ES2529226T3 - Nuevos componentes que se unen a FXR (NR1H4) y modulan su actividad - Google Patents

Nuevos componentes que se unen a FXR (NR1H4) y modulan su actividad Download PDF

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ES2529226T3
ES2529226T3 ES10747171.6T ES10747171T ES2529226T3 ES 2529226 T3 ES2529226 T3 ES 2529226T3 ES 10747171 T ES10747171 T ES 10747171T ES 2529226 T3 ES2529226 T3 ES 2529226T3
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alkyl
independently selected
optionally substituted
thiazolyl
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Claus Kremoser
Ulrich Abel
Christoph Steeneck
Olaf Kinzel
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Phenex Pharmaceuticals AG
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Un compuesto de acuerdo coo la siguiente fórmula (1), un enantiómero. dlastereómero, tautómero. o sal fannacéuticamente aceptable del mismo**Fórmula** en donde R es seleccionado del grupo que consiste de COORe" CONR7Ra. tetrazolllo o H. con Re independientemente seleccionado del grupo que consiste de H, o alquilo C1-6, y R7 y R8 Independientemente uno del otro seleccionado del grupo que consiste de H. alquilo C1-6, haloalquilo C1-6, alqulleno C1-6-R9. SO2 alquilo-C1-6 , donde R9 es seleccionado del grupo que consiste de COOH. OH. o SO3,H; A es seleccionado del grupo que consiste de lenilo, plrldilo, pirazolilo. Indolilo, tienllo. benzotlenilo. indazolllo, benzisoxazolilo, benzofuranllo, benzotriazolilo, furanllo, benzotiazolllo. tiazolilo. cada uno opcionalmente sustituido con uno o dos grupos independientemente seleccionados del grupo que consiste de OH, alquilo C1-6, ciCloalquilo C3-6, o halógeno; A es seleccionado del grupo que consiste de tenllo, pirldilo. tiazolllo, tiofenilo. plrlmidilo cada uno opcionalmente sustituido con uno o dos gnJpos independientemente seleccionados del gnJpo que consiste de alquilo C1-6. halógeno o CF3; o en donde R es seleccionado del grupo que consiste de COOA6. CONR7R8, tetrazolllo o H, con R6. R7 Y R8 independientemente seleccionados del grupo que consiste de H Y alquilo C1-6 ; A es seleccionado del grupo que consiste de fenilo, piridilo, indolilo. tienilo, benzotienilo, Indazolilo. benzisoxazolilo, benzofuranilo. benzotrlazolilo, furanilo. benzotlazolilo, tiazolilo. cada uno opcionalmente sustituido con uno o dos grupos independientemente seleccionados del grupo que consiste de OH. alquilo C1-6. cicloalquilo C3-6. Q es seleccionado del grupo que consiste de lenilo, piridilo. tiazolilo, tiofenilo, pirimidilo. cada uno opcionalmente sustituido con uno o dos grupos independientemente seleccionados del grupo que consiste de alquilo C1-6. halógeno y CF3;**Fórmula**

Description

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Claims (1)

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ES10747171.6T 2009-08-19 2010-08-19 Nuevos componentes que se unen a FXR (NR1H4) y modulan su actividad Active ES2529226T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23511709P 2009-08-19 2009-08-19
EP09010676 2009-08-19
EP09010676A EP2289883A1 (en) 2009-08-19 2009-08-19 Novel FXR (NR1H4) binding and activity modulating compounds
US235117P 2009-08-19
PCT/EP2010/005093 WO2011020615A1 (en) 2009-08-19 2010-08-19 Novel fxr (nr1h4 ) binding and activity modulating compounds

Publications (1)

Publication Number Publication Date
ES2529226T3 true ES2529226T3 (es) 2015-02-18

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ES10747171.6T Active ES2529226T3 (es) 2009-08-19 2010-08-19 Nuevos componentes que se unen a FXR (NR1H4) y modulan su actividad

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US (1) US8952042B2 (es)
EP (2) EP2289883A1 (es)
JP (1) JP5692934B2 (es)
KR (1) KR101712466B1 (es)
CN (1) CN102548974B (es)
AU (1) AU2010285175B2 (es)
BR (1) BR112012003554A2 (es)
CA (1) CA2771445C (es)
CL (1) CL2012000369A1 (es)
DK (1) DK2467366T3 (es)
EA (1) EA024083B1 (es)
ES (1) ES2529226T3 (es)
GE (1) GEP20146109B (es)
HK (1) HK1172325A1 (es)
HR (1) HRP20150159T1 (es)
IL (1) IL217676A (es)
IN (1) IN2012DN00790A (es)
MA (1) MA33575B1 (es)
ME (1) ME02047B (es)
MX (1) MX2012002119A (es)
MY (1) MY163109A (es)
NZ (1) NZ598328A (es)
PL (1) PL2467366T3 (es)
PT (1) PT2467366E (es)
RS (1) RS53812B1 (es)
SG (1) SG178336A1 (es)
SI (1) SI2467366T1 (es)
SM (1) SMT201500029B (es)
UA (1) UA108209C2 (es)
WO (1) WO2011020615A1 (es)
ZA (1) ZA201200730B (es)

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