ES8702389A1 - Un procedimiento para preparar nuevos compuestos con anillo condensado de siete miembros. - Google Patents

Un procedimiento para preparar nuevos compuestos con anillo condensado de siete miembros.

Info

Publication number
ES8702389A1
ES8702389A1 ES540548A ES540548A ES8702389A1 ES 8702389 A1 ES8702389 A1 ES 8702389A1 ES 540548 A ES540548 A ES 540548A ES 540548 A ES540548 A ES 540548A ES 8702389 A1 ES8702389 A1 ES 8702389A1
Authority
ES
Spain
Prior art keywords
condensed
lower alkyl
membered ring
ring compounds
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540548A
Other languages
English (en)
Other versions
ES540548A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1984/000119 external-priority patent/WO1985004402A1/ja
Priority claimed from PCT/JP1984/000172 external-priority patent/WO1985004657A1/ja
Priority claimed from US06/599,187 external-priority patent/US4564612A/en
Priority claimed from PCT/JP1984/000363 external-priority patent/WO1986000618A1/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8702389A1 publication Critical patent/ES8702389A1/es
Publication of ES540548A0 publication Critical patent/ES540548A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS COMPUESTOS CON ANILLO CONDENSADO DE SIETE MIEMBROS. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UNA BASE COMO HIDROXIDO DE SODIO O CARBONATO DE POTASIO, CON ACETONITRILO O DIMETILFORMAMIDA Y A UNA TEMPERATURA ENTRE C20J Y B150JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SALES ACIDAS O BASICAS FARMACEUTICAMENTE ACEPTABLES. SIENDO: A, UNA CADENA DE ALQUILENO; R1 Y R2, H, HAL, TRIFLUOROMETILO Y OTROS; R3 Y R5, H, ALQUILO INFERIOR O ARALQUILO; R6, UN GRUPO HETERO-ALICICLICO CONDENSADO QUE CONTIENE UN ATOMO DE O, N Y S COMO FORMADOR DE ANILLOS QUE PUEDE ESTAR SUSTITUIDO; RA, ALQUILO INFERIOR, TRIFLUOROMETILO Y OTROS; WA, HAL O RASO2-O-, Y N, 1 O 2. SE UTILIZAN PARA TRATAR ENFERMEDADES CIRCULATORIAS COMO LA HIPERTENCION, CARDIOPATIA Y APOPLEJIA CEREBRAL.
ES540548A 1984-03-24 1985-02-20 Un procedimiento para preparar nuevos compuestos con anillo condensado de siete miembros. Expired ES8702389A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/JP1984/000119 WO1985004402A1 (en) 1984-03-24 1984-03-24 Fused 7-membered ring compounds and process for their preparation
PCT/JP1984/000172 WO1985004657A1 (en) 1984-04-06 1984-04-06 Fused 7-membered ring compounds and process for their preparation
US06/599,187 US4564612A (en) 1983-04-22 1984-04-11 Condensed, seven-membered ring compounds and their use
PCT/JP1984/000363 WO1986000618A1 (en) 1984-07-13 1984-07-13 Condensed 7-membered ring compounds and process for their preparation

Publications (2)

Publication Number Publication Date
ES8702389A1 true ES8702389A1 (es) 1987-01-01
ES540548A0 ES540548A0 (es) 1987-01-01

Family

ID=27466903

Family Applications (2)

Application Number Title Priority Date Filing Date
ES540548A Expired ES8702389A1 (es) 1984-03-24 1985-02-20 Un procedimiento para preparar nuevos compuestos con anillo condensado de siete miembros.
ES557636A Expired ES8801653A1 (es) 1984-03-24 1987-07-29 Un procedimiento para preparar derivados de 3-amino-4-oxo-2,3,4,5-benzoxapina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557636A Expired ES8801653A1 (es) 1984-03-24 1987-07-29 Un procedimiento para preparar derivados de 3-amino-4-oxo-2,3,4,5-benzoxapina

Country Status (8)

Country Link
EP (1) EP0156455A3 (es)
JP (1) JPH0215060A (es)
ES (2) ES8702389A1 (es)
FI (1) FI82465C (es)
IE (1) IE850148L (es)
IL (1) IL74004A (es)
NO (1) NO160712C (es)
PH (1) PH23261A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0657707B2 (ja) * 1987-05-25 1994-08-03 吉富製薬株式会社 ピペリジン化合物
EP0359004A1 (en) * 1988-09-05 1990-03-21 Takeda Chemical Industries, Ltd. Transdermal therapeutic composition for the treatment of hypertension
ATE107517T1 (de) * 1989-05-25 1994-07-15 Takeda Chemical Industries Ltd Transdermales therapeutisches mittel.
JPH0338583A (ja) * 1989-07-04 1991-02-19 Nippon Soda Co Ltd １‐（４‐テトラヒドロピラニル）‐１‐ブテン‐３‐オンの製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
EP0068173B1 (en) * 1981-06-05 1984-09-26 Merck & Co. Inc. Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same
US4564612A (en) * 1983-04-22 1986-01-14 Takeda Chemical Industries, Ltd. Condensed, seven-membered ring compounds and their use
DE3423743A1 (de) * 1983-06-29 1985-01-10 Mitsui Toatsu Chemicals, Inc., Tokio/Tokyo Benzothiazepin-derivate und verfahren zu ihrer herstellung
IL72523A (en) * 1983-08-12 1988-06-30 Takeda Chemical Industries Ltd 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them
DE3426720A1 (de) * 1984-07-20 1986-01-23 Hoechst Ag, 6230 Frankfurt Benzthiazepinon- und benzthiazocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung

Also Published As

Publication number Publication date
EP0156455A2 (en) 1985-10-02
FI82465C (fi) 1991-03-11
ES557636A0 (es) 1988-02-16
NO160712B (no) 1989-02-13
NO850045L (no) 1985-09-23
FI851154A0 (fi) 1985-03-22
FI851154L (fi) 1985-09-23
JPH0215060A (ja) 1990-01-18
IL74004A (en) 1991-12-15
NO160712C (no) 1989-05-24
IE850148L (en) 1985-09-22
FI82465B (fi) 1990-11-30
IL74004A0 (en) 1985-04-30
ES540548A0 (es) 1987-01-01
ES8801653A1 (es) 1988-02-16
EP0156455A3 (en) 1987-07-22
JPH0563468B2 (es) 1993-09-10
PH23261A (en) 1989-06-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603