ES2650806T3 - Procedimiento para la preparación de bencilaminas disustituidas halogenadas, particularmente dialquilbencilaminas halogenadas - Google Patents
Procedimiento para la preparación de bencilaminas disustituidas halogenadas, particularmente dialquilbencilaminas halogenadas Download PDFInfo
- Publication number
- ES2650806T3 ES2650806T3 ES14808633.3T ES14808633T ES2650806T3 ES 2650806 T3 ES2650806 T3 ES 2650806T3 ES 14808633 T ES14808633 T ES 14808633T ES 2650806 T3 ES2650806 T3 ES 2650806T3
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- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- halogenated
- alkenyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/84—Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento para la preparación de compuestos de Fórmula (I)**Fórmula** donde R1 representa hidrógeno, alquilo de 1 a 8 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, cicloalquilo de 3 a 6 átomos de carbono, alcoxi de 1 a 8 átomos de carbono, alcoxi de 1 a 6 átomos de carbono-alquenilo de 2 a 6 átomos de carbono, fenilo, bencilo; R2, R3 representan cada uno independientemente alquilo de 1 a 8 átomos de carbono, arilo, heteroarilo, alquenilo de 2 a 6 átomos de carbono, cicloalquilo de 3 a 8 átomos de carbono, alcoxi de 1 a 6 átomos de carbono, haloalquilo de 1 a 6 átomos de carbono, haloalcoxi de 1 a 6 átomos de carbono; X representa cloro o bromo, y N es 0, 1, 2, 3 o 4; caracterizado porque comprende inicialmente cargar como medio de reacción un hidróxido de metal alcalino en una concentración del 20 % a 50 %, haciendo reaccionar posteriormente en una primera etapa A) los compuestos (II) y (III)**Fórmula** donde R1, R2, R3 y X son como se definió anteriormente y Y representa cloro, bromo, yodo, un alquilsulfonato (-OSO2-alquilo, preferiblemente -OSO2CH3, -OSO2CF3) o un arilsulfonato (-OSO2-arilo); en una relación molar de 0,9 a 2,5, y añadir a la mezcla de reacción en una segunda etapa B) de 0 a 9 moles de agua, con respecto a 1 mol del compuesto de Fórmula (III), y posteriormente separar la fase acuosa del producto.
Description
Claims (1)
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imagen1 imagen2
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13196718 | 2013-12-11 | ||
EP13196718 | 2013-12-11 | ||
PCT/EP2014/076822 WO2015086490A1 (de) | 2013-12-11 | 2014-12-08 | Verfahren zur herstellung von halogenierten di-substituierten benzylaminen, insbesondere halogenierten dialkylbenzylaminen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2650806T3 true ES2650806T3 (es) | 2018-01-22 |
Family
ID=49753069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14808633.3T Active ES2650806T3 (es) | 2013-12-11 | 2014-12-08 | Procedimiento para la preparación de bencilaminas disustituidas halogenadas, particularmente dialquilbencilaminas halogenadas |
Country Status (11)
Country | Link |
---|---|
US (1) | US9670135B2 (es) |
EP (1) | EP3080070B1 (es) |
JP (1) | JP6457527B2 (es) |
KR (1) | KR20160097235A (es) |
CN (1) | CN105814012B (es) |
DK (1) | DK3080070T3 (es) |
ES (1) | ES2650806T3 (es) |
IL (1) | IL246030B (es) |
MX (1) | MX361614B (es) |
TW (1) | TWI648247B (es) |
WO (1) | WO2015086490A1 (es) |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3646147A (en) | 1970-03-18 | 1972-02-29 | Baird Chemical Ind Inc | Two-phase iodide-catalysed system for preparing tertiary amines |
JPS5932457B2 (ja) * | 1978-11-29 | 1984-08-09 | エフ・ホフマン−ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト | 放射性ヨウ素化アミン |
CA1171431A (en) | 1980-02-04 | 1984-07-24 | S. Richard Turner | Process for preparing arylamines |
JP3824735B2 (ja) * | 1997-05-13 | 2006-09-20 | ポーラ化成工業株式会社 | アミン誘導体 |
US7101910B2 (en) * | 2001-06-12 | 2006-09-05 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
JP2003026640A (ja) * | 2001-07-13 | 2003-01-29 | Shionogi & Co Ltd | 芳香族ケトンの製造方法 |
ITRM20040178A1 (it) * | 2004-04-07 | 2004-07-07 | Sigma Tau Ind Farmaceuti | Composti ad attivita' antipsicotica atipica. |
US20070073086A1 (en) | 2005-09-28 | 2007-03-29 | Appleton Papers Inc. | Process for manufacturing diphenylamines |
WO2008125592A1 (en) | 2007-04-12 | 2008-10-23 | Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg | Improved process for preparing o-chloromethylphenylglyoxylic esters, improved process for preparing (e)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters, and novel intermediates for their preparation |
CN102548975A (zh) * | 2009-07-07 | 2012-07-04 | 安瑟生物科技私人有限公司 | 组蛋白去乙酰化酶抑制剂 |
DE102011017027A1 (de) | 2011-04-14 | 2012-10-18 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von aromatischen und heteroaromatischen Aminen |
CN107011176B (zh) | 2011-08-04 | 2021-07-06 | 朗盛德国有限责任公司 | 用于制备环上卤代的n,n-二烷基苄胺的方法 |
CN102503837A (zh) * | 2011-10-17 | 2012-06-20 | 太原理工大学 | 一种含有双长链及苄基的叔胺和有机硅季铵盐及其制备方法 |
-
2014
- 2014-12-08 US US15/103,110 patent/US9670135B2/en not_active Expired - Fee Related
- 2014-12-08 EP EP14808633.3A patent/EP3080070B1/de not_active Not-in-force
- 2014-12-08 WO PCT/EP2014/076822 patent/WO2015086490A1/de active Application Filing
- 2014-12-08 DK DK14808633.3T patent/DK3080070T3/en active
- 2014-12-08 MX MX2016007260A patent/MX361614B/es active IP Right Grant
- 2014-12-08 ES ES14808633.3T patent/ES2650806T3/es active Active
- 2014-12-08 KR KR1020167017075A patent/KR20160097235A/ko not_active Application Discontinuation
- 2014-12-08 CN CN201480066925.4A patent/CN105814012B/zh not_active Expired - Fee Related
- 2014-12-08 JP JP2016538017A patent/JP6457527B2/ja not_active Expired - Fee Related
- 2014-12-09 TW TW103142732A patent/TWI648247B/zh not_active IP Right Cessation
-
2016
- 2016-06-05 IL IL246030A patent/IL246030B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP3080070A1 (de) | 2016-10-19 |
IL246030A0 (en) | 2016-08-02 |
JP2017504583A (ja) | 2017-02-09 |
KR20160097235A (ko) | 2016-08-17 |
CN105814012B (zh) | 2018-01-26 |
MX361614B (es) | 2018-11-07 |
JP6457527B2 (ja) | 2019-01-23 |
IL246030B (en) | 2018-12-31 |
WO2015086490A1 (de) | 2015-06-18 |
TW201538458A (zh) | 2015-10-16 |
MX2016007260A (es) | 2016-09-07 |
US20160304435A1 (en) | 2016-10-20 |
TWI648247B (zh) | 2019-01-21 |
CN105814012A (zh) | 2016-07-27 |
US9670135B2 (en) | 2017-06-06 |
EP3080070B1 (de) | 2017-11-01 |
DK3080070T3 (en) | 2017-12-04 |
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