FI943430A - Lääkkeenantojärjestelmä entsyymeillä ja valolle aktivoitavien lääkkeiden samanaikaiseksi vapauttamiseksi - Google Patents
Lääkkeenantojärjestelmä entsyymeillä ja valolle aktivoitavien lääkkeiden samanaikaiseksi vapauttamiseksi Download PDFInfo
- Publication number
- FI943430A FI943430A FI943430A FI943430A FI943430A FI 943430 A FI943430 A FI 943430A FI 943430 A FI943430 A FI 943430A FI 943430 A FI943430 A FI 943430A FI 943430 A FI943430 A FI 943430A
- Authority
- FI
- Finland
- Prior art keywords
- drug
- attached
- copolymeric
- carrier
- anticancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Processing Of Solid Wastes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/822,924 US5258453A (en) | 1992-01-21 | 1992-01-21 | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
PCT/US1993/000683 WO1993014142A1 (en) | 1992-01-21 | 1993-01-21 | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
Publications (2)
Publication Number | Publication Date |
---|---|
FI943430A0 FI943430A0 (fi) | 1994-07-20 |
FI943430A true FI943430A (fi) | 1994-09-20 |
Family
ID=25237341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI943430A FI943430A (fi) | 1992-01-21 | 1994-07-20 | Lääkkeenantojärjestelmä entsyymeillä ja valolle aktivoitavien lääkkeiden samanaikaiseksi vapauttamiseksi |
Country Status (14)
Country | Link |
---|---|
US (1) | US5258453A (pl) |
EP (1) | EP0621880B1 (pl) |
JP (1) | JPH08500327A (pl) |
KR (1) | KR100217186B1 (pl) |
AT (1) | ATE184201T1 (pl) |
AU (1) | AU663167B2 (pl) |
CA (1) | CA2128330A1 (pl) |
DE (1) | DE69326322T2 (pl) |
DK (1) | DK0621880T3 (pl) |
FI (1) | FI943430A (pl) |
HU (1) | HUT68082A (pl) |
PL (1) | PL172184B1 (pl) |
RU (1) | RU94038047A (pl) |
WO (1) | WO1993014142A1 (pl) |
Families Citing this family (78)
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US5827819A (en) * | 1990-11-01 | 1998-10-27 | Oregon Health Sciences University | Covalent polar lipid conjugates with neurologically active compounds for targeting |
US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
US5474765A (en) * | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
US5482719A (en) * | 1992-10-30 | 1996-01-09 | Guillet; James E. | Drug delivery systems |
US20040071637A1 (en) * | 1993-04-27 | 2004-04-15 | Elia James P. | Method for repairing a damaged portion of a human organ |
US5449720A (en) * | 1993-05-24 | 1995-09-12 | Biotech Australia Pty Limited | Amplification of the VB12 uptake system using polymers |
GB9320781D0 (en) * | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
US5444650A (en) * | 1994-01-25 | 1995-08-22 | Nippondenso Co., Ltd. | Semiconductor programmable read only memory device |
US5599831A (en) * | 1994-05-27 | 1997-02-04 | Poretz; Ronald D. | Method of preparation of pharmaceutical compositions |
NO180167C (no) * | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
CN1090022C (zh) * | 1995-04-04 | 2002-09-04 | 俄克拉荷马创伤治疗所 | 通过光动力疗法与免疫佐剂联合应用治疗癌症 |
US6316007B1 (en) | 1995-04-04 | 2001-11-13 | Wound Healing Of Oklahoma | Combined physical and immunotherapy for cancer |
US5776925A (en) * | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
US6375930B2 (en) | 1996-06-04 | 2002-04-23 | Board Of Regents, The University Of Texas System | Membrane incorporation of texaphyrins |
US6493570B1 (en) | 1998-11-02 | 2002-12-10 | Photogen, Inc. | Method for improved imaging and photodynamic therapy |
WO1999002139A1 (en) * | 1997-07-10 | 1999-01-21 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
EP1011705A4 (en) * | 1997-08-05 | 2000-09-20 | Watson Pharmaceuticals Inc | CONJUGATES TARGETED AT THE INTERLEUKIN-2 RECEPTOR |
US6251866B1 (en) | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
US8974363B2 (en) | 1997-12-11 | 2015-03-10 | Provectus Pharmatech, Inc. | Topical medicaments and methods for photodynamic treatment of disease |
JP2002500201A (ja) | 1998-01-05 | 2002-01-08 | ユニバーシティ オブ ワシントン | 膜破壊剤を使用する増強された輸送 |
US6087952A (en) * | 1998-03-06 | 2000-07-11 | Mobile Information Systems, Inc. | Remote mobile data suite and method |
US6223071B1 (en) | 1998-05-01 | 2001-04-24 | Dusa Pharmaceuticals Inc. | Illuminator for photodynamic therapy and diagnosis which produces substantially uniform intensity visible light |
US20030223978A1 (en) * | 1998-05-22 | 2003-12-04 | Nabi Ivan R. | Conjugates of an AMF ligand and a cytotoxic molecule for use in cancer therapy |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
US6986740B2 (en) * | 1998-11-02 | 2006-01-17 | Xantech Pharmaceuticals, Inc. | Ultrasound contrast using halogenated xanthenes |
US6222093B1 (en) * | 1998-12-28 | 2001-04-24 | Rosetta Inpharmatics, Inc. | Methods for determining therapeutic index from gene expression profiles |
US20030114366A1 (en) * | 1999-01-11 | 2003-06-19 | Francis J. Martin | Microfabricated particles and method for treating solid tumors |
GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
WO2001036002A1 (en) * | 1999-11-17 | 2001-05-25 | School Of Pharmacy, University Of London | Conjugates of hpma copolymer and ellipticin |
WO2001051092A2 (en) * | 2000-01-07 | 2001-07-19 | University Of Washington | Enhanced transport of agents using membrane disruptive agents |
US6455073B1 (en) | 2000-07-10 | 2002-09-24 | Enzrel, Inc. | Covalent microparticle-drug conjugates for biological targeting |
US6454790B1 (en) * | 2000-07-21 | 2002-09-24 | Ceramoptec Industries, Inc. | Treatment for Barrett's syndrome |
CN100558903C (zh) | 2000-11-29 | 2009-11-11 | Pci生物技术联合股份有限公司 | 将分子输递进胞质溶胶的光化学内化法 |
AU2002216864A1 (en) * | 2000-12-21 | 2002-07-01 | Mcgill University | Conjugates of antibodies and anticancer drugs |
IL158623A0 (en) * | 2001-04-30 | 2004-05-12 | Symbiontics Inc | Subcellular targeting of therapeutic proteins |
US7629309B2 (en) * | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
US20040005309A1 (en) * | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
WO2002090390A1 (en) * | 2001-05-04 | 2002-11-14 | University Of Utah Research Foundation | Hyaluronic acid containing bioconjugates : targeted delivery of anti-cancer drugs to cancer cells |
US20030124742A1 (en) * | 2001-08-22 | 2003-07-03 | Prakash Ramesh K. | Conjugates targeted to target receptors |
US20030072761A1 (en) * | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
EP1501352B1 (en) * | 2001-12-14 | 2015-02-18 | The University Of Wyoming | Controlled release of oxycodone |
US6846311B2 (en) * | 2002-04-02 | 2005-01-25 | Acueity, Inc. | Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence |
CA2483696A1 (en) * | 2002-05-06 | 2003-11-20 | University Of Utah Research Foundation | Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents |
EP1556061B1 (en) | 2002-10-04 | 2007-04-18 | Photokinetix Inc | Photokinetic delivery of biologically active substances using pulsed incoherent light |
US20050244400A1 (en) * | 2004-02-10 | 2005-11-03 | Zystor Therapeutics, Inc. | Acid alpha-glucosidase and fragments thereof |
CA2557448C (en) * | 2004-03-31 | 2015-06-23 | University Of Utah Research Foundation | Macromolecular delivery systems for non-invasive imaging, evaluation and treatment of arthritis and other inflammatory diseases |
US20070287680A1 (en) * | 2004-05-10 | 2007-12-13 | University Of Utah Research Foundation | Combined Active and Passive Targeting of Biologically Active Agents |
EP1888115A2 (en) * | 2005-05-16 | 2008-02-20 | Universite De Geneve | Compounds for photochemotherapy |
US7465312B2 (en) | 2006-05-02 | 2008-12-16 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like spider veins |
US20090326435A1 (en) * | 2006-05-02 | 2009-12-31 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like varicose or spider veins |
US20070299431A1 (en) * | 2006-05-02 | 2007-12-27 | Green Medical, Inc. | Systems and methods for treating superficial venous malformations like spider veins |
CA2656298A1 (en) | 2006-06-02 | 2007-12-13 | President And Fellows Of Harvard College | Protein surface remodeling |
WO2007143209A2 (en) * | 2006-06-02 | 2007-12-13 | University Of Virginia Patent Foundation | Luminescent diketonate polymers |
GB0618524D0 (en) | 2006-09-20 | 2006-11-01 | Isis Innovation | Multimeric particles |
CA2669347A1 (en) * | 2006-11-13 | 2008-05-29 | Zystor Therapeutics, Inc. | Methods for treating pompe disease |
HUE034850T2 (en) | 2008-05-07 | 2018-03-28 | Biomarin Pharm Inc | Lysosomal targeting peptides and their use |
US9434610B2 (en) * | 2008-10-07 | 2016-09-06 | Rexahn Pharmaceuticals, Inc. | HPMA—docetaxel conjugates and uses therefore |
KR20100083632A (ko) * | 2009-01-14 | 2010-07-22 | 울산대학교 산학협력단 | 표적 단백질 분해효소 감응형 항암제 전구체 |
WO2010129023A2 (en) * | 2009-04-28 | 2010-11-11 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
EP2475376B1 (en) | 2009-06-17 | 2016-03-30 | BioMarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
KR101721865B1 (ko) | 2009-10-13 | 2017-04-03 | 렉산 파마슈티컬스, 인코포레이티드 | 항암제의 전달을 위한 폴리머 시스템 |
US8492339B2 (en) * | 2009-10-26 | 2013-07-23 | Empire Technology Development Llc | Angiogenesis promoted by caged growth factors |
US9289510B2 (en) | 2010-03-08 | 2016-03-22 | University Of Utah Research Foundation | Polymeric drug delivery conjugates and methods of making and using thereof |
EP3858385A3 (en) | 2010-05-25 | 2021-10-27 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
US8883503B2 (en) | 2011-06-23 | 2014-11-11 | Indian Institute Of Technology Kanpur | Hydrogel scaffolds for tissue engineering |
HUE032791T2 (en) | 2011-09-05 | 2017-11-28 | Hiroshi Maeda | Polymer-type fluorescent molecule probe |
LT2804611T (lt) | 2012-01-20 | 2020-11-25 | Immunophotonics, Inc. | Chitozano darinių kompozicijos |
US11773188B2 (en) | 2012-01-20 | 2023-10-03 | Immunophotonics, Inc | Chitosan-derived compositions |
BR112015025892A2 (pt) | 2013-04-10 | 2017-07-25 | Syndevrx Inc | inibidores de metap2 e métodos para tratar obesidade |
US20190002594A1 (en) | 2014-07-16 | 2019-01-03 | Immunophotonics, Inc. | Chitosan-Derived Compositions |
JP2019501898A (ja) | 2015-12-10 | 2019-01-24 | シンデブルックス,インコーポレイティド | フマギロール誘導体およびその多形体 |
WO2017123603A1 (en) | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
JP2019523783A (ja) | 2016-06-16 | 2019-08-29 | オンコセレクト セラピューティクス,エルエルシー | がんの治療に有用なポルフィリン化合物及び組成物 |
BR112019021742A2 (pt) | 2017-04-17 | 2020-05-05 | Univ Chicago | composição, sistema, composição farmacêutica, composição alimentícia ou nutracêutica, método e uso da composição |
JP6894747B2 (ja) * | 2017-04-19 | 2021-06-30 | キヤノン株式会社 | 重合体 |
JP2022512826A (ja) | 2018-10-26 | 2022-02-07 | シンデブルックス,インコーポレイティド | MetAP2阻害剤のバイオマーカーとその応用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0103184B1 (en) * | 1982-08-12 | 1990-01-17 | Kanegafuchi Chemical Industry Co., Ltd. | Activation of biocompatible terpolymers with biologicals whose binding complements are pathological effectors |
GB8500209D0 (en) * | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
EP0213811A3 (en) * | 1985-08-16 | 1987-09-09 | Johnson Matthey, Inc., | Bateriocin-targeted compounds for cancer therapy |
-
1992
- 1992-01-21 US US07/822,924 patent/US5258453A/en not_active Expired - Fee Related
-
1993
- 1993-01-21 DK DK93904633T patent/DK0621880T3/da active
- 1993-01-21 HU HU9402142A patent/HUT68082A/hu unknown
- 1993-01-21 AU AU35930/93A patent/AU663167B2/en not_active Ceased
- 1993-01-21 WO PCT/US1993/000683 patent/WO1993014142A1/en active IP Right Grant
- 1993-01-21 CA CA002128330A patent/CA2128330A1/en not_active Abandoned
- 1993-01-21 PL PL93304685A patent/PL172184B1/pl unknown
- 1993-01-21 KR KR1019940702485A patent/KR100217186B1/ko not_active IP Right Cessation
- 1993-01-21 AT AT93904633T patent/ATE184201T1/de not_active IP Right Cessation
- 1993-01-21 EP EP93904633A patent/EP0621880B1/en not_active Expired - Lifetime
- 1993-01-21 RU RU94038047/14A patent/RU94038047A/ru unknown
- 1993-01-21 JP JP5512746A patent/JPH08500327A/ja not_active Ceased
- 1993-01-21 DE DE69326322T patent/DE69326322T2/de not_active Expired - Fee Related
-
1994
- 1994-07-20 FI FI943430A patent/FI943430A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
EP0621880B1 (en) | 1999-09-08 |
JPH08500327A (ja) | 1996-01-16 |
ATE184201T1 (de) | 1999-09-15 |
KR100217186B1 (ko) | 1999-09-01 |
DK0621880T3 (da) | 1999-12-20 |
EP0621880A1 (en) | 1994-11-02 |
DE69326322D1 (de) | 1999-10-14 |
RU94038047A (ru) | 1996-06-10 |
DE69326322T2 (de) | 2000-02-17 |
AU663167B2 (en) | 1995-09-28 |
AU3593093A (en) | 1993-08-03 |
WO1993014142A1 (en) | 1993-07-22 |
US5258453A (en) | 1993-11-02 |
PL172184B1 (pl) | 1997-08-29 |
EP0621880A4 (en) | 1995-04-19 |
FI943430A0 (fi) | 1994-07-20 |
CA2128330A1 (en) | 1993-07-22 |
HU9402142D0 (en) | 1994-09-28 |
HUT68082A (en) | 1995-05-29 |
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