ES8707535A1 - Un procedimiento para preparar nuevos derivados de carbapenem - Google Patents
Un procedimiento para preparar nuevos derivados de carbapenemInfo
- Publication number
- ES8707535A1 ES8707535A1 ES557035A ES557035A ES8707535A1 ES 8707535 A1 ES8707535 A1 ES 8707535A1 ES 557035 A ES557035 A ES 557035A ES 557035 A ES557035 A ES 557035A ES 8707535 A1 ES8707535 A1 ES 8707535A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- carbapenem compounds
- hydrogen
- compounds
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 -CONR4R5 Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 231100000417 nephrotoxicity Toxicity 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CARBAPENEM, DE FORMULA GENERAL (I), Y SUS SALES Y ESTERES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN COMPUESTO DE FOSFORO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). DICHO COMPUESTO DE FORMULA GENERAL (III) SE CALIENTA Y SI ES NECESARIO SE SEPARAN GRUPOS PROTECTORES.DE APLICACION EN MEDICINA Y FARMACIA COMO ANTIBIOTICOS, LOS CUALES TIENEN UTILIDAD EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS EN MAMIFEROS Y EN EL HOMBRE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28170084 | 1984-12-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8707535A1 true ES8707535A1 (es) | 1987-08-01 |
ES557035A0 ES557035A0 (es) | 1987-08-01 |
Family
ID=17642759
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES550403A Expired ES8706148A1 (es) | 1984-12-25 | 1985-12-24 | Un procedimiento para preparar nuevos derivados de carbapenem. |
ES557035A Expired ES8707535A1 (es) | 1984-12-25 | 1986-08-22 | Un procedimiento para preparar nuevos derivados de carbapenem |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES550403A Expired ES8706148A1 (es) | 1984-12-25 | 1985-12-24 | Un procedimiento para preparar nuevos derivados de carbapenem. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4740507A (es) |
EP (1) | EP0186525B1 (es) |
JP (1) | JPS61275279A (es) |
KR (1) | KR930005332B1 (es) |
CN (1) | CN1014246B (es) |
AT (1) | ATE51624T1 (es) |
AU (1) | AU575232B2 (es) |
CA (1) | CA1254562A (es) |
DE (1) | DE3576957D1 (es) |
DK (1) | DK169384B1 (es) |
ES (2) | ES8706148A1 (es) |
FI (1) | FI81576C (es) |
HU (1) | HU196071B (es) |
IE (1) | IE58823B1 (es) |
NO (1) | NO163957C (es) |
NZ (1) | NZ214676A (es) |
PH (1) | PH25391A (es) |
ZA (1) | ZA859797B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | 1―置換カルバペネム―3―カルボン酸誘導体 |
JPS6426580A (en) * | 1987-07-21 | 1989-01-27 | Sankyo Co | Production of carbapenem derivative |
US5102877A (en) * | 1989-04-28 | 1992-04-07 | Fujisawa Pharmaceutical Co., Ltd. | 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds |
US5286721A (en) * | 1990-10-15 | 1994-02-15 | Fujisawa Pharmaceutical Co., Ltd. | 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds |
TW209220B (es) * | 1991-11-27 | 1993-07-11 | Manyu Seiyaku Kk | |
GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
GB9210096D0 (en) * | 1992-05-11 | 1992-06-24 | Fujisawa Pharmaceutical Co | 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation |
JP2696807B2 (ja) * | 1992-08-06 | 1998-01-14 | 田辺製薬株式会社 | カルバペネム誘導体の製法 |
CA2280273A1 (en) * | 1997-02-07 | 1998-08-13 | Masayasu Kasai | Carbapenem compounds, use thereof, and intermediate compounds of the same |
NZ508493A (en) | 1998-05-01 | 2002-06-28 | Kyoto Pharma Ind | Carbapenem derivatives, utilization thereof and intermediate compounds of the same |
HUP0400444A3 (en) * | 2001-05-21 | 2007-02-28 | Kyoto Pharmaceutical Ind | Carbapenem compound, pharmaceutical compositions containing them and their use |
GB0400382D0 (en) * | 2004-01-09 | 2004-02-11 | Glaxo Group Ltd | Novel processes |
US7932381B2 (en) * | 2005-02-15 | 2011-04-26 | Shionogi & Co., Ltd. | Process for producing carbapenem derivative and intermediate crystal therefor |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4383946A (en) * | 1980-03-27 | 1983-05-17 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals |
US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
JPS5913757A (ja) * | 1982-07-14 | 1984-01-24 | Sankyo Co Ltd | 3−メルカプトピロリジン誘導体及びその製法 |
JPS5916892A (ja) * | 1982-07-19 | 1984-01-28 | Sankyo Co Ltd | カルバペネム−3−カルボン酸誘導体およびその製法 |
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
JPS59205379A (ja) * | 1983-05-09 | 1984-11-20 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物及びその製造法 |
-
1985
- 1985-12-20 FI FI855128A patent/FI81576C/fi not_active IP Right Cessation
- 1985-12-20 JP JP60285663A patent/JPS61275279A/ja active Pending
- 1985-12-23 HU HU854957A patent/HU196071B/hu not_active IP Right Cessation
- 1985-12-23 IE IE330085A patent/IE58823B1/en not_active IP Right Cessation
- 1985-12-23 NZ NZ214676A patent/NZ214676A/xx unknown
- 1985-12-23 NO NO855241A patent/NO163957C/no unknown
- 1985-12-23 US US06/812,344 patent/US4740507A/en not_active Expired - Fee Related
- 1985-12-23 ZA ZA859797A patent/ZA859797B/xx unknown
- 1985-12-23 CN CN85109699A patent/CN1014246B/zh not_active Expired
- 1985-12-23 DK DK604485A patent/DK169384B1/da active
- 1985-12-24 CA CA000498605A patent/CA1254562A/en not_active Expired
- 1985-12-24 ES ES550403A patent/ES8706148A1/es not_active Expired
- 1985-12-24 PH PH33239A patent/PH25391A/en unknown
- 1985-12-24 AU AU51699/85A patent/AU575232B2/en not_active Ceased
- 1985-12-24 KR KR1019850009792A patent/KR930005332B1/ko not_active IP Right Cessation
- 1985-12-30 EP EP85309537A patent/EP0186525B1/en not_active Expired - Lifetime
- 1985-12-30 AT AT85309537T patent/ATE51624T1/de not_active IP Right Cessation
- 1985-12-30 DE DE8585309537T patent/DE3576957D1/de not_active Expired - Fee Related
-
1986
- 1986-08-22 ES ES557035A patent/ES8707535A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
HU196071B (en) | 1988-09-28 |
CA1254562A (en) | 1989-05-23 |
ES8706148A1 (es) | 1987-06-01 |
NO163957C (no) | 1990-08-15 |
DK604485D0 (da) | 1985-12-23 |
AU5169985A (en) | 1986-07-03 |
IE58823B1 (en) | 1993-11-17 |
DE3576957D1 (de) | 1990-05-10 |
FI855128A0 (fi) | 1985-12-20 |
CN85109699A (zh) | 1986-08-13 |
KR860004892A (ko) | 1986-07-14 |
ES557035A0 (es) | 1987-08-01 |
NO163957B (no) | 1990-05-07 |
ZA859797B (en) | 1986-09-24 |
JPS61275279A (ja) | 1986-12-05 |
CN1014246B (zh) | 1991-10-09 |
FI81576B (fi) | 1990-07-31 |
DK604485A (da) | 1986-06-26 |
AU575232B2 (en) | 1988-07-21 |
PH25391A (en) | 1991-06-03 |
FI855128A (fi) | 1986-06-26 |
EP0186525A1 (en) | 1986-07-02 |
US4740507A (en) | 1988-04-26 |
EP0186525B1 (en) | 1990-04-04 |
DK169384B1 (da) | 1994-10-17 |
KR930005332B1 (ko) | 1993-06-17 |
NO855241L (no) | 1986-06-26 |
IE853300L (en) | 1986-06-25 |
ES550403A0 (es) | 1987-06-01 |
NZ214676A (en) | 1988-06-30 |
HUT39182A (en) | 1986-08-28 |
ATE51624T1 (de) | 1990-04-15 |
FI81576C (fi) | 1990-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8700672A1 (es) | Un procedimiento para la preparacion de derivados de amino alquilentio-alquilentiofosfonatos. | |
AU582148B2 (en) | Carbapenem derivatives and compositions containing them | |
IL73258A0 (en) | 7-aminoazolo(1,5-a)pyrimidines,their preparation and their use as fungicides | |
ES8706148A1 (es) | Un procedimiento para preparar nuevos derivados de carbapenem. | |
ES8607252A1 (es) | Procedimiento para preparar derivados de imidazol | |
ATE12224T1 (de) | Verbindungen mit antifibrinolytischer wirksamkeit. | |
ES8406440A1 (es) | Procedimiento para preparar derivados de 2-amino-3-acilamino-6-bencilamino-piridina | |
ES2001794A6 (es) | Un procedimiento para la preparacion de derivados de quinolina | |
ES8506594A1 (es) | Un procedimiento para obtener derivados de indanilbenzamida | |
ES8703869A1 (es) | Procedimiento para preparar compuestos de 5-alaquil-1-fenil-2-piperazinoalquilpirazolin-3-ona. | |
ES8605249A1 (es) | Un procedimiento para la preparacion de tiazolidinas | |
ES8601151A1 (es) | Procedimiento para la obtencion de derivados de fenilsulfonil-isotiourea sustituidos de efecto herbicida | |
ES8609302A1 (es) | Un procedimiento para la preparacion de 4-amino-2-fenilqui- nolinas | |
ES8403911A1 (es) | Procedimiento de preparacion de mononitratos de 1.4,3.6- dianhidro-hexito sustituidos en 2-0 y 5-0 | |
ES8800220A1 (es) | Procedimiento para la produccion de 8-alfa-acilamino-ergolinas. | |
ES8607951A1 (es) | Procedimiento para la obtencion de un derivado de sulfonilguanidina | |
ES2004384A6 (es) | Procedimiento para preparar compuestos antibioticos macrolidos y metodo para combatir plagas con ellos. | |
ES8707727A1 (es) | Un procedimiento para producir un derivado de tiofenosulfonamida. | |
ES475780A1 (es) | Un proceso para la produccion de nueva penicilina y deriva- dos cefalosporinicos | |
ES8801648A1 (es) | Procedimiento de preparar derivados bisimidazolinoamino, utiles como compuestos antialergicos. | |
ES8405015A1 (es) | Un procedimiento para la preparacion de derivados de acido clavulanico. | |
IE41906L (en) | But-2-enoanilides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000403 |