ES227622A1 - Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture - Google Patents
Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufactureInfo
- Publication number
- ES227622A1 ES227622A1 ES0227622A ES227622A ES227622A1 ES 227622 A1 ES227622 A1 ES 227622A1 ES 0227622 A ES0227622 A ES 0227622A ES 227622 A ES227622 A ES 227622A ES 227622 A1 ES227622 A1 ES 227622A1
- Authority
- ES
- Spain
- Prior art keywords
- chloro
- bromo
- dimethylaniline
- diethylaminoacetyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises diethylaminoacetyl-4-chloro-2 : 6-dimethylanilide and the corresponding 4-bromo compound their watersoluble salts and their preparation by reacting a halogen-acetyl-4-chloro or bromo-2 : 6-dimethyl-anilide with diethylamine. This process may be combined with the preparation of the anilide starting material, which need not be isolated, by reacting a halogen-acetyl chloride or bromide with 4-chloro-or-bromo-2 : 6-dimethylaniline. The former reaction may be carried out in a solvent, e.g. benzene, toluene or acetone, or in an excess of the diethylamine, and the latter reaction may also take place in a solvent such as one of the above-mentioned solvents or glacial acetic acid, and in presence of an acid-binding agent, e.g. an inorganic or tertiary organic base, or in an excess of the halogen-2 : 6-dimethylaniline alternatively, an acid-binding agent, e.g. sodium acetate, may be added after the reaction. Examples are given. 4-Chloro-or-bromo-2 : 6-dimethylaniline is obtained by direct chlorination or bromination of 2 : 6-dimethylaniline, in, for example, glacial acetic acid, carbon tetrachloride or chloroform. In the first Provisional Specification the 4-halogeno compounds in general are referred to.ALSO:Local anaesthetic compositions comprise a mixture of diethylaminoacetyl-4-chloro-and-bromo-2:6-di-methyl-anilides or salts therof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB964455A GB845742A (en) | 1955-04-01 | 1955-04-01 | Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture |
Publications (1)
Publication Number | Publication Date |
---|---|
ES227622A1 true ES227622A1 (en) | 1956-03-16 |
Family
ID=9875981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0227622A Expired ES227622A1 (en) | 1955-04-01 | 1956-03-28 | Nuclear substituted diethylaminoacetyl-2:6-dimethylanilides and process for their manufacture |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES227622A1 (en) |
GB (1) | GB845742A (en) |
-
1955
- 1955-04-01 GB GB964455A patent/GB845742A/en not_active Expired
-
1956
- 1956-03-28 ES ES0227622A patent/ES227622A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB845742A (en) | 1960-08-24 |
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