FI109698B - Menetelmä uusien, asyklisten, amidiiniryhmiä sisältävien difosfonihappojohdannaisten valmistamiseksi - Google Patents
Menetelmä uusien, asyklisten, amidiiniryhmiä sisältävien difosfonihappojohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI109698B FI109698B FI950259A FI950259A FI109698B FI 109698 B FI109698 B FI 109698B FI 950259 A FI950259 A FI 950259A FI 950259 A FI950259 A FI 950259A FI 109698 B FI109698 B FI 109698B
- Authority
- FI
- Finland
- Prior art keywords
- eller
- alkyl
- med
- carbon atoms
- diphosphonic acid
- Prior art date
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- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical class OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 title claims description 6
- 125000002015 acyclic group Chemical group 0.000 title description 2
- 125000003368 amide group Chemical group 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 13
- 239000001257 hydrogen Substances 0.000 claims abstract description 13
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 7
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims abstract description 5
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims abstract description 4
- 150000002367 halogens Chemical class 0.000 claims abstract description 4
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 3
- 150000002431 hydrogen Chemical class 0.000 claims abstract 2
- -1 phosphorous halide Chemical class 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 17
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 229910052698 phosphorus Inorganic materials 0.000 claims description 5
- 239000011574 phosphorus Substances 0.000 claims description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 230000007062 hydrolysis Effects 0.000 claims description 3
- 238000006460 hydrolysis reaction Methods 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 241000277284 Salvelinus fontinalis Species 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 2
- 229910052760 oxygen Inorganic materials 0.000 abstract description 2
- 239000001301 oxygen Substances 0.000 abstract description 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000011575 calcium Substances 0.000 description 10
- 229910052791 calcium Inorganic materials 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 150000004492 retinoid derivatives Chemical class 0.000 description 7
- 229940122361 Bisphosphonate Drugs 0.000 description 6
- 150000004663 bisphosphonates Chemical class 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 5
- 150000005690 diesters Chemical class 0.000 description 4
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- YJWIQRSUKPXZMI-UHFFFAOYSA-N 2-methyl-4,5-dihydro-1h-pyrimidin-6-one Chemical compound CC1=NC(=O)CCN1 YJWIQRSUKPXZMI-UHFFFAOYSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
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- 239000000706 filtrate Substances 0.000 description 3
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- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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- 229910019213 POCl3 Inorganic materials 0.000 description 2
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- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 101000794475 Schistosoma mansoni Calcium-binding protein Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001409 amidines Chemical class 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N anhydrous trimethylamine Natural products CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 239000008139 complexing agent Substances 0.000 description 2
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 description 2
- 230000000668 effect on calcium Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 208000027202 mammary Paget disease Diseases 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000007127 saponification reaction Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Natural products CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 2
- TWNBBEOYRZALBX-UHFFFAOYSA-N (2-amino-1-hydroxy-3-imino-1-phosphonobutyl)phosphonic acid Chemical compound CC(=N)C(N)C(O)(P(O)(O)=O)P(O)(O)=O TWNBBEOYRZALBX-UHFFFAOYSA-N 0.000 description 1
- YMBVDXGPGSZTHR-UHFFFAOYSA-N (2-amino-1-hydroxy-3-imino-1-phosphonopropyl)phosphonic acid Chemical compound N=CC(N)C(O)(P(O)(O)=O)P(O)(O)=O YMBVDXGPGSZTHR-UHFFFAOYSA-N 0.000 description 1
- XKPAQOIZAYOWLP-UHFFFAOYSA-N (2-amino-1-hydroxy-4-imino-1-phosphonobutyl)phosphonic acid Chemical compound OC(C(CC=N)N)(P(O)(=O)O)P(O)(=O)O XKPAQOIZAYOWLP-UHFFFAOYSA-N 0.000 description 1
- DIMRBKAYAVLZHW-UHFFFAOYSA-N (2-amino-1-hydroxy-4-imino-1-phosphonoheptyl)phosphonic acid Chemical compound OC(C(CC(CCC)=N)N)(P(O)(=O)O)P(O)(=O)O DIMRBKAYAVLZHW-UHFFFAOYSA-N 0.000 description 1
- MRRQSYUCPNGBQA-UHFFFAOYSA-N (2-amino-1-hydroxy-4-imino-3-methyl-1-phosphonohexyl)phosphonic acid Chemical compound OC(C(C(C)C(CC)=N)N)(P(O)(=O)O)P(O)(=O)O MRRQSYUCPNGBQA-UHFFFAOYSA-N 0.000 description 1
- STRSOGNZTNWCDT-UHFFFAOYSA-N (2-amino-1-hydroxy-4-imino-3-methyl-1-phosphonopentyl)phosphonic acid Chemical compound OC(C(C(C)C(C)=N)N)(P(O)(=O)O)P(O)(=O)O STRSOGNZTNWCDT-UHFFFAOYSA-N 0.000 description 1
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- LYSMWDCVQUHXQU-UHFFFAOYSA-N (2-amino-1-hydroxy-5-imino-1-phosphonohexyl)phosphonic acid Chemical compound OC(C(CCC(C)=N)N)(P(O)(=O)O)P(O)(=O)O LYSMWDCVQUHXQU-UHFFFAOYSA-N 0.000 description 1
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- QAFBVMQZLUNCPW-UHFFFAOYSA-N (2-amino-1-hydroxy-5-imino-3-methyl-1-phosphonohexyl)phosphonic acid Chemical compound OC(C(C(CC(C)=N)C)N)(P(O)(=O)O)P(O)(=O)O QAFBVMQZLUNCPW-UHFFFAOYSA-N 0.000 description 1
- MSHJGFUBDSDTTE-UHFFFAOYSA-N (2-amino-1-hydroxy-6-imino-1-phosphonoheptyl)phosphonic acid Chemical compound OC(C(CCCC(C)=N)N)(P(O)(=O)O)P(O)(=O)O MSHJGFUBDSDTTE-UHFFFAOYSA-N 0.000 description 1
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- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
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- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 description 1
- 229940046231 pamidronate Drugs 0.000 description 1
- 210000002990 parathyroid gland Anatomy 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 208000008281 urolithiasis Diseases 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4223940 | 1992-07-21 | ||
| DE4223940A DE4223940A1 (de) | 1992-07-21 | 1992-07-21 | Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| EP9301833 | 1993-07-13 | ||
| PCT/EP1993/001833 WO1994002492A1 (de) | 1992-07-21 | 1993-07-13 | Neue acyclische amidingruppen-haltige diphosphonsäurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI950259A0 FI950259A0 (fi) | 1995-01-20 |
| FI950259A FI950259A (fi) | 1995-01-20 |
| FI109698B true FI109698B (fi) | 2002-09-30 |
Family
ID=6463698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI950259A FI109698B (fi) | 1992-07-21 | 1995-01-20 | Menetelmä uusien, asyklisten, amidiiniryhmiä sisältävien difosfonihappojohdannaisten valmistamiseksi |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5543561A (no) |
| EP (1) | EP0651757B1 (no) |
| JP (1) | JP3489830B2 (no) |
| KR (1) | KR100246809B1 (no) |
| CN (1) | CN1040110C (no) |
| AT (1) | ATE148467T1 (no) |
| AU (1) | AU670307B2 (no) |
| CA (1) | CA2138127C (no) |
| DE (2) | DE4223940A1 (no) |
| DK (1) | DK0651757T3 (no) |
| ES (1) | ES2099960T3 (no) |
| FI (1) | FI109698B (no) |
| GR (1) | GR3023109T3 (no) |
| HU (1) | HU221496B (no) |
| IL (1) | IL106393A (no) |
| MX (1) | MX9304313A (no) |
| NO (1) | NO304792B1 (no) |
| NZ (1) | NZ254130A (no) |
| WO (1) | WO1994002492A1 (no) |
| ZA (1) | ZA935224B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW258729B (no) * | 1992-06-22 | 1995-10-01 | Ciba Geigy | |
| US6298081B1 (en) | 1996-05-31 | 2001-10-02 | Telefonaktiebolaget Lm Ericsson (Publ) | Channel hopping in a radio communications system |
| KR100327786B1 (ko) * | 1999-03-25 | 2002-03-14 | 유승필 | 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법 |
| EP1284754B1 (en) * | 2000-05-05 | 2006-01-04 | F. Hoffmann-La Roche Ag | Gel-like pharmaceutical composition for subcutaneous administration comprising bisphosphonic acids or their salts |
| KR100327787B1 (ko) * | 2001-02-27 | 2002-03-15 | 유승필 | 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196315B (it) * | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
| DE3930130A1 (de) * | 1989-09-09 | 1991-03-21 | Boehringer Mannheim Gmbh | Neue amidingruppen-haltige diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DK0531253T3 (da) * | 1991-08-27 | 1997-01-27 | Ciba Geigy Ag | N-substituerede aminomethandiphosphonsyrer |
| TW222637B (no) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
| TW258729B (no) * | 1992-06-22 | 1995-10-01 | Ciba Geigy | |
| DE59309360D1 (de) * | 1992-12-02 | 1999-03-18 | Hoechst Ag | Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US5366965A (en) * | 1993-01-29 | 1994-11-22 | Boehringer Mannheim Gmbh | Regimen for treatment or prophylaxis of osteoporosis |
-
1992
- 1992-07-21 DE DE4223940A patent/DE4223940A1/de not_active Withdrawn
-
1993
- 1993-07-13 AT AT93915895T patent/ATE148467T1/de active
- 1993-07-13 DK DK93915895.2T patent/DK0651757T3/da active
- 1993-07-13 ES ES93915895T patent/ES2099960T3/es not_active Expired - Lifetime
- 1993-07-13 US US08/367,325 patent/US5543561A/en not_active Expired - Lifetime
- 1993-07-13 NZ NZ254130A patent/NZ254130A/en not_active IP Right Cessation
- 1993-07-13 AU AU45680/93A patent/AU670307B2/en not_active Expired
- 1993-07-13 KR KR1019950700005A patent/KR100246809B1/ko not_active IP Right Cessation
- 1993-07-13 DE DE59305351T patent/DE59305351D1/de not_active Expired - Lifetime
- 1993-07-13 JP JP50411994A patent/JP3489830B2/ja not_active Expired - Lifetime
- 1993-07-13 HU HU9500180A patent/HU221496B/hu unknown
- 1993-07-13 CA CA002138127A patent/CA2138127C/en not_active Expired - Lifetime
- 1993-07-13 EP EP93915895A patent/EP0651757B1/de not_active Expired - Lifetime
- 1993-07-13 WO PCT/EP1993/001833 patent/WO1994002492A1/de active IP Right Grant
- 1993-07-16 MX MX9304313A patent/MX9304313A/es unknown
- 1993-07-19 IL IL10639393A patent/IL106393A/en not_active IP Right Cessation
- 1993-07-20 ZA ZA935224A patent/ZA935224B/xx unknown
- 1993-07-21 CN CN93108873A patent/CN1040110C/zh not_active Expired - Lifetime
-
1995
- 1995-01-20 NO NO945015A patent/NO304792B1/no not_active IP Right Cessation
- 1995-01-20 FI FI950259A patent/FI109698B/fi not_active IP Right Cessation
-
1997
- 1997-04-11 GR GR970400771T patent/GR3023109T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1040110C (zh) | 1998-10-07 |
| NZ254130A (en) | 1996-11-26 |
| MX9304313A (es) | 1994-02-28 |
| NO304792B1 (no) | 1999-02-15 |
| ZA935224B (en) | 1995-01-20 |
| JP3489830B2 (ja) | 2004-01-26 |
| EP0651757A1 (de) | 1995-05-10 |
| JPH09502158A (ja) | 1997-03-04 |
| AU670307B2 (en) | 1996-07-11 |
| HUT72603A (en) | 1996-05-28 |
| ATE148467T1 (de) | 1997-02-15 |
| WO1994002492A1 (de) | 1994-02-03 |
| US5543561A (en) | 1996-08-06 |
| KR100246809B1 (ko) | 2000-04-01 |
| CN1084852A (zh) | 1994-04-06 |
| NO950221D0 (no) | 1995-01-20 |
| DK0651757T3 (da) | 1997-07-28 |
| IL106393A (en) | 1999-05-09 |
| HU9500180D0 (en) | 1995-03-28 |
| KR950702566A (ko) | 1995-07-29 |
| DE4223940A1 (de) | 1994-01-27 |
| FI950259A0 (fi) | 1995-01-20 |
| CA2138127C (en) | 2006-01-24 |
| GR3023109T3 (en) | 1997-07-30 |
| IL106393A0 (en) | 1993-11-15 |
| DE59305351D1 (de) | 1997-03-13 |
| NO950221L (no) | 1995-01-20 |
| EP0651757B1 (de) | 1997-01-29 |
| HU221496B (en) | 2002-10-28 |
| FI950259A (fi) | 1995-01-20 |
| CA2138127A1 (en) | 1994-02-03 |
| ES2099960T3 (es) | 1997-06-01 |
| AU4568093A (en) | 1994-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Name/ company changed in application |
Owner name: ROCHE DIAGNOSTICS GMBH |
|
| MA | Patent expired |