ES2072982T3 - Nuevo procedimiento para la preparacion de un derivado antihipertensivo de benzopirano. - Google Patents

Nuevo procedimiento para la preparacion de un derivado antihipertensivo de benzopirano.

Info

Publication number
ES2072982T3
ES2072982T3 ES90307975T ES90307975T ES2072982T3 ES 2072982 T3 ES2072982 T3 ES 2072982T3 ES 90307975 T ES90307975 T ES 90307975T ES 90307975 T ES90307975 T ES 90307975T ES 2072982 T3 ES2072982 T3 ES 2072982T3
Authority
ES
Spain
Prior art keywords
preparation
benzopirano
hypertensive
derivative
new procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90307975T
Other languages
English (en)
Inventor
Tibor Timar
Tibor Eszenyi
Peter Sebok
Vilmos Galamb
Julia Fazekas
Terezia Istvan
Eva Kovach
Erika Nagy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkaloida Chemical Co Zrt
Original Assignee
Alkaloida Chemical Co Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Chemical Co Zrt filed Critical Alkaloida Chemical Co Zrt
Application granted granted Critical
Publication of ES2072982T3 publication Critical patent/ES2072982T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

EL INVENTO SE REFIERE A UN PROCESO PARA LA PREPARACION (MAS O MENOS ) RANS LA FORMULA (I), QUE COMPRENDE LA REACCION DEL 4 CIANO DE LA FORMULA (I) CON ISOPRENO A 30 PRESENCIA DE METALES ALCALI Y/O CATALIZADORES, LO QUE PRODUCE BENZOPIRAN AM O POR BROMINACION DE LOS COMPUESTOS OBTENIDOS DE LA FORMULA (X); A) PREPARAR EN UN PASO 6 UN SOLVENTE A 0 ON 2 OMO CIANO SE HACE REACCIONAR CON 2 PIRROLIDONA, EN PRESENCIA DE METALES ALCALI A 20 LA (VI).
ES90307975T 1989-07-21 1990-07-20 Nuevo procedimiento para la preparacion de un derivado antihipertensivo de benzopirano. Expired - Lifetime ES2072982T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU893699A HU207861B (en) 1989-07-21 1989-07-21 Process for producing benzopirane derivative of blood pressure lowering activity

Publications (1)

Publication Number Publication Date
ES2072982T3 true ES2072982T3 (es) 1995-08-01

Family

ID=10965123

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90307975T Expired - Lifetime ES2072982T3 (es) 1989-07-21 1990-07-20 Nuevo procedimiento para la preparacion de un derivado antihipertensivo de benzopirano.

Country Status (12)

Country Link
US (1) US5145985A (es)
EP (1) EP0409651B1 (es)
JP (1) JPH0358988A (es)
CZ (1) CZ283969B6 (es)
DE (1) DE69019080T2 (es)
ES (1) ES2072982T3 (es)
HU (1) HU207861B (es)
IL (1) IL95143A (es)
PL (1) PL286145A1 (es)
RU (2) RU2036196C1 (es)
SK (1) SK362990A3 (es)
YU (1) YU139090A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391815A (en) * 1976-04-02 1983-07-05 Beecham Group Limited Cyanobenzano[b]pyrans
DE2851207A1 (de) * 1977-12-06 1979-06-07 Garcia De Lama Javier Verfahren zur herstellung substituierter 4h-pyran-4-one
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds
HU194214B (en) * 1983-02-15 1988-01-28 Alkaloida Vegyeszeti Gyar Process for producing 7-alkoxy-2h-chromene derivatives and insecticide and nematocide compositions containing them as active components
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds

Also Published As

Publication number Publication date
PL286145A1 (en) 1991-07-15
EP0409651B1 (en) 1995-05-03
DE69019080D1 (de) 1995-06-08
YU139090A (sh) 1993-05-28
CZ362990A3 (cs) 1998-03-18
EP0409651A1 (en) 1991-01-23
IL95143A (en) 1996-10-31
SK278873B6 (sk) 1998-04-08
JPH0358988A (ja) 1991-03-14
RU2041223C1 (ru) 1995-08-09
HU207861B (en) 1993-06-28
SK362990A3 (en) 1998-04-08
CZ283969B6 (cs) 1998-07-15
IL95143A0 (en) 1991-06-10
HUT58321A (en) 1992-02-28
DE69019080T2 (de) 1995-11-02
RU2036196C1 (ru) 1995-05-27
US5145985A (en) 1992-09-08

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