FI950699A - Menetelmä insuliinin saamiseksi, jossa on oikein sitoutuneet kystiinisillat - Google Patents

Menetelmä insuliinin saamiseksi, jossa on oikein sitoutuneet kystiinisillat Download PDF

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Publication number
FI950699A
FI950699A FI950699A FI950699A FI950699A FI 950699 A FI950699 A FI 950699A FI 950699 A FI950699 A FI 950699A FI 950699 A FI950699 A FI 950699A FI 950699 A FI950699 A FI 950699A
Authority
FI
Finland
Prior art keywords
insulin
arg
peptide
lys
protein
Prior art date
Application number
FI950699A
Other languages
English (en)
Swedish (sv)
Other versions
FI950699A0 (fi
FI115916B (fi
Inventor
Rainer Obermeier
Martin Gerl
Juergen Ludwig
Walter Sabel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI950699A0 publication Critical patent/FI950699A0/fi
Publication of FI950699A publication Critical patent/FI950699A/fi
Application granted granted Critical
Publication of FI115916B publication Critical patent/FI115916B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI950699A 1994-02-18 1995-02-16 Menetelmä insuliinin saamiseksi, jossa on oikein sitoutuneet kystiinisillat FI115916B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4405179A DE4405179A1 (de) 1994-02-18 1994-02-18 Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DE4405179 1994-02-18

Publications (3)

Publication Number Publication Date
FI950699A0 FI950699A0 (fi) 1995-02-16
FI950699A true FI950699A (fi) 1995-08-19
FI115916B FI115916B (fi) 2005-08-15

Family

ID=6510552

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950699A FI115916B (fi) 1994-02-18 1995-02-16 Menetelmä insuliinin saamiseksi, jossa on oikein sitoutuneet kystiinisillat

Country Status (15)

Country Link
US (1) US5663291A (fi)
EP (1) EP0668292B1 (fi)
JP (1) JP3863579B2 (fi)
KR (1) KR100371824B1 (fi)
AT (1) ATE166069T1 (fi)
AU (1) AU699817B2 (fi)
CA (1) CA2142780C (fi)
DE (2) DE4405179A1 (fi)
DK (1) DK0668292T3 (fi)
ES (1) ES2119241T3 (fi)
FI (1) FI115916B (fi)
HK (1) HK1010457A1 (fi)
IL (1) IL112680A0 (fi)
NO (1) NO318424B1 (fi)
SG (1) SG46683A1 (fi)

Families Citing this family (38)

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ES2218622T3 (es) 1996-07-26 2004-11-16 Aventis Pharma Deutschland Gmbh Derivados de insulina con actividad de union al zinc incrementada.
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19735711C2 (de) * 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
FI107115B (fi) 1998-09-30 2001-06-15 Valio Oy Menetelmä naudan insuliinin poistamiseksi
ATE257514T1 (de) * 1998-10-09 2004-01-15 Scil Proteins Gmbh Verfahren zur gewinnung von aktivem beta-ngf
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
AR025646A1 (es) * 2000-09-13 2002-12-04 Beta Lab Sa Cepa de levaduras metilotroficas recombinantes productoras de un precursor de insulina, construcciones de adn y metodo para obtener la cepa.
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
AU2002316807A1 (en) * 2001-06-08 2002-12-23 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
ATE455849T1 (de) * 2003-12-05 2010-02-15 Hoffmann La Roche Rekombinante carboxypeptidase b und ihre aufreinigung
DE102004015965A1 (de) * 2004-04-01 2005-10-20 Aventis Pharma Gmbh Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
MX2010009033A (es) * 2008-02-19 2010-12-21 Biocon Ltd Un metodo para obtener insulinas heterologas purificadas expresadas en levadura.
CA2724510C (en) * 2008-04-30 2015-10-27 Wockhardt Research Centre Processes for refolding of insulin
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
SI3228320T1 (sl) 2008-10-17 2020-03-31 Sanofi-Aventis Deutschland Gmbh Kombinacija inzulina in agonista GLP-1
UA91281C2 (ru) * 2008-11-26 2010-07-12 Общество С Ограниченной Ответственностью «Мако» Способ получения рекомбинантного инсулина человека
JP5973918B2 (ja) 2009-11-13 2016-08-23 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
RU2546520C2 (ru) 2010-08-30 2015-04-10 Санофи-Авентис Дойчланд Гмбх Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа
WO2012135595A2 (en) 2011-04-01 2012-10-04 3M Innovative Properties Company Films including triazine-based ultraviolet absorbers
DK2739646T3 (en) * 2011-05-10 2018-02-26 Stefan Hermann COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
KR101983982B1 (ko) 2011-08-29 2019-05-30 사노피-아벤티스 도이칠란트 게엠베하 2형 당뇨병 환자의 혈당 조절에 사용하기 위한 약제학적 병용물
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
EP2931301B2 (en) 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
US10407483B2 (en) 2014-03-14 2019-09-10 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
MA41138B1 (fr) 2014-12-12 2023-07-31 Sanofi Aventis Deutschland Formulation à rapport fixe d'insuline glargine/lixisenatide
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2017040363A1 (en) 2015-09-02 2017-03-09 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (14)

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NZ196609A (en) * 1980-03-27 1984-02-03 Lilly Co Eli Preparation of proinsulin-like insulin precursors
NZ199391A (en) * 1981-01-02 1985-12-13 Genentech Inc Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin
US4616078A (en) * 1985-04-08 1986-10-07 Eli Lilly And Company Process for purifying proinsulin-like materials
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
ES2061797T3 (es) * 1988-06-23 1994-12-16 Hoechst Ag Mini-proinsulina, su preparacion y empleo.
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
IL95495A (en) * 1989-08-29 1996-10-16 Hoechst Ag Fusion proteins their preparation and use
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
US5231178A (en) * 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
EP0599303A3 (en) * 1992-11-27 1998-07-29 Takeda Chemical Industries, Ltd. Peptide conjugate
DE59305396D1 (de) * 1992-12-02 1997-03-20 Hoechst Ag Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
US5523293A (en) * 1994-05-25 1996-06-04 Iowa State University Research Foundation, Inc. Soy protein-based thermoplastic composition for preparing molded articles

Also Published As

Publication number Publication date
HK1010457A1 (en) 1999-06-17
NO950592D0 (no) 1995-02-17
ATE166069T1 (de) 1998-05-15
FI950699A0 (fi) 1995-02-16
AU699817B2 (en) 1998-12-17
CA2142780A1 (en) 1995-08-19
IL112680A0 (en) 1995-05-26
CA2142780C (en) 2008-10-14
EP0668292B1 (de) 1998-05-13
NO318424B1 (no) 2005-04-18
DE4405179A1 (de) 1995-08-24
DE59502138D1 (de) 1998-06-18
JP3863579B2 (ja) 2006-12-27
US5663291A (en) 1997-09-02
NO950592L (no) 1995-08-21
ES2119241T3 (es) 1998-10-01
FI115916B (fi) 2005-08-15
EP0668292A2 (de) 1995-08-23
KR950032282A (ko) 1995-12-20
JPH07265092A (ja) 1995-10-17
EP0668292A3 (de) 1996-02-07
DK0668292T3 (da) 1998-11-23
AU1228895A (en) 1995-08-31
SG46683A1 (en) 1998-02-20
KR100371824B1 (ko) 2003-04-10

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