ES2124712T3 - Oligonucleotidos cataliticos sinteticos. - Google Patents

Oligonucleotidos cataliticos sinteticos.

Info

Publication number
ES2124712T3
ES2124712T3 ES92110298T ES92110298T ES2124712T3 ES 2124712 T3 ES2124712 T3 ES 2124712T3 ES 92110298 T ES92110298 T ES 92110298T ES 92110298 T ES92110298 T ES 92110298T ES 2124712 T3 ES2124712 T3 ES 2124712T3
Authority
ES
Spain
Prior art keywords
formula
nucleotides
nucleotide
alkyl
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92110298T
Other languages
English (en)
Inventor
Brian Dr Sproat
Angus Dr Lamond
Giovanni Dr Paolella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Europaisches Laboratorium fuer Molekularbiologie EMBL
Original Assignee
Europaisches Laboratorium fuer Molekularbiologie EMBL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Europaisches Laboratorium fuer Molekularbiologie EMBL filed Critical Europaisches Laboratorium fuer Molekularbiologie EMBL
Application granted granted Critical
Publication of ES2124712T3 publication Critical patent/ES2124712T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base

Abstract

UNA ESTRUCTURA DE UN OLIGONUCLEOTIDO SINTETICO CATALITICO Y NUCLEOTIDOS CON LA FORMULA ESTRUCTURAL GENERAL (I), CONTIENE: EN DONDE B EQUIVALE A UNA BASE NUCLEOSIDA, SELECCIONADA ESPECIALMENTE DEL GRUPO COMPUESTO DE ADENIN CIL Y 2 UCLEOTIDO UN GRUPO O PUEDEN SER IGUAL O DISTINTOS EN UN NUCLEOTIDO E INDEPENDIENTEMENTE ENTRE SI GRUPOS O -, S -, NH2 -, ALQUILO O ALCOXI CON 1 HASTA 10, PREFERENTEMENTE 1 HASTA 14, ATOMOS DE CARBONO, R HIDROGENO O UN GRUPO ALQUILO, ALQUENILO O ALQUINILO DE CADENA RECTA O RADIFICADA, SUSTITUIDO DADO EL CASO POR GRUPOS HALOGENO, CIANO, ISOCIANO, NITRO, AMINO, CARBOXILO, HIDROXILO Y/O MERCAPTO, CON 1 HASTA 10 ATOMOS DE CARBONO, Y EN DONDE AL MENOS UNO DE LOS NUCLEOTIDOS EL RESTO R EN LA FORMULA (I) SE DIFERENTE DE HIDROGENO, ES APROPIADA PARA EL DESDOBLAMIENTO DE UNA SECUENCIA DE DESTINO DEL ACIDO NUCLEINICO.
ES92110298T 1991-06-20 1992-06-17 Oligonucleotidos cataliticos sinteticos. Expired - Lifetime ES2124712T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4120406 1991-06-20
DE4216134A DE4216134A1 (de) 1991-06-20 1992-05-15 Synthetische katalytische oligonukleotidstrukturen

Publications (1)

Publication Number Publication Date
ES2124712T3 true ES2124712T3 (es) 1999-02-16

Family

ID=25904724

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97121976T Expired - Lifetime ES2155959T3 (es) 1991-06-20 1992-06-17 Oligonucleotidos cataliticos sinteticos.
ES92110298T Expired - Lifetime ES2124712T3 (es) 1991-06-20 1992-06-17 Oligonucleotidos cataliticos sinteticos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES97121976T Expired - Lifetime ES2155959T3 (es) 1991-06-20 1992-06-17 Oligonucleotidos cataliticos sinteticos.

Country Status (10)

Country Link
US (1) US5334711A (es)
EP (3) EP0519463B1 (es)
JP (3) JP3512818B2 (es)
AT (2) ATE172468T1 (es)
AU (1) AU658634B2 (es)
CA (1) CA2071446C (es)
DE (3) DE4216134A1 (es)
DK (2) DK0519463T3 (es)
ES (2) ES2155959T3 (es)
PT (1) PT845476E (es)

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