ES8707205A1 - Procedimiento para preparar un derivado de oxadiazolilimidazobenzodiazepina - Google Patents

Procedimiento para preparar un derivado de oxadiazolilimidazobenzodiazepina

Info

Publication number
ES8707205A1
ES8707205A1 ES555035A ES555035A ES8707205A1 ES 8707205 A1 ES8707205 A1 ES 8707205A1 ES 555035 A ES555035 A ES 555035A ES 555035 A ES555035 A ES 555035A ES 8707205 A1 ES8707205 A1 ES 8707205A1
Authority
ES
Spain
Prior art keywords
oxadiazol
imidazo
cyclopropyl
dihydro
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555035A
Other languages
English (en)
Other versions
ES555035A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrosan ApS
Original Assignee
Ferrosan ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK220485A external-priority patent/DK220485D0/da
Priority claimed from DK365985A external-priority patent/DK365985D0/da
Priority claimed from DK476985A external-priority patent/DK476985D0/da
Application filed by Ferrosan ApS filed Critical Ferrosan ApS
Publication of ES555035A0 publication Critical patent/ES555035A0/es
Publication of ES8707205A1 publication Critical patent/ES8707205A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyethers (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE OXADIAZOLIHIMIDAZO-BENZODIAZEPINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE HIDRURO ALCALINO, EN DIMETILFORMAMIDA Y ENTRE C40JC Y 30JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO Y UN GRUPO SALIENTE COMO HAL, ARALQUITIO Y METILTIO. SE UTILIZA EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL (ANTICONVULSIVOS Y ANSIOLITICOS).
ES555035A 1985-05-17 1986-05-16 Procedimiento para preparar un derivado de oxadiazolilimidazobenzodiazepina Expired ES8707205A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK220485A DK220485D0 (da) 1985-05-17 1985-05-17 Nye oxadiazolylimidazobenzodiazepinderivater samt fremgangsmaade tilfremstilling heraf
DK365985A DK365985D0 (da) 1985-08-12 1985-08-12 Nye oxadiazolylimidazobenzodiazepinderivater samt fremgangsmaade tilfremstilling heraf
DK476985A DK476985D0 (da) 1985-10-17 1985-10-17 Fremgangsmaade til fremstilling af oxadiazolylderivater af imidazobenzodiazepiner og mellemprodukt til brug ved fremgangsmaaden

Publications (2)

Publication Number Publication Date
ES555035A0 ES555035A0 (es) 1987-07-16
ES8707205A1 true ES8707205A1 (es) 1987-07-16

Family

ID=27221528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES555035A Expired ES8707205A1 (es) 1985-05-17 1986-05-16 Procedimiento para preparar un derivado de oxadiazolilimidazobenzodiazepina

Country Status (16)

Country Link
US (2) US4622320A (es)
EP (1) EP0201678B1 (es)
JP (1) JPH01279877A (es)
AT (1) ATE35266T1 (es)
AU (2) AU590273B2 (es)
CA (2) CA1256863A (es)
DE (2) DE201678T1 (es)
DK (2) DK157194C (es)
ES (1) ES8707205A1 (es)
FI (1) FI82049C (es)
GR (1) GR861260B (es)
IE (1) IE59494B1 (es)
IL (1) IL78790A (es)
NO (1) NO163228C (es)
NZ (1) NZ216202A (es)
PT (1) PT82594B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE110726T1 (de) * 1984-01-19 1994-09-15 Hoffmann La Roche Imidazodiazepin-derivate.
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
US4771051A (en) * 1985-05-17 1988-09-13 A/S Ferrosan 3-substituted-4,5-dihydro-5-oxo imidazoquinazolines, their preparation, and their use in treating benzodiazepin receptor-related ailments
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
ATE80392T1 (de) * 1985-10-17 1992-09-15 Novo Nordisk As Oxadiazolylacetonitrile, ihre herstellung und anwendung.
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
DK522187D0 (da) * 1987-10-06 1987-10-06 Ferrosan As Imidozothienopyrimidiner, deres fremstilling og anvendelse
GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
CA2143246C (en) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
FI101305B1 (fi) * 1996-03-18 1998-05-29 Map Medical Technologies Oy Radiofarmaseuttisena aineena käyttökelpoiset radiojodatut bentsodiatsepiini-johdannaiset ja niiden käyttö diagnostiikassa
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
BRPI0815579A2 (pt) 2007-08-20 2015-02-18 Evotec Neurosciences Gmbh Tratamento de distúrbio do sono

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031029A (en) * 1975-07-02 1977-06-21 General Electric Company Process for producing uranium oxide rich compositions from uranium hexafluoride using fluid injection into the reaction zone
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
ATE110726T1 (de) * 1984-01-19 1994-09-15 Hoffmann La Roche Imidazodiazepin-derivate.
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
ATE80392T1 (de) * 1985-10-17 1992-09-15 Novo Nordisk As Oxadiazolylacetonitrile, ihre herstellung und anwendung.
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme

Also Published As

Publication number Publication date
US4622321A (en) 1986-11-11
DE201678T1 (de) 1987-02-26
FI862061A0 (fi) 1986-05-16
NO861954L (no) 1986-11-18
PT82594A (en) 1986-06-01
EP0201678B1 (en) 1988-06-22
AU3933389A (en) 1989-11-23
AU5742986A (en) 1986-11-20
ES555035A0 (es) 1987-07-16
FI82049B (fi) 1990-09-28
FI82049C (fi) 1991-01-10
EP0201678A1 (en) 1986-11-20
DK63288A (da) 1988-02-08
DK157194C (da) 1990-04-23
AU614407B2 (en) 1991-08-29
GR861260B (en) 1986-09-10
DK160097B (da) 1991-01-28
IL78790A (en) 1990-01-18
NZ216202A (en) 1989-08-29
FI862061A (fi) 1986-11-18
NO163228B (no) 1990-01-15
AU590273B2 (en) 1989-11-02
IE59494B1 (en) 1994-02-23
IE861306L (en) 1986-11-17
NO163228C (no) 1990-04-25
CA1256863A (en) 1989-07-04
JPH01279877A (ja) 1989-11-10
DE3660331D1 (en) 1988-07-28
DK157194B (da) 1989-11-20
DK231686D0 (da) 1986-05-16
DK231686A (da) 1986-11-18
CA1256864A (en) 1989-07-04
ATE35266T1 (de) 1988-07-15
PT82594B (pt) 1988-03-03
DK63288D0 (da) 1988-02-08
US4622320A (en) 1986-11-11
DK160097C (da) 1991-06-24
IL78790A0 (en) 1986-08-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503