ES2172697T3 - Metodo y composiciones para la sintesis de nucleosidos de dioxolano que tienen una configuracion beta. - Google Patents
Metodo y composiciones para la sintesis de nucleosidos de dioxolano que tienen una configuracion beta.Info
- Publication number
- ES2172697T3 ES2172697T3 ES96941539T ES96941539T ES2172697T3 ES 2172697 T3 ES2172697 T3 ES 2172697T3 ES 96941539 T ES96941539 T ES 96941539T ES 96941539 T ES96941539 T ES 96941539T ES 2172697 T3 ES2172697 T3 ES 2172697T3
- Authority
- ES
- Spain
- Prior art keywords
- compositions
- synthesis
- nucleosids
- dioxolan
- beta configuration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9525606.1A GB9525606D0 (en) | 1995-12-14 | 1995-12-14 | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2172697T3 true ES2172697T3 (es) | 2002-10-01 |
Family
ID=10785435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96941539T Expired - Lifetime ES2172697T3 (es) | 1995-12-14 | 1996-12-13 | Metodo y composiciones para la sintesis de nucleosidos de dioxolano que tienen una configuracion beta. |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US5922867A (en, 2012) |
| EP (1) | EP0970074B1 (en, 2012) |
| JP (1) | JP3229990B2 (en, 2012) |
| KR (1) | KR100406159B1 (en, 2012) |
| CN (1) | CN1080263C (en, 2012) |
| AP (1) | AP879A (en, 2012) |
| AT (1) | ATE214699T1 (en, 2012) |
| AU (1) | AU706328B2 (en, 2012) |
| BR (1) | BR9612351A (en, 2012) |
| CA (1) | CA2237730C (en, 2012) |
| DE (1) | DE69620042T2 (en, 2012) |
| DK (1) | DK0970074T3 (en, 2012) |
| EA (1) | EA000844B1 (en, 2012) |
| ES (1) | ES2172697T3 (en, 2012) |
| GB (1) | GB9525606D0 (en, 2012) |
| HU (1) | HU224076B1 (en, 2012) |
| IL (3) | IL144155A (en, 2012) |
| IN (1) | IN187349B (en, 2012) |
| MX (1) | MX9804701A (en, 2012) |
| NO (1) | NO309901B1 (en, 2012) |
| NZ (1) | NZ323855A (en, 2012) |
| OA (1) | OA11094A (en, 2012) |
| PL (1) | PL188447B1 (en, 2012) |
| PT (1) | PT970074E (en, 2012) |
| TW (1) | TW341574B (en, 2012) |
| WO (1) | WO1997021706A1 (en, 2012) |
| ZA (1) | ZA9610544B (en, 2012) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001518899A (ja) | 1997-04-07 | 2001-10-16 | トライアングル ファーマシューティカルズ，インコーポレイティド | 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用 |
| DE69921829T2 (de) | 1998-08-12 | 2005-10-27 | Gilead Sciences, Inc., Foster City | Verfahren zur herstellung von 1,3-oxathiolannukleoside |
| US6979561B1 (en) * | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
| ES2209532T3 (es) | 1998-12-23 | 2004-06-16 | Shire Biochem Inc. | Analogos de nucleosidos antivirales. |
| EP1151133A1 (en) * | 1999-02-11 | 2001-11-07 | McGILL UNIVERSITY | Stereoselective synthesis of nucleoside analogues |
| DE60011637T2 (de) * | 1999-09-24 | 2004-11-11 | Shire Biochem Inc., Laval | Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen |
| US6566365B1 (en) * | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
| WO2001058920A2 (en) * | 2000-02-10 | 2001-08-16 | Mitsui Chemicals, Inc. | Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside |
| EP1265890B1 (en) | 2000-02-11 | 2007-04-18 | Shire BioChem Inc. | Stereoselective synthesis of nucleoside analogues |
| WO2002051852A1 (fr) * | 2000-12-27 | 2002-07-04 | Mitsui Chemicals, Inc. | Procede de production d'un derive de saccharide non naturel |
| EP1389207B1 (en) | 2001-03-01 | 2005-12-07 | Gilead Sciences, Inc. | Polymorphic and other crystalline forms of cis-ftc |
| WO2003020222A2 (en) * | 2001-09-04 | 2003-03-13 | Merck & Co., Inc. | PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE |
| JP2005512984A (ja) * | 2001-11-02 | 2005-05-12 | シャイアー バイオケム インコーポレイテッド | ジオキソランヌクレオシド類似体を含む白血病の治療のための医薬組成物 |
| CN100560073C (zh) * | 2001-12-14 | 2009-11-18 | 法玛塞特公司 | 用于治疗病毒感染的n4-酰基胞嘧啶核苷 |
| WO2003062229A1 (en) | 2002-01-25 | 2003-07-31 | Shire Biochem Inc. | Process for producing dioxolane nucleoside analogues |
| IL166682A0 (en) | 2002-08-06 | 2006-01-15 | Pharmasset Ltd | Processes for preparing 1,3-dioxolane nucleosides |
| AU2003304716A1 (en) | 2002-10-15 | 2005-11-25 | Exxonmobil Chemical Patents Inc. | Polyolefin adhesive compositions and articles made therefrom |
| DE10335061B4 (de) | 2003-07-31 | 2005-11-17 | Wacker-Chemie Gmbh | Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten |
| BRPI0507363A (pt) * | 2004-02-03 | 2007-07-03 | Univ Emory | métodos para manufatura de 1,3-dioxolano nucleosìdeos |
| US7749531B2 (en) * | 2005-06-08 | 2010-07-06 | Indicator Systems International | Apparatus and method for detecting bacterial growth beneath a wound dressing |
| BRPI0813036A2 (pt) * | 2007-07-30 | 2017-10-24 | Rfs Pharma Llc | processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. |
| CN101862676B (zh) * | 2009-04-17 | 2012-01-25 | 中国石油化工股份有限公司 | 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用 |
| CN103288806A (zh) * | 2013-07-02 | 2013-09-11 | 山东大学 | 一种曲沙他滨的合成方法 |
| WO2018022263A1 (en) | 2016-07-29 | 2018-02-01 | Exxonmobil Chemical Patents Inc. | Polymerization processes using high molecular weight polyhydric quenching agents |
| JP7337539B2 (ja) * | 2018-06-21 | 2023-09-04 | メディヴィル・アクチエボラーグ | 白血病療法のための塩基修飾シチジンヌクレオチド |
| WO2019245444A1 (en) | 2018-06-21 | 2019-12-26 | Medivir Ab | Base-modified cytidine nucleotides for leukemia therapy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| KR940005654A (ko) * | 1992-06-22 | 1994-03-22 | 리로이 휘테커 | 입체선택적인 음이온 글리코실화 방법 |
-
1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
-
1996
- 1996-12-13 PL PL96327443A patent/PL188447B1/pl not_active IP Right Cessation
- 1996-12-13 DE DE69620042T patent/DE69620042T2/de not_active Expired - Lifetime
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/ko not_active Expired - Fee Related
- 1996-12-13 PT PT96941539T patent/PT970074E/pt unknown
- 1996-12-13 IL IL14415596A patent/IL144155A/xx not_active IP Right Cessation
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en active IP Right Grant
- 1996-12-13 AT AT96941539T patent/ATE214699T1/de not_active IP Right Cessation
- 1996-12-13 HU HU9901050A patent/HU224076B1/hu active IP Right Grant
- 1996-12-13 NZ NZ323855A patent/NZ323855A/xx unknown
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 BR BR9612351A patent/BR9612351A/pt not_active Application Discontinuation
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/xx unknown
- 1996-12-13 JP JP52157397A patent/JP3229990B2/ja not_active Expired - Lifetime
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 TW TW085115392A patent/TW341574B/zh active
- 1996-12-13 DK DK96941539T patent/DK0970074T3/da active
- 1996-12-13 ES ES96941539T patent/ES2172697T3/es not_active Expired - Lifetime
- 1996-12-13 EA EA199800555A patent/EA000844B1/ru not_active IP Right Cessation
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 CN CN96199879A patent/CN1080263C/zh not_active Expired - Lifetime
- 1996-12-13 EP EP96941539A patent/EP0970074B1/en not_active Expired - Lifetime
-
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/es unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/no unknown
-
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
-
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/xx unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
-
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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