ES2057608T3 - Derivado de 1-fenilalquil-3-fenilurea. - Google Patents

Derivado de 1-fenilalquil-3-fenilurea.

Info

Publication number
ES2057608T3
ES2057608T3 ES91100515T ES91100515T ES2057608T3 ES 2057608 T3 ES2057608 T3 ES 2057608T3 ES 91100515 T ES91100515 T ES 91100515T ES 91100515 T ES91100515 T ES 91100515T ES 2057608 T3 ES2057608 T3 ES 2057608T3
Authority
ES
Spain
Prior art keywords
integer
alkyl
phenylalkyl
alkoxyl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91100515T
Other languages
English (en)
Inventor
Tetsuo Sekiya
Shinya Inoue
Chiaki Hyodo
Hiromi Okushima
Kohei Umezu
Kazuo Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Application granted granted Critical
Publication of ES2057608T3 publication Critical patent/ES2057608T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

UN DERIVADO NOVEL 1-FENILALQUIL-3-FENILUREA REPRESENTADO POR LA SIGUIENTE FORMULA (I): EN DONDE R ELEVADO A 1 Y R ELEVADO A 6 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO, C SUB 1 UB 5 ALQUILO, C SUB 1 REPRESENTA HIDROGENO O C SUB 1 3 REPRESENTA C SUB 1 ENTA JUNTO CON R ELEVADO A 2 C SUB 2 EVADO A 4 Y R ELEVADO A 5 REPRESENTAN INDEPENDIENTEMENTE C SUB 1 ESENTA OXIGENO O SULFURO; Y REPRESENTA -O-(CH SUB 2) SUB L-O EN DONDE L ES UN NUMERO ENTERO DE 1 A 3 O -(CH SUB 2) SUB P DONDE P ES UN NUMERO ENTERO DE 3 A 5; M ES O O UN NUMERO ENTERO DE 1 A 5; N ES O O UN NUMERO ENTERO DE 1 A 3. EL DERIVADO (I) I-FENILALQUIL-3-FENILUREA ACTUA REDUCIENDO EL COLESTEROL EN SANGRE POR INHIBICION ACAT, Y POR TANTO UTIL PARA EL TRATAMIENTO HYPERLIPEMIA Y ARTEROSCLEROSIS.
ES91100515T 1990-01-22 1991-01-17 Derivado de 1-fenilalquil-3-fenilurea. Expired - Lifetime ES2057608T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1223590 1990-01-22
JP2876890 1990-02-08

Publications (1)

Publication Number Publication Date
ES2057608T3 true ES2057608T3 (es) 1994-10-16

Family

ID=26347808

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91100515T Expired - Lifetime ES2057608T3 (es) 1990-01-22 1991-01-17 Derivado de 1-fenilalquil-3-fenilurea.

Country Status (10)

Country Link
US (1) US5202351A (es)
EP (1) EP0439059B1 (es)
JP (1) JPH05310678A (es)
KR (1) KR910014366A (es)
AT (1) ATE110375T1 (es)
AU (1) AU636946B2 (es)
CA (1) CA2034673A1 (es)
DE (1) DE69103535T2 (es)
DK (1) DK0439059T3 (es)
ES (1) ES2057608T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100915A (en) * 1991-02-19 1996-03-31 Erba Carlo Spa Double-transformed urea and theories, their preparation and pharmaceutical preparations containing them
JPH07503737A (ja) * 1992-05-28 1995-04-20 フアイザー・インコーポレイテツド アシル補酵素ａ：コレステロールアシルトランスフェラーゼ（ａｃａｔ）の阻害剤としての新規なｎ−アリールおよびｎ−ヘテロアリール尿素誘導体
CA2107196A1 (en) * 1992-09-29 1994-03-30 Mitsubishi Chemical Corporation Carboxamide derivatives
US5534529A (en) * 1993-06-30 1996-07-09 Sankyo Company, Limited Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
US6133326A (en) 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
CA2185737A1 (en) * 1995-09-18 1997-03-19 Akira Yoshida Amid and urea derivatives
EP0773218A1 (en) * 1995-11-13 1997-05-14 Mitsubishi Chemical Corporation N-(Piperazinylalkoxyphenyl)-N'phenylalkylurea derivatives as ACAT inhibitors for the treatment of atheroschlerosis
AP2002002612A0 (en) * 2000-02-02 2002-09-30 Warner Lambert Co Dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders
WO2005044814A1 (en) 2003-11-07 2005-05-19 F. Hoffmann-La Roche Ag BENZO [b][1,4] DIOXEPINE DERIVATIVES

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2485600A (en) * 1946-04-01 1949-10-25 Harold W Moburg Derivatives of safrol and isosafrol
FR6183M (es) * 1967-03-10 1968-07-15
US4102673A (en) * 1971-06-21 1978-07-25 Hercules Incorporated 1-Phenyl-hexyl ureas as herbicides
JPS5312844A (en) * 1976-07-20 1978-02-04 Nippon Tokushu Noyaku Seizo Kk Nn44halogenobenzyllnnmethyl*or nonsubstitutedd*cycloalkylln**phenylurea or thiourea compounds* their preparation and fungicides containing the same as active constituents
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
US4473579A (en) * 1982-01-26 1984-09-25 American Cyanamid Company Antiatherosclerotic tetrasubstituted ureas and thioureas
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
DE68911203T2 (de) * 1988-03-30 1994-04-14 Warner Lambert Co N-[[(2,6-disubstituierte)phenyl]N'- arylalkyl] Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.
IL89997A0 (en) * 1988-04-25 1989-12-15 Lilly Co Eli Propanamine derivatives
JPH02124884A (ja) * 1988-07-08 1990-05-14 Zhongguo Yixuekexueyuan Yaowo Yanjiusuo Ｎ―置換アミド誘導体
CA2010184A1 (en) * 1989-02-17 1990-08-17 Bharat K. Trivedi Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds
CA2022346A1 (en) * 1989-08-04 1991-02-05 Mitsubishi Chemical Corporation 1-phenylalkyl-3-phenylurea derivatives

Also Published As

Publication number Publication date
AU6948291A (en) 1991-07-25
EP0439059B1 (en) 1994-08-24
DK0439059T3 (da) 1994-12-19
ATE110375T1 (de) 1994-09-15
EP0439059A3 (en) 1991-11-13
CA2034673A1 (en) 1991-07-23
KR910014366A (ko) 1991-08-31
JPH05310678A (ja) 1993-11-22
EP0439059A2 (en) 1991-07-31
DE69103535T2 (de) 1995-01-26
AU636946B2 (en) 1993-05-13
DE69103535D1 (de) 1994-09-29
US5202351A (en) 1993-04-13

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