FI111646B - Menetelmä terapeuttisesti käyttökelpoisten syklisen peptidin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten syklisen peptidin valmistamiseksi Download PDF

Info

Publication number
FI111646B
FI111646B FI924580A FI924580A FI111646B FI 111646 B FI111646 B FI 111646B FI 924580 A FI924580 A FI 924580A FI 924580 A FI924580 A FI 924580A FI 111646 B FI111646 B FI 111646B
Authority
FI
Finland
Prior art keywords
asp25
boc
mmol
seq
vip
Prior art date
Application number
FI924580A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924580A (fi
FI924580A0 (fi
Inventor
David Robert Bolin
Margaret O'donnell
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI924580A0 publication Critical patent/FI924580A0/fi
Publication of FI924580A publication Critical patent/FI924580A/fi
Priority to FI20010185A priority Critical patent/FI111647B/fi
Application granted granted Critical
Publication of FI111646B publication Critical patent/FI111646B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/17—Vasoactive intestinal peptides; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI924580A 1991-10-11 1992-10-09 Menetelmä terapeuttisesti käyttökelpoisten syklisen peptidin valmistamiseksi FI111646B (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI20010185A FI111647B (fi) 1991-10-11 2001-01-31 Menetelmä terapeuttisesti käyttökelpoisten syklisten peptidien valmistamiseksi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77374791A 1991-10-11 1991-10-11
US77374791 1991-10-11

Publications (3)

Publication Number Publication Date
FI924580A0 FI924580A0 (fi) 1992-10-09
FI924580A FI924580A (fi) 1993-04-12
FI111646B true FI111646B (fi) 2003-08-29

Family

ID=25099195

Family Applications (2)

Application Number Title Priority Date Filing Date
FI924580A FI111646B (fi) 1991-10-11 1992-10-09 Menetelmä terapeuttisesti käyttökelpoisten syklisen peptidin valmistamiseksi
FI20002041A FI20002041A (fi) 1991-10-11 2000-09-15 Syklisiä verisuoniin vaikuttavia peptidejä

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20002041A FI20002041A (fi) 1991-10-11 2000-09-15 Syklisiä verisuoniin vaikuttavia peptidejä

Country Status (26)

Country Link
US (1) US5677419A (ja)
EP (1) EP0536741B1 (ja)
JP (1) JP2515473B2 (ja)
KR (1) KR970001580B1 (ja)
CN (3) CN1034943C (ja)
AT (1) ATE132165T1 (ja)
AU (1) AU656230B2 (ja)
BG (1) BG61125B2 (ja)
BR (1) BR9203959A (ja)
CA (1) CA2080272C (ja)
CZ (1) CZ281818B6 (ja)
DE (1) DE69207138T2 (ja)
DK (1) DK0536741T3 (ja)
ES (1) ES2082317T3 (ja)
FI (2) FI111646B (ja)
GR (1) GR3019326T3 (ja)
HU (2) HUT62606A (ja)
IL (3) IL117252A (ja)
MX (1) MX9205822A (ja)
NO (3) NO304523B1 (ja)
NZ (1) NZ244644A (ja)
RU (1) RU2095368C1 (ja)
SK (1) SK279399B6 (ja)
TW (1) TW305846B (ja)
UY (2) UY23488A1 (ja)
ZA (1) ZA927724B (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872803B1 (en) 1993-09-21 2005-03-29 Kyowa Hakko Kogyo Co., Ltd. Peptides
KR100493795B1 (ko) * 1996-02-09 2005-09-09 에프. 호프만-라 로슈 아게 혈관활성장펩타이드유사체의합성방법
AU725827B2 (en) 1996-07-12 2000-10-19 Immunomedics Inc. Radiometal-binding peptide analogues
WO1998002453A2 (en) * 1996-07-15 1998-01-22 Universite Libre De Bruxelles Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
HUP0202175A3 (en) * 1999-09-28 2005-01-28 Bayer Corp Berkeley Pituitary adenylate cyclase activating peptide (pacap) receptor 3 (r3) agonists and their pharmacological methods of use
AU2000263935A1 (en) 2000-02-18 2001-08-27 Dabur Research Foundation Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
WO2001060862A1 (en) 2000-02-18 2001-08-23 Dabur Research Foundation Vasoactive intestinal peptide analogs
US6828304B1 (en) 2000-07-31 2004-12-07 Dabur Research Foundation Peptides for treatment of cancer
US7507714B2 (en) * 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
AU2072002A (en) 2000-11-28 2002-06-11 Mondobiotech Sa Compounds with the biological activity of vasoactive intestinal peptide for the treatment of pulmonary and arteriolar hypertension
WO2003103702A1 (en) 2002-06-10 2003-12-18 Mondobiotech Laboratories Anstalt Use of compounds having the biological activity of vasoactive intestinal peptide for the treatment of sarcoidosis
WO2005072385A2 (en) * 2004-01-27 2005-08-11 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use
US20090118167A1 (en) * 2004-08-18 2009-05-07 Eli Lilly And Company Patent Division Selective Vpac2 Receptor Peptide Agonists
US20080085860A1 (en) * 2004-08-18 2008-04-10 Eli Lilly And Company Selective Vpac2 Receptor Peptide Agonists
BRPI0708341A2 (pt) * 2006-02-28 2011-05-24 Lilly Co Eli agonistas peptìdicos seletivos do receptor vpac2
KR20090027239A (ko) * 2006-07-06 2009-03-16 에프. 호프만-라 로슈 아게 혈관작용성 장 펩티드의 유사체
CN101906144B (zh) * 2009-06-03 2013-06-19 首都医科大学 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
PT3311828T (pt) 2009-08-14 2021-05-05 Phasebio Pharmaceuticals Inc Péptidos intestinais vasoativos modificados
CA2797033C (en) 2010-04-22 2021-10-19 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
CA2873553C (en) 2011-06-06 2020-01-28 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
US9789164B2 (en) 2013-03-15 2017-10-17 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same
GB201421647D0 (en) * 2014-12-05 2015-01-21 Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases
AU2016219513B2 (en) 2015-02-09 2021-09-30 Immunoforge Co., Ltd. Methods and compositions for treating muscle disease and disorders
SG11201902818PA (en) 2016-09-30 2019-05-30 Fujifilm Corp Cyclic peptide, affinity chromatography support, labeled antibody, antibody drug conjugate, and pharmaceutical preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
US4835252A (en) * 1987-02-26 1989-05-30 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
GB8729802D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
US5141924A (en) * 1989-06-30 1992-08-25 Hoffmann-La Roche, Inc. Synthetic vasoactive intestinal peptide analogs

Also Published As

Publication number Publication date
NO923929L (no) 1993-04-13
US5677419A (en) 1997-10-14
NO304523B1 (no) 1999-01-04
BG61125B2 (bg) 1996-11-29
HU211534A9 (en) 1995-12-28
EP0536741B1 (en) 1995-12-27
ATE132165T1 (de) 1996-01-15
NO975023D0 (no) 1997-10-31
FI20002041A (fi) 2000-09-15
IL117252A (en) 1999-11-30
ES2082317T3 (es) 1996-03-16
KR970001580B1 (ko) 1997-02-11
NO923929D0 (no) 1992-10-09
JPH05213996A (ja) 1993-08-24
CN1153785A (zh) 1997-07-09
CN1152579A (zh) 1997-06-25
TW305846B (ja) 1997-05-21
FI924580A (fi) 1993-04-12
BR9203959A (pt) 1993-04-27
IL103396A0 (en) 1993-03-15
DK0536741T3 (da) 1996-04-22
EP0536741A2 (en) 1993-04-14
IL117252A0 (en) 1996-06-18
AU2622892A (en) 1993-04-22
DE69207138D1 (de) 1996-02-08
GR3019326T3 (en) 1996-06-30
UY25084A1 (es) 1998-12-21
RU2095368C1 (ru) 1997-11-10
UY23488A1 (es) 1993-04-20
DE69207138T2 (de) 1996-06-13
CN1034943C (zh) 1997-05-21
ZA927724B (en) 1994-04-07
SK279399B6 (sk) 1998-11-04
MX9205822A (es) 1993-06-01
CN1198841C (zh) 2005-04-27
JP2515473B2 (ja) 1996-07-10
CN1072415A (zh) 1993-05-26
CZ281818B6 (cs) 1997-02-12
AU656230B2 (en) 1995-01-27
SK308692A3 (en) 1995-03-08
HUT62606A (en) 1993-05-28
NO980377L (no) 1993-04-13
CZ308692A3 (en) 1993-08-11
NO980377D0 (no) 1998-01-28
EP0536741A3 (ja) 1994-04-06
CA2080272A1 (en) 1993-04-12
HU9203194D0 (en) 1992-12-28
KR930007972A (ko) 1993-05-20
NZ244644A (en) 1995-04-27
IL103396A (en) 1997-11-20
FI924580A0 (fi) 1992-10-09
CA2080272C (en) 2002-09-17
NO975023L (no) 1993-04-13
CN1225473C (zh) 2005-11-02

Similar Documents

Publication Publication Date Title
FI111646B (fi) Menetelmä terapeuttisesti käyttökelpoisten syklisen peptidin valmistamiseksi
US4605641A (en) Synthetic vasoactive intestinal peptide analogs
US4835252A (en) Vasoactive intestinal peptide analogs
US4939224A (en) Vasoactive intestinal peptide analogs
US4734400A (en) Synthetic vasoactive intestinal peptide analogs
US5141924A (en) Synthetic vasoactive intestinal peptide analogs
US5234907A (en) Synthetic vasoactive intestinal peptide analogs
AU8237187A (en) Derivatives of atrial natriuretic peptides
US5149779A (en) Humoral hypercalcemic factor antagonists
EP0350318A2 (en) Novel peptides
CA2196308C (en) Peptide, bronchodilator and blood flow ameliorant
Yamaguchi et al. Synthesis and biological activity of analogs of substance P, modified for conformational information by D-amino acids
WO1989010935A1 (en) Atrial peptide derivatives
EP0315118A2 (en) DNA coding for endothelin and use thereof
IE53488B1 (en) Crf and analogues
Bolin et al. Structure‐activity studies of vasoactive intestinal peptide (VIP): cyclic disulfide analogs
FI111647B (fi) Menetelmä terapeuttisesti käyttökelpoisten syklisten peptidien valmistamiseksi