FI832922A7 - 1-fenetyyli- -fenyylipiperidin-3- propannitriilijohdannaiset, niiden valmistus ja terapeuttinen soveltamsoveltaminen. - Google Patents

1-fenetyyli- -fenyylipiperidin-3- propannitriilijohdannaiset, niiden valmistus ja terapeuttinen soveltamsoveltaminen. Download PDF

Info

Publication number
FI832922A7
FI832922A7 FI832922A FI832922A FI832922A7 FI 832922 A7 FI832922 A7 FI 832922A7 FI 832922 A FI832922 A FI 832922A FI 832922 A FI832922 A FI 832922A FI 832922 A7 FI832922 A7 FI 832922A7
Authority
FI
Finland
Prior art keywords
phenylpiperidine
phenethyl
preparation
therapeutic application
propanenitrile derivatives
Prior art date
Application number
FI832922A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI832922L (fi
FI832922A0 (fi
Inventor
Philippe Manoury
Gerard Defosse
Jean Binet
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of FI832922A0 publication Critical patent/FI832922A0/fi
Publication of FI832922A7 publication Critical patent/FI832922A7/fi
Publication of FI832922L publication Critical patent/FI832922L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI832922A 1982-08-16 1983-08-12 1-fenetyl- -fenylpiperidin-3-propannitrilderivat, deras framstaellning och terapeutiska tillaempning FI832922L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8214154A FR2531702A1 (fr) 1982-08-16 1982-08-16 Derives de phenethyl-1a-phenylperidine-3-propanenitrile, leur preparation et leur application en therapeutique

Publications (3)

Publication Number Publication Date
FI832922A0 FI832922A0 (fi) 1983-08-12
FI832922A7 true FI832922A7 (fi) 1984-02-17
FI832922L FI832922L (fi) 1984-02-17

Family

ID=9276888

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832922A FI832922L (fi) 1982-08-16 1983-08-12 1-fenetyl- -fenylpiperidin-3-propannitrilderivat, deras framstaellning och terapeutiska tillaempning

Country Status (19)

Country Link
US (1) US4481207A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0103500B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5953467A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE31924T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU559173B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1239406A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3375299D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK367983D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8404329A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI832922L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2531702A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR78689B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU190729B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL69490A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX155971A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO832897L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ205250A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT77194B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA835970B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB930459A (en) * 1963-09-26 1963-07-03 Aspro Nicholas Ltd Diphenyl methane derivatives and methods for the preparation thereof
GB1057145A (en) * 1963-08-16 1967-02-01 Bellon Labor Sa Roger Phenylcyclohexylacetonitrile derivatives
FR2302739A1 (fr) * 1975-03-03 1976-10-01 Synthelabo Nouveaux derives du phenyl-2(piperidinyl-4)-2 acetonitrile, leurs sels, leur preparation et les medicaments qui en contiennent
US4399286A (en) * 1981-07-16 1983-08-16 Mead Johnson & Company Antiarrhythmic phenethylpiperidine compounds

Also Published As

Publication number Publication date
PT77194A (fr) 1983-09-01
DE3375299D1 (en) 1988-02-18
EP0103500B1 (fr) 1988-01-13
ATE31924T1 (de) 1988-01-15
DK367983D0 (da) 1983-08-12
FR2531702A1 (fr) 1984-02-17
FI832922L (fi) 1984-02-17
GR78689B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-09-27
EP0103500A3 (en) 1984-11-28
PT77194B (fr) 1986-03-21
ZA835970B (en) 1984-04-25
AU1793483A (en) 1984-02-23
ES524907A0 (es) 1984-05-01
IL69490A (en) 1986-11-30
ES8404329A1 (es) 1984-05-01
JPS5953467A (ja) 1984-03-28
US4481207A (en) 1984-11-06
MX155971A (es) 1988-06-03
NO832897L (no) 1984-02-17
EP0103500A2 (fr) 1984-03-21
AU559173B2 (en) 1987-02-26
NZ205250A (en) 1985-07-31
CA1239406A (en) 1988-07-19
JPS6125708B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-06-17
FR2531702B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-12-07
FI832922A0 (fi) 1983-08-12
HU190729B (en) 1986-10-28

Similar Documents

Publication Publication Date Title
FI832382A7 (fi) Fenyylialfa- asyylioksiasetamidijohdannaiset ja niiden terapeuttinen käyttö.
FI844775A7 (fi) Sfingosiinijohdannaisia, niiden valmistusja farmaseuttinen valmiste.
FI831457A7 (fi) 1-sulfo-2-atsetidinon-johdannaiset, niiden valmistus ja käyttö.
IT8219730A0 (it) Derivati 5-amminometil-ossazolidinici, procedimento per la loro preparazione, e loro applicazione in terapia.
FI853626A7 (fi) Isoksatsolikarboksyylihappojohdannaiset, niiden valmistus ja käyttö.
FI844199A7 (fi) Lääkeainevalmiste.
FI830719A7 (fi) Uudet organopolysiloksaanit, niiden valmistusmenetelmät ja näiden organopolysiloksaanien käyttö.
FI824314A7 (fi) Thienopyrimidiinijohdannaiset, niiden valmistus ja niiden lääketieteellinen käyttö.
FI873010A7 (fi) Nitrofuraanijohdannaiset, niiden valmistus ja niiden terapeuttinen sovellutus.
NL970029I2 (nl) Benzimidazoolderivaten, bereiding en therapeutische toepassing.
FI842459A7 (fi) Tetrahydropyridatsinonijohdannaisia, menetelmiä niiden valmistamiseksi sekä niiden käyttö.
FI830163A7 (fi) Fenyylietyleeni-johdannaisia, niiden valmistus ja käyttö lääkeaineina.
FI832575A7 (fi) Uusia 6,16- dimetyylikortikoideja, niiden valmistus ja käyttö.
FI831926A7 (fi) (+)-syanidan-3-olijohdannaisia sisältävät farmaseuttiset valmisteet ja niiden käyttö, uudet substituosubstituoidut (+)-syanidan-3-oli- johdannaiset ja menetelmät niiden vavalmistamiseksi.
DK172183D0 (da) Ozazolderivater, deres fremstilling og anvendelse
FI823022A7 (fi) Amino-organoaminosilaanit, niiden valmistusmenetelmä ja niiden käyttö.
FI831475A7 (fi) Uusia atsepiinoindoleja, niiden valmistus ja niitä sisältäviä farmaseuttisia yhdistelmiä.
FI832519A7 (fi) Farmaseuttisia menetelmiä ja koostumuksia.
FI852657A7 (fi) Heterosyklisiä farmaseuttisia yhdisteitä, valmistus ja käyttö.
FI850266A7 (fi) Atsolyyliaryylialkanolijohdoksia, menetelmä niiden valmistamiseksi ja niiden käyttö.
FI861526A7 (fi) Nitrofuraanin johdannaiset, niiden valmistus ja soveltaminen terapiassa.
FI821288A7 (fi) Fenetanoliamiini-johdannaisia, niiden valmistus ja niiden terapeuttinen käyttö.
IT8323925A0 (it) Derivati bezilidenici solforati, loro preparazione e loro applicazione in terapia.
FI810835A7 (fi) Uusia tioformamidijohdannaisia, niiden valmistaminen ja niitä sisältävät lääkkeet.
FI832520A7 (fi) Farmaseuttisia menetelmiä ja koostumuksia.

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: SYNTHELABO