO117850B1 (fi) |
RU (1) | RU2160733C2 (fi) |
SI (1) | SI0729463T1 (fi) |
SK (1) | SK283240B6 (fi) |
TJ (1) | TJ320B (fi) |
WO (1) | WO1995014011A2 (fi) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0862651A2 (en) * | 1995-10-16 | 1998-09-09 | Chiron Corporation | Method of screening for factors that modulate gene expression |
CA2235394A1 (en) | 1995-11-13 | 1997-05-22 | Gerard Voerman | Anti-viral isolates obtainable from leeches |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
US6087455A (en) * | 1997-12-19 | 2000-07-11 | Shell Oil Company | Process for hydrogenation of macromolecular organic substrates |
CA2339275A1 (en) | 1998-09-11 | 2000-03-23 | Warner-Lambert Company | 5,6-dihydro-4-hydroxy-2-pyranones as hiv aspartyl protease inhibitors |
DE10030094A1 (de) | 2000-06-19 | 2001-12-20 | Bayer Ag | Phenylsubstituierte 5,6-Dihydro-pyron-Derivate |
DE10100175A1 (de) * | 2001-01-04 | 2002-07-11 | Bayer Ag | Hetarylsubstituierte Homotetram-und Homotetronsäuren |
DOP2003000641A (es) | 2002-05-10 | 2003-11-15 | Pfizer | Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan |
US7148226B2 (en) | 2003-02-21 | 2006-12-12 | Agouron Pharmaceuticals, Inc. | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same |
AP2313A (en) | 2004-08-18 | 2011-10-31 | Pfizer | Inhibitors of hepatitis C virus RNA-dependent RNA ploymerase, and compositions and treatments using the same. |
US9012471B2 (en) * | 2008-04-11 | 2015-04-21 | The Trustees Of Columbia University In The City Of New York | Glucose metabolism modulating compounds |
CN112353791A (zh) | 2013-11-11 | 2021-02-12 | 夸利蒂赫布丘蒂克斯公司 | 卡瓦衍生的治疗性化合物及其使用方法 |
WO2016179587A1 (en) * | 2015-05-07 | 2016-11-10 | Kuality Herbceutics Llc | Therapeutic compounds and methods of use thereof |
EP3468952B1 (en) * | 2016-06-14 | 2020-11-25 | Bristol-Myers Squibb Company | 4-hydroxy-3-sulfonylpyridin-2(1h)-ones as apj receptor agonists |
SG11201903348UA (en) | 2016-10-17 | 2019-05-30 | Genentech Inc | Therapeutic compounds and methods of use thereof |
GB201707856D0 (en) | 2017-05-16 | 2017-06-28 | Arctic Pharma As | Compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3206276A (en) * | 1961-09-28 | 1965-09-14 | Minerals Engineering Company | Process for recovery of pure v2o5 from vanadium bearing materials |
US3206476A (en) * | 1962-06-04 | 1965-09-14 | Sterling Drug Inc | 3-substituted-4-hydroxy-6-aryl-2-pyrones and preparation |
US3931235A (en) * | 1972-12-18 | 1976-01-06 | The Dow Chemical Company | Process for preparing sulfur-containing hydroxy pyrones |
US3818046A (en) * | 1972-12-18 | 1974-06-18 | Dow Chemical Co | Sulfur-containing hydroxy pyrones and alkali metal salts thereof |
MA21177A1 (fr) * | 1987-02-11 | 1988-10-01 | May & Baker Ltd | Diones cycliques. |
WO1989007939A2 (en) * | 1988-03-01 | 1989-09-08 | The Upjohn Company | Coumarins to inhibit reverse transcriptase in humans |
JPH03227923A (ja) * | 1990-01-30 | 1991-10-08 | Sawai Seiyaku Kk | ひと免疫不全ウイルス疾患処置剤 |
EP0614599A4 (en) * | 1991-11-18 | 1995-01-04 | Motorola Inc | User selectable noise reduction for a portable microphone. |
ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
-
1994
- 1994-10-26 SK SK646-96A patent/SK283240B6/sk unknown
- 1994-10-26 TJ TJ96000290A patent/TJ320B/xx unknown
- 1994-10-26 CZ CZ19961368A patent/CZ291856B6/cs not_active IP Right Cessation
- 1994-10-26 CA CA002176041A patent/CA2176041A1/en not_active Abandoned
- 1994-10-26 SI SI9430417T patent/SI0729463T1/xx unknown
- 1994-10-26 RU RU96113141/04A patent/RU2160733C2/ru not_active IP Right Cessation
- 1994-10-26 WO PCT/US1994/012234 patent/WO1995014011A2/en active IP Right Grant
- 1994-10-26 RO RO96-01015A patent/RO117850B1/ro unknown
- 1994-10-26 HU HU9601349A patent/HUT75225A/hu not_active Application Discontinuation
- 1994-10-26 AT AT94932030T patent/ATE217871T1/de not_active IP Right Cessation
- 1994-10-26 NZ NZ275318A patent/NZ275318A/xx unknown
- 1994-10-26 AU AU80900/94A patent/AU680064B2/en not_active Ceased
- 1994-10-26 ES ES94932030T patent/ES2176263T3/es not_active Expired - Lifetime
- 1994-10-26 EE EE9600045A patent/EE9600045A/xx unknown
- 1994-10-26 DE DE69430671T patent/DE69430671T2/de not_active Expired - Fee Related
- 1994-10-26 DK DK94932030T patent/DK0729463T3/da active
- 1994-10-26 MD MD96-0172D patent/MD1560F2/xx not_active IP Right Cessation
- 1994-10-26 JP JP51445495A patent/JP3698435B2/ja not_active Expired - Fee Related
- 1994-10-26 PT PT94932030T patent/PT729463E/pt unknown
- 1994-10-26 EP EP94932030A patent/EP0729463B1/en not_active Expired - Lifetime
- 1994-10-26 MD MD96-0172A patent/MD1560G2/ro not_active IP Right Cessation
- 1994-10-26 PL PL94314483A patent/PL180634B1/pl not_active IP Right Cessation
- 1994-11-17 HR HR940936A patent/HRP940936B1/xx not_active IP Right Cessation
- 1994-11-17 IL IL11167394A patent/IL111673A/xx not_active IP Right Cessation
-
1996
- 1996-05-03 BG BG100563A patent/BG63012B1/bg unknown
- 1996-05-13 FI FI962021A patent/FI962021A/fi unknown
- 1996-05-15 NO NO19962018A patent/NO315117B1/no not_active IP Right Cessation
-
1998
- 1998-05-15 US US09/079,689 patent/US5936128A/en not_active Expired - Fee Related
Also Published As
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