FI940903A7 - Steroidisulfataasi-inhibiittorit - Google Patents

Steroidisulfataasi-inhibiittorit Download PDF

Info

Publication number
FI940903A7
FI940903A7 FI940903A FI940903A FI940903A7 FI 940903 A7 FI940903 A7 FI 940903A7 FI 940903 A FI940903 A FI 940903A FI 940903 A FI940903 A FI 940903A FI 940903 A7 FI940903 A7 FI 940903A7
Authority
FI
Finland
Prior art keywords
steroid sulfatase
sulfatase inhibitors
inhibitors
steroid
sulfatase
Prior art date
Application number
FI940903A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI940903A0 (fi
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Imperial College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College filed Critical Imperial College
Publication of FI940903A0 publication Critical patent/FI940903A0/fi
Publication of FI940903A7 publication Critical patent/FI940903A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI940903A 1991-08-29 1994-02-25 Steroidisulfataasi-inhibiittorit FI940903A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors
PCT/GB1992/001587 WO1993005064A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Publications (2)

Publication Number Publication Date
FI940903A0 FI940903A0 (fi) 1994-02-25
FI940903A7 true FI940903A7 (fi) 1994-04-20

Family

ID=10700604

Family Applications (5)

Application Number Title Priority Date Filing Date
FI940903A FI940903A7 (fi) 1991-08-29 1994-02-25 Steroidisulfataasi-inhibiittorit
FI20002261A FI20002261A7 (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien lääkeaineiden valmistamiseksi
FI20002259A FI20002259L (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreiden valmistamiseksi
FI20002260A FI20002260L (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien farmaseuttisten koostumusten valmistamiseksi
FI20050991A FI20050991L (fi) 1991-08-29 2005-10-03 Sulfamaattiryhmän sisältävän yhdisteen käyttö steroidisulfataasi-inhibiittoreiden valmistamiseksi

Family Applications After (4)

Application Number Title Priority Date Filing Date
FI20002261A FI20002261A7 (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien lääkeaineiden valmistamiseksi
FI20002259A FI20002259L (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreiden valmistamiseksi
FI20002260A FI20002260L (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien farmaseuttisten koostumusten valmistamiseksi
FI20050991A FI20050991L (fi) 1991-08-29 2005-10-03 Sulfamaattiryhmän sisältävän yhdisteen käyttö steroidisulfataasi-inhibiittoreiden valmistamiseksi

Country Status (25)

Country Link
US (3) US5616574A (OSRAM)
EP (6) EP1522543A1 (OSRAM)
JP (6) JP3219408B2 (OSRAM)
KR (4) KR100258396B1 (OSRAM)
AT (5) ATE237333T1 (OSRAM)
AU (2) AU689043B2 (OSRAM)
BR (1) BR9206434A (OSRAM)
CA (4) CA2305758A1 (OSRAM)
CY (4) CY2253B1 (OSRAM)
CZ (1) CZ295939B6 (OSRAM)
DE (5) DE69233020T2 (OSRAM)
DK (4) DK0982032T3 (OSRAM)
ES (4) ES2204059T3 (OSRAM)
FI (5) FI940903A7 (OSRAM)
GB (1) GB9118478D0 (OSRAM)
GE (6) GEP20022802B (OSRAM)
GR (1) GR3034579T3 (OSRAM)
HU (1) HUT66097A (OSRAM)
LV (1) LV12618B (OSRAM)
NO (6) NO307301B1 (OSRAM)
RU (4) RU2001125673A (OSRAM)
SG (7) SG103820A1 (OSRAM)
SK (4) SK282189B6 (OSRAM)
UA (4) UA41875C2 (OSRAM)
WO (1) WO1993005064A1 (OSRAM)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
US6011024A (en) * 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6903084B2 (en) 1991-08-28 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
GB9603325D0 (en) 1996-02-16 1996-04-17 Imperial College A compound
AU2112995A (en) * 1994-04-05 1995-10-23 Celltech Therapeutics Limited Use of estrone derivatives as steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4429398C2 (de) * 1994-08-09 1997-09-11 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
JP2000506161A (ja) * 1996-03-05 2000-05-23 インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン スルファメート基を有する化合物
US6087347A (en) * 1996-09-12 2000-07-11 Teikoku Hormone Mfg. Co., Ltd. 3-substituted-D-homo-1,3,5(10)-estratriene derivatives
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US6642220B1 (en) * 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
WO1999064013A1 (en) 1998-06-10 1999-12-16 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6288050B1 (en) 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2331988B (en) * 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
GB9807779D0 (en) 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
EP1173182A2 (en) * 1999-04-30 2002-01-23 Sterix Limited Use of estrone derivatives as antitumour agents
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
JP4931312B2 (ja) * 1999-12-13 2012-05-16 ステリックス リミテッド ステロイドスルファターゼのインヒビターとしてのハロゲン化スルファメート−、ホスホネート−、チオホスホネート−、スルホネート−、およびスルホンアミド−化合物
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
AU2001248849A1 (en) * 2000-04-24 2001-11-07 Kyowa Hakko Kogyo Co. Ltd. Estra-1,3,5(10)-triene derivatives
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
EP1406634A1 (en) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
EP1657247B1 (en) * 2001-10-18 2008-09-17 Sterix Limited Steroidal compounds for inhibiting steroid sulphotase
ATE319734T1 (de) * 2001-10-18 2006-03-15 Sterix Ltd Steroidale verbindungen zur inhibierung von steroidsulfatasen
US20040254241A1 (en) * 2002-08-28 2004-12-16 Yoji Ino Aryl sulfamate derivatives
CA2501556A1 (en) * 2002-10-09 2004-04-29 Kyowa Hakko Kogyo Co., Ltd. Remedy for hormone-dependent cancer
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
BR0318295A (pt) * 2003-05-16 2006-07-11 Theramex derivados de sulfamato de benzotiofeno utilizados como inibidores da esteróide sulfatase
AU2004240842B2 (en) 2003-05-21 2009-11-05 Aska Pharmaceutical Co., Ltd. Cyclicamino-Phenyl Sulfamate Derivatives
TWI331154B (en) * 2003-11-12 2010-10-01 Solvay Pharm Gmbh Novel 17-hydroxysteroid dehydrogenase type i inhibitors
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
US20100204146A1 (en) 2007-09-17 2010-08-12 Preglem S.A. Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women
EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
KR101741629B1 (ko) 2009-05-06 2017-05-31 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN110974840A (zh) * 2019-12-27 2020-04-10 天津市肿瘤医院 一种类固醇硫酸酯酶抑制剂及其药物用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE114806C (OSRAM) *
DE1593846A1 (de) * 1967-01-28 1971-02-25 Hoechst Ag Verfahren zur Herstellung von Sulfamidsaeure-arylestern
US3647738A (en) * 1970-11-03 1972-03-07 Union Carbide Corp Alpha-olefin polymer compositions
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DE2418217A1 (de) * 1974-04-13 1975-11-06 Hoechst Ag Sulfamidsaeureester und verfahren zu ihrer herstellung
DD114806A1 (OSRAM) * 1974-10-11 1975-08-20
US4340602A (en) * 1978-10-18 1982-07-20 Wayne State University Compositions inhibiting estrogen sulfotransferase activity
US4810700A (en) * 1978-10-18 1989-03-07 Wayne State University Compositions inhibiting estrogen sulfotransferase activity
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
PT94305B (pt) * 1989-06-12 1997-02-28 Robins Co Inc A H Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
JP2000506161A (ja) * 1996-03-05 2000-05-23 インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン スルファメート基を有する化合物
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Also Published As

Publication number Publication date
NO995076D0 (no) 1999-10-18
US6159960A (en) 2000-12-12
NO995075L (no) 1994-04-29
EP0982032B1 (en) 2003-08-06
JP3219408B2 (ja) 2001-10-15
SK24694A3 (en) 1994-11-09
CZ44094A3 (en) 1995-01-18
NO995075D0 (no) 1999-10-18
NO308903B1 (no) 2000-11-13
ATE246706T1 (de) 2003-08-15
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
NO940635L (OSRAM) 1994-04-29
SG103820A1 (en) 2004-05-26
NO308774B1 (no) 2000-10-30
SG103374A1 (en) 2004-04-29
JP2002255993A (ja) 2002-09-11
AU1007799A (en) 1999-03-04
ATE194843T1 (de) 2000-08-15
SG106116A1 (en) 2004-09-30
EP0982032A2 (en) 2000-03-01
NO2595A (no) 1994-04-29
ES2204059T3 (es) 2004-04-16
CA2305758A1 (en) 1993-03-18
DE69231280D1 (de) 2000-08-24
FI20002261L (fi) 2000-10-13
HK1019753A1 (en) 2000-02-25
BR9206434A (pt) 1994-09-27
EP0928609A3 (en) 2001-11-07
FI20002259A7 (fi) 2000-10-13
EP1099706B1 (en) 2004-10-06
CY2398B1 (en) 2004-09-10
JP3581821B2 (ja) 2004-10-27
EP0921130A3 (en) 2001-09-05
HK1020672A1 (en) 2000-05-19
EP0921130B1 (en) 2003-05-07
RU2207134C2 (ru) 2003-06-27
GEP20022766B (en) 2002-08-26
GEP20063773B (en) 2006-03-27
EP1099706A3 (en) 2002-09-04
RU2210574C2 (ru) 2003-08-20
EP0982032A3 (en) 2002-03-20
NO318009B1 (no) 2005-01-17
SG88782A1 (en) 2002-05-21
ES2196483T3 (es) 2003-12-16
NO20025725D0 (no) 2002-11-28
DE69233020D1 (de) 2003-05-22
UA70957C2 (uk) 2004-11-15
GEP20022637B (en) 2002-02-25
ATE237333T1 (de) 2003-05-15
UA70956C2 (uk) 2004-11-15
SG115508A1 (en) 2005-10-28
RU2182152C2 (ru) 2002-05-10
KR100322650B1 (ko) 2002-03-20
SG88783A1 (en) 2002-05-21
KR100321018B1 (ko) 2002-03-20
FI20050991A7 (fi) 2005-10-03
GEP20022803B (en) 2002-09-25
JP3581820B2 (ja) 2004-10-27
SK282186B6 (sk) 2001-12-03
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
FI20002259L (fi) 2000-10-13
ATE239753T1 (de) 2003-05-15
SK282188B6 (sk) 2001-12-03
EP1099706A2 (en) 2001-05-16
UA41875C2 (uk) 2001-10-15
ES2193475T3 (es) 2003-11-01
HK1025051A1 (en) 2000-11-03
FI20002260A7 (fi) 2000-10-13
GR3034579T3 (en) 2001-01-31
CY2397B1 (en) 2004-09-10
NO995076L (no) 1994-04-29
EP1522543A1 (en) 2005-04-13
DE69233020T2 (de) 2003-11-06
ATE278704T1 (de) 2004-10-15
US5616574A (en) 1997-04-01
CA2305767A1 (en) 1993-03-18
DE69233053D1 (de) 2003-06-12
DE69231280T2 (de) 2000-11-30
EP0641355B1 (en) 2000-07-19
CA2114630A1 (en) 1993-03-18
KR100258396B1 (ko) 2000-08-01
ES2148178T3 (es) 2000-10-16
SK282189B6 (sk) 2001-12-03
EP0921130A2 (en) 1999-06-09
WO1993005064A1 (en) 1993-03-18
JP2000355598A (ja) 2000-12-26
NO20025725L (no) 1994-04-29
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
SG73391A1 (en) 2006-08-30
CY2253B1 (en) 2003-07-04
FI940903A0 (fi) 1994-02-25
LV12618A (en) 2001-02-20
JP2000355542A (ja) 2000-12-26
CA2305749A1 (en) 1993-03-18
DK0928609T3 (da) 2003-07-21
JP2000038341A (ja) 2000-02-08
NO20002595D0 (no) 2000-05-19
GB9118478D0 (en) 1991-10-16
SK282187B6 (sk) 2001-12-03
DE69233053T2 (de) 2003-11-20
EP0928609A2 (en) 1999-07-14
JP2003176297A (ja) 2003-06-24
NO20044458L (no) 1994-04-29
AU5837396A (en) 1996-09-05
FI20002260L (fi) 2000-10-13
CA2114630C (en) 2003-09-30
AU717116B2 (en) 2000-03-16
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
KR100321019B1 (ko) 2002-03-20
JPH07501515A (ja) 1995-02-16
NO940635D0 (no) 1994-02-24
DE69233149T2 (de) 2004-06-24
DK0982032T3 (da) 2003-11-03
HU9400583D0 (en) 1994-05-30
CZ295939B6 (cs) 2005-12-14
JP3581802B2 (ja) 2004-10-27
RU2001125673A (ru) 2003-06-27
HUT66097A (en) 1994-09-28
LV12618B (en) 2001-07-20
FI20002261A7 (fi) 2000-10-13
DE69233431T2 (de) 2006-02-23
FI20050991L (fi) 2005-10-03
EP0641355A1 (en) 1995-03-08
NO314287B1 (no) 2003-03-03
GEP20033094B (en) 2003-10-27
AU668882B2 (en) 1996-05-23
GEP20022802B (en) 2002-09-25
AU689043B2 (en) 1998-03-19
DK0921130T3 (da) 2003-07-21
NO307301B1 (no) 2000-03-13
US5830886A (en) 1998-11-03

Similar Documents

Publication Publication Date Title
FI940903A7 (fi) Steroidisulfataasi-inhibiittorit
FI942568L (fi) Sukupuolisteroidiaktiviteetti-inhibiittorit
FI933303L (fi) Adenosinkinasinhibitorer
FI904101A7 (fi) 17B-asyyli-4-atsa-5a-androst-1-en-3-en-3-oneja 5a-reduktaasi-inhibiittoreina
NO942064D0 (no) yminhibitorer
FI932249L (fi) Dubbelverkande inhibitorer
PT87380A (pt) Steroid 5-alpha-reductase inhibitors
FI963597L (fi) Isoprenyylitransferaasi-inhibiittoreita
NO972930D0 (no) Fibronectin-adhesjonsinhibitorer
DE69227227D1 (de) Korrosionsinhibitoren
FI972160A0 (fi) Matriisimetalloproteaasi-inhibiittorit
FI933363L (fi) 17-spirometylensteroider
FI933451A7 (fi) Uudet steroidiesterit
FI933450A7 (fi) Uudet steroidit
NO931117D0 (no) Steroidderivater
FI945416L (fi) Dolastatiinijohdannaisia
DE59308714D1 (de) Cyclobutan-benzol-derivate
DE69526475D1 (de) 5-Alphareduktase-Inhibitoren
DK210689A (da) Steroidderivater
ITMI920393A0 (it) Formulazioni di steroidi
FI953130L (fi) Uudet steroidit
NO923339L (no) Korrosjonsinhibitor
DE69313890D1 (de) 5-Aminoflavon-Derivate
FI946081A7 (fi) Steroidaalinen beta-0-sellobiosidihepta-alkanoaattimenetelmä
FI946189A7 (fi) 5-alfa-reduktaasi-inhibiittoreina käyttökelpoiset 17-alkyyliketonister oidit

Legal Events

Date Code Title Description
FCK Appeal rejected

Free format text: APPLICATION REJECTED