FI20000815A - Compounds containing a fused bicyclic ring and a process for their preparation - Google Patents

Compounds containing a fused bicyclic ring and a process for their preparation Download PDF

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Publication number
FI20000815A
FI20000815A FI20000815A FI20000815A FI20000815A FI 20000815 A FI20000815 A FI 20000815A FI 20000815 A FI20000815 A FI 20000815A FI 20000815 A FI20000815 A FI 20000815A FI 20000815 A FI20000815 A FI 20000815A
Authority
FI
Finland
Prior art keywords
preparation
compounds containing
bicyclic ring
fused bicyclic
chem
Prior art date
Application number
FI20000815A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI111950B (en
Inventor
Jollie D Godfrey Jr
David R Kronenthal
Jeffrey A Robl
Original Assignee
Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FI20000815A publication Critical patent/FI20000815A/en
Application granted granted Critical
Publication of FI111950B publication Critical patent/FI111950B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compounds of the formula <CHEM> wherein X is O or S-(O)t; n is one or two; m is zero or one; Y is CH2, O, or S-(O)t provided that Y is O or S-(O)t only when m is one; and A is <CHEM> are dual inhibitors of NEP and ACE. Compounds wherein A is <CHEM> are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.
FI20000815A 1993-06-15 2000-04-06 5-oxo-7H-pyrido [2,1-b] [1,3] thiazepine, 4-oxo-2H, 6H-pyrido [2,1-b] [1,3] thiazine and 5-oxo- [2,1-b] [1,3] tiazepinderivat FI111950B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7797893A 1993-06-15 1993-06-15
US7797893 1993-06-15

Publications (2)

Publication Number Publication Date
FI20000815A true FI20000815A (en) 2000-04-06
FI111950B FI111950B (en) 2003-10-15

Family

ID=22141128

Family Applications (3)

Application Number Title Priority Date Filing Date
FI942793A FI106464B (en) 1993-06-15 1994-06-13 Process for Preparation of New Therapeutically Useful Pyridothiazepine, Pyridoxazepine, Pyridothiazine, Pyrroloxoxazepine and Pyrrolothiazepine Derivatives
FI20000815A FI111950B (en) 1993-06-15 2000-04-06 5-oxo-7H-pyrido [2,1-b] [1,3] thiazepine, 4-oxo-2H, 6H-pyrido [2,1-b] [1,3] thiazine and 5-oxo- [2,1-b] [1,3] tiazepinderivat
FI20000814A FI111947B (en) 1993-06-15 2000-04-06 A process for the preparation of novel therapeutically useful derivatives of 5-oxo [1,4] oxazino [3,4-b] [1,3] oxazepine and thiazepine-7-carboxylic acid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI942793A FI106464B (en) 1993-06-15 1994-06-13 Process for Preparation of New Therapeutically Useful Pyridothiazepine, Pyridoxazepine, Pyridothiazine, Pyrroloxoxazepine and Pyrrolothiazepine Derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20000814A FI111947B (en) 1993-06-15 2000-04-06 A process for the preparation of novel therapeutically useful derivatives of 5-oxo [1,4] oxazino [3,4-b] [1,3] oxazepine and thiazepine-7-carboxylic acid

Country Status (38)

Country Link
US (5) US5508272A (en)
EP (1) EP0629627B1 (en)
JP (1) JP3569550B2 (en)
KR (1) KR100395604B1 (en)
CN (1) CN1046525C (en)
AT (1) ATE266032T1 (en)
AU (1) AU672899B2 (en)
BG (1) BG62139B1 (en)
BR (1) BR1100970A (en)
CA (1) CA2124375C (en)
CY (1) CY2492B1 (en)
CZ (1) CZ289488B6 (en)
DE (1) DE69433752T2 (en)
DK (1) DK0629627T3 (en)
EE (1) EE03178B1 (en)
EG (1) EG20537A (en)
ES (1) ES2219644T3 (en)
FI (3) FI106464B (en)
GE (1) GEP19981301B (en)
HK (1) HK1001814A1 (en)
HU (1) HU216791B (en)
IL (2) IL109924A (en)
LT (1) LT3626B (en)
LV (1) LV10622B (en)
MY (1) MY123673A (en)
NO (1) NO306405B1 (en)
NZ (1) NZ260736A (en)
PH (1) PH30830A (en)
PL (1) PL178469B1 (en)
PT (1) PT629627E (en)
RO (1) RO112870B1 (en)
RU (1) RU2125056C1 (en)
SG (1) SG46510A1 (en)
SK (1) SK282529B6 (en)
TW (1) TW329423B (en)
UA (1) UA39924C2 (en)
UY (1) UY23787A1 (en)
ZA (1) ZA944163B (en)

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