FI902850A0 - N-heteroarylpurin-6-aminer, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel. - Google Patents

N-heteroarylpurin-6-aminer, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel.

Info

Publication number
FI902850A0
FI902850A0 FI902850A FI902850A FI902850A0 FI 902850 A0 FI902850 A0 FI 902850A0 FI 902850 A FI902850 A FI 902850A FI 902850 A FI902850 A FI 902850A FI 902850 A0 FI902850 A0 FI 902850A0
Authority
FI
Finland
Prior art keywords
dem
heteroarylpurin
aminer
lower alkyl
foerfarande foer
Prior art date
Application number
FI902850A
Other languages
English (en)
Finnish (fi)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Larry Davis
Gordon Edward Olsen
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI902850A0 publication Critical patent/FI902850A0/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Television Signal Processing For Recording (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
FI902850A 1989-06-09 1990-06-07 N-heteroarylpurin-6-aminer, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel. FI902850A0 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,837 US5017578A (en) 1989-06-09 1989-06-09 N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents

Publications (1)

Publication Number Publication Date
FI902850A0 true FI902850A0 (fi) 1990-06-07

Family

ID=23431950

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902850A FI902850A0 (fi) 1989-06-09 1990-06-07 N-heteroarylpurin-6-aminer, foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel.

Country Status (21)

Country Link
US (1) US5017578A (el)
EP (1) EP0402752B1 (el)
JP (1) JPH06102663B2 (el)
KR (2) KR100199524B1 (el)
CN (1) CN1029968C (el)
AT (1) ATE127807T1 (el)
AU (1) AU636351B2 (el)
CA (1) CA2018563C (el)
DE (1) DE69022294T2 (el)
DK (1) DK0402752T3 (el)
ES (1) ES2078267T3 (el)
FI (1) FI902850A0 (el)
GR (1) GR3017743T3 (el)
HU (1) HU207320B (el)
IE (1) IE68433B1 (el)
IL (1) IL94665A (el)
MX (1) MX21088A (el)
NO (1) NO902555L (el)
NZ (1) NZ233970A (el)
PT (1) PT94297B (el)
ZA (1) ZA904443B (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
JP3355237B2 (ja) * 1993-10-15 2002-12-09 呉羽化学工業株式会社 Ｎ−（置換アミノ）ピロール誘導体、その製造方法及び除草剤
HUT75338A (en) * 1994-05-10 1997-05-28 Sandoz Ag Adenosine derivatives, their preparation and use, and pharmaceutical preparations containing them
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
BRPI0413563A (pt) * 2003-08-15 2006-10-17 Irm Llc compostos e composições como inibidores de atividade do receptor de quìnase de tirosina
CN100447143C (zh) * 2003-08-15 2008-12-31 Irm责任有限公司 作为rtk抑制剂的6-取代的苯胺基嘌呤
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
EP3395372B1 (en) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Glutathione-based drug delivery system
SG175896A1 (en) 2009-05-06 2011-12-29 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN104744470A (zh) * 2014-10-31 2015-07-01 合肥平光制药有限公司 一种茶碱的合成方法
US10653681B2 (en) 2016-03-16 2020-05-19 Recurium Ip Holdings, Llc Analgesic compounds
CN106632339B (zh) * 2016-12-16 2018-11-27 温州医科大学 一种6-取代-9h-嘌呤类衍生物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016378A (en) * 1959-07-01 1962-01-09 Thomae Gmbh Dr K Amino-substituted purine derivatives
BE768925A (fr) * 1970-06-30 1971-11-03 Takeda Chemical Industries Ltd Derives d'adenosine et procede de preparation
JPS4935635B1 (el) * 1970-12-28 1974-09-25
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
US3936454A (en) * 1973-08-14 1976-02-03 Warner-Lambert Company 5-Amino-4-chloro-6-(substituted amino)-pyrimidines
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
US4514405A (en) * 1981-09-17 1985-04-30 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of adenosine derivatives as anticonvulsants
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
DE3587717T2 (de) * 1984-04-18 1994-04-28 Whitby Research Inc N-6-thienyl-substituierte Adenosinderivate als herzgefässerweiternde Mittel.
US4657897A (en) * 1984-06-22 1987-04-14 Warner-Lambert Company N6 -substituted adenosines for treating pain
CA1254888A (en) * 1984-10-26 1989-05-30 Bharat Trivedi N.sup.6-bicycloadenosines
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
US4780452A (en) * 1986-09-08 1988-10-25 Burroughs Wellcome Co. F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
JPH0324080A (ja) 1991-02-01
NO902555L (no) 1990-12-10
JPH06102663B2 (ja) 1994-12-14
DK0402752T3 (da) 1996-01-15
IE902077L (en) 1990-12-09
IL94665A0 (en) 1991-04-15
CA2018563A1 (en) 1990-12-09
KR100210179B1 (ko) 1999-07-15
US5017578A (en) 1991-05-21
MX21088A (es) 1993-11-01
KR910000730A (ko) 1991-01-30
IL94665A (en) 1994-06-24
PT94297B (pt) 1997-01-31
HU903768D0 (en) 1990-11-28
NO902555D0 (no) 1990-06-08
AU636351B2 (en) 1993-04-29
CN1029968C (zh) 1995-10-11
PT94297A (pt) 1991-02-08
ZA904443B (en) 1991-03-27
ATE127807T1 (de) 1995-09-15
KR100199524B1 (ko) 1999-06-15
GR3017743T3 (en) 1996-01-31
EP0402752A1 (en) 1990-12-19
HU207320B (en) 1993-03-29
HUT54156A (en) 1991-01-28
AU5691990A (en) 1990-12-13
DE69022294T2 (de) 1996-03-14
ES2078267T3 (es) 1995-12-16
CA2018563C (en) 2000-09-19
NZ233970A (en) 1993-02-25
CN1047866A (zh) 1990-12-19
DE69022294D1 (de) 1995-10-19
EP0402752B1 (en) 1995-09-13
IE68433B1 (en) 1996-06-12

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Legal Events

Date Code Title Description
FA Application withdrawn

Owner name: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED