ES8403492A1 - Procedimiento para la preparacion de derivados de acidos difosfonicos. - Google Patents

Procedimiento para la preparacion de derivados de acidos difosfonicos.

Info

Publication number
ES8403492A1
ES8403492A1 ES523786A ES523786A ES8403492A1 ES 8403492 A1 ES8403492 A1 ES 8403492A1 ES 523786 A ES523786 A ES 523786A ES 523786 A ES523786 A ES 523786A ES 8403492 A1 ES8403492 A1 ES 8403492A1
Authority
ES
Spain
Prior art keywords
derivatives
pharmaceutical preparations
preparations containing
diphosphonic acids
cyanomethanebis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523786A
Other languages
English (en)
Other versions
ES523786A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8403492A1 publication Critical patent/ES8403492A1/es
Publication of ES523786A0 publication Critical patent/ES523786A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3869—Polyphosphonic acids containing carboxylic acid or carboxylic acid derivative substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PRA LA OBTENCION DE DERIVADOS DE ACIDOS DIFOSFONICOS, DE FORMULA (I), EN LA QUE X ES GRUPO CIANO O DIMETILAMINOMETILENO; Y R ES HIDROGENO, METAL ALCALINO O ALCOHILO C1-4.CONSISTE EN LA REACCION DE DIMETILFORMAMIDO-DIALCOHI LACETAL DE FORMULA (CH3)2NOH(ORK)2, CON UN METAN-BIS (FOSFONATO DIALCOHILICO), DE FORMULA CH2(PO3R2)2, EN LAS QUE RK ES ALCOHILO C1-4 Y R ES EL MISMO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO CALENTANDO LA MEZCLA EN PRESENCIA DE UNA BASE.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIINFLAMATORIA Y ANTIALERGICA.
ES523786A 1982-07-05 1983-07-01 Procedimiento para la preparacion de derivados de acidos difosfonicos. Granted ES523786A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823225469 DE3225469A1 (de) 1982-07-05 1982-07-05 Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
ES8403492A1 true ES8403492A1 (es) 1984-04-01
ES523786A0 ES523786A0 (es) 1984-04-01

Family

ID=6167887

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523786A Granted ES523786A0 (es) 1982-07-05 1983-07-01 Procedimiento para la preparacion de derivados de acidos difosfonicos.

Country Status (13)

Country Link
US (1) US4645762A (es)
EP (1) EP0098567A3 (es)
JP (1) JPS5973593A (es)
AU (1) AU1656983A (es)
CA (1) CA1222252A (es)
DE (1) DE3225469A1 (es)
DK (1) DK311383A (es)
ES (1) ES523786A0 (es)
FI (1) FI832467L (es)
GB (1) GB2122999A (es)
GR (1) GR77589B (es)
IL (1) IL69164A0 (es)
ZA (1) ZA834908B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
DE3512536A1 (de) * 1985-04-06 1986-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeure-derivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
GB8530603D0 (en) * 1985-12-12 1986-01-22 Leo Pharm Prod Ltd Chemical compounds
DE3724654A1 (de) * 1987-07-25 1989-02-02 Henkel Kgaa Hydroxyacetonitrildiphosphonsaeure, verfahren zu ihrer herstellung und ihre verwendung
JP3021035B2 (ja) * 1988-11-01 2000-03-15 アーク・デベロップメント・コーポレーション ホスホン酸及び分離におけるその使用
FI89364C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
EP0496520A1 (en) * 1991-01-22 1992-07-29 Merck & Co. Inc. Novel bone acting agents
TW222637B (es) * 1991-12-12 1994-04-21 Hoechst Ag
DE4228552A1 (de) * 1992-08-27 1994-03-03 Boehringer Mannheim Gmbh Diphosphonsäuren und deren Salze enthaltende Arzneimittel
CA2372450A1 (en) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4634186Y1 (es) * 1967-12-29 1971-11-26
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
US3813456A (en) * 1972-01-17 1974-05-28 Gates Rubber Co Process for preparing amino-substituted phosphonates
DE2405254C2 (de) * 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
DE2602030C2 (de) * 1976-01-21 1983-12-01 Henkel KGaA, 4000 Düsseldorf Diphosphonoalkancarbonsäuren und Verfahren zu deren Herstellung
JPS52127682U (es) * 1976-03-25 1977-09-28
SU739076A1 (ru) * 1976-05-19 1980-06-05 Институт Химической Кинетики И Горения Со Ан Ссср Способ получени -аминоэтилидендифосфоновых кислот
EP0000061B1 (de) * 1977-06-14 1980-10-15 Hoechst Aktiengesellschaft Phosphorhaltige Carbonsäure-Derivate, Verfahren zu deren Herstellung, sowie ihre Verwendung
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1194748B (it) * 1981-02-12 1988-09-28 Gentili Ist Spa Composizioni farmaceutiche per il trattamento di osteopatie

Also Published As

Publication number Publication date
CA1222252A (en) 1987-05-26
AU1656983A (en) 1984-01-26
GB2122999A (en) 1984-01-25
GR77589B (es) 1984-09-24
JPS5973593A (ja) 1984-04-25
GB8318157D0 (en) 1983-08-03
EP0098567A2 (de) 1984-01-18
EP0098567A3 (de) 1984-02-22
DE3225469A1 (de) 1984-01-05
ZA834908B (en) 1984-03-28
FI832467A0 (fi) 1983-07-05
US4645762A (en) 1987-02-24
DK311383D0 (da) 1983-07-05
FI832467L (fi) 1984-01-06
IL69164A0 (en) 1983-11-30
ES523786A0 (es) 1984-04-01
DK311383A (da) 1984-01-06

Similar Documents

Publication Publication Date Title
IL110216A0 (en) Valproic acid amide and 2-valproenoic acid amide derivatives, their preparation and pharmaceutical compositions containing them
ZA83566B (en) Diphosphonic acid derivatives, process for their preparation and pharmaceutical preparations containing them
IL83149A (en) 1-hydroxy-3-(n-methyl-n-propylamino)propane-1,1-diphosphonic acid,processes for the preparation thereof and pharmaceutical compositions containing same
HUT38364A (en) Process for preparing new diphosphonic acid derivatives further pharmaceutical compositions containing thereof
AU584759B2 (en) New diphosphonic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
ES8403492A1 (es) Procedimiento para la preparacion de derivados de acidos difosfonicos.
ES8404184A1 (es) Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
CA2065104A1 (en) Erucyl, brassidyl and nervonyl derivatives
ES8301927A1 (es) Procedimiento de preparacion de acidos azabiciclohexano car-boxilicos y de sus sales
ES8307239A1 (es) Procedimiento para la preparacion de acidos (2-oxo-3-tetrahidrotienilcarbamoil)-alquiltio aceticos.
EP0193148A3 (en) 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides
ES2026746A6 (es) Un procedimiento para la preparacion de tetrazoles.
ES8401945A1 (es) Procedimiento para preparar derivados de dibenzo(de,g)quinoleina.
DE3853490D1 (de) Ätherfreie organometallische Amidverbindungen.
DE3462400D1 (en) Carboxylic acid derivatives, processes for their production and pharmaceutical preparations containing them
EP0064286A3 (en) New derivatives of alkanediols having hypolipidaemic activity, methods for their preparation and pharmaceutical compositions containing them
ES8307252A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido clavulanico.
ES8403123A1 (es) "procedimiento para la preparacion de esteres del acido alcoxivincaminico".
ES8307246A1 (es) "procedimiento de preparacion de nuevos compuestos de lactama".
ES8703484A1 (es) Procedimiento para preparar esteres de acidos 6-bromopiridin-2-il-fosforicos
GB1308875A (en) Thiono phosphoric phosphonic acid esters and ester amides a process for their preparation and their use as insecticides and acaricides
IL62324A (en) Preparation of 1,1-dihalogeno-alkenes
HUT34678A (en) Insecticid,miticide and nematocide compositions containing new esters of phosphoric acid as active ingredients and process for producing the active ingredients
GB1513070A (en) 1-alkoxycarbonylvinyl(thiono)(thiol)phosphoric(phosphonic)acid esters and ester-amides process for their preparation and their use as insecticides and acaricides
GB1380946A (en) Pesticidal esteramides of phosphoric and thionophosphoric acids

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001