ES8307095A1 - Un procedimiento para la estabilizacion de una composicion farmaceutica de trihidrato de amoxicilina y de clavulanato depotasio. - Google Patents
Un procedimiento para la estabilizacion de una composicion farmaceutica de trihidrato de amoxicilina y de clavulanato depotasio.Info
- Publication number
- ES8307095A1 ES8307095A1 ES505803A ES505803A ES8307095A1 ES 8307095 A1 ES8307095 A1 ES 8307095A1 ES 505803 A ES505803 A ES 505803A ES 505803 A ES505803 A ES 505803A ES 8307095 A1 ES8307095 A1 ES 8307095A1
- Authority
- ES
- Spain
- Prior art keywords
- amoxycillin
- desiccant
- clavulanic acid
- pharmaceutical formulation
- equivalent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA ESTABILIZACION DE COMPOSICIONES FARMACEUTICAS DE TRIHIDRATO DE AMOXICILINA Y CLAVULANO DE POTASIO. CONSISTE EN MEZCLAR UN DESECANTE COMESTIBLE, TAL COMO GEL DE SILICE O ALUMINIO-SILICATO CRISTALINO DE SODIO, POTASIO O CALCIO, CON TRIHIDRATO DE AMOXICILINA EQUIVALENTE A 20-1500 MG. DE AMOXICILINA Y CLAVULANATO DE POTASIO EQUIVALENTE A 20-500 MG. DE ACIDO CLAVULANICO, PULVERIZADOS AMBOS A PARTICULAS DE TAMAÑO ENTRE 400 Y 700 MICRAS; Y COMPRIMIR LOS COMPONENTES MEZCLADOS EN FORMA DE TABLETA; TODO ELLO EN AMBIENTE CON HUMEDAD RELATIVA INFERIOR AL 30% Y TEMPERATURAS ENTRE 10 C Y 30 C. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INFECCIONES ANTIBACTERIANAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8031298 | 1980-09-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES505803A0 ES505803A0 (es) | 1983-06-16 |
ES8307095A1 true ES8307095A1 (es) | 1983-06-16 |
Family
ID=10516342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505803A Expired ES8307095A1 (es) | 1980-09-27 | 1981-09-25 | Un procedimiento para la estabilizacion de una composicion farmaceutica de trihidrato de amoxicilina y de clavulanato depotasio. |
Country Status (15)
Country | Link |
---|---|
US (1) | US4537887A (es) |
EP (1) | EP0049061B1 (es) |
JP (1) | JPS5791921A (es) |
AU (1) | AU549321B2 (es) |
CA (1) | CA1187796A (es) |
DE (1) | DE3172028D1 (es) |
ES (1) | ES8307095A1 (es) |
GB (1) | GB2084016B (es) |
GR (1) | GR75049B (es) |
HK (1) | HK17386A (es) |
IE (1) | IE51597B1 (es) |
MY (1) | MY8600353A (es) |
NZ (1) | NZ198241A (es) |
PT (1) | PT73686A (es) |
ZA (1) | ZA816272B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0080862B1 (en) * | 1981-12-02 | 1985-09-25 | Beecham Group Plc | Pharmaceutical formulation comprising beta-lactam antibiotics |
JPS59104319A (ja) * | 1982-12-06 | 1984-06-16 | Chugai Pharmaceut Co Ltd | 抗菌剤およびそのキツト |
ES2061623T3 (es) * | 1987-03-02 | 1994-12-16 | Brocades Pharma Bv | Procedimiento para la obtencion de una composicion farmaceutica y un granulado farmaceutico. |
US5211958A (en) * | 1987-11-30 | 1993-05-18 | Gist-Brocades, N.V. | Pharmaceutical composition and process for its preparation |
ES2060737T3 (es) * | 1988-02-25 | 1994-12-01 | Yamanouchi Europ Bv | Procedimiento de preparacion de un granulado farmaceutico. |
US5643902A (en) * | 1990-04-26 | 1997-07-01 | Pfizer Inc. | Veterinary treatment |
GB9408117D0 (en) * | 1994-04-23 | 1994-06-15 | Smithkline Beecham Corp | Pharmaceutical formulations |
GB9413542D0 (en) * | 1994-07-05 | 1994-08-24 | Smithkline Beecham Plc | Pharmaceutical formulations |
ES2171192T3 (es) * | 1994-08-05 | 2002-09-01 | Smithkline Beecham Plc | Recipiente para material sensible a la humedad y metodos correspondientes de desecacion y de reduccion de la descomposicion de productos farmaceuticos. |
GB9416600D0 (en) * | 1994-08-17 | 1994-10-12 | Smithkline Beecham Plc | Pharmaceutical formulation |
DZ1926A1 (fr) * | 1994-09-03 | 2002-02-17 | Smithkline Beckman P L C | Formulations pharmaceutiques. |
ES2079327B1 (es) * | 1994-12-13 | 1996-08-01 | Lilly Sa | Formulaciones farmaceuticas de cefaclor. |
DZ2028A1 (fr) * | 1995-05-03 | 2002-10-23 | Smithkline Beecham Plc | Médicaments destinés au traitement d'infections bactériennes en pédiatrie. |
US20030109503A1 (en) * | 1995-06-06 | 2003-06-12 | Smithkline Beecham P.L.C. | Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics |
CZ299595B6 (cs) * | 1995-09-07 | 2008-09-17 | Smithkline Beecham Plc | Farmaceutický prípravek a lécivo pro empirickou lécbu infekcí |
ITMI952354A1 (it) * | 1995-11-16 | 1997-05-16 | Smithkline Beecham Spa | Composizione farmaceutica |
US5801796A (en) * | 1996-05-10 | 1998-09-01 | International Business Machines Corporation | Stacked parallax-free liquid crystal display cell |
GB9617780D0 (en) * | 1996-08-24 | 1996-10-02 | Smithkline Beecham Plc | Method of treatment |
US20030124187A1 (en) * | 1997-02-14 | 2003-07-03 | Smithkline Beecham Laboratoires Pharmaceutiques, | Pharmaceutical formulations comprising amoxycillin and clavulanate |
CN1194687C (zh) * | 1997-02-14 | 2005-03-30 | 史密斯克莱恩比彻姆药物实验室 | 含有阿莫西林和克拉维酸盐的药物制剂 |
US6296871B1 (en) * | 1998-04-12 | 2001-10-02 | Ranbaxy Laboratories Limited | Stable solid pharmaceutical compositions containing enalapril maleate |
US6177421B1 (en) | 1999-05-04 | 2001-01-23 | Fuisz International Ltd. | Amoxicillin and clavulanate composition |
IE990159A1 (en) * | 1999-02-26 | 2000-09-20 | Fuisz Internat Ltd | Storage Stable Amoxycillin and Clavulanate Suspension Composition. |
US6878386B1 (en) | 1999-04-13 | 2005-04-12 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate |
US6294199B1 (en) * | 1999-04-13 | 2001-09-25 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection comprising administering amoxycillin |
US7250176B1 (en) * | 1999-04-13 | 2007-07-31 | Beecham Pharmaceuticals (Pte) Limited | Method of treating a bacterial infection |
US6426342B2 (en) * | 1999-08-16 | 2002-07-30 | Revaax Pharmaceuticals, Llc | Use of β-lactamase inhibitors as neuroprotectants |
EP2305251A3 (en) * | 1999-08-16 | 2011-05-18 | Revaax Pharmaceuticals LLC | Pharmaceutical compositions comprising clavulanic acid or derivative thereof for the treatment of sexual disorder |
WO2002030392A2 (en) | 2000-10-12 | 2002-04-18 | Beecham Pharmaceuticals (Pte) Limited | Formulation containing amoxicillin |
US6756057B2 (en) | 2000-10-12 | 2004-06-29 | Beecham Pharmaceuticals (Pte) Limited | Amoxicillin and potassium clavulanate dosage form |
CA2359812C (en) * | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
KR100456833B1 (ko) * | 2002-08-01 | 2004-11-10 | 주식회사 대웅 | 아목시실린 및 클라불라네이트를 함유하는 유핵정 |
EP1902708A1 (de) | 2006-09-25 | 2008-03-26 | Losan Pharma GmbH | Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung |
US20100255099A1 (en) * | 2007-10-26 | 2010-10-07 | Rexahn Pharmaceuticals, Inc. | Clavulanate formulation for neuroprotection and treatment of neurodegenerative disorders |
JP2011500811A (ja) * | 2007-10-26 | 2011-01-06 | レクサン ファーマシューティカルズ インコーポレイテッド | クラブラン酸の医薬品製剤 |
US9919007B2 (en) | 2013-03-15 | 2018-03-20 | Braintree Laboratories, Inc. | Dual use oral pharmaceutical composition tablets of sulfate salts and methods of use thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE888444C (de) * | 1951-11-10 | 1953-08-31 | Benckiser Gmbh Joh A | Verfahren zum Tablettieren von hygroskopischen Praeparaten |
US3432593A (en) * | 1963-09-18 | 1969-03-11 | Key Pharm Inc | Delayed and sustained release type pharmaceutical preparation |
GB1209634A (en) * | 1967-06-29 | 1970-10-21 | Rit Rech Ind Therapeut | Stabilized antibiotic compositions for animal feeding and process for preparing them |
DE2512247A1 (de) * | 1975-03-20 | 1976-10-14 | Thomae Gmbh Dr K | Gegen feuchtigkeit stabilisierte presslinge mit feuchtigkeitsempfindlichen inhaltsstoffen |
US4140755A (en) * | 1976-02-13 | 1979-02-20 | Hoffmann-La Roche Inc. | Sustained release tablet formulations |
JO984B1 (en) * | 1977-10-11 | 1979-12-01 | بيتشام غروب ليمتد | A dry pharmaceutical compound with a suitable dosage unit for oral administration |
IL58461A0 (en) * | 1978-10-27 | 1980-01-31 | Beecham Group Ltd | Intramammary compositions comprising a clavulanic acid salt |
US4226849A (en) * | 1979-06-14 | 1980-10-07 | Forest Laboratories Inc. | Sustained release therapeutic compositions |
-
1981
- 1981-09-02 NZ NZ198241A patent/NZ198241A/xx unknown
- 1981-09-08 EP EP81304086A patent/EP0049061B1/en not_active Expired
- 1981-09-08 DE DE8181304086T patent/DE3172028D1/de not_active Expired
- 1981-09-10 ZA ZA816272A patent/ZA816272B/xx unknown
- 1981-09-14 GB GB8127649A patent/GB2084016B/en not_active Expired
- 1981-09-16 PT PT73686A patent/PT73686A/pt unknown
- 1981-09-23 GR GR66117A patent/GR75049B/el unknown
- 1981-09-25 IE IE2232/81A patent/IE51597B1/en not_active IP Right Cessation
- 1981-09-25 AU AU75684/81A patent/AU549321B2/en not_active Expired
- 1981-09-25 CA CA000386670A patent/CA1187796A/en not_active Expired
- 1981-09-25 ES ES505803A patent/ES8307095A1/es not_active Expired
- 1981-09-28 JP JP56153513A patent/JPS5791921A/ja active Granted
-
1983
- 1983-10-05 US US06/539,099 patent/US4537887A/en not_active Expired - Lifetime
-
1986
- 1986-03-13 HK HK173/86A patent/HK17386A/xx not_active IP Right Cessation
- 1986-12-30 MY MY353/86A patent/MY8600353A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
MY8600353A (en) | 1986-12-31 |
JPH0155244B2 (es) | 1989-11-22 |
EP0049061A1 (en) | 1982-04-07 |
AU7568481A (en) | 1982-04-08 |
AU549321B2 (en) | 1986-01-23 |
ES505803A0 (es) | 1983-06-16 |
JPS5791921A (en) | 1982-06-08 |
US4537887A (en) | 1985-08-27 |
IE812232L (en) | 1982-03-27 |
HK17386A (en) | 1986-03-21 |
GB2084016A (en) | 1982-04-07 |
GB2084016B (en) | 1985-04-17 |
ZA816272B (en) | 1982-09-29 |
DE3172028D1 (en) | 1985-10-03 |
EP0049061B1 (en) | 1985-08-28 |
IE51597B1 (en) | 1987-01-21 |
PT73686A (pt) | 1981-10-01 |
CA1187796A (en) | 1985-05-28 |
NZ198241A (en) | 1983-12-16 |
GR75049B (es) | 1984-07-12 |
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