ES2595079T3 - Ácido ribonucleico de interferencia corto (ARNip) - Google Patents
Ácido ribonucleico de interferencia corto (ARNip) Download PDFInfo
- Publication number
- ES2595079T3 ES2595079T3 ES14163854.4T ES14163854T ES2595079T3 ES 2595079 T3 ES2595079 T3 ES 2595079T3 ES 14163854 T ES14163854 T ES 14163854T ES 2595079 T3 ES2595079 T3 ES 2595079T3
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- vegfr
- bfgfr
- il8rb
- il8ra
- fas
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- 229920002477 rna polymer Polymers 0.000 title abstract 2
- 230000000295 complement effect Effects 0.000 abstract description 33
- 230000004048 modification Effects 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 description 52
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 description 52
- 101100481408 Danio rerio tie2 gene Proteins 0.000 description 52
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 description 52
- 101000916059 Homo sapiens C-X-C chemokine receptor type 2 Proteins 0.000 description 52
- 101100481410 Mus musculus Tek gene Proteins 0.000 description 52
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 description 52
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 52
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 description 52
- 102000016548 Vascular Endothelial Growth Factor Receptor-1 Human genes 0.000 description 50
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 description 50
- 102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 description 50
- 102100037182 Cation-independent mannose-6-phosphate receptor Human genes 0.000 description 45
- 101001028831 Homo sapiens Cation-independent mannose-6-phosphate receptor Proteins 0.000 description 45
- 108020004459 Small interfering RNA Proteins 0.000 description 44
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000002491 angiogenic effect Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 101100160997 Mus musculus Rchy1 gene Proteins 0.000 description 2
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 description 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 2
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
- 101100297347 Caenorhabditis elegans pgl-3 gene Proteins 0.000 description 1
- 101100044298 Drosophila melanogaster fand gene Proteins 0.000 description 1
- 101150064015 FAS gene Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- -1 bFGFR Proteins 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000004862 vasculogenesis Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
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- 2007-05-02 CN CN2007800161675A patent/CN101437944B/zh not_active Expired - Fee Related
- 2007-05-02 WO PCT/EP2007/003867 patent/WO2007128477A2/en not_active Ceased
- 2007-05-02 CA CA2846732A patent/CA2846732C/en active Active
- 2007-05-02 JP JP2009508205A patent/JP2009535045A/ja active Pending
- 2007-05-02 MX MX2008014007A patent/MX2008014007A/es active IP Right Grant
- 2007-05-02 CA CA2846817A patent/CA2846817A1/en not_active Abandoned
- 2007-05-02 EP EP09169772A patent/EP2135950B1/en not_active Not-in-force
- 2007-05-02 CN CN2013101469750A patent/CN103224934A/zh active Pending
- 2007-05-02 EP EP14163856.9A patent/EP2762568A1/en not_active Withdrawn
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- 2007-05-02 EP EP16174066.7A patent/EP3121278B1/en active Active
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2010
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2013
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2014
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