ES2112430T3 - Sulfonilalcanoilamino hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. - Google Patents
Sulfonilalcanoilamino hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.Info
- Publication number
- ES2112430T3 ES2112430T3 ES93920214T ES93920214T ES2112430T3 ES 2112430 T3 ES2112430 T3 ES 2112430T3 ES 93920214 T ES93920214 T ES 93920214T ES 93920214 T ES93920214 T ES 93920214T ES 2112430 T3 ES2112430 T3 ES 2112430T3
- Authority
- ES
- Spain
- Prior art keywords
- protease inhibitors
- sulfonilalcanoilamino
- retroviral protease
- sulfonamides useful
- hydroxyethylamino sulfonamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93507192A true | 1992-08-25 | 1992-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2112430T3 true ES2112430T3 (es) | 1998-04-01 |
Family
ID=25466549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93920214T Expired - Lifetime ES2112430T3 (es) | 1992-08-25 | 1993-08-24 | Sulfonilalcanoilamino hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. |
Country Status (14)
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
| US6743929B1 (en) * | 1992-08-25 | 2004-06-01 | G. D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| USRE43802E1 (en) | 1992-08-25 | 2012-11-13 | G.D. Searle Llc | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US6022994A (en) * | 1992-08-25 | 2000-02-08 | G. D. Searle &. Co. | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| USRE43596E1 (en) | 1992-08-25 | 2012-08-21 | G.D. Searle Llc | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| AU669223B2 (en) * | 1992-08-25 | 1996-05-30 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| US6004957A (en) * | 1995-06-07 | 1999-12-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| US5783701A (en) * | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| DE69326077D1 (de) * | 1992-10-30 | 1999-09-23 | Searle & Co | Sulfonylalkanoylaminohydroxyethylaminosulfaminsäuren verwendbar als inhibitoren retroviraler proteasen |
| US6337398B1 (en) * | 1992-10-30 | 2002-01-08 | G.D. Searle & Co. | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors |
| US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US6716991B1 (en) | 1993-11-30 | 2004-04-06 | G. D. Searle & Co. | Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation |
| DE69512220D1 (en) * | 1994-03-07 | 1999-10-21 | Vertex Pharma | Sulfonamidderivate als aspartylprotease-inhibitoren |
| WO1995033464A2 (en) * | 1994-06-03 | 1995-12-14 | G.D. Searle & Co. | Retroviral protease inhibitor combinations |
| WO1996022287A1 (en) | 1995-01-20 | 1996-07-25 | G.D. Searle & Co. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
| US6169085B1 (en) | 1995-03-10 | 2001-01-02 | G. D. Searle & Company | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5705500A (en) * | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6667307B2 (en) | 1997-12-19 | 2003-12-23 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6861539B1 (en) | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6143788A (en) * | 1995-03-10 | 2000-11-07 | G.D. Searle & Co. | Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors |
| US6150556A (en) | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| EP1188766A1 (en) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5985870A (en) * | 1995-03-10 | 1999-11-16 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US7339078B2 (en) | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
| WO1997018205A1 (en) * | 1995-11-15 | 1997-05-22 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| DE69608121D1 (de) * | 1995-11-16 | 2000-06-08 | Searle & Co | N-geschützte/n-substituierte beta-aminohydroxysulfonate |
| US6653331B2 (en) * | 1996-07-03 | 2003-11-25 | Pharmacia & Upjohn Company | Targeted drug delivery using sulfonamide derivatives |
| US20030207813A1 (en) * | 1996-12-09 | 2003-11-06 | G.D. Searle | Retroviral protease inhibitor combinations |
| GB9702194D0 (en) | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| OA11573A (en) | 1998-06-19 | 2004-07-01 | Vertex Pharma | Sulfonamide inhibitors of aspartyl protease. |
| WO2000002862A1 (en) * | 1998-07-08 | 2000-01-20 | G.D. Searle & Co. | Retroviral protease inhibitors |
| DK1181323T3 (da) | 1999-02-01 | 2011-10-17 | Eidgenoess Tech Hochschule | Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper |
| US7291673B2 (en) * | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| EP1637518A3 (en) * | 1999-02-12 | 2013-04-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
| US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
| US6548706B2 (en) * | 1999-12-23 | 2003-04-15 | Aerojet Fine Chemicals Llc | Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| US6737420B2 (en) | 2000-03-23 | 2004-05-18 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| PE02762002A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
| US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| EP1666452A2 (en) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| WO2002002506A2 (en) | 2000-06-30 | 2002-01-10 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
| US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| US7132475B2 (en) * | 2000-10-19 | 2006-11-07 | Ecole Polytechnique Federale De Lausanne | Block copolymers for multifunctional self-assembled systems |
| US6506786B2 (en) | 2001-02-13 | 2003-01-14 | Pharmacor Inc. | HIV protease inhibitors based on amino acid derivatives |
| US20030044468A1 (en) * | 2001-03-20 | 2003-03-06 | Francesco Cellesi | Two-phase processing of thermosensitive polymers for use as biomaterials |
| AR035960A1 (es) * | 2001-04-23 | 2004-07-28 | Elan Pharm Inc | Epoxidos sustituidos y procesos para prepararlos |
| US6982264B2 (en) * | 2001-06-27 | 2006-01-03 | Elan Pharmaceuticals, Inc. | Substituted alcohols useful in treatment of Alzheimer's disease |
| US20030179692A1 (en) * | 2002-03-19 | 2003-09-25 | Yoshitaka Ohotomo | Storage medium |
| EP1565428A1 (en) * | 2002-11-27 | 2005-08-24 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
| US7388008B2 (en) * | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| EP1855672A4 (en) * | 2005-03-11 | 2011-11-30 | Glaxosmithkline Llc | Hiv protease inhibitors |
| EP1877091B1 (en) * | 2005-04-27 | 2015-03-25 | TaiMed Biologics, Inc. | Method for improving pharmacokinetics of protease inhibitors and protease inhibitor precursors |
| US9505867B2 (en) * | 2005-05-31 | 2016-11-29 | Ecole Polytechmique Fédérale De Lausanne | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| ES2452718T3 (es) * | 2005-11-30 | 2014-04-02 | Taimed Biologics, Inc. | Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación |
| CN102083793A (zh) * | 2006-09-21 | 2011-06-01 | 安布林生物制药公司 | 蛋白酶抑制剂 |
| ES2428569T3 (es) | 2007-06-18 | 2013-11-08 | Lg Electronics Inc. | Procedimiento para llevar a cabo una sincronización de enlace ascendente en un sistema de comunicación inalámbrica |
| ES2390645T3 (es) * | 2008-06-05 | 2012-11-15 | Asahi Kasei Pharma Corporation | Compuesto de sulfonamida y su aplicación |
| EP2356228A4 (en) | 2008-11-25 | 2015-05-13 | Cole Polytechnique Fédérale De Lausanne Epfl | Block copolymers and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3269604D1 (de) * | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| DE3377497D1 (de) * | 1982-09-15 | 1988-09-01 | Haessle Ab | Enzyme inhibitors |
| US4668770A (en) * | 1982-12-27 | 1987-05-26 | Merck & Co., Inc. | Renin inhibitory tripeptides |
| DE3381565D1 (de) * | 1982-12-27 | 1990-06-21 | Merck & Co Inc | Reninhemmende tripeptide. |
| EP0316965A3 (en) * | 1983-02-07 | 1989-08-09 | Aktiebolaget Hässle | Enzyme inhibitors |
| JPS59227851A (en) * | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | Peptides having inhibitory action on renin |
| US4514391A (en) * | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
| US4477441A (en) * | 1983-09-14 | 1984-10-16 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal disulfide cycle |
| US4645759A (en) * | 1984-06-22 | 1987-02-24 | Abbott Laboratories | Renin inhibiting compounds |
| US4616088A (en) * | 1984-10-29 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitor |
| US4977277A (en) * | 1988-05-09 | 1990-12-11 | Abbott Laboratories | Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof |
| US4599198A (en) | 1985-08-02 | 1986-07-08 | Pfizer Inc. | Intermediates in polypeptide synthesis |
| US4668769A (en) * | 1985-08-02 | 1987-05-26 | Hoover Dennis J | Oxa- and azahomocyclostatine polypeptides |
| CA1282549C (en) * | 1985-11-12 | 1991-04-02 | Eric M. Gordon | Aminocarbonyl renin inhibitors |
| US4757050A (en) * | 1985-12-23 | 1988-07-12 | E. R. Squibb Sons, Inc. | Ureido renin inhibitors |
| CA1297631C (en) * | 1985-12-23 | 1992-03-17 | Sesha I. Natarajan | Ureido renin inhibitors |
| US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
| DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
| NL8800100A (nl) | 1987-01-21 | 1988-08-16 | Sandoz Ag | Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten. |
| USH725H (en) * | 1987-02-26 | 1990-01-02 | E. R. Squibb & Sons, Inc. | Ureido amino and imino acids, compositions and methods for use |
| GB8707412D0 (en) * | 1987-03-27 | 1987-04-29 | Fujisawa Pharmaceutical Co | Peptide compounds |
| FR2620451B1 (fr) | 1987-09-15 | 1993-12-24 | Sandoz Sa | Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments |
| IL89900D0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| IL90218D0 (en) * | 1988-05-13 | 1989-12-15 | Abbott Lab | Retroviral protease inhibitors |
| CA1340588C (en) | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| IL91307D0 (en) * | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
| CA2012306A1 (en) * | 1989-03-28 | 1990-09-28 | Werner Neidhart | Amino acid derivatives |
| JP2701932B2 (ja) * | 1989-04-10 | 1998-01-21 | サントリー株式会社 | タンパク質分解酵素阻害剤 |
| DE3912829A1 (de) * | 1989-04-19 | 1990-10-25 | Bayer Ag | Verwendung von renininhibitorischen peptiden als mittel gegen retroviren |
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| TW225540B (patent-search.search_20190331_RC00) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
| AU9125191A (en) * | 1990-11-19 | 1992-06-11 | Monsanto Company | Retroviral protease inhibitors |
| ES2059295T3 (es) * | 1990-11-19 | 1998-06-01 | Monsanto Co | Inhibidores de las proteasas retrovirales. |
| AU669223B2 (en) * | 1992-08-25 | 1996-05-30 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| EP0656887B1 (en) * | 1992-08-25 | 1998-10-28 | G.D. SEARLE & CO. | Hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| DE69326077D1 (de) * | 1992-10-30 | 1999-09-23 | Searle & Co | Sulfonylalkanoylaminohydroxyethylaminosulfaminsäuren verwendbar als inhibitoren retroviraler proteasen |
-
1993
- 1993-08-24 AU AU50820/93A patent/AU669223B2/en not_active Expired
- 1993-08-24 WO PCT/US1993/007816 patent/WO1994004493A1/en active IP Right Grant
- 1993-08-24 DK DK93920214T patent/DK0656888T3/da active
- 1993-08-24 RU RU95106996A patent/RU2146668C1/ru active
- 1993-08-24 CA CA 2140928 patent/CA2140928C/en not_active Expired - Lifetime
- 1993-08-24 DE DE1993616223 patent/DE69316223D1/de not_active Expired - Lifetime
- 1993-08-24 US US08/110,913 patent/US5521219A/en not_active Expired - Lifetime
- 1993-08-24 EP EP19930920214 patent/EP0656888B1/en not_active Expired - Lifetime
- 1993-08-24 ES ES93920214T patent/ES2112430T3/es not_active Expired - Lifetime
- 1993-08-24 AT AT93920214T patent/AT161828T/de unknown
- 1993-08-24 DE DE1993616223 patent/DE69316223T2/de not_active Expired - Lifetime
- 1993-08-24 JP JP50653294A patent/JP4091654B2/ja not_active Expired - Lifetime
-
1995
- 1995-02-14 NO NO950550A patent/NO303540B1/no not_active IP Right Cessation
- 1995-02-14 FI FI950651A patent/FI120343B/fi not_active IP Right Cessation
- 1995-05-31 US US08/455,947 patent/US5510388A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,051 patent/US5508294A/en not_active Expired - Lifetime
-
1996
- 1996-01-17 US US08/587,688 patent/US5639769A/en not_active Expired - Lifetime
-
1997
- 1997-06-06 US US08/867,430 patent/US5760064A/en not_active Expired - Lifetime
-
1998
- 1998-01-21 GR GR980400128T patent/GR3025958T3/el unknown
- 1998-03-26 US US09/048,034 patent/US5965588A/en not_active Expired - Lifetime
-
1999
- 1999-07-13 US US09/352,215 patent/US6147117A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5508294A (en) | 1996-04-16 |
| CA2140928A1 (en) | 1994-02-26 |
| JP4091654B2 (ja) | 2008-05-28 |
| DE69316223T2 (de) | 1998-05-28 |
| FI120343B1 (patent-search.search_20190331_RC00) | |
| US5521219A (en) | 1996-05-28 |
| NO303540B1 (no) | 1998-07-27 |
| DK0656888T3 (da) | 1998-02-09 |
| US5965588A (en) | 1999-10-12 |
| EP0656888B1 (en) | 1998-01-07 |
| NO950550A (no) | 1995-02-14 |
| EP0656888A1 (en) | 1995-06-14 |
| CA2140928C (en) | 2008-01-29 |
| FI950651A (fi) | 1995-02-14 |
| US5639769A (en) | 1997-06-17 |
| RU95106996A (ru) | 1996-11-20 |
| GR3025958T3 (en) | 1998-04-30 |
| US6147117A (en) | 2000-11-14 |
| JPH08500825A (ja) | 1996-01-30 |
| RU2146668C1 (ru) | 2000-03-20 |
| DE69316223D1 (de) | 1998-02-12 |
| US5510388A (en) | 1996-04-23 |
| US5760064A (en) | 1998-06-02 |
| AT161828T (de) | 1998-01-15 |
| WO1994004493A1 (en) | 1994-03-03 |
| AU669223B2 (en) | 1996-05-30 |
| FI950651A0 (fi) | 1995-02-14 |
| FI950651D0 (patent-search.search_20190331_RC00) | |
| NO950550D0 (no) | 1995-02-14 |
| FI120343B (fi) | 2009-09-30 |
| DK656888T3 (patent-search.search_20190331_RC00) | |
| AU5082093A (en) | 1994-03-15 |
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| Date | Code | Title | Description |
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| FG2A | Definitive protection |
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