ES2486441B1 - Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico - Google Patents

Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico Download PDF

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Publication number
ES2486441B1
ES2486441B1 ES201430479A ES201430479A ES2486441B1 ES 2486441 B1 ES2486441 B1 ES 2486441B1 ES 201430479 A ES201430479 A ES 201430479A ES 201430479 A ES201430479 A ES 201430479A ES 2486441 B1 ES2486441 B1 ES 2486441B1
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Prior art keywords
phosphate
calcium phosphate
prevention
treatment
application
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ES201430479A
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ES2486441A1 (es
Inventor
Félix Grases Freixedas
Antonia COSTA BAUZÁ
Rafel María PRIETO ALMIRALL
Adrián RODRÍGUEZ RODRÍGUEZ
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Universitat de les Illes Balears
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Universitat de les Illes Balears
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Priority to ES201430479A priority Critical patent/ES2486441B1/es
Publication of ES2486441A1 publication Critical patent/ES2486441A1/es
Priority to ES15717192T priority patent/ES2773628T3/es
Priority to US15/300,486 priority patent/US20170106032A1/en
Priority to EP15717192.7A priority patent/EP3130352B1/en
Priority to PCT/ES2015/070249 priority patent/WO2015150608A1/es
Priority to KR1020167030405A priority patent/KR20160133002A/ko
Priority to MX2016012302A priority patent/MX2016012302A/es
Priority to CN201580015787.1A priority patent/CN106232143B/zh
Application granted granted Critical
Publication of ES2486441B1 publication Critical patent/ES2486441B1/es
Priority to US16/257,113 priority patent/US11207365B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/70—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/02—Ammonia; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico.#La presente invención se refiere al uso de una combinación separada, secuencial o simultánea de al menos un acidificante urinario con al menos un inhibidor de la cristalización del fosfato cálcico para la acidificación de la orina, y evitar así el pH en el que se produce sobresaturación de fosfato cálcico y como consecuencia, la litiasis renal.

Description

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Claims (1)

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ES201430479A 2014-04-02 2014-04-02 Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico Active ES2486441B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES201430479A ES2486441B1 (es) 2014-04-02 2014-04-02 Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico
PCT/ES2015/070249 WO2015150608A1 (es) 2014-04-02 2015-03-31 Combinación de acidificantes urinarios e inhibidores de la cristalización del fosfato cálcico para el tratamiento o la prevención de la litiasis renal
US15/300,486 US20170106032A1 (en) 2014-04-02 2015-03-31 Combination of a urinary acidifier and a calcium phosphate crystallisation inhibitor for the treatment or prevention of renal lithiasis
EP15717192.7A EP3130352B1 (en) 2014-04-02 2015-03-31 Combination of a urinary acidifier and a calcium phosphate crystallisation inhibitor for the treatment or prevention of renal lithiasis
ES15717192T ES2773628T3 (es) 2014-04-02 2015-03-31 Combinación de un acidificante urinario y un inhibidor de la cristalización del fosfato cálcico para el tratamiento o prevención de la litiasis renal
KR1020167030405A KR20160133002A (ko) 2014-04-02 2015-03-31 신장 결석증의 치료 또는 예방을 위한 뇨 산성화제와 인산칼슘 결정화 저해제의 조합물
MX2016012302A MX2016012302A (es) 2014-04-02 2015-03-31 Preparaciones combinadas de acidificantes urunarios e inhibidores de la cristalizacion y su aplicacion para el tratamiento o prevencion de la litiasis renal fosfatica o inducida por fosfato calcico.
CN201580015787.1A CN106232143B (zh) 2014-04-02 2015-03-31 尿酸化剂和结晶抑制剂的组合制剂以及其用于治疗或预防磷酸盐或磷酸钙诱导的肾结石的应用
US16/257,113 US11207365B2 (en) 2014-04-02 2019-01-25 Combined preparations of urinary acidifiers and crystallization inhibitors and application thereof for the treatment or prevention of phosphatic or calcium phosphate-induced renal lithiasis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201430479A ES2486441B1 (es) 2014-04-02 2014-04-02 Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico

Publications (2)

Publication Number Publication Date
ES2486441A1 ES2486441A1 (es) 2014-08-18
ES2486441B1 true ES2486441B1 (es) 2015-06-11

Family

ID=51301461

Family Applications (2)

Application Number Title Priority Date Filing Date
ES201430479A Active ES2486441B1 (es) 2014-04-02 2014-04-02 Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico
ES15717192T Active ES2773628T3 (es) 2014-04-02 2015-03-31 Combinación de un acidificante urinario y un inhibidor de la cristalización del fosfato cálcico para el tratamiento o prevención de la litiasis renal

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15717192T Active ES2773628T3 (es) 2014-04-02 2015-03-31 Combinación de un acidificante urinario y un inhibidor de la cristalización del fosfato cálcico para el tratamiento o prevención de la litiasis renal

Country Status (7)

Country Link
US (2) US20170106032A1 (es)
EP (1) EP3130352B1 (es)
KR (1) KR20160133002A (es)
CN (1) CN106232143B (es)
ES (2) ES2486441B1 (es)
MX (1) MX2016012302A (es)
WO (1) WO2015150608A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200316002A1 (en) * 2019-04-03 2020-10-08 Devicare SL Prevention of urinary tract device encrustation
WO2021136765A1 (en) * 2019-12-30 2021-07-08 Devicare, S.L. Compositions for clinical complications associated to devices implanted in the urinary tract
CN114948989A (zh) * 2021-02-19 2022-08-30 中国人民解放军海军军医大学 氢化镁在制备防治肾结晶结石病的药物中的应用
CN115006465B (zh) * 2022-07-13 2023-06-13 四川省畜牧科学研究院 治疗动物尿结石的冲洗液及其制备方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
GB520248A (en) * 1938-10-15 1940-04-18 Alfred Pollak Improvements relating to bread conditioners
JPS61109730A (ja) * 1984-10-31 1986-05-28 Wakayama Pref Gov 尿路に発生する結石の予防叉は治療に使用する薬剤
DE3445253A1 (de) * 1984-12-12 1986-06-26 Dr. Madaus & Co, 5000 Köln Nephrologisch-urologisches arzneimittel
JP2509619B2 (ja) * 1987-05-14 1996-06-26 ニチモウ株式会社 海藻健康育成物
US4902718A (en) * 1988-04-08 1990-02-20 Bayless Robert K Calcium homeostasis compositions and methods for controlling calcium metabolism
US5041429A (en) * 1988-06-01 1991-08-20 Sanwa Kagaku Kenkyusho Co., Ltd. Cell activators, circulatory ameliorators and edible compositions
US5762911A (en) * 1996-03-05 1998-06-09 The Research Foundation Of State University Of New York Anti-caries oral compositions
WO2005112667A1 (ja) * 2004-05-20 2005-12-01 Takashi Omori 健康食品
ITRM20050344A1 (it) * 2005-06-30 2007-01-01 Luca Maria De Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi.
ES2280136B1 (es) * 2006-02-17 2008-08-16 Universitat De Les Illes Balears Asociacion a dosis fija de fitato y zinc.
CN103204874A (zh) * 2012-01-12 2013-07-17 辽宁科硕营养科技有限公司 植酸盐及其制备方法与用途
AU2014236553B2 (en) * 2013-03-15 2019-01-17 General Hospital Corporation Citrate containing beverage

Also Published As

Publication number Publication date
CN106232143A (zh) 2016-12-14
WO2015150608A1 (es) 2015-10-08
US20170106032A1 (en) 2017-04-20
KR20160133002A (ko) 2016-11-21
ES2773628T3 (es) 2020-07-13
ES2486441A1 (es) 2014-08-18
CN106232143B (zh) 2019-11-12
EP3130352B1 (en) 2019-11-27
US11207365B2 (en) 2021-12-28
MX2016012302A (es) 2017-06-30
US20190216873A1 (en) 2019-07-18
EP3130352A1 (en) 2017-02-15

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