ES2131805T3 - Derivados de benzoxacina, sus procedimientos de obtencion y su utilizacion como medicamentos. - Google Patents
Derivados de benzoxacina, sus procedimientos de obtencion y su utilizacion como medicamentos.Info
- Publication number
- ES2131805T3 ES2131805T3 ES95906357T ES95906357T ES2131805T3 ES 2131805 T3 ES2131805 T3 ES 2131805T3 ES 95906357 T ES95906357 T ES 95906357T ES 95906357 T ES95906357 T ES 95906357T ES 2131805 T3 ES2131805 T3 ES 2131805T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- representing
- pct
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Electrochemistry (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE LA BENZOXACINA, DE FORMULA (I) EN LA QUE: R{SUB,1} Y R{SUB,2}, INDEPENDIENTEMENTE UNO DE OTRO, REPRESENTAN UN GRUPO ALQUILO DE 1 A 3 ATOMOS DE CARBONO, O UN GRUPO DE FORMULA -CH{SUB,2}-OR}{SUB,A}, REPRESENTANDO R{SUB,A} UN ATOMO DE HIDROGENO O UN GRUPO METILO, R{SUB,X} REPRESENTA: UN GRUPO ALQUILO DE 1 A 3 ATOMOS DE CARBONO, PARTICULARMENTE UN GRUPO METILO, O UN GRUPO OR{SUB,X1}, REPRESENTANDO R{SUB,X1} UN GRUPO ALQUILO DE 1 A 3 ATOMOS DE CARBONO, PARTICULARMENTE UN GRUPO METOXI, O UN GRUPO DE FORMULA -CH{SUB,2-X EN LA QUE X REPRESENTA UN ATOMO DE HALOGENO, PARTICULARMENTE CLORO, O UN GRUPO DE FORMULA (A) EN LA QUE: R{SUB,3} Y R{SUB,5} INDEPENDIENTEMENTE UNO DE OTRO REPRESENTAN UN ATOMO DE HIDROGENO, O UN GRUPO -OH, O UN GRUPO -OCH{SUB,3}; R{SUB,4} REPRESENTA UN ATOMO DE HIDROGENO, O UN GRUPO -OR{SUB,B}, REPRESENTANDO R{SUB,B} UN ATOMO DE HIDROGENO O UN GRUPO METILO, O R{SUB,4} REPRESENTA UN GRUPO DE FORMULA OR{SUB,C}, REPRESENTANDO R{SUB,C} UN GRUPO DE FORMULA -CH{SUB,2}CO-C{SUB,6}H{SUB,4}R'' EN LA QUE R'' REPRESENTA UN ATOMO DE HIDROGENO, -CN O -OCH{SUB,3}; BIEN R{SUB,6} REPRESENTA UN GRUPO -OR{SUB,D}, REPRESENTANDO R{SUB,D} UN ATOMO DE HIDROGENO O UN GRUPO METILO, CUANDO R{SUB,7} Y R{SUB,8} SE ASOCIAN PARA FORMAR UN DOBLE ENLACE, BIEN R{SUB,8} REPRESENTA UN GRUPO -OR{SUB,E} EN EL QUE R{SUB,E} REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO METILO, CUANDO R{SUB,6} Y R{SUB,7} SE ASOCIAN PARA FORMAR CON EL ATOMO DE CARBONO EN POSICION 8 DEL CICLO, UN GRUPO C = O, ASI COMO SUS PROCEDIMIENTOS DE OBTENCION. LA INVENCION APUNTA TAMBIEN A LAS COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN ESTOS DERIVADOS, Y SUS UTILIZACIONES PARTICULARMENTE EN EL MARCO DEL TRATAMIENTO DE PATOLOGIAS ASOCIADAS A LA PRESENCIA DE RADICALES LIBRES, Y MAS PARTICULARMENTE DE LA ENFERMEDAD DE ALZHEIMER.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9315836A FR2714381B1 (fr) | 1993-12-29 | 1993-12-29 | Dérivés de la benzoxazine, leurs procédés d'obtention et leur utilisation en tant que médicaments . |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2131805T3 true ES2131805T3 (es) | 1999-08-01 |
Family
ID=9454544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95906357T Expired - Lifetime ES2131805T3 (es) | 1993-12-29 | 1994-12-29 | Derivados de benzoxacina, sus procedimientos de obtencion y su utilizacion como medicamentos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5804580A (es) |
EP (1) | EP0737187B1 (es) |
JP (1) | JPH09507483A (es) |
AT (1) | ATE179704T1 (es) |
AU (1) | AU1510495A (es) |
DE (1) | DE69418347T2 (es) |
DK (1) | DK0737187T3 (es) |
ES (1) | ES2131805T3 (es) |
FR (1) | FR2714381B1 (es) |
GR (1) | GR3030567T3 (es) |
WO (1) | WO1995018114A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2779144B1 (fr) * | 1998-05-29 | 2000-06-30 | Adir | Nouveaux composes 8-amino-1,4-benzoxaziniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GR1007084B (el) * | 2008-08-07 | 2010-11-26 | Ευτυχια Κοϊνη | 1,4- βενζοξαζινικα αναλογα |
CN102552233B (zh) * | 2011-12-26 | 2014-05-14 | 暨南大学 | 3,4-二羟基苯甲酸甲酯在制备防治神经退行性疾病药物中的应用 |
CN113106473B (zh) * | 2021-04-14 | 2022-02-18 | 南京工业大学 | 一种通过连续电化学微反应器装置制备1,3-苯并噁嗪衍生物的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2377202A2 (fr) * | 1977-01-12 | 1978-08-11 | Pharmascience Lab | Compositions pharmaceutiques contenant de l'hexahydroxy-2,3,4,3',4',5'-benzophenone |
US4263322A (en) * | 1979-03-01 | 1981-04-21 | Riet Bartholomeus Van T | Hydroxy benzohydroxamic acids and benzamides |
FR2504917B1 (fr) * | 1981-05-04 | 1987-09-25 | Delalande Sa | Nouveau systeme oxydant selectif et son application a la preparation de derives aromatiques ortho-dihydroxyles ou ortho-dialcoxyles |
US4956372A (en) * | 1987-10-02 | 1990-09-11 | Kyorin Pharmaceutical Co., Ltd. | Cyclic anthranilic acid derivatives and process for their preparation |
US5124325A (en) * | 1989-06-13 | 1992-06-23 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agents of metabolic bone disease |
US5208247A (en) * | 1991-08-01 | 1993-05-04 | American Cyanamid Company | Pyridinium compounds which are useful as antagonists of platelet activating factor |
-
1993
- 1993-12-29 FR FR9315836A patent/FR2714381B1/fr not_active Expired - Fee Related
-
1994
- 1994-12-29 ES ES95906357T patent/ES2131805T3/es not_active Expired - Lifetime
- 1994-12-29 AU AU15104/95A patent/AU1510495A/en not_active Abandoned
- 1994-12-29 WO PCT/FR1994/001557 patent/WO1995018114A1/fr active IP Right Grant
- 1994-12-29 DE DE69418347T patent/DE69418347T2/de not_active Expired - Fee Related
- 1994-12-29 AT AT95906357T patent/ATE179704T1/de not_active IP Right Cessation
- 1994-12-29 JP JP7517831A patent/JPH09507483A/ja active Pending
- 1994-12-29 DK DK95906357T patent/DK0737187T3/da active
- 1994-12-29 US US08/666,552 patent/US5804580A/en not_active Expired - Fee Related
- 1994-12-29 EP EP95906357A patent/EP0737187B1/fr not_active Expired - Lifetime
-
1999
- 1999-06-17 GR GR990401650T patent/GR3030567T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE179704T1 (de) | 1999-05-15 |
FR2714381A1 (fr) | 1995-06-30 |
US5804580A (en) | 1998-09-08 |
AU1510495A (en) | 1995-07-17 |
DK0737187T3 (da) | 1999-11-15 |
GR3030567T3 (en) | 1999-10-29 |
JPH09507483A (ja) | 1997-07-29 |
EP0737187A1 (fr) | 1996-10-16 |
FR2714381B1 (fr) | 1996-02-02 |
DE69418347T2 (de) | 1999-11-18 |
EP0737187B1 (fr) | 1999-05-06 |
WO1995018114A1 (fr) | 1995-07-06 |
DE69418347D1 (de) | 1999-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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