ES2085035T3 - Soporte de particulas solidas de lipidos para medicamentos (nanoesferas solidas de lipidos (sln)). - Google Patents

Soporte de particulas solidas de lipidos para medicamentos (nanoesferas solidas de lipidos (sln)).

Info

Publication number
ES2085035T3
ES2085035T3 ES92919477T ES92919477T ES2085035T3 ES 2085035 T3 ES2085035 T3 ES 2085035T3 ES 92919477 T ES92919477 T ES 92919477T ES 92919477 T ES92919477 T ES 92919477T ES 2085035 T3 ES2085035 T3 ES 2085035T3
Authority
ES
Spain
Prior art keywords
solid lipid
sln
spheres
medicines
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92919477T
Other languages
English (en)
Other versions
ES2085035T5 (es
Inventor
Stefan Lucks
Rainer Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Original Assignee
Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6441225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2085035(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medac Gesellschaft fuer Klinische Spezialpraeparate mbH filed Critical Medac Gesellschaft fuer Klinische Spezialpraeparate mbH
Application granted granted Critical
Publication of ES2085035T3 publication Critical patent/ES2085035T3/es
Publication of ES2085035T5 publication Critical patent/ES2085035T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides

Abstract

LOS SOPORTES DE MEDICACION DISPONEN DE PARTICULAS OBTENIDAS A PARTIR DE MATERIALES LIPIDOS, SIMILARES A LIPIDOS (LIPOIDES) O MEZCLA DE ELLOS, CON UN DIAMETRO DESDE 10 NM HASTA 10 MICRAS, QUE SON SOLIDOS A TEMPERATURA AMBIENTE. DEBIDO A SU NUCLEO SOLIDO, ESTOS SOPORTES DE MEDICACION PERMITEN SUSTANCIAS ACTIVAS QUE SON CONTROLADAS UNA VEZ LIBERADAS DURANTE UN LARGO PERIODO, PERMITIENDO A LOS MEDICAMENTOS HIDROFILICOS QUE SEAN INCORPORADOS EN EL NUCLEO SOLIDO Y SEAN DE DESCOMPOSICION RELATIVAMENTE RAPIDA, NO PRODUCIENDO PRODUCTOS TOXICOS.
ES92919477T 1991-09-18 1992-09-16 Soporte de particulas solidas de lipidos para medicamentos (nanoesferas solidas de lipidos (sln)). Expired - Lifetime ES2085035T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4131562A DE4131562A1 (de) 1991-09-18 1991-09-18 Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)

Publications (2)

Publication Number Publication Date
ES2085035T3 true ES2085035T3 (es) 1996-05-16
ES2085035T5 ES2085035T5 (es) 1999-06-16

Family

ID=6441225

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92919477T Expired - Lifetime ES2085035T5 (es) 1991-09-18 1992-09-16 Soporte de particulas solidas de lipidos para medicamentos (nanoesferas solidas de lipidos (sln)).

Country Status (13)

Country Link
EP (1) EP0605497B2 (es)
JP (1) JP2683575B2 (es)
KR (1) KR0141504B1 (es)
AT (1) ATE135567T1 (es)
AU (1) AU672177B2 (es)
CA (1) CA2119253C (es)
CZ (1) CZ289253B6 (es)
DE (2) DE4131562A1 (es)
DK (1) DK0605497T4 (es)
ES (1) ES2085035T5 (es)
GR (2) GR3019750T3 (es)
HU (1) HU227680B1 (es)
WO (1) WO1993005768A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4308282C2 (de) * 1993-03-16 1994-12-22 Beiersdorf Ag Vorzugsweise in Form von Mikrosphärulen vorliegende galenische Matrices
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
DE4336407A1 (de) * 1993-10-21 1995-04-27 Rotring Int Gmbh Wasserfeste Kosmetik
CA2214029A1 (en) * 1995-04-25 1996-10-31 Magda Marquet Single-vial formulations of dna/lipid complexes
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
EP1010435B1 (en) * 1997-09-05 2010-11-03 Maruho K.K. Nanocapsule preparations for treating intraarticular diseases
IT1296914B1 (it) 1997-12-01 1999-08-03 Maria Rosa Gasco Composizione farmaceutica comprendente microparticelle atte al passaggio transmucosale ed al superamento della barriera
US8415329B1 (en) 1998-05-29 2013-04-09 Jagotec Ag Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations
BR9915738A (pt) 1998-11-20 2001-10-02 Rtp Pharma Inc Micropartìculas estabilizadas em fosfolipìdeos dispersìveis
DE19856432A1 (de) 1998-12-08 2000-06-15 Basf Ag Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
KR20020011985A (ko) 1999-05-07 2002-02-09 파르마솔 게엠베하 액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법
US7431943B1 (en) * 1999-06-14 2008-10-07 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical compositions
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
BR0012445A (pt) * 1999-07-13 2002-04-02 Pharmasol Gmbh Agentes com ação absorvente e/ou refletora de radiação uv para proteção contra radiação uv nociva à saúde e para reforçar a barreira natural da pele
WO2002026272A1 (en) * 2000-09-29 2002-04-04 Salvona L.L.C. Multi component controlled release system for sanitary paper products
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
KR20010090030A (ko) * 2001-08-09 2001-10-18 임정옥 경피마취효과가 월등한 혼합형 마취제의 제형방법
KR100452165B1 (ko) * 2002-01-29 2004-10-08 주식회사 태평양 리포펩티드계 보조 계면활성제를 이용한 나노에멀젼 및이를 함유하는 화장료 조성물
DE10312763A1 (de) 2003-03-21 2004-09-30 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Verfahren zur Herstellung einer SLN-Dispersion
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
US8716214B2 (en) 2003-05-07 2014-05-06 Otc Gmbh Compositions for the targetted release of fragrances and aromas
FR2864900B1 (fr) * 2004-01-09 2007-10-12 Oreal Dispersion aqueuse de nanocapsules a coeur huileux
MXPA06010950A (es) * 2004-03-26 2007-04-16 Cell Therapeutics Europe Srl Formulaciones en nano-particulas de compuestos de platino.
EP1674081A1 (de) 2004-12-23 2006-06-28 KTB Tumorforschungsgesellschaft mbH Herstellung von lipidbasierten Nanopartikeln unter Einsatz einer dualen asymmetrischen Zentrifuge
JP4533185B2 (ja) * 2005-02-24 2010-09-01 花王株式会社 固体脂質粒子製剤
BRPI0611433A2 (pt) * 2005-05-05 2010-09-08 Sanofi Aventis Us Llc formulações estáveis de nanopartìcula
CA2627459C (en) 2005-10-25 2011-08-09 Evonik Degussa Gmbh Preparations containing hyperbranched polymers
ITMI20061274A1 (it) * 2006-06-30 2008-01-01 Consiglio Nazionale Ricerche Vettori nanoparticellari lipidici contenenti riluzolo e composizioni farmaceutiche che li contengono
US9114077B2 (en) 2006-11-17 2015-08-25 Abbvie Deutschland Gmbh & Co Kg Nanocrystals for use in topical cosmetic formulations and method of production thereof
EP1982698A1 (de) * 2007-04-18 2008-10-22 Evonik Degussa GmbH Präparate zur gesteuerten Freisetzung von bioaktiven Naturstoffen
EP2108361A1 (de) * 2008-04-09 2009-10-14 ROVI Cosmetics International GmbH Emulgierende Mikropartikel aus Lipiden zur Stabilisierung lipophiler Wirkstoffe für die kosmetische Anwendung
EP2218447B1 (en) 2008-11-04 2017-04-19 PharmaSol GmbH Compositions containing lipid micro- or nanoparticles for the enhancement of the dermal action of solid particles
FR2950253B1 (fr) 2009-09-24 2011-09-23 Ethypharm Sa Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
ES2384060B1 (es) 2010-03-24 2013-09-23 Lipotec S.A. Cápsulas de nanopartículas lipídicas.
GB201021937D0 (en) * 2010-12-24 2011-02-02 Reckitt & Colman Overseas Skin sanitizer compositions comprising alcohol based emulsion
CA2821061A1 (en) 2010-12-28 2012-07-05 Unilever Plc Method for production of an emulsion
US20140079785A1 (en) * 2011-03-24 2014-03-20 Leo Pharma A/S Composition comprising lipid nanoparticles and a corticosteroid or vitamin d derivative
DE102011018499A1 (de) 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
DE102011116069A1 (de) 2011-10-18 2013-04-18 Dr. Rimpler Gmbh Lipidnanopartikeldispersion, Verfahren zu deren Herstellung sowie ihre Verwendung
ITBO20130376A1 (it) 2013-07-18 2015-01-19 Ferbi Srl Metodo per la preparazione di nanoparticelle lipidiche solide contenenti anticorpi in forma di coppia ionica, mediante la tecnica della coacervazione degli acidi grassi
WO2016100228A2 (en) * 2014-12-15 2016-06-23 Nanosphere Health Sciences, Llc Methods of treating inflammatory disorders and global inflammation with compositions comprising phospholipid nanoparticle encapsulations of nsaids
CA3089686A1 (en) 2015-03-10 2016-09-15 Nanosphere Health Sciences, Llc A nanoparticle drug delivery comprising liquid lipids and cannabinoids encapsulated in a single layer of essential phospholipids
CZ307681B6 (cs) 2016-02-29 2019-02-13 Ústav makromolekulární chemie AV ČR, v. v. i. Fotoaktivovatelná nanočástice pro fotodynamické aplikace, způsob její přípravy, farmaceutická kompozice ji obsahující a jejich použití
WO2019116062A1 (en) 2017-12-12 2019-06-20 Lead Biotherapeutics Ltd. Solid lipid nanoparticle for intracellular release of active substances and method for production the same
US11504327B1 (en) 2019-01-21 2022-11-22 Eric Morrison Method of preparing nanoparticles by hot-melt extrusion
IT201900009258A1 (it) 2019-06-17 2020-12-17 R Bio Transfer S R L Metodo per la preparazione di nanoparticelle lipidiche
IT201900013353A1 (it) 2019-07-30 2021-01-30 Univ Della Calabria Sistema di veicolazione di olio essenziale di bergamotto basato su nanotecnologie, metodo di preparazione del sistema e suoi usi.
US20230000980A1 (en) 2021-06-30 2023-01-05 Novocure Gmbh Compositions and methods for using alternating electric fields to disrupt lipid capsules
IT202100023570A1 (it) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente Metodo per la preparazione di nanoparticelle lipidiche
DE202023100649U1 (de) 2023-02-10 2023-03-22 Cineolux Gmbh Dispersion und Zubereitung zur topischen Anwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
AU645003B2 (en) * 1988-11-08 1994-01-06 Takeda Chemical Industries Ltd. Sustained release preparations
LU87410A1 (fr) * 1988-12-20 1990-07-10 Cird Composition cosmetique ou pharmaceutique contenant des microspheres de polymeres ou de corps gras chargees d'au moins un produit actif
FR2651680B1 (fr) * 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.

Also Published As

Publication number Publication date
ES2085035T5 (es) 1999-06-16
JPH06510772A (ja) 1994-12-01
AU2561592A (en) 1993-04-27
ATE135567T1 (de) 1996-04-15
CA2119253A1 (en) 1993-04-01
EP0605497A1 (de) 1994-07-13
DK0605497T3 (da) 1996-08-05
HU227680B1 (en) 2011-11-28
DK0605497T4 (da) 1999-10-25
CZ59694A3 (en) 1994-07-13
HU9400779D0 (en) 1994-06-28
CZ289253B6 (cs) 2001-12-12
GR3019750T3 (en) 1996-07-31
EP0605497B1 (de) 1996-03-20
HUT75165A (en) 1997-04-28
CA2119253C (en) 1998-11-03
DE4131562A1 (de) 1993-03-25
EP0605497B2 (de) 1999-04-14
JP2683575B2 (ja) 1997-12-03
WO1993005768A1 (de) 1993-04-01
AU672177B2 (en) 1996-09-26
KR0141504B1 (ko) 1998-06-01
DE59205783D1 (de) 1996-04-25
GR3030291T3 (en) 1999-09-30

Similar Documents

Publication Publication Date Title
ES2085035T3 (es) Soporte de particulas solidas de lipidos para medicamentos (nanoesferas solidas de lipidos (sln)).
ES2167308T3 (es) Un sistema de distribucion de fosfolipidos.
IT1243745B (it) Composizioni terapeutiche transdermali contenenti farmaco e/o agente promotore dell'assorbimento cutaneo supportato su particelle microporose e microsfere polimeriche e loro preparazione.
DE69835162D1 (de) Geschmacksmaskierte pharmazeutische zusammensetzungen
DE69219600D1 (de) Pharmazeutischer träger
JPS6452458A (en) Multilayer administration system
FR2622442B1 (fr) Supports de medicaments
AR002009A1 (es) Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.
ES2134501T5 (es) Composicion farmaceutica conteniendo un soporte fundible y procedimiento para su fabricacion.
ES2193161T3 (es) Procedimiento para preparar microesferas lipidicas rellenas de gas y microesferas lipidicas relleneas de gas.
FR2683146B1 (fr) Compositions pharmaceutiques a liberation reglee de la substance medicamenteuse.
ATE162072T1 (de) Kleine partikeln enthaltende arzneistoffzusammensetzung
ATE464885T1 (de) Verfahern zur herstellung von festen verabreichungssystemen für eingekapselte und nicht-eingekapselte pharmazeutische wirkstoffe
ES2149164T3 (es) Nanoparticulas de farmacos de superficie modificada.
ES2029880T3 (es) Dispositivo de liberacion de productos farmaceuticos.
ES2145992T3 (es) Forma medicamentosa que sirve para administrar sustancias activas a las heridas.
ATE290854T1 (de) Carbamazepinformulierung mit verzögerter freigabe
SE9704400D0 (sv) Porous inorganic particles as carriers for drug substances
YU48228B (sh) Transdermalni sistem sa stupnjevitim otpuštanjem aktivne materije
ATE87467T1 (de) Pharmazeutische zubereitung.
DK165044C (da) Indretning til intraruminal indgivelse af medikamenter
ES2054029T3 (es) Formulacion de acetato de flecainida con liberacion controlada.
CO4230076A1 (es) Proceso de infusion termica para preparar formas de medica- mentos de dosis solidas con liberacion controlada para ad- ministracion oral y los medicamentos preparados mediante es- te proceso.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 605497

Country of ref document: ES