ES8604887A1 - Procedimiento para la obtencion de derivados del 3-(ureidociclo-hexilamino)-propan-1,2-diol. - Google Patents
Procedimiento para la obtencion de derivados del 3-(ureidociclo-hexilamino)-propan-1,2-diol.Info
- Publication number
- ES8604887A1 ES8604887A1 ES522723A ES522723A ES8604887A1 ES 8604887 A1 ES8604887 A1 ES 8604887A1 ES 522723 A ES522723 A ES 522723A ES 522723 A ES522723 A ES 522723A ES 8604887 A1 ES8604887 A1 ES 8604887A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- preparation
- pharmaceutical preparations
- preparations containing
- ureidocyclohexylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL 3-(UREIDOCICLOHEXILAMINO)-PROPAN-1,2-DIOL. CONSISTE EN CONDENSAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER DERIVADOS DEL 3-(UREIDOCICLOHEXILAMINO)-PROPAN-1,2-DIOL DE FORMULA (I) DONDE AR SIGNIFICA UN RESTO AROMATICO, CARBOCICLICO O HETEROCICLICO; R ES H, ALCANOILO O AROILO; R1 Y R2 SIGNIFICAN H O ALQUILO INFERIOR; R3 Y R4, INDEPENDIENTEMENTE ENTRE SI, SIGNIFICAN H O ALQUILO INFERIOR; Y X SIGNIFICA OXO (O) O TIO (S). SE UTILIZAN FARMACOLOGICAMENTE COMO AGENTES CARDIOVASCULARES POR POSEER EFECTOS ANTIHIPERTENSIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38304982A | 1982-05-28 | 1982-05-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES522723A0 ES522723A0 (es) | 1986-02-16 |
ES8604887A1 true ES8604887A1 (es) | 1986-02-16 |
Family
ID=23511486
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522723A Expired ES8604887A1 (es) | 1982-05-28 | 1983-05-26 | Procedimiento para la obtencion de derivados del 3-(ureidociclo-hexilamino)-propan-1,2-diol. |
ES535963A Expired ES8608492A1 (es) | 1982-05-28 | 1984-09-14 | Procedimiento para la obtencion de derivados de 3-(ureidociclohexilamino) propan-1, 2-diol |
ES535964A Expired ES8607943A1 (es) | 1982-05-28 | 1984-09-14 | Procedimiento para la obtencion de derivados del 3-(ureidociclohexilamino)-propan-1, 2-diol |
ES535965A Expired ES8607942A1 (es) | 1982-05-28 | 1984-09-14 | Procedimiento para la obtencion de derivados de 3-(ureidociclohexilamino)-propan-1, 2-diol |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535963A Expired ES8608492A1 (es) | 1982-05-28 | 1984-09-14 | Procedimiento para la obtencion de derivados de 3-(ureidociclohexilamino) propan-1, 2-diol |
ES535964A Expired ES8607943A1 (es) | 1982-05-28 | 1984-09-14 | Procedimiento para la obtencion de derivados del 3-(ureidociclohexilamino)-propan-1, 2-diol |
ES535965A Expired ES8607942A1 (es) | 1982-05-28 | 1984-09-14 | Procedimiento para la obtencion de derivados de 3-(ureidociclohexilamino)-propan-1, 2-diol |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0096006A3 (es) |
JP (1) | JPS5931753A (es) |
KR (1) | KR840004729A (es) |
AU (1) | AU559970B2 (es) |
CA (1) | CA1215711A (es) |
DD (1) | DD210266A5 (es) |
DK (1) | DK238083A (es) |
ES (4) | ES8604887A1 (es) |
FI (1) | FI831863L (es) |
GR (1) | GR79228B (es) |
IL (1) | IL68794A0 (es) |
NO (1) | NO158343C (es) |
NZ (1) | NZ204383A (es) |
PH (1) | PH20374A (es) |
PT (1) | PT76772B (es) |
ZA (1) | ZA833861B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3689111D1 (de) * | 1985-12-13 | 1993-11-04 | Ciba Geigy | Verbessertes verfahren zur herstellung von glycidylverbindungen. |
SE9802208D0 (sv) * | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
EA200300145A1 (ru) * | 2000-07-13 | 2003-06-26 | Эли Лилли Энд Компани | АГОНИСТЫ β-АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ |
CA2517291C (en) | 2003-03-19 | 2012-05-08 | Exelixis, Inc. | Ortho-substituted aryl and heteroaryl tie-2 modulators and methods of use |
FR2935141B1 (fr) * | 2008-08-21 | 2010-10-08 | Sanofi Aventis | Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate |
-
1983
- 1983-05-24 EP EP83810218A patent/EP0096006A3/de not_active Withdrawn
- 1983-05-25 FI FI831863A patent/FI831863L/fi not_active Application Discontinuation
- 1983-05-26 GR GR71464A patent/GR79228B/el unknown
- 1983-05-26 IL IL68794A patent/IL68794A0/xx unknown
- 1983-05-26 ES ES522723A patent/ES8604887A1/es not_active Expired
- 1983-05-26 PH PH28959A patent/PH20374A/en unknown
- 1983-05-26 CA CA000428992A patent/CA1215711A/en not_active Expired
- 1983-05-27 DK DK238083A patent/DK238083A/da not_active Application Discontinuation
- 1983-05-27 KR KR1019830002349A patent/KR840004729A/ko not_active Application Discontinuation
- 1983-05-27 NO NO831901A patent/NO158343C/no unknown
- 1983-05-27 PT PT76772A patent/PT76772B/pt unknown
- 1983-05-27 ZA ZA833861A patent/ZA833861B/xx unknown
- 1983-05-27 AU AU15201/83A patent/AU559970B2/en not_active Ceased
- 1983-05-27 NZ NZ204383A patent/NZ204383A/xx unknown
- 1983-05-27 JP JP58092576A patent/JPS5931753A/ja active Pending
- 1983-05-27 DD DD83251330A patent/DD210266A5/de unknown
-
1984
- 1984-09-14 ES ES535963A patent/ES8608492A1/es not_active Expired
- 1984-09-14 ES ES535964A patent/ES8607943A1/es not_active Expired
- 1984-09-14 ES ES535965A patent/ES8607942A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
PH20374A (en) | 1986-12-08 |
PT76772A (en) | 1983-06-01 |
DK238083D0 (da) | 1983-05-27 |
NO831901L (no) | 1983-11-29 |
ES535964A0 (es) | 1986-06-01 |
ES8607942A1 (es) | 1986-06-01 |
ZA833861B (en) | 1984-02-29 |
ES535965A0 (es) | 1986-06-01 |
ES8607943A1 (es) | 1986-06-01 |
AU559970B2 (en) | 1987-03-26 |
FI831863A0 (fi) | 1983-05-25 |
NZ204383A (en) | 1985-12-13 |
ES535963A0 (es) | 1986-06-16 |
ES522723A0 (es) | 1986-02-16 |
CA1215711A (en) | 1986-12-23 |
NO158343C (no) | 1988-08-24 |
KR840004729A (ko) | 1984-10-24 |
NO158343B (no) | 1988-05-16 |
IL68794A0 (en) | 1983-09-30 |
DK238083A (da) | 1983-11-29 |
AU1520183A (en) | 1983-12-01 |
ES8608492A1 (es) | 1986-06-16 |
FI831863L (fi) | 1983-11-29 |
EP0096006A2 (de) | 1983-12-07 |
EP0096006A3 (de) | 1984-12-19 |
JPS5931753A (ja) | 1984-02-20 |
GR79228B (es) | 1984-10-22 |
PT76772B (en) | 1986-03-27 |
DD210266A5 (de) | 1984-06-06 |
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