ES2160521B1 - Proteina cd29 porcina, acido nucleico que codifica para dicha proteina, y sus aplicaciones. - Google Patents

Proteina cd29 porcina, acido nucleico que codifica para dicha proteina, y sus aplicaciones.

Info

Publication number
ES2160521B1
ES2160521B1 ES009902193A ES9902193A ES2160521B1 ES 2160521 B1 ES2160521 B1 ES 2160521B1 ES 009902193 A ES009902193 A ES 009902193A ES 9902193 A ES9902193 A ES 9902193A ES 2160521 B1 ES2160521 B1 ES 2160521B1
Authority
ES
Spain
Prior art keywords
protein
nucleic acid
swine
gal
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009902193A
Other languages
English (en)
Other versions
ES2160521A1 (es
Inventor
Pavon Juan Jose Garrido
Ruiz Diego Llanes
Medina Manuel Babancho
Marin Angeles Maria Jimenez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Cordoba
Original Assignee
Universidad de Cordoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Cordoba filed Critical Universidad de Cordoba
Priority to ES009902193A priority Critical patent/ES2160521B1/es
Priority to AU77903/00A priority patent/AU7790300A/en
Priority to EP00967909A priority patent/EP1241181A1/en
Priority to PCT/ES2000/000374 priority patent/WO2001025279A1/es
Publication of ES2160521A1 publication Critical patent/ES2160521A1/es
Priority to US10/117,295 priority patent/US20020182678A1/en
Application granted granted Critical
Publication of ES2160521B1 publication Critical patent/ES2160521B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/7055—Integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Proteína CD29 porcina, acido nucleico que codifica para dicha proteína, y sus aplicaciones. La proteína CD29 porcina nativa contiene epítopos Gal-alfa-(1,3)-Gal que son reconocidos por anticuerpos naturales humanos xenoreactivos desencadenándose un rechazo hiperagudo del xenoinjerto. Se describen proteínas basadas en la CD29 porcina con una secuencia de aminoácidos como la de la proteína CD29 nativa o con una secuencia de aminoácidos modificada con una expresión igual, reducida o nula del epítopo Gal-alfa-(1,3)-Gal, así como moléculas de ácido nucleico que codifican para dichas proteínas, y el empleo de dichas proteínas y moléculas de ácido nucleico en el desarrollo de estrategias parra reducir o evitar el rechazo hiperagudo asociado a terapias de xenotransplante.
ES009902193A 1999-10-05 1999-10-05 Proteina cd29 porcina, acido nucleico que codifica para dicha proteina, y sus aplicaciones. Expired - Fee Related ES2160521B1 (es)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES009902193A ES2160521B1 (es) 1999-10-05 1999-10-05 Proteina cd29 porcina, acido nucleico que codifica para dicha proteina, y sus aplicaciones.
AU77903/00A AU7790300A (en) 1999-10-05 2000-10-04 Cd29 pig protein, nucleic acid coding for said protein and the applications thereof
EP00967909A EP1241181A1 (en) 1999-10-05 2000-10-04 Cd29 pig protein, nucleic acid coding for said protein and the applications thereof
PCT/ES2000/000374 WO2001025279A1 (es) 1999-10-05 2000-10-04 Proteina cd29 porcina, acido nucleico que codifica para dicha proteina, y sus aplicaciones
US10/117,295 US20020182678A1 (en) 1999-10-05 2002-04-05 CD29 pig protein, nucleic acid coding for said protein, and applications thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902193A ES2160521B1 (es) 1999-10-05 1999-10-05 Proteina cd29 porcina, acido nucleico que codifica para dicha proteina, y sus aplicaciones.

Publications (2)

Publication Number Publication Date
ES2160521A1 ES2160521A1 (es) 2001-11-01
ES2160521B1 true ES2160521B1 (es) 2002-08-01

Family

ID=8310151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009902193A Expired - Fee Related ES2160521B1 (es) 1999-10-05 1999-10-05 Proteina cd29 porcina, acido nucleico que codifica para dicha proteina, y sus aplicaciones.

Country Status (5)

Country Link
US (1) US20020182678A1 (es)
EP (1) EP1241181A1 (es)
AU (1) AU7790300A (es)
ES (1) ES2160521B1 (es)
WO (1) WO2001025279A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080080302A1 (en) * 2006-09-29 2008-04-03 Fujifilm Corporation Droplet mixing method and apparatus
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2157659C (en) * 1993-03-16 2003-10-21 Mauro S. Sandrin Use of porcine gal .alpha. (1,3) galactosyl transferase in xenograft therapies
AU708880B2 (en) * 1994-06-03 1999-08-12 Diacrin, Inc. Modified cells and methods for inhibiting hyperacute rejection of xenogeneic transplants

Also Published As

Publication number Publication date
US20020182678A1 (en) 2002-12-05
AU7790300A (en) 2001-05-10
EP1241181A1 (en) 2002-09-18
ES2160521A1 (es) 2001-11-01
WO2001025279A1 (es) 2001-04-12

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