ES235737A1 - UN MÉTODO DE PREPARACIoN DE ANTIBIoTICOS DE DEMETILTITRACICLINA - Google Patents

UN MÉTODO DE PREPARACIoN DE ANTIBIoTICOS DE DEMETILTITRACICLINA

Info

Publication number
ES235737A1
ES235737A1 ES0235737A ES235737A ES235737A1 ES 235737 A1 ES235737 A1 ES 235737A1 ES 0235737 A ES0235737 A ES 0235737A ES 235737 A ES235737 A ES 235737A ES 235737 A1 ES235737 A1 ES 235737A1
Authority
ES
Spain
Prior art keywords
demethyltetracycline
epimers
demethyltetracyclines
preparing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0235737A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES235737A1 publication Critical patent/ES235737A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P29/00Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/886Streptomyces
    • Y10S435/889Streptomyces aureofaciens

Abstract

Método de preparación de antibiótico de demetiltetraciclina ( comprendiendo demetiltetraciclina) y epímeros de ellas, caracterizado por fermentar aerobiamente un medio nutricio acuoso que tiene un contenido controlado de ión cloruro y/o bromuro con una cepa de s. aureofaciens productora de demetiltetraciclina, recuperar si se desea los antibióticos de demetiltetraciclina resultantes del medio de fermentación y, si se desea, ajustar el valor del pH de una solución concentrada de los mismos para producir los epímeros de ellos.
ES0235737A 1956-05-28 1957-05-27 UN MÉTODO DE PREPARACIoN DE ANTIBIoTICOS DE DEMETILTITRACICLINA Expired ES235737A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US587518A US2878289A (en) 1956-05-28 1956-05-28 6-demethyltetracyclines and methods for preparing the same

Publications (1)

Publication Number Publication Date
ES235737A1 true ES235737A1 (es) 1957-12-01

Family

ID=24350126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0235737A Expired ES235737A1 (es) 1956-05-28 1957-05-27 UN MÉTODO DE PREPARACIoN DE ANTIBIoTICOS DE DEMETILTITRACICLINA

Country Status (5)

Country Link
US (1) US2878289A (es)
CH (1) CH365484A (es)
DK (1) DK104507C (es)
ES (1) ES235737A1 (es)
IS (1) IS469B6 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105016A (en) * 1956-04-25 1963-09-24 American Cyanamid Co Process of producing bromo-tetracycline
US2996499A (en) * 1958-06-20 1961-08-15 American Cyanamid Co Cosynthetic factor-1, and its production
US3047626A (en) * 1959-09-24 1962-07-31 Pfizer & Co C 4-desdimethylamino-6-deoxy-tetracycline derivatives
US3023239A (en) * 1959-12-09 1962-02-27 American Cyanamid Co Recrystallization of demethylchlortetracycline
US3019172A (en) * 1960-03-14 1962-01-30 American Cyanamid Co Production of 7-chloro-6-demethyltetracycline
US3070514A (en) * 1960-05-04 1962-12-25 Lepetit Spa Process for the manufacture of 6-demethyltetracycline
FR1430859A (es) * 1960-05-23 1966-05-25
US3159537A (en) * 1960-12-20 1964-12-01 American Cyanamid Co Potentiation of tetracycline by phosphinic acid
US3028311A (en) * 1960-08-05 1962-04-03 Olin Mathieson Process for preparing 6-demethyltetracyclines
US3172822A (en) * 1960-10-31 1965-03-09 Process for preparing g-demethyl- tetracyclines
US3166474A (en) * 1961-05-26 1965-01-19 American Cyanamid Co Stable aqueous propylene glycol solutions of aluminum gluconate complexes of certain tetracycline antibiotics
US3335055A (en) * 1961-08-30 1967-08-08 American Cyanamid Co More stable and more soluble tetracycline compositions suitable for parenteral use and method of preparing same
US3069326A (en) * 1961-10-31 1962-12-18 American Cyanamid Co Method of preparing 6-amino-5-hydroxy-1, 3-cyclohexadiene-1-carboxylic acid
US3160570A (en) * 1961-12-20 1964-12-08 Merck & Co Inc Method for producing 6-demethylchlortetracycline
US3155586A (en) * 1963-01-23 1964-11-03 American Cyanamid Co Stable liquid preparations of 6-demethyltetracyclines
US3155587A (en) * 1963-01-23 1964-11-03 American Cyanamid Co Stable liquid preparations of 7-chlorotetracycline
FR2607M (fr) * 1963-01-30 1964-06-22 Soc Ind Fab Antibiotiques Sifa Nouveau dérivé de la tétracycline.
US3364260A (en) * 1963-05-06 1968-01-16 Squibb & Sons Inc 4n-demethyl-4n-ethyl tetracyclines
US3434844A (en) * 1964-01-21 1969-03-25 American Cyanamid Co Stabilization of animal and poultry feeds containing a tetracycline antibiotic
US3427166A (en) * 1964-01-21 1969-02-11 American Cyanamid Co Stabilization of animal and poultry feeds containing a tetracycline antibiotic
US3639214A (en) * 1964-06-04 1972-02-01 Upjohn Co Production of 6-demethyltetracycline
US3298927A (en) * 1964-11-09 1967-01-17 Olin Mathieson Process for preparing 6-demethyltetracyclines using ethionine sulfoxide
US3446841A (en) * 1966-04-22 1969-05-27 American Cyanamid Co Isolation of 5-hydroxy-7-chlortetracycline
US3607311A (en) * 1968-02-16 1971-09-21 Gerhard Julius Hass Obtulinum exotoxin inhibited foods
US3795707A (en) * 1970-12-28 1974-03-05 Rachelle Labor Italia Spa Manufacture of alpha-6-deoxytetracyclines
US4200630A (en) * 1977-12-15 1980-04-29 University Of Pennsylvania Inhibition of ADH-stimulated osmotic water flow and aldosterone-stimulated sodium transport
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
EP1069112A4 (en) * 1998-02-13 2001-04-18 Kureha Chemical Ind Co Ltd N- (PHENYLSULFONYL) PICOLINAMIDE DERIVATIVES, METHOD FOR THEIR PREPARATION AND HERBICIDES
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
PT108978B (pt) 2015-11-24 2020-03-09 Hovione Farm S A Sais de tetraciclinas
CN111100900A (zh) * 2019-12-19 2020-05-05 河北圣雪大成制药有限责任公司 一种发酵法制备去甲基四环素的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2482055A (en) * 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
BE487301A (es) * 1948-02-11
BE530983A (es) * 1953-09-28
US2699054A (en) * 1953-10-09 1955-01-11 Lloyd H Conover Tetracycline
NL103776C (es) * 1953-12-04
US2712517A (en) * 1954-03-03 1955-07-05 Bristol Lab Inc Production of tetracycline and substituted tetracyclines

Also Published As

Publication number Publication date
IS469B6 (is) 1961-12-06
US2878289A (en) 1959-03-17
DK104507C (da) 1966-05-31
IS986A7 (is) 1957-11-29
CH365484A (fr) 1962-11-15

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