ES227622A1 - Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture - Google Patents

Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture

Info

Publication number
ES227622A1
ES227622A1 ES0227622A ES227622A ES227622A1 ES 227622 A1 ES227622 A1 ES 227622A1 ES 0227622 A ES0227622 A ES 0227622A ES 227622 A ES227622 A ES 227622A ES 227622 A1 ES227622 A1 ES 227622A1
Authority
ES
Spain
Prior art keywords
chloro
bromo
dimethylaniline
diethylaminoacetyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0227622A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHILDY FELIX WICKER RONALD
Original Assignee
SCHILDY FELIX WICKER RONALD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of ES227622A1 publication Critical patent/ES227622A1/en
Application filed by SCHILDY FELIX WICKER RONALD filed Critical SCHILDY FELIX WICKER RONALD
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises diethylaminoacetyl-4-chloro-2 : 6-dimethylanilide and the corresponding 4-bromo compound their watersoluble salts and their preparation by reacting a halogen-acetyl-4-chloro or bromo-2 : 6-dimethyl-anilide with diethylamine. This process may be combined with the preparation of the anilide starting material, which need not be isolated, by reacting a halogen-acetyl chloride or bromide with 4-chloro-or-bromo-2 : 6-dimethylaniline. The former reaction may be carried out in a solvent, e.g. benzene, toluene or acetone, or in an excess of the diethylamine, and the latter reaction may also take place in a solvent such as one of the above-mentioned solvents or glacial acetic acid, and in presence of an acid-binding agent, e.g. an inorganic or tertiary organic base, or in an excess of the halogen-2 : 6-dimethylaniline alternatively, an acid-binding agent, e.g. sodium acetate, may be added after the reaction. Examples are given. 4-Chloro-or-bromo-2 : 6-dimethylaniline is obtained by direct chlorination or bromination of 2 : 6-dimethylaniline, in, for example, glacial acetic acid, carbon tetrachloride or chloroform. In the first Provisional Specification the 4-halogeno compounds in general are referred to.ALSO:Local anaesthetic compositions comprise a mixture of diethylaminoacetyl-4-chloro-and-bromo-2:6-di-methyl-anilides or salts therof.
ES0227622A 1955-04-01 1956-03-28 Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture Expired ES227622A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB964455A GB845742A (en) 1955-04-01 1955-04-01 Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture

Publications (1)

Publication Number Publication Date
ES227622A1 true ES227622A1 (en) 1956-03-16

Family

ID=9875981

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0227622A Expired ES227622A1 (en) 1955-04-01 1956-03-28 Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture

Country Status (2)

Country Link
ES (1) ES227622A1 (en)
GB (1) GB845742A (en)

Also Published As

Publication number Publication date
GB845742A (en) 1960-08-24

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