ES3014615T3 - Method of reducing pulmonary exacerbations in respiratory disease patients - Google Patents
Method of reducing pulmonary exacerbations in respiratory disease patients Download PDFInfo
- Publication number
- ES3014615T3 ES3014615T3 ES19811606T ES19811606T ES3014615T3 ES 3014615 T3 ES3014615 T3 ES 3014615T3 ES 19811606 T ES19811606 T ES 19811606T ES 19811606 T ES19811606 T ES 19811606T ES 3014615 T3 ES3014615 T3 ES 3014615T3
- Authority
- ES
- Spain
- Prior art keywords
- acebilustat
- patient
- cftr
- patients
- pulmonary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862678964P | 2018-05-31 | 2018-05-31 | |
| US201862702038P | 2018-07-23 | 2018-07-23 | |
| PCT/US2019/034810 WO2019232306A1 (en) | 2018-05-31 | 2019-05-31 | Method of reducing pulmonary exacerbations in respiratory disease patients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES3014615T3 true ES3014615T3 (en) | 2025-04-23 |
Family
ID=68694908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19811606T Active ES3014615T3 (en) | 2018-05-31 | 2019-05-31 | Method of reducing pulmonary exacerbations in respiratory disease patients |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10898484B2 (https=) |
| EP (1) | EP3801559B1 (https=) |
| JP (2) | JP7386815B2 (https=) |
| AU (1) | AU2019278935B2 (https=) |
| ES (1) | ES3014615T3 (https=) |
| WO (1) | WO2019232306A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3801559B1 (en) * | 2018-05-31 | 2025-01-01 | Celltaxis, LLC | Method of reducing pulmonary exacerbations in respiratory disease patients |
| US20240016941A1 (en) * | 2020-03-24 | 2024-01-18 | Antabio Sas | Combination therapy |
| CA3207882A1 (en) * | 2021-01-15 | 2022-07-21 | Children's Hospital Medical Center | Methods for optimizing cftr-modulator therapy |
| WO2024254377A2 (en) * | 2023-06-09 | 2024-12-12 | Celltaxis, Llc | Methods of treating lipedema and lymphatic disease of the subcutaneous tissue |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6815872A (https=) | 1967-11-22 | 1969-05-27 | ||
| JPS5614663B2 (https=) | 1971-08-21 | 1981-04-06 | ||
| US4582833A (en) | 1984-04-16 | 1986-04-15 | American Cyanamid Company | 2-(substituted-1-piperazinyl)[1,2,4]triazolo[1,5-a]pyrimidines |
| US4576943A (en) | 1984-10-09 | 1986-03-18 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines |
| US5308852A (en) | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
| US6506876B1 (en) | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| AU1952597A (en) | 1996-02-13 | 1997-09-02 | G.D. Searle & Co. | Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor |
| US5952349A (en) | 1996-07-10 | 1999-09-14 | Schering Corporation | Muscarinic antagonists for treating memory loss |
| JP2000516611A (ja) | 1996-08-14 | 2000-12-12 | ワーナー―ランバート・コンパニー | Ｍｃｐ―１アンタゴニストとしての２―フェニルベンズイミダゾール誘導体 |
| US6309561B1 (en) | 1997-12-24 | 2001-10-30 | 3M Innovative Properties Company | Liquid crystal compounds having a chiral fluorinated terminal portion |
| US6380203B1 (en) | 1998-01-14 | 2002-04-30 | Merck & Co., Inc. | Angiogenesis inhibitors |
| GB9815880D0 (en) | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
| GB9919776D0 (en) | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
| AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| US6699873B1 (en) | 1999-08-04 | 2004-03-02 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| WO2001056990A2 (en) | 2000-02-03 | 2001-08-09 | Eli Lilly And Company | Pyridine derivates as potentiators of glutamate receptors |
| US6552023B2 (en) | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
| US6451798B2 (en) | 2000-02-22 | 2002-09-17 | Cv Therapeutics, Inc. | Substituted alkyl piperazine derivatives |
| JP2001354657A (ja) | 2000-06-09 | 2001-12-25 | Sds Biotech:Kk | 置換ピペラジン誘導体及び農園芸用殺菌剤 |
| EP1170353B1 (en) | 2000-07-06 | 2005-11-02 | Fuji Photo Film Co., Ltd. | Liquid crystal composition comprising liquid crystal molecules and aligment promoter |
| WO2002064211A1 (en) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
| EP1372655B1 (en) | 2001-03-02 | 2008-10-01 | Merck Frosst Canada Ltd. | Cathepsin cysteine protease inhibitors |
| AUPR362001A0 (en) | 2001-03-08 | 2001-04-05 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| FR2826011B1 (fr) | 2001-06-14 | 2004-12-10 | Oreal | Nouveaux derives de la 7-oxo-dhea et utilisation cosmetique |
| SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| EP1435946B8 (en) | 2001-09-14 | 2013-12-18 | Amgen Inc. | Linked biaryl compounds |
| AU2002363236A1 (en) | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
| EP1693061A1 (en) | 2002-10-04 | 2006-08-23 | Ucb, S.A. | Use of 4-aminoderivatives for the preparation of a medicament for treating neurological diseases |
| US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
| AU2003290527A1 (en) | 2002-10-17 | 2004-05-04 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction |
| WO2004058683A2 (en) | 2002-12-20 | 2004-07-15 | Migenix Corp. | Ligands of adenine nucleotide translocase (ant) and compositions and methods related thereto |
| WO2004089410A1 (ja) | 2003-04-03 | 2004-10-21 | Kyowa Hakko Kogyo Co., Ltd. | 神経因性疼痛の予防及び／または治療剤 |
| WO2004099164A1 (en) | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection |
| JP2005008581A (ja) | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| CN1856490A (zh) | 2003-07-28 | 2006-11-01 | 詹森药业有限公司 | 苯并咪唑、苯并噻唑和苯并噁唑衍生物及其作为lta4h调节剂的应用 |
| US20050272051A1 (en) | 2003-09-17 | 2005-12-08 | Decode Genetics Ehf. | Methods of preventing or treating recurrence of myocardial infarction |
| WO2005033079A1 (ja) | 2003-09-30 | 2005-04-14 | Eisai Co., Ltd. | ヘテロ環化合物を含有する新規な抗真菌剤 |
| GB0326632D0 (en) | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
| DE10356579A1 (de) | 2003-12-04 | 2005-07-07 | Merck Patent Gmbh | Aminderivate |
| SE0303480D0 (sv) | 2003-12-19 | 2003-12-19 | Biovitrum Ab | Benzofuranes |
| WO2005066238A1 (en) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Medicinal compositions and method for the preparation thereof |
| DE602005015682D1 (de) | 2004-02-04 | 2009-09-10 | Neurosearch As | Dimere azacyclische verbindungen und deren verwendung |
| WO2006033795A2 (en) | 2004-09-17 | 2006-03-30 | Wyeth | Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth |
| ES2570332T3 (es) | 2005-03-16 | 2016-05-17 | Meda Pharma Gmbh & Co Kg | La combinación de anticolinérgicos y antagonistas del receptor de leucotrieno para el tratamiento de enfermedades respiratorias |
| US20060223792A1 (en) | 2005-03-31 | 2006-10-05 | Butler Christopher R | Phenyl and pyridyl LTA4H modulators |
| GB0514018D0 (en) | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| US20070078263A1 (en) | 2005-09-21 | 2007-04-05 | Decode Chemistry, Inc. | Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation |
| CN1947717B (zh) | 2005-10-14 | 2012-09-26 | 卓敏 | 选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用 |
| DE102005049954A1 (de) | 2005-10-19 | 2007-05-31 | Sanofi-Aventis Deutschland Gmbh | Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen |
| WO2007079078A1 (en) | 2005-12-29 | 2007-07-12 | Bayer Schering Pharma Aktiengesellschaft | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| WO2007079003A2 (en) | 2005-12-29 | 2007-07-12 | Bayer Schering Pharma Aktiengesellschaft | Amide inhibitors of leukotriene a4 hydrolase |
| CN102633783A (zh) | 2006-02-10 | 2012-08-15 | 转化技术制药公司 | 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法 |
| US20100029619A1 (en) | 2006-08-04 | 2010-02-04 | Takeda Pharmaceutical Company Limted | Fused heterocyclic compound |
| JP5167265B2 (ja) | 2006-10-19 | 2013-03-21 | エフ．ホフマン−ラ ロシュ アーゲー | 微量アミン関連受容体に親和性を有するアミノメチル−２−イミダゾール |
| HRP20170621T1 (hr) | 2006-12-14 | 2017-07-28 | Janssen Pharmaceutica N.V. | Postupak za pripremanje derivata piperazinil i diazepanil benzamida |
| FR2911140B1 (fr) | 2007-01-05 | 2009-02-20 | Sanofi Aventis Sa | Nouveaux derives de 2-anilino 4-heteroaryle pyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| FR2911138B1 (fr) | 2007-01-05 | 2009-02-20 | Sanofi Aventis Sa | Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| FR2911139A1 (fr) | 2007-01-05 | 2008-07-11 | Sanofi Aventis Sa | Nouveaux derives de phenyl-(4-phenyl-pyrimidin-2-yl)amines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
| CN101687844B (zh) | 2007-07-02 | 2013-11-13 | 弗·哈夫曼-拉罗切有限公司 | 用作ccr2受体拮抗剂的咪唑衍生物 |
| AR068498A1 (es) | 2007-09-27 | 2009-11-18 | Merck & Co Inc | Compuestos de oxadiazol para inhibicion de biosintesis de leucotrienos |
| WO2009074829A1 (en) | 2007-12-12 | 2009-06-18 | Astrazeneca Ab | Peptidyl nitriles and use thereof as dipeptidyl peptidase i inhibitors |
| US20110009429A1 (en) | 2008-02-26 | 2011-01-13 | Paul Oakley | Heterocyclic compounds as inhibitors of cxcr2 |
| FR2928070A1 (fr) | 2008-02-27 | 2009-09-04 | Sumitomo Chemical Co | Composition agricole, utilisation d'un compose pour sa production et procede pour matriser ou prevenir les maladies des plantes. |
| US20100029657A1 (en) | 2008-02-29 | 2010-02-04 | Wyeth | Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof |
| SI2336125T1 (sl) | 2008-04-11 | 2013-04-30 | Janssen Pharmaceutica N.V. | Tiazolopiridin-2-iloksi-fenil in tiazolopirazin-2-iloksi-fenil amini kot modulatorji levkotrien a4 hidrolaze |
| EP2110374A1 (en) | 2008-04-18 | 2009-10-21 | Merck Sante | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators |
| WO2010011912A1 (en) | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Trpv4 antagonists |
| ES2399179T3 (es) | 2008-08-07 | 2013-03-26 | Pulmagen Therapeutics (Inflammation) Limited | Tratamiento de enfermedad respiratoria |
| RU2589823C2 (ru) | 2009-04-09 | 2016-07-10 | Алкермес Фарма Айэленд Лимитед | Композиция для доставки лекарственных средств |
| CN102030700B (zh) | 2009-09-30 | 2016-06-01 | 中国医学科学院药物研究所 | 苯甲酰胺基羧酸类化合物及其制法和药物用途 |
| JP5781527B2 (ja) | 2009-10-30 | 2015-09-24 | ヤンセン ファーマシューティカ エヌ．ベー． | ４−置換−２−フェノキシ−フェニルアミンデルオピオイド受容体調節因子 |
| PH12012501068A1 (en) | 2009-12-07 | 2013-02-04 | Targacept Inc | 3,6-diazabicyclo [3.1.1] heptanes as neuronal nicotinic acetylcholine receptor ligands |
| BR112013002112B1 (pt) | 2010-07-29 | 2021-04-06 | Rigel Pharmaceuticals, Inc. | Composto, composição farmacêutica, e, uso de um composto, ou de um respectivo sal farmaceuticamente aceitável, ou de uma composição |
| WO2012067822A1 (en) | 2010-11-16 | 2012-05-24 | Abbott Laboratories | Pyrazolo [1, 5 -a] pyrimidin potassium channel modulators |
| CA2835617C (en) | 2011-03-14 | 2020-07-21 | Boehringer Ingelheim International Gmbh | Benzodioxane inhibitors of leukotriene production |
| PH12013501882A1 (en) | 2011-03-15 | 2013-10-14 | Rib X Pharmaceuticals Inc | Antimicrobial agents |
| KR101862291B1 (ko) | 2011-04-12 | 2018-05-29 | 모레 매트릭스 인코포레이티드 | 이상 섬유모세포 증식 및 세포외 기질 침착을 특징으로 하는 질병, 질환, 또는 과정을 예방하거나 치료하기 위한 조성물 및 방법 |
| WO2012162407A1 (en) | 2011-05-23 | 2012-11-29 | Janssen Pharmaceutica Nv | Picolinamido - propanoic acid derivatives useful as glucagon receptor antagonists |
| EP2589381B1 (en) | 2011-11-04 | 2016-08-31 | Rabindra Tirouvanziam | Compositions for improving or preserving lung function in a patient with a pulmonary disorder |
| CN103159742B (zh) | 2011-12-16 | 2015-08-12 | 北京韩美药品有限公司 | 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用 |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9233089B2 (en) | 2012-03-23 | 2016-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of pulmonary hypertension with leukotriene inhibitors |
| ES2864862T3 (es) * | 2013-03-12 | 2021-10-14 | Celltaxis Llc | Métodos de inhibición de la leucotrieno A4 hidrolasa |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| RU2678196C2 (ru) | 2013-03-14 | 2019-01-24 | Селтакссис, Инк. | Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы |
| WO2014152536A2 (en) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| US9480676B2 (en) * | 2014-05-15 | 2016-11-01 | Celgene Corporation | Use of PDE4 inhibitors and combinations thereof for the treatment of cystic fibrosis |
| MA41253A (fr) * | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| HUP1600271A2 (hu) * | 2016-04-25 | 2017-10-30 | Druggability Tech Ip Holdco Ltd | Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei |
| EP3801559B1 (en) * | 2018-05-31 | 2025-01-01 | Celltaxis, LLC | Method of reducing pulmonary exacerbations in respiratory disease patients |
-
2019
- 2019-05-31 EP EP19811606.3A patent/EP3801559B1/en active Active
- 2019-05-31 JP JP2020566936A patent/JP7386815B2/ja active Active
- 2019-05-31 US US16/427,571 patent/US10898484B2/en active Active
- 2019-05-31 WO PCT/US2019/034810 patent/WO2019232306A1/en not_active Ceased
- 2019-05-31 ES ES19811606T patent/ES3014615T3/es active Active
- 2019-05-31 AU AU2019278935A patent/AU2019278935B2/en active Active
-
2021
- 2021-01-11 US US17/145,586 patent/US11890282B2/en active Active
-
2023
- 2023-11-14 JP JP2023193448A patent/JP7603775B2/ja active Active
- 2023-12-20 US US18/390,000 patent/US12558353B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20210236484A1 (en) | 2021-08-05 |
| AU2019278935B2 (en) | 2025-02-13 |
| US20240358699A1 (en) | 2024-10-31 |
| JP2024014938A (ja) | 2024-02-01 |
| US20190365750A1 (en) | 2019-12-05 |
| AU2019278935A1 (en) | 2020-12-10 |
| CA3102077A1 (en) | 2019-12-05 |
| EP3801559A1 (en) | 2021-04-14 |
| US10898484B2 (en) | 2021-01-26 |
| JP7603775B2 (ja) | 2024-12-20 |
| JP2021525763A (ja) | 2021-09-27 |
| JP7386815B2 (ja) | 2023-11-27 |
| EP3801559A4 (en) | 2022-03-02 |
| US12558353B2 (en) | 2026-02-24 |
| EP3801559C0 (en) | 2025-01-01 |
| EP3801559B1 (en) | 2025-01-01 |
| US11890282B2 (en) | 2024-02-06 |
| WO2019232306A1 (en) | 2019-12-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES3014615T3 (en) | Method of reducing pulmonary exacerbations in respiratory disease patients | |
| Glassberg | Overview of idiopathic pulmonary fibrosis, evidence-based guidelines, and recent developments in the treatment landscape | |
| Borghardt et al. | Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes | |
| US11975005B2 (en) | Treatment of respiratory diseases | |
| Rybak et al. | Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists | |
| Konstan et al. | Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: the EAGER trial | |
| Flume et al. | State of progress in treating cystic fibrosis respiratory disease | |
| Chalmers et al. | Management of bronchiectasis in adults | |
| Brodlie et al. | Targeted therapies to improve CFTR function in cystic fibrosis | |
| Proesmans et al. | Comparison of two treatment regimens for eradication of Pseudomonas aeruginosa infection in children with cystic fibrosis | |
| Faniyi et al. | Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways | |
| Dhand | The rationale and evidence for use of inhaled antibiotics to control Pseudomonas aeruginosa infection in non-cystic fibrosis bronchiectasis | |
| Jóźwiak et al. | Safety of everolimus in patients younger than 3 years of age: results from EXIST-1, a randomized, controlled clinical trial | |
| Smith et al. | STOP 301: A Phase 3, open‐label study of safety, tolerability, and exploratory efficacy of INP104, Precision Olfactory Delivery (POD®) of dihydroergotamine mesylate, over 24/52 weeks in acute treatment of migraine attacks in adult patients | |
| Elborn et al. | Empire-CF study: A phase 2 clinical trial of leukotriene A4 hydrolase inhibitor acebilustat in adult subjects with cystic fibrosis | |
| Karimzadeh et al. | Aminoglycosides: single-or multiple-daily dosing? An updated qualitative systematic review of randomized trials on toxicity and efficacy | |
| Özkarakaş et al. | Risks of polymyxin B nephrotoxicity and its precursors in the intensive care unit: a retrospective cohort study | |
| Gilchrist et al. | ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis | |
| Ratjen | Update in cystic fibrosis 2008 | |
| CA3102077C (en) | Method of reducing pulmonary exacerbations in respiratory disease patients | |
| Goralski et al. | Improving complex medical care while awaiting next‐generation CFTR potentiators and correctors: the current pipeline of therapeutics | |
| Higgins et al. | Extended interval tobramycin pharmacokinetics in a pediatric patient with primary ciliary dyskinesia presenting with an acute respiratory exacerbation | |
| US20250002488A1 (en) | Glioblastoma Multiforme Treatments | |
| Rodriguez Colomo et al. | Impact of administration of vancomycin or linezolid to critically ill patients with impaired renal function | |
| Biswas et al. | Impact of Appropriate Antibiotics within 1hr of Patients Admission |